公开(公告)号：HK1162672A1

公开(公告)日：2012-08-31

申请号：HK12103090

申请日：2012-03-28

Applicant: HOFFMANN LA ROCHE

Inventor： KNAPPE WOLFGANG-REINHOLD ,  HILLER BERND ,  LEHR URSULA ,  ZIMMER VOLKER ,  PETRICH WOLFGANG ,  BEDON-GOMEZ LUIS DAVID

IPC: G01N20060101 ,  B01L20060101

Abstract: The invention relates to a test element for detecting at least one analyte in a sample, in particular for detecting at least one metabolite in a bodily fluid. The test element comprises at least one test field with a test field surface. The test field comprises at least one detection reagent that is adapted to undergo a detectable reaction in the presence of the analyte. The test element further comprises at least one distribution element that has at least one distribution surface facing the test field surface. Between the distribution surface and the test field surface is at least one capillary gap, wherein the capillary gap is adapted to allow a layer of the sample with a layer thickness of no more than 50 μm to form within the capillary gap.

公开(公告)号：NZ591742A

公开(公告)日：2012-12-21

申请号：NZ59174209

申请日：2009-11-06

Applicant: HOFFMANN LA ROCHE

Inventor： KNAPPE WOLFGANG-REINHOLD ,  HILLER BERND ,  LEHR URSULA ,  ZIMMER VOLKER ,  PETRICH WOLFGANG ,  BEDON-GOMEZ LUIS DAVID

IPC: G01N33/52 ,  B01L3/00 ,  G01N21/86

Abstract: A diagnostic test element (110) for detecting an analyte in a sample of a bodily fluid (126). The element comprises a test field (116) with at least one detection reagent. The detection reagent is adapted to go through at least one detectable change in the presence of the analyte. The test field comprises a detection layer (118) that comprises the detection reagent and the detection layer comprises particles, wherein 90% of all the particles have a size of less than 10 micrometers. The test field has a loading side for applying the sample and the detection side for detecting a change in the detection reagent. The test field further comprises a removal layer (122) arranged on the side of the detection layer facing the loading side, wherein the removal layer comprise a pigment. The body fluid can be whole blood, the analyte can be glucose and the change in the detection reagent can be an optical change. The particles can be sodium aluminium silicate, aluminium or titanium oxide or a nanoparticulate oxidic matieral of silicon oxide, aluminium oxide and titanium oxide. The pigment can be titanium dioxide, zirconium dioxide, barium titanate, barium zirconate or zirconium silicate.

公开(公告)号：HUE044628T2

公开(公告)日：2019-11-28

申请号：HUE09753073

申请日：2009-11-06

Applicant: HOFFMANN LA ROCHE

Inventor： KNAPPE WOLFGANG-REINHOLD ,  HILLER BERND ,  LEHR URSULA ,  ZIMMER VOLKER ,  PETRICH WOLFGANG ,  BEDON-GOMEZ LUIS

IPC: B01L3/00 ,  G01N21/84 ,  G01N33/52

公开(公告)号：CA2743068C

公开(公告)日：2015-12-29

申请号：CA2743068

申请日：2009-11-06

Applicant: HOFFMANN LA ROCHE

Inventor： KNAPPE WOLFGANG-REINHOLD ,  HILLER BERND ,  LEHR URSULA ,  ZIMMER VOLKER ,  PETRICH WOLFGANG ,  BEDON-GOMEZ LUIS DAVID

IPC: G01N33/52 ,  B01L3/00 ,  G01N21/86

Abstract: There is proposed a diagnostic test element (110) for detecting an analyte in a sample (126) of a body fluid, more particularly in whole blood. The diagnostic test element (110) comprises at least one test field (116) having at least one detection reagent, wherein the detection reagent is set up to pass through at least one detectable change in the presence of the analyte, more particularly an optical change. The test field (116) has at least one detection layer (118) which comprises the detection reagent and which comprises particles (137). At least 90% of all particles (137) of the detection layer (118) have an actual particle size of less than 10 micrometers.

公开(公告)号：AU2009312781C1

公开(公告)日：2013-10-03

申请号：AU2009312781

申请日：2009-11-06

Applicant: HOFFMANN LA ROCHE

Inventor： KNAPPE WOLFGANG-REINHOLD ,  HILLER BERND ,  LEHR URSULA ,  ZIMMER VOLKER ,  PETRICH WOLFGANG ,  BEDON-GOMEZ LUIS DAVID

IPC: G01N33/52 ,  B01L3/00 ,  G01N21/86

Abstract: A diagnostic test element (110) for detecting an analyte in a sample (126) of a bodily fluid, in particular in whole blood, is proposed. The diagnostic test element (110) comprises at least one test field (116) with at least one detection reagent, wherein the detection reagent is adapted to go through at least one detectable change in the presence of the analyte, in particular an optical change. The test field (116) comprises at least one detection layer (118) that comprises the detection reagent, said layer comprising particles (137). In the process, at least 90% of all particles (137) of the detection layer (118) have an actual particle size of less than 10 micrometers.

公开(公告)号：AU2009312781B2

公开(公告)日：2013-03-07

申请号：AU2009312781

申请日：2009-11-06

Applicant: HOFFMANN LA ROCHE

Inventor： KNAPPE WOLFGANG-REINHOLD ,  HILLER BERND ,  LEHR URSULA ,  ZIMMER VOLKER ,  PETRICH WOLFGANG ,  BEDON-GOMEZ LUIS DAVID

IPC: G01N33/52 ,  B01L3/00 ,  G01N21/86

Abstract: A diagnostic test element (110) for detecting an analyte in a sample (126) of a bodily fluid, in particular in whole blood, is proposed. The diagnostic test element (110) comprises at least one test field (116) with at least one detection reagent, wherein the detection reagent is adapted to go through at least one detectable change in the presence of the analyte, in particular an optical change. The test field (116) comprises at least one detection layer (118) that comprises the detection reagent, said layer comprising particles (137). In the process, at least 90% of all particles (137) of the detection layer (118) have an actual particle size of less than 10 micrometers.

公开(公告)号：CA2743068A1

公开(公告)日：2010-05-14

申请号：CA2743068

申请日：2009-11-06

Applicant: HOFFMANN LA ROCHE

Inventor： KNAPPE WOLFGANG-REINHOLD ,  HILLER BERND ,  LEHR URSULA ,  ZIMMER VOLKER ,  PETRICH WOLFGANG ,  BEDON-GOMEZ LUIS DAVID

IPC: G01N33/52 ,  B01L3/00 ,  G01N21/86

Abstract: A diagnostic test element (110) for detecting an analyte in a sample (126) of a bodily fluid, in particular in whole blood, is proposed. The diagnostic test element (110) comprises at least one test field (116) with at least one detection reagent, wherein the detection reagent is adapted to go through at least one detectable change in the presence of the analyte, in particular an optical change. The test field (116) comprises at least one detection layer (118) that comprises the detection reagent, said layer comprising particles (137). In the process, at least 90% of all particles (137) of the detection layer (118) have an actual particle size of less than 10 micrometers.

公开(公告)号：PL2359136T3

公开(公告)日：2019-07-31

申请号：PL09753073

申请日：2009-11-06

Applicant: HOFFMANN LA ROCHE

Inventor： KNAPPE WOLFGANG-REINHOLD ,  HILLER BERND ,  LEHR URSULA ,  ZIMMER VOLKER ,  PETRICH WOLFGANG ,  BEDON-GOMEZ LUIS DAVID

IPC: B01L3/00 ,  G01N21/84 ,  G01N33/52 ,  G01N33/552

公开(公告)号：ES2721173T3

公开(公告)日：2019-07-29

申请号：ES09753073

申请日：2009-11-06

Applicant: HOFFMANN LA ROCHE

Inventor： KNAPPE WOLFGANG-REINHOLD ,  HILLER BERND ,  LEHR URSULA ,  ZIMMER VOLKER ,  PETRICH WOLFGANG ,  BEDON-GOMEZ LUIS

IPC: B01L3/00 ,  G01N21/84 ,  G01N33/52 ,  G01N33/552

Abstract: Un elemento de prueba de diagnóstico (110) para detectar un analito en una muestra (126) de fluido corporal, en particular, sangre entera, que comprende al menos un campo de prueba (116) que tiene al menos un reactivo de detección, en el que el reactivo de detección está diseñado para sufrir al menos un cambio detectable en presencia del analito, en particular, un cambio óptico, en el que el campo de prueba (116) presenta al menos una capa de detección que comprende el reactivo de detección (118), en el que la capa de detección (118) presenta partículas (137), en las que al menos 90 % de todas las partículas (137) de la capa de detección (118) presentan un tamaño de partícula real inferior a 10 micrómetros, en las que se emplea un procedimiento de microscopía electrónica para determinar la distribución de tamaño de las partículas, en el que solo las partículas a partir de un tamaño de 200 nanómetros se tienen en cuenta para determinar la distribución de tamaño de las partículas, en el que el campo de prueba (116) presenta un lado de aplicación (128) para aplicar la muestra (126) y un lado de detección (120) para detectar un cambio en el reactivo de detección, en particular, un cambio óptico, en el que el campo de prueba (116) presenta además al menos una capa de separación (122), en la que la capa de separación (122) está dispuesta del lado más cercano al lado de aplicación (128) de la capa de detección (118), en la que la capa de separación (122) comprende al menos un pigmento, caracterizado por que al menos 70 % de todas las partículas (137) de la capa de detección (118) presenta un tamaño de partícula real inferior a 900 nanómetros.

公开(公告)号：ZA201103253B

公开(公告)日：2012-01-25

申请号：ZA201103253

申请日：2011-05-05

Applicant: HOFFMANN LA ROCHE

Inventor： KNAPPE WOLFGANG-REINHOLD ,  HILLER BERND ,  LEHR URSULA ,  ZIMMER VOLKER ,  PETRICH WOLFGANG ,  BEDON-GOMEZ LUIS DAVID

IPC: B01L20060101 ,  G01N20060101

Abstract: The invention relates to a test element for detecting at least one analyte in a sample, in particular for detecting at least one metabolite in a bodily fluid. The test element comprises at least one test field with a test field surface. The test field comprises at least one detection reagent that is adapted to undergo a detectable reaction in the presence of the analyte. The test element further comprises at least one distribution element that has at least one distribution surface facing the test field surface. Between the distribution surface and the test field surface is at least one capillary gap, wherein the capillary gap is adapted to allow a layer of the sample with a layer thickness of no more than 50 μm to form within the capillary gap.