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    1.
    发明专利
    未知

    公开(公告)号：DK69589A

    公开(公告)日：1989-08-17

    申请号：DK69589

    申请日：1989-02-15

    Applicant: HOECHST AG

    Inventor： RIPPEL ROBERT ,  FLEMMING HANS-WOLFRAM ,  RUKWIED MANFRED

    IPC: C07D333/36 ,  C07D333/38 ,  C07D333/48

    Abstract: Thiophene derivatives with an optionally substituted amino group on the thiophene ring are prepared by dehydrogenation of dihydrothiophenes which are substituted in the same manner as the desired thiophene derivatives, using H2O2, the dihydrothiophenes being reacted in a first reaction step with H2O2 in neutral medium to give the corresponding sulphoxides, and, in the second reaction step, these are then rearranged with acid to give the thiophene derivatives. The dihydrothiophene-1-oxides which are formed in this process as intermediates are novel compounds. They, and equally the thiophene derivatives obtained from them by rearrangement with acid, are intermediates mainly in the crop protection agent sector and pharmaceutical sector.

    Process for the preparation of thiophene derivatives and also dihydrothiophene 1-oxides
    2.
    发明专利
    Process for the preparation of thiophene derivatives and also dihydrothiophene 1-oxides 未知

    公开(公告)号：IE63074B1

    公开(公告)日：1995-03-22

    申请号：IE483889

    申请日：1989-02-14

    Applicant: HOECHST AG

    Inventor： RIPPEL ROBERT ,  FLEMMING HANS-WOLFRAM ,  RUKWIED MANFRED

    IPC: C07D333/36 ,  C07D333/38 ,  C07D333/48

    Abstract: Thiophene derivatives with an optionally substituted amino group on the thiophene ring are prepared by dehydrogenation of dihydrothiophenes which are substituted in the same manner as the desired thiophene derivatives, using H2O2, the dihydrothiophenes being reacted in a first reaction step with H2O2 in neutral medium to give the corresponding sulphoxides, and, in the second reaction step, these are then rearranged with acid to give the thiophene derivatives. The dihydrothiophene-1-oxides which are formed in this process as intermediates are novel compounds. They, and equally the thiophene derivatives obtained from them by rearrangement with acid, are intermediates mainly in the crop protection agent sector and pharmaceutical sector.

    PROCESS FOR THE PREPARATION OF THIOPHENE DERIVATIVES AND ALSO NEW DIHYDROTHIOPHENE 1-OXIDES
    5.
    发明专利
    PROCESS FOR THE PREPARATION OF THIOPHENE DERIVATIVES AND ALSO NEW DIHYDROTHIOPHENE 1-OXIDES 未知

    公开(公告)号：AU612788B2

    公开(公告)日：1991-07-18

    申请号：AU2997689

    申请日：1989-02-15

    Applicant: HOECHST AG

    Inventor： RIPPEL ROBERT ,  FLEMMING HANS-WOLFRAM ,  RUKWIED MANFRED

    IPC: C07D333/36 ,  C07D333/38 ,  C07D333/48

    Abstract: Thiophene derivatives with an optionally substituted amino group on the thiophene ring are prepared by dehydrogenation of dihydrothiophenes which are substituted in the same manner as the desired thiophene derivatives, using H2O2, the dihydrothiophenes being reacted in a first reaction step with H2O2 in neutral medium to give the corresponding sulphoxides, and, in the second reaction step, these are then rearranged with acid to give the thiophene derivatives. The dihydrothiophene-1-oxides which are formed in this process as intermediates are novel compounds. They, and equally the thiophene derivatives obtained from them by rearrangement with acid, are intermediates mainly in the crop protection agent sector and pharmaceutical sector.

    PROCESS FOR THE PREPARATION OF TRIPEPTIDES
    8.
    发明专利
    PROCESS FOR THE PREPARATION OF TRIPEPTIDES 未知

    公开(公告)号：CA1335493C

    公开(公告)日：1995-05-09

    申请号：CA614545

    申请日：1989-09-29

    Applicant: HOECHST AG

    Inventor： FLEMMING HANS-WOLFRAM ,  RUKWIED MANFRED ,  SCHMIDT MANFRED

    IPC: C12P21/02 ,  C07K1/08 ,  C07K1/113 ,  C07K5/08 ,  C07K5/097

    Abstract: A process for the preparation of tripeptides A process for the preparation of tripeptides of the general formula I U - A - B - C - OH I in which U denotes hydrogen or a urethane protective group and A, B and C denote amino acids, by reaction of a compound of the general formula II U' - B - OH II in which U' is a urethane protective group which can be eliminated by hydrogenolysis, with a compound of the general formula III H - C - OR III in which R denotes alkyl, by the PPA method, elimination of U', reaction of the resulting compound with a compound of the general formula IV H - B - C - OR IV by the PPA method and subsequent enzymatic elimination of R. The tripeptides are intermediates used in the synthesis of bioactive peptides.

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