公开(公告)号：KR780000065B1

公开(公告)日：1978-03-30

申请号：KR700001164

申请日：1970-08-14

Applicant: HOECHST AG

Inventor： RUSCHIG HEINRICH ,  RIPPEL ROBERT ,  SCHOORR MANFRED ,  LINDNER ERNST

公开(公告)号：US3687977A

公开(公告)日：1972-08-29

申请号：US3687977D

申请日：1969-09-05

Applicant: HOECHST AG

Inventor： RIPPEL ROBERT ,  DITTMAR WALTER ,  SCHORR MANFRED

IPC: C07D333/36 ,  C07D333/38 ,  A61K27/00 ,  C07D63/16

CPC classification number: C07D333/36 ,  C07D333/38

Abstract: Thiophene-3-isonitriles of the formula IN WHICH R1 is hydrogen, alkyl, carbalkoxy, cyano or phenyl, R2 is hydrogen, alkyl, alkoxy, carbalkoxy, cyano or phenyl, R3 is hydrogen, alkyl, carbalkoxy or phenyl, or R2 and R3 together represent an alkylene chain, are disclosed as having antimycotic and antibacterial properties.

Abstract translation: 噻吩-3-异腈，其中R1是氢，烷基，烷氧基，氰基或苯基，R2是氢，烷基，烷氧基，烷氧基，氰基或苯基，R3是氢，烷基，烷氧基或苯基，或R2和R3 一起表示亚烷基链，被公开为具有抗真菌性和抗菌性。

公开(公告)号：OA9846A

公开(公告)日：1994-08-15

申请号：OA60452

申请日：1993-12-24

Applicant: HOECHST AG

Inventor： DURCKHEIMER WALTER ,  ISERT DIETER ,  RIPPEL ROBERT ,  RANGOONWALA RAMAZAN ,  DORNAUER HORST

IPC: A61K31/535 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C02F1/20 ,  C02F1/28 ,  C02F1/42 ,  C02F1/44 ,  C02F1/469 ,  C07D333/38 ,  C07D333/40 ,  C07D463/00 ,  C07D498/00 ,  C07D501/00 ,  C07D501/20 ,  C07D501/22 ,  C07D501/34 ,  C07D501/36 ,  C07D501/46 ,  C07D501/59 ,  C07D505/00 ,  C07D498/053

CPC classification number: C07D501/00 ,  C07D333/40

公开(公告)号：PL301623A1

公开(公告)日：1994-06-27

申请号：PL30162393

申请日：1993-12-23

Applicant: HOECHST AG

Inventor： DUERCKHEIMER WALTER ,  ISERT DIETER ,  RIPPEL ROBERT ,  RANGOONWALA RAMAZAN ,  DORNAUER HORST

IPC: A61K31/535 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C02F1/20 ,  C02F1/28 ,  C02F1/42 ,  C02F1/44 ,  C02F1/469 ,  C07D333/38 ,  C07D333/40 ,  C07D463/00 ,  C07D498/00 ,  C07D501/00 ,  C07D501/20 ,  C07D501/22 ,  C07D501/34 ,  C07D501/36 ,  C07D501/46 ,  C07D501/59 ,  C07D505/00

Abstract: The invention relates to cephalosporin salts of the general formula (I), [cephalosporin] x[BxH ] n (I> in which the salt-forming anion contains an antibiotically active cephalosporin having a group (m = 1) which is capable of anion formation, or having several groups of this nature (m = 2 or 3), and the base, which can be present as a pure (+) or (-) enantiomer or in racemic form, possesses the general formula (B), R is straight-chain or branched alkyl having 1-8 C atoms which is optionally substituted by hydroxyl or phenyl or by phenyl which is substituted by alkoxy or halogen; preferably is a methyl, ethyl, propyl, butyl or benzyl group, R , R , R and R can be identical or different and be hydrogen or straight-chain or branched alkyl having 1-4 C atoms, R preferably being propyl, R and R preferably being methyl, and R preferably being hydrogen, and m and n depending on the number of salt-forming groups in the cephalosporin moiety, have a number of from 1 to 3 for m, preferably 1 and 2, and for n 0.1 to 3, preferably 0.1 to 2. The cephalosporin salts according to the invention possess very good antibacterial activity and can therefore be used as drugs (medicaments, pharmaceuticals, medicines).

公开(公告)号：FI933902A

公开(公告)日：1994-03-10

申请号：FI933902

申请日：1993-09-07

Applicant: HOECHST AG

Inventor： HEMMERLE HORST ,  SCHINDLER PETER ,  UTZ ROLAND ,  RIPPEL ROBERT ,  HERLING ANDREAS

IPC: A61K31/185 ,  A61K31/16 ,  A61K31/19 ,  A61K31/215 ,  A61K31/235 ,  A61K31/255 ,  A61K31/36 ,  A61K31/38 ,  A61K31/381 ,  A61K31/415 ,  A61K31/44 ,  A61K31/66 ,  A61K31/67 ,  A61K31/675 ,  A61P3/08 ,  A61P3/10 ,  A61P11/00 ,  A61P43/00 ,  C07C49/04 ,  C07C49/20 ,  C07C61/08 ,  C07C69/013 ,  C07C69/03 ,  C07C69/533 ,  C07C69/612 ,  C07C69/63 ,  C07C69/65 ,  C07C69/67 ,  C07C69/73 ,  C07C69/732 ,  C07C69/734 ,  C07C205/56 ,  C07C235/36 ,  C07C327/06 ,  C07C327/10 ,  C07D213/55 ,  C07D333/24 ,  C07D333/32 ,  C07F9/38 ,  C07F9/40 ,  C07C69/88

Abstract: Esters of cyclohexane derivatives of the formula I in which A-B, R , R , R , Y and Z have the stated meanings, for use as inhibitors of the glucose-6-phosphatase system in the liver of mammals are described. The compounds are suitable for producing pharmaceutical products.

公开(公告)号：NO170155C

公开(公告)日：1992-09-16

申请号：NO870666

申请日：1987-02-19

Applicant: HOECHST AG

Inventor： LANG HANS-JOCHEN ,  RIPPEL ROBERT ,  HERLING ANDREAS W ,  WEIDMANN KLAUS

IPC: A61K31/41 ,  A61K31/415 ,  A61K31/435 ,  A61K31/44 ,  A61P1/04 ,  A61P1/12 ,  C07D213/68 ,  C07D213/89 ,  C07D495/04

Abstract: The invention relates to compounds of the formula in which A represents (a) (b) (c) T denotes -S-, -SO- or -SO2-, and R1 to R9 have the meanings given in the description, to a process for their preparation, to pharmaceutical compositions containing them, and to their use as inhibitors of gastric acid secretion.

公开(公告)号：PH26118A

公开(公告)日：1992-02-24

申请号：PH37218

申请日：1988-07-13

Applicant: HOECHST AG

Inventor： NIMMESGERN HILDEGARD ,  WEIDMANN KLAUS ,  LANG HANS-JOCHEN ,  RIPPEL ROBERT ,  HERLING ANDREAS W

IPC: A61K31/495 ,  A61P1/00 ,  A61P1/04 ,  A61P1/12 ,  C07D495/04 ,  A61K31/415

Abstract: Compounds of the formula … … T denotes -S-, -SO- or -SO2-, and… R to R , X, Y and Z have the meanings given in the description.

公开(公告)号：AU597750B2

公开(公告)日：1990-06-07

申请号：AU8144887

申请日：1987-11-20

Applicant: HOECHST AG

Inventor： LANG HANS-JOCHEN ,  ROSNER MANFRED ,  WEIDMANN KLAUS ,  RIPPEL ROBERT ,  HERLING ANDREAS W

IPC: A61K31/395 ,  A61P1/04 ,  C07D495/04 ,  A61K31/415

Abstract: Thienoimidazole-toluidines of the formula I (I) in which A represents T denotes -S-, -SO- or -SO2-, and R1 to R9 have the meanings stated in the description, and a process for their preparation, pharmaceutical compositions containing them, and their use as inhibitors of gastric acid secretion, are described.

公开(公告)号：DK69589A

公开(公告)日：1989-08-17

申请号：DK69589

申请日：1989-02-15

Applicant: HOECHST AG

Inventor： RIPPEL ROBERT ,  FLEMMING HANS-WOLFRAM ,  RUKWIED MANFRED

IPC: C07D333/36 ,  C07D333/38 ,  C07D333/48

Abstract: Thiophene derivatives with an optionally substituted amino group on the thiophene ring are prepared by dehydrogenation of dihydrothiophenes which are substituted in the same manner as the desired thiophene derivatives, using H2O2, the dihydrothiophenes being reacted in a first reaction step with H2O2 in neutral medium to give the corresponding sulphoxides, and, in the second reaction step, these are then rearranged with acid to give the thiophene derivatives. The dihydrothiophene-1-oxides which are formed in this process as intermediates are novel compounds. They, and equally the thiophene derivatives obtained from them by rearrangement with acid, are intermediates mainly in the crop protection agent sector and pharmaceutical sector.

公开(公告)号：FI883738A

公开(公告)日：1989-02-16

申请号：FI883738

申请日：1988-08-11

Applicant: HOECHST AG

Inventor： LANG HANS-JOCHEN ,  WEIDMANN KLAUS ,  RIPPEL ROBERT ,  SCHEUNEMANN KARL-HEINZ ,  HERLING ANDREAS W

IPC: A61K20060101 ,  A61K31/415 ,  A61K31/44 ,  A61P1/04 ,  A61P1/12 ,  C07D20060101 ,  C07D495/04 ,  C07D

Abstract: Compounds of the formula I T denotes -S-, -SO- or -SO2-, R denotes hydrogen, alkanoyl, alkylcarbamoyl, alkoxycarbonyl, benzyloxycarbonyl or another physiologically tolerable protective group, R and R represent hydrogen or alkyl, R and R denote hydrogen, halogen, alkyl or a substituent of the formula -O-[CH2]o-CpH(2p+1-q)Halq and R is hydrogen, (substd.) alkyl, (substd.) alkoxy, -O-[CH2]o-CpH(2p+1-q)Halq, NR'R'', alkylmercapto, alkylsulphinyl or alkylsulphonyl, are used as medicaments.