公开(公告)号：JP2007052010A

公开(公告)日：2007-03-01

申请号：JP2006215494

申请日：2006-08-08

Applicant: F Hoffmann La Roche Ag ,  エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft

Inventor： GRISS PATRICK ,  HEIN HEINZ-MICHAEL ,  JAEGGI RAINER ,  SAVATIC GORAN

IPC: G01N21/27 ,  G01N21/13 ,  G01N21/15

CPC classification number: G01N21/0303 ,  B01L3/502715 ,  B01L2300/0654 ,  B01L2300/0806 ,  B01L2300/168 ,  G01N35/00069

Abstract: PROBLEM TO BE SOLVED: To optimize a manufacturing method of an analyzer for photodetection, wherein it is guaranteed that the greater part of the surface of a reflecting face or a mirror-shaped face has the optimum reflection characteristic and thereby polarized light of a beam is not influenced by an optional defect on the surface.
SOLUTION: A plurality of containers 7 for a fluid sample and an optical means 9 for guiding a beam through the containers are arranged on the analyzer for photodetection of a chemical sample and/or the fluid sample equipped with a rotating disk-shaped body 1. At least a part of the optical means 9 is designed and/or arranged so that at least a part of the beam is deflected at some angle in an outward direction of the radius direction on the disk-shaped body 1, namely, at some angle with respect to the radius connecting each optical means to a rotating shaft 9 of the disk-shaped body 1 and guided through the containers.
COPYRIGHT: (C)2007,JPO&INPIT

Abstract translation: 要解决的问题：为了优化用于光电检测的分析仪的制造方法，其中确保反射面或镜面的大部分表面具有最佳的反射特性，从而确保 光束不受表面上可选缺陷的影响。 解决方案：用于流体样品的多个容器7和用于引导梁通过容器的光学装置9布置在用于对化学样品和/或配备有旋转盘形的流体样品进行光电检测的分析器 光学装置9的至少一部分被设计和/或布置成使得光束的至少一部分在盘形体1上的半径方向的外侧方向上以某种角度偏转，即， 相对于将每个光学装置连接到盘形主体1的旋转轴9并将其引导通过容器的半径以一定角度。 版权所有（C）2007，JPO＆INPIT

公开(公告)号：JP2011039050A

公开(公告)日：2011-02-24

申请号：JP2010176298

申请日：2010-08-05

Applicant: F Hoffmann-La Roche Ag ,  エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト

Inventor： MIKHAIL GROSER ,  OLIVER GUTMANN ,  HEIN HEINZ-MICHAEL ,  MIKHAIL HEINRICH ,  JAEGGI RAINER D ,  OOSTERBROEK EDWIN

IPC: G01N35/08 ,  G01N37/00

CPC classification number: G01N35/1095 ,  B01L2200/027 ,  G01N35/085 ,  G01N2035/00158 ,  G01N2035/1034

Abstract: PROBLEM TO BE SOLVED: To provide a new system for automatically analyzing a liquid sample capable of serving various analyses in a concrete diagnosis test method such as clinical chemistry analysis and immunoassay. SOLUTION: The system 1 for automatically analyzing a liquid sample includes at least one processing unit 3 for reacting between a sample and at least one reagent and thereby obtaining a reaction product, a sample unit for supplying a sample to at least a sample processing unit 3, a reagent unit with a plurality of reagent vessel 8 for storing at least one reagent to mix with the sample, a distribution unit 6 with a plurality of distribution lines 13 in which at least a part of the distribution unit is connected to at least the reagent vessel 8 and the one processing unit 3, for distributing a fluid containing at least one reagent, and an analysis unit 2 for analyzing the sample based on a reaction product, including at least one piece of detector 4 for detecting reaction product. COPYRIGHT: (C)2011,JPO&INPIT

Abstract translation: 要解决的问题：提供一种用于在具体的诊断测试方法如临床化学分析和免疫测定中自动分析能够服务于各种分析的液体样品的新系统。 解决方案：用于自动分析液体样品的系统1包括至少一个处理单元3，用于在样品和至少一种试剂之间反应，从而获得反应产物，用于将样品供应至少一个样品的样品单元 处理单元3，具有用于存储至少一种试剂与样品混合的多个试剂容器8的试剂单元，具有多个分配管线13的分配单元6，其中分配单元的至少一部分连接到 至少用于分配含有至少一种试剂的流体的试剂容器8和一个处理单元3和用于基于反应产物分析样品的分析单元2，包括至少一个用于检测反应产物的检测器4 。 版权所有（C）2011，JPO＆INPIT

公开(公告)号：JP2010115647A

公开(公告)日：2010-05-27

申请号：JP2009256430

申请日：2009-11-09

Applicant: F Hoffmann-La Roche Ag ,  エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト

Inventor： HEIN HEINZ-MICHAEL ,  SAROFIM EMAD ,  SCHENK LOTAR ,  WAHL HANS-PETER

IPC: B03C1/30 ,  B04B5/10

CPC classification number: B03C1/01 ,  B03C1/288 ,  B03C2201/18 ,  B03C2201/26 ,  Y10T436/111666

Abstract: PROBLEM TO BE SOLVED: To provide a method for separating a component of interest bound to magnetic particles from a solution. SOLUTION: The method includes the following steps: providing a container device having one or more flat chamber(s) each composed of an angular bottom ascending to the outer part 25 of the compartment and means for trapping fluids 10, the means being positioned inside the outer part of the compartment of the container 11 and a magnet 12 for capturing the magnetic particles 21 and the component of interest bound to the magnetic particles; disposing the solution including the component of interest in the interior volume of the chamber(s), while the container is rotating around an axis 19 located outside the inner part of the container and adjacent to the magnet; adding to the solution the magnetic particles coated with a reaction component that binds the component of interest; mixing the solution with the magnetic particles to produce a mixture composed of magnetic particles and a supernatant liquid; and separating the magnetic particles and the liquid by rotating the container, wherein the liquid is trapped by centrifugal forces into the trapping means and a magnetic field is applied such that magnetic particles bind to the inner side of the inner part of the interior volume. COPYRIGHT: (C)2010,JPO&INPIT

Abstract translation: 要解决的问题：提供一种从溶液中分离与磁性颗粒结合的感兴趣成分的方法。 解决方案：该方法包括以下步骤：提供一种具有一个或多个平坦室的容器装置，每个平坦室由沿着隔室的外部部分25上升的角度底部构成，并且用于捕获流体10的装置 位于容器11的隔室的外部部分的内部;磁体12，用于捕获与磁性颗粒结合的磁性颗粒21和感兴趣的组分; 将包含感兴趣的部件的溶液放置在室的内部容积中，同时容器围绕位于容器的内部部分外部并且与磁体相邻的轴线19旋转; 向溶液中加入涂覆有结合感兴趣组分的反应组分的磁性颗粒; 将溶液与磁性颗粒混合以产生由磁性颗粒和上清液组成的混合物; 并且通过旋转容器来分离磁性颗粒和液体，其中液体被离心力捕获到捕获装置中，并且施加磁场，使得磁性颗粒结合到内部体积的内部部分的内侧。 版权所有（C）2010，JPO＆INPIT

公开(公告)号：WO2004090779A3

公开(公告)日：2005-08-11

申请号：PCT/EP2004003613

申请日：2004-04-06

Applicant: ROCHE DIAGNOSTICS GMBH ,  HOFFMANN LA ROCHE ,  PETRICH WOLFANG ,  WERNER GERHARD ,  HEIN HEINZ-MICHAEL ,  KUHR HANS-JUERGEN

Inventor： PETRICH WOLFANG ,  WERNER GERHARD ,  HEIN HEINZ-MICHAEL ,  KUHR HANS-JUERGEN

IPC: G06F19/00

CPC classification number: G16H10/40 ,  G16H50/50

Abstract: The invention relates to analysis methods for diagnosing diseases on human and animal samples. Said invention also relates to an evaluation method for diagnosing the individual stages of a disease in such a way that it is possible to display the progression thereof. Said invention also makes it possible to identify diseases in an early manner and to carry out therapeutic controls. The inventive method consists in carrying out actually known multivariable evaluation methods for classifying samples. Nevertheless, the invention is characterised in that no sample is allocated to a certain class, but it is classified in a data record based on the interpolation between different classes.

Abstract translation: 本发明涉及的是适合于疾病的人类和动物样品中的诊断分析方法的字段。 本发明还公开了通过其使得可以诊断个体疾病阶段，使得疾病的过程可以被成像的评价方法。 这使得疾病和治疗监测的早期检测可以做到的等 本发明的方法使基获利本领域中已知的用于样品的多变量分类的评价方法。 然而，根据本发明的没有样品的一类分配，但在一组从不同类之间的内插得到的数据进行了分类不像在现有技术中发生的。

公开(公告)号：WO02069790A2

公开(公告)日：2002-09-12

申请号：PCT/EP0201944

申请日：2002-02-23

Applicant: ROCHE DIAGNOSTICS GMBH ,  HOFFMANN LA ROCHE ,  KRAEMER UWE ,  HEIN HEINZ-MICHAEL ,  VOLZ DIETMAR

Inventor： KRAEMER UWE ,  HEIN HEINZ-MICHAEL ,  VOLZ DIETMAR

IPC: A61B5/00

CPC classification number: A61B5/1455 ,  A61B5/14532 ,  A61B2562/0242 ,  Y10T436/144444

Abstract: Method for the selective determination of a light transport parameter, characteristic of the light scattering in a biological matrix (5), in particular for the purpose of non-invasive determination of the concentration of glucose in the biological matrix. The above includes a number of detection measurements in which light is injected into the biological sample as primary light and an intensity value for escaping secondary light measured in a detection location, which is found at various separations from the location of light injection for the number of detection measurements. The light transport parameter which is characteristic for the light scattering in the biological matrix is derived from the intensity values in an analytical step by means of an analytical algorithm. According to the invention, the scattering coefficient can be selectively determined, whereby the analytical algorithm comprises a step in which a value for change with time DELTA tI(r) describing the change with time of the intensity value is derived from at least two different intensity values from different times.

Abstract translation: 用于选择性测定生物基质（5）中光散射特征的光传输参数的方法，特别是用于无创测定生物基质中葡萄糖浓度的目的。 它包括多个检测测量值的，在各照射光作为一次光到生物基体和在其位于所述多个在从照射部位不同的测量距离检测测量的被检测部位的强度测量值的，易失性次级光被测量。 在评估步骤中，通过评估算法从强度测量值导出生物基质中光散射的光传输参数特征。 为散射系数的选择性测定建议评估算法包括其中所获得的组成测量的强度值的至少两个不同的时间的步骤中，强度测量值描述时间导数值DELTA的Ti（R）随时间的变化被计算。

公开(公告)号：AT556311T

公开(公告)日：2012-05-15

申请号：AT06014095

申请日：2006-07-07

Applicant: ROCHE DIAGNOSTICS GMBH ,  HOFFMANN LA ROCHE

Inventor： GRISS PATRICK ,  HEIN HEINZ-MICHAEL ,  JAEGGI RAINER ,  SAVATIC GORAN

IPC: G01N21/07

Abstract: On an analytical device for photometric detection of chemistry and/or fluid samples comprising a rotatable disc like body (1) a plurality of receptables (7) for fluid samples and optical means (9) for guiding light beams through the receptables are arranged. At least part of the optical means (9) are designed and/or arranged such, that at least part of the light beams is deflected and guided through the receptables in an angle to the radially outward direction on the disc like body (1) which means in an angle to the radius, connecting the respective optical means with the rotation axis (9) of the disc like body (1).

公开(公告)号：AU2006286841B2

公开(公告)日：2009-10-29

申请号：AU2006286841

申请日：2006-08-05

Applicant: HOFFMANN LA ROCHE

Inventor： HEIN HEINZ-MICHAEL ,  LIST HANS ,  CALASSO IRIO

IPC: A61B5/15

Abstract: Method involves an opening to be produced on the skin, on the point of the hole, on the epidermis in the skin-opening step. A sample obtaining hole is created by means of a pricking element, wherein the skin opening is deepened by means of the pricking element and then the hole is produced. Thereby, a temporal distance of 1 msec to 1 sec is kept between skin-opening step and sample obtaining step. An independent claim is also included for hand held unit with drive to move pricking element and controller for movement control of element.

公开(公告)号：AT259379T

公开(公告)日：2004-02-15

申请号：AT01940413

申请日：2001-05-08

Applicant: HOFFMANN LA ROCHE

Inventor： HEIN HEINZ-MICHAEL ,  KRAEMER UWE ,  REITER RUDOLF ,  GRETZ NORBERT ,  DEUS CARSTEN

IPC: A61K49/00 ,  C08B37/00

公开(公告)号：PL1868500T3

公开(公告)日：2010-03-31

申请号：PL06724086

申请日：2006-04-06

Applicant: HOFFMANN LA ROCHE

Inventor： SAROFIM EMAD ,  CALASSO IRIO GIUSEPPE ,  KORNER STEPHAN ,  ABT RETO ,  HEIN HEINZ-MICHAEL ,  JAEGGI RAINER ,  GRISS PATRICK

IPC: A61B5/151

公开(公告)号：DE502006005187D1

公开(公告)日：2009-12-03

申请号：DE502006005187

申请日：2006-04-06

Applicant: ROCHE DIAGNOSTICS GMBH ,  HOFFMANN LA ROCHE

Inventor： SAROFIM EMAD ,  CALASSO IRIO GIUSEPPE ,  KORNER STEPHAN ,  ABT RETO ,  HEIN HEINZ-MICHAEL ,  JAEGGI RAINER ,  GRISS PATRICK

IPC: A61B5/151

Abstract: The pricking element (10): is withdrawn with uniform speed after the forward movement in a back pulling movement from the deepest pricking position into a back pulling position by smaller pricking depth; is withdrawn in the area of stratum corneums; and is moved backward during the collecting phase around 2-0.1 mm. The reception of the blood is controlled over the detection of the blood fluid contact, and a given collecting duration is awaited for the reception of the blood during the detection of the blood contact. The blood fluid contact is detected: at a renewed pricking in the point of reversal for the back pulling movement; in the back pulling position; in the area of the stratum corneums; by capacitive or inductive or resistive measuring parameters, capillary structure or a light conductor within the body part; over the pricking element and a contact element (30) standing in a unit with the body part; and over the pricking element by impedance measurement in relation to the skin. An error signal is generated in missing blood contact and the withdrawal of the blood is interrupted. The blood is received over the sting channel as a connection to a blood-giving zone of the body part. The duration of the back pulling phase is selected in the order of magnitude of the duration of the forward movement. The collecting phase is extended in relation to the back pulling phase around 10-10.000 times. The movement of the pricking element is controlled by time detection or position detection. An independent claim is included for device for removal of blood.