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    Sensor electroquímico que tiene áreas sensibles a analito distribuidas simétricamente
    1.
    发明专利
    Sensor electroquímico que tiene áreas sensibles a analito distribuidas simétricamente 未知

    公开(公告)号：ES2906449T3

    公开(公告)日：2022-04-18

    申请号：ES11769782

    申请日：2011-10-01

    Applicant: HOFFMANN LA ROCHE

    Inventor： BUCK HARVEY ,  LICA GEORGETA ,  KOELKER KARL-HEINZ ,  RIEGER EWALD

    IPC: A61B5/1473 ,  G01N27/327

    Abstract: Un sensor electroquímico (320) para uso in vivo, que comprende: un sustrato (332) que es preferentemente plano; un electrodo de trabajo (336) formado sobre o en el sustrato y que tiene múltiples áreas de electrodo de trabajo (370) expuestas para su contacto con un líquido corporal; en el que las áreas de electrodo de trabajo (370) están preferentemente espaciadas a lo largo de una dirección longitudinal del sensor (320), un segundo electrodo formado sobre o en el sustrato y que tiene al menos un área de segundo electrodo expuesta para su contacto con un líquido corporal, preferentemente el segundo electrodo comprende múltiples áreas de segundo electrodo; y un contraelectrodo (334) formado sobre o en el sustrato (332), comprendiendo el contraelectrodo al menos un área de contraelectrodo (368) expuesta para su contacto con el líquido corporal; caracterizado por que las múltiples áreas de electrodo de trabajo (370), la al menos un área de segundo electrodo y la al menos un área de contraelectrodo (368) están dispuestas simétricamente entre sí, de modo que se produzca una distribución de potencial simétrica cuando se aplique una señal de CA al sensor (320) y todas las áreas de electrodo de trabajo (370) expuestas tengan sustancialmente el mismo potencial.

    SENSOR ELECROQUIMICO QUE TIENE AREAS SENSIBLES A ANALITOS DISTRIBUIDAS SIMETRICAMENTE.
    3.
    发明专利
    SENSOR ELECROQUIMICO QUE TIENE AREAS SENSIBLES A ANALITOS DISTRIBUIDAS SIMETRICAMENTE. 未知

    公开(公告)号：MX2013003471A

    公开(公告)日：2013-05-31

    申请号：MX2013003471

    申请日：2011-10-01

    Applicant: HOFFMANN LA ROCHE

    Inventor： RIEGER EWALD ,  BUCK HARVEY ,  LICA GEORGETA ,  KOELKER KARL-HEINZ

    IPC: A61B5/1473 ,  G01N27/327

    Abstract: La presente invención proporciona un sensor electroquímico que emplea múltiples áreas de electrodo que están compuestas para contacto con un fluido corporal, por ejemplo, cuando el sensor es insertado subcutáneamente dentro de una piel del paciente. Las áreas del electrodo expuestas están arregladas simétricamente, de acuerdo con estas enseñanzas pueden ser usadas ventajosamente con señales de CA para determinar características del sensor y así mejorar el funcionamiento del sensor. Estas enseñanzas también proporcionan un sensor biocompatible con múltiples áreas del electrodo e referencia que son expuestas para contacto con fluido corporal.

    SYSTEM AND METHOD FOR MEASURING COAGULATION TIME WITHOUT THERMOSTATIC CONTROL
    4.
    发明专利
    SYSTEM AND METHOD FOR MEASURING COAGULATION TIME WITHOUT THERMOSTATIC CONTROL 未知

    公开(公告)号：CA2514540C

    公开(公告)日：2010-07-06

    申请号：CA2514540

    申请日：2004-01-24

    Applicant: HOFFMANN LA ROCHE

    Inventor： HILL JAMES L ,  UNKRIG VOLKER ,  RIEGER EWALD

    IPC: G01N33/49 ,  G01N33/86

    Abstract: System and method for the determination of a coagulation parameter comprising a disposable test element (2) and an instrument (1) for evaluation thereof. The coagulation time is determined at a non-standard temperature different from a standard temperature for the respective coagulation parameter, said non-standard temperature being measured by a temperature measurement device (7) of the instrument, the instrument (1) has a non-volatile memory (18) containing data which define a mathematical relationship of coagulation time versus temperature which relationship is independent of the individual patient whose blood is examined, and the coagulation parameter for the standard temperature is calculated from the coagulation time measured at said non-standard temperature, using said mathematical relationship.

    5.
    发明专利
    未知

    公开(公告)号：AT376670T

    公开(公告)日：2007-11-15

    申请号：AT04704993

    申请日：2004-01-24

    Applicant: HOFFMANN LA ROCHE

    Inventor： HILL JAMES ,  UNKRIG VOLKER ,  RIEGER EWALD

    IPC: G01N33/49 ,  G01N33/86

    Abstract: System and Method for the determination of a coagulation parameter of a blood or plasma sample of a patient, including a reagent system (5) to be mixed with the sample, thereby forming a coagulation detection liquid, a space (4) for receiving the coagulation detection liquid, and an instrument (1) adapted for monitoring coagulation of the coagulation detection liquid, and measuring a coagulation time. The coagulation time is determined at a non-standard temperature of the coagulation detection liquid different from a standard temperature for the respective coagulation parameter, said non-standard temperature being measured, and the coagulation parameter for the standard temperature is calculated from the coagulation time measured at said non-standard temperature, using a mathematical relationship of coagulation time versus temperature which relationship is independent of the individual patient whose blood is examined.

    SYSTEM AND METHOD FOR MEASURING COAGULATION TIME WITHOUT THERMOSTATIC CONTROL
    6.
    发明专利
    SYSTEM AND METHOD FOR MEASURING COAGULATION TIME WITHOUT THERMOSTATIC CONTROL 未知

    公开(公告)号：CA2514540A1

    公开(公告)日：2004-08-12

    申请号：CA2514540

    申请日：2004-01-24

    Applicant: HOFFMANN LA ROCHE

    Inventor： RIEGER EWALD ,  HILL JAMES L ,  UNKRIG VOLKER

    IPC: G01N33/49 ,  G01N33/86

    Abstract: System and Method for the determination of a coagulation parameter of a blood or plasma sample of a patient, including a reagent system (5) to be mixed with the sample, thereby forming a coagulation detection liquid, a space (4) for receiving the coagulation detection liquid, and an instrument (1) adapted for monitoring coagulation of the coagulation detection liquid, and measuring a coagulation time. The coagulation time is determined at a non-standard temperature of the coagulation detection liquid different from a standard temperature for the respective coagulation parameter, said non-standard temperature being measured, and the coagulation parameter for the standard temperature is calculated from the coagulation time measured at said non-standard temperature, using a mathematical relationship of coagulation time versus temperature which relationship is independent of the individual patient whose blood is examined.

    Test element for detecting at least one analyte in a body fluid
    8.
    发明专利
    Test element for detecting at least one analyte in a body fluid 未知

    公开(公告)号：AU2014276829B2

    公开(公告)日：2017-08-17

    申请号：AU2014276829

    申请日：2014-06-06

    Applicant: HOFFMANN LA ROCHE

    Inventor： HILLER BERND ,  PACHL RUDOLF ,  PFIFFI DANIELA ,  RIEGER EWALD ,  STERNBERGER CHRISTA

    IPC: G01N33/543 ,  C12Q1/54

    Abstract: A test element (110) for detecting at least one analyte in a body fluid is disclosed. The test element (110) comprises a housing (112) having at least one base element (114) and at least one cover element (116). The test element (110) further comprises at least one fluid channel (124) formed within the housing (112). The fluid channel (124) comprises a capillary region (126) and a measurement region (130), wherein the capillary region (126) and the measurement region (130) have differing aspect ratios. The cover element (116) comprises at least one test field (138) having at least one test chemical (140). The test chemical (140) is adapted to change at least one optically measurable property in the presence of the analyte. The cover element (116) is mounted to the base element (114) by using at least one adhesive (134) which contacts the test field (138).

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