公开(公告)号：JP2002131315A

公开(公告)日：2002-05-09

申请号：JP2001263901

申请日：2001-08-31

Applicant: HOFFMANN LA ROCHE

Inventor： GAA OTTO ,  ALBRECHT GERTRUD ,  LOCH-LEROUX DIETER

IPC: G01N31/22 ,  G01N21/78 ,  G01N33/52 ,  G01N33/66 ,  G01N33/96

Abstract: PROBLEM TO BE SOLVED: To provide an easy and reliable method for inspecting the suitability of an analysis element to an objective. SOLUTION: According to this method, a control reference value and a first standard reference value are formed, deviation of the quotient of a control value divided by the standard reference value is inspected by comparing it with a first reference quotient, and when the deviation is out of a prescribed tolerance, an inspected analysis element is discarded. An evaluation device using this method is provided.

公开(公告)号：JP2008246204A

公开(公告)日：2008-10-16

申请号：JP2008063259

申请日：2008-03-12

Applicant: F Hoffmann-La Roche Ag ,  エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト

Inventor： ROESICKE BERND ,  OBERMAIER KARIN ,  LINDEGGER STEFAN ,  MENKE ANDREAS ,  SCHERER JOERG ,  SCHWIND KARIN ,  GAA OTTO ,  BAINCZYK GREGOR ,  MARQUANT MICHAEL ,  NIEDERHAEUSER SANDRO ,  SCHOEMAKER MICHAEL ,  MUERI MARTIN

IPC: A61B5/145

CPC classification number: A61B5/0031 ,  A61B5/0002 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1459 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/6849 ,  A61B5/7232 ,  A61B5/742 ,  A61B90/98 ,  A61B2560/0209 ,  A61B2560/0219 ,  A61B2560/0481

Abstract: PROBLEM TO BE SOLVED: To improve reliability of a system for in-vivo measurement of analyte concentration.
SOLUTION: The system for in-vivo measurement of analyte concentration in a human or animal body having at least an implantable sensor 3 for generating measuring signals that are correlated to the analyte concentration to be measured, a base station 2 that can be coupled to the sensor 3 and contains an electronic analytical unit 47 for analysis of the measuring signals of the sensor 3 connected to it, and a transmitter 31 for wireless transmission of analytical results, and a display 4 that has a receiver for receiving the analytical results transmitted by the base station 2 and a display 29 for displaying analyte concentration values. The invention provides the sensor 3 to be a part of a replaceable sensor housing unit 10 that has a closed housing 12 inside of which the sensor 3 is disposed, and provides the sensor housing unit 10 to fit to the base station 2 in order to couple the sensor 3 to the base station 2.
COPYRIGHT: (C)2009,JPO&INPIT

Abstract translation: 要解决的问题：提高用于体内测量分析物浓度的系统的可靠性。 解决方案：用于体内测量人体或动物体中分析物浓度的系统，其具有至少可植入传感器3，用于产生与要测量的分析物浓度相关的测量信号，基站2可以是 耦合到传感器3并且包含用于分析连接到其的传感器3的测量信号的电子分析单元47和用于分析结果的无线传输的发送器31以及具有用于接收分析结果的接收器的显示器4 由基站2发送，显示器29显示分析物浓度值。 本发明将传感器3设置为可更换的传感器壳体单元10的一部分，该传感器壳体单元10具有封闭的壳体12，内部设置有传感器3，并将传感器壳体单元10配合到基站2以便耦合 传感器3到基站2.版权所有（C）2009，JPO＆INPIT

公开(公告)号：WO2004003549A3

公开(公告)日：2004-04-22

申请号：PCT/EP0306613

申请日：2003-06-24

Applicant: ROCHE DIAGNOSTICS GMBH ,  HOFFMANN LA ROCHE ,  FREY GUENTER ,  HORN CARINA ,  GAA OTTO ,  KINTZIG HANS ,  MURAWSKI HANS-RUEDIGER

Inventor： FREY GUENTER ,  HORN CARINA ,  GAA OTTO ,  KINTZIG HANS ,  MURAWSKI HANS-RUEDIGER

IPC: G01N21/77 ,  G01N21/35 ,  G01N27/416 ,  G01N33/487 ,  G01N33/96 ,  G01N33/483

CPC classification number: G01N33/96 ,  Y10T436/10 ,  Y10T436/104165 ,  Y10T436/104998 ,  Y10T436/106664 ,  Y10T436/25

Abstract: The invention relates to a method for automatically differentiating between a sample solution and a control solution, in particular within the context of analytical measuring systems. According to the invention, the differentiation takes place using the existence of a specific characteristic of the control solution and/or at least two criteria. In addition, The invention also relates to corresponding control solutions that are suitable for the novel method.

Abstract translation: 本发明涉及一种用于对样品流体和控制流体之间自动区分，特别是在与分析测量系统连接，其特征在于，被用于区分所述控制流体和/或至少两个标准的特定特征的存在的方法。 此外，本发明涉及对应的，适合于新的处理控制的液体。

公开(公告)号：CA2881067C

公开(公告)日：2018-06-26

申请号：CA2881067

申请日：2013-09-05

Applicant: HOFFMANN LA ROCHE

Inventor： ALBRECHT GERTRUD ,  GAA OTTO ,  LORENZ ROBERT ,  RUECKERT FRANK

IPC: G01N21/84

Abstract: The invention concerns a method and a device for determining sample application on an analytical test element in a photometric reflectance measuring device (10) specifically for glucose measurements, where the following measures are proposed: providing a disposable test element (12) for application of a body fluid sample, taking a sequence of reflectance readings from the test element (12), monitoring a change of the reflectance readings with respect to a sample application condition, adjusting the sample application condition in accordance with a drift correction. A value for drift correction of the reflectance readings caused by ambient measurement conditions, specifically, humidity, temperature, or UV radiation can be considered in a predefined signal decrease or in a predefined signal threshold for adjusting the sample application condition.

公开(公告)号：HK1210263A1

公开(公告)日：2016-04-15

申请号：HK15110821

申请日：2015-11-03

Applicant: HOFFMANN LA ROCHE

Inventor： ALBRECHT GERTRUD ,  GAA OTTO ,  LORENZ ROBERT ,  RUECKERT FRANK

IPC: G01N20060101

Abstract: Methods are provided for photometrically determining/detecting sample application to an analytical test element for use with a blood glucose measuring device, where the method includes obtaining a sequence of reflectance readings from the test element with the measuring device, including a blank value prior to sample application, and then monitoring changes of the reflectance readings from the test element with respect to a sample application condition defined by a limit for a reflectance decrease or a reflectance threshold. The methods also can include adjusting the sample application condition in accordance with a drift correction and can include determining an analyte concentration in the body fluid sample. In addition, photometric blood glucose measuring devices are provided that incorporate the methods disclosed herein.

公开(公告)号：AU2003242747A8

公开(公告)日：2004-01-19

申请号：AU2003242747

申请日：2003-06-24

Applicant: HOFFMANN LA ROCHE

Inventor： MURAWSKI HANS-RUEDIGER ,  FREY GUENTER ,  KINTZIG HANS ,  GAA OTTO ,  HORN CARINA

IPC: G01N21/77 ,  G01N21/35 ,  G01N27/416 ,  G01N33/487 ,  G01N33/96 ,  G01N33/483

公开(公告)号：DE50100121D1

公开(公告)日：2003-04-24

申请号：DE50100121

申请日：2001-08-08

Applicant: ROCHE DIAGNOSTICS GMBH ,  HOFFMANN LA ROCHE

Inventor： GAA OTTO ,  ALBRECHT GERTRUD ,  LOCH-LEROUX DIETER

IPC: G01N31/22 ,  G01N21/78 ,  G01N33/52 ,  G01N33/66 ,  G01N33/96

Abstract: Test strips to control the usefulness of analysis (1), and the like, comprises initially, a reference value measurement takes a standard reference value at a reference control agent (4) as a standardized reference value for the control parameter. To control the usefulness of analysis test strips, and the like, the control parameter of the new test strip is determined as a control value to give a quotient with the first standard reference value as a control quotient. Any deviation between the control quotient and the first reference quotient is measured, and the test strip is rejected if the difference is outside a given tolerance range. The deviation is registered by a relative difference between the control quotient and the first reference quotient, or the actual difference. The new test strip is rejected if the control quotient is smaller than the first reference quotient by a given percentage or a given difference value. The tolerance range is specific to the actual charge of the test strip. The initial test strip and the further test strip are taken from the same package or dispenser, within a long-life packing, where they are each protected by separate wrappings. The test is made when a new package is used, when the first test strip is taken from the pack or on opening a long-life packing. The test stages are repeated if it is shown by the control measurement that test readings or the values measured by an analysis apparatus would be potentially affected. When a given deviation is noted, the control value for the second strip is taken as a new control reference value to give a new reference quotient for the control of further test strips. A new reference quotient is formed if the control quotient is greater than the reference quotient by more than a set threshold value, related to the actual charge of the test strip. One or more of the test stages can be automated. The reference control agent gives a higher measured value for the control parameter. The test strip has a test field (3) and a reference control agent for the measurement of the control reference value or control value. The control parameter is an optical measured value and especially a remission value.

公开(公告)号：ES2606862T3

公开(公告)日：2017-03-28

申请号：ES13707185

申请日：2013-03-05

Applicant: HOFFMANN LA ROCHE

Inventor： CHEMNITIUS GABRIELE ,  GAA OTTO ,  NAGEL THOMAS ,  RECHT KARL

IPC: C12Q1/32

Abstract: Una composición seca que comprende los componentes: (a) una deshidrogenasa; (b) un cofactor redox; (c) un agente capaz de inducir un cambio en al menos una propiedad óptica de un reactivo indicador en presencia de equivalentes redox; (d) un reactivo indicador; y (e) al menos un soluto compatible que es ectoína o un derivado de la misma, en la que dicha deshidrogenasa es una glucosa deshidrogenasa y en la que dicho derivado de ectoína se selecciona entre el grupo que consiste en: hidroxiectoína, homoectoína, un éster de hidroxiectoína, un éter de hidroxiectoína, un derivado de sulfonilo de ectoína o un derivado de sulfonilo esterificado de ectoína y una amida de un derivado de sulfonilo de ectoína.

公开(公告)号：CA2881067A1

公开(公告)日：2014-03-13

申请号：CA2881067

申请日：2013-09-05

Applicant: HOFFMANN LA ROCHE

Inventor： ALBRECHT GERTRUD ,  GAA OTTO ,  LORENZ ROBERT ,  RUECKERT FRANK

IPC: G01N21/84

Abstract: The invention concerns a method and a device for determining sample application on an analytical test element in a photometric reflectance measuring device (10) specifically for glucose measurements, where the following measures are proposed: providing a disposable test element (12) for application of a body fluid sample, taking a sequence of reflectance readings from the test element (12), monitoring a change of the reflectance readings with respect to a sample application condition, adjusting the sample application condition in accordance with a drift correction. A value for drift correction of the reflectance readings caused by ambient measurement conditions, specifically, humidity, temperature, or UV radiation can be considered in a predefined signal decrease or in a predefined signal threshold for adjusting the sample application condition.

公开(公告)号：CA2861054A1

公开(公告)日：2013-09-12

申请号：CA2861054

申请日：2013-03-05

Applicant: HOFFMANN LA ROCHE

Inventor： CHEMNITIUS GABRIELE ,  GAA OTTO ,  NAGEL THOMAS ,  RECHT KARL

IPC: C12Q1/32

Abstract: The present invention is concerned with means and methods for maintaining and preserving enzymatic activity. In particular, the invention relates to a dry composition comprising a dehydrogenase, a redox cofactor, an agent capable of eliciting at least one optical change in an optical property of an indicator reagent in the presence of redox equivalents, an indicator reagent, and at least one compatible solute being ectoine or a derivative thereof. The invention further contemplates a diagnostic test element for the determination of an analyte from a body fluid sample and a method for the manufacture of such a test element. Further envisaged by the present invention is the use of at least one compatibie solute as mentioned above for reducing a decrease of the enzymatic activity of at least one enzyme in a composition under dry conditions. Furthermore, contemplated is a method for determining the presence or amount analyte in a body fluid sample based on the test element according to the invention.