公开(公告)号：WO2014140177A3

公开(公告)日：2014-11-06

申请号：PCT/EP2014054962

申请日：2014-03-13

Applicant: ROCHE DIAGNOSTICS GMBH ,  HOFFMANN LA ROCHE ,  ROCHE DIAGNOSTICS OPERATIONS

Inventor： BUCK HARVEY ,  CARPENTER SCOTT E ,  PAN ZHENG ZHENG

IPC: G01N27/327

CPC classification number: G01N27/3274

Abstract: Methods are disclosed for measuring an analyte concentration in a fluidic sample. Such methods further allow one to provide an error code or correct and/or compensate for interferents such as an antioxidant before providing an analyte concentration. The measurement methods utilize information obtained from test sequences having at least one DC block, such as a slow-ramped bi-polar waveform, where a closed circuit condition is maintained during the DC block. The methods use information relating to status of a redox mediator feature during the electrochemical analysis to provide an antioxidant failsafe if the antioxidant is interfering with the analyte concentration. Also disclosed are devices, apparatuses and systems incorporating the various measurement methods.

Abstract translation: 公开了用于测量流体样品中的分析物浓度的方法。 这样的方法还允许在提供分析物浓度之前提供错误代码或纠正和/或补偿诸如抗氧化剂之类的干扰物。 测量方法利用从具有至少一个DC块（例如慢斜率双极波形）的测试序列获得的信息，其中在DC块期间保持闭合电路状态。 在电化学分析期间，该方法使用与氧化还原介体特征的状态相关的信息，以提供抗氧化剂故障保护，如果抗氧化剂干扰分析物浓度。 还公开了结合各种测量方法的装置，装置和系统。

公开(公告)号：WO2007065285A2

公开(公告)日：2007-06-14

申请号：PCT/CH2006000682

申请日：2006-12-04

Applicant: HOFFMANN LA ROCHE ,  ROCHE DIAGNOSTICS GMBH

Inventor： WEINERT STEFAN ,  GALLEY PAUL ,  THUKRAL AJAY ,  CHITTAJALLU SIVA ,  BUCK HARVEY ,  WAGNER ROBIN ,  MARCO KYM ,  LONG JAMES R ,  BOUSAMRA STEVEN

IPC: G06F19/00

CPC classification number: G06F19/3456 ,  G06F9/4443 ,  G16H40/63

Abstract: A system for determining drug administration information may comprise an input device providing for user input of feed forward information having a first parameter component and a second parameter component, a data storage device and a processor. The data storage de-vice may have stored therein a map correlating values of the first and second parameters to drug administration information. The processor may be responsive to user input of the feed forward information to determine corresponding drug administration information according to the map.

Abstract translation: 用于确定药物管理信息的系统可以包括提供用户输入具有第一参数组件和第二参数组件的前馈信息的输入设备，数据存储设备和处理器。 数据存储装置可以在其中存储将第一和第二参数的值与药物管理信息相关联的图。 处理器可以响应于前馈信息的用户输入，以根据地图确定相应的药物管理信息。

公开(公告)号：WO2014140177A2

公开(公告)日：2014-09-18

申请号：PCT/EP2014054962

申请日：2014-03-13

Applicant: ROCHE DIAGNOSTICS GMBH ,  HOFFMANN LA ROCHE ,  ROCHE DIAGNOSTICS OPERATIONS

Inventor： BUCK HARVEY ,  CARPENTER SCOTT E ,  PAN ZHENG ZHENG

IPC: G01N27/327

CPC classification number: G01N27/3274

Abstract: Methods are disclosed for measuring an analyte concentration in a fluidic sample. Such methods further allow one to provide an error code or correct and/or compensate for interferents such as an antioxidant before providing an analyte concentration. The measurement methods utilize information obtained from test sequences having at least one DC block, such as a slow-ramped bi-polar waveform, where a closed circuit condition is maintained during the DC block. The methods use information relating to status of a redox mediator feature during the electrochemical analysis to provide an antioxidant failsafe if the antioxidant is interfering with the analyte concentration. Also disclosed are devices, apparatuses and systems incorporating the various measurement methods.

Abstract translation: 公开了用于测量流体样品中的分析物浓度的方法。 这样的方法还允许在提供分析物浓度之前提供错误代码或校正和/或补偿诸如抗氧化剂的干扰物。 测量方法利用从具有至少一个DC块的测试序列获得的信息，诸如缓慢变化的双极波形，其中在DC块期间保持闭合状态。 该方法在电化学分析期间使用与氧化还原介体特征状态有关的信息，以在抗氧化剂干扰分析物浓度时提供抗氧化剂失效保护。 还公开了结合各种测量方法的设备，装置和系统。

公开(公告)号：CA2963351C

公开(公告)日：2021-08-24

申请号：CA2963351

申请日：2015-11-03

Applicant: HOFFMANN LA ROCHE

Inventor： BEATY TERRY ,  BUCK HARVEY ,  DIEBOLD ERIC ,  GERBER MARTIN

IPC: G01N27/416 ,  G01N27/403

Abstract: Electrode arrangements for test elements, test elements and methods of determining sample sufficiency, monitoring fill time, establishing fill directions and/or confirming electrode coverage by a sample for test elements are disclosed. The test elements have an electrode-support substrate including a spacer having an edge defining a boundary of a capillary channel. The electrode-support substrate also includes a first electrode pair and a second electrode pair, wherein the first electrode pair is positioned between the second electrode pair. The method includes dosing the test sensor with the fluid sample; applying a signal to the first electrode pair and the second electrode pair, detecting a first response to the signal from the first electrode pair, and detecting a second response to the signal from the second electrode pair; determining a time period between the first response and the second response

公开(公告)号：PL2330527T3

公开(公告)日：2021-07-19

申请号：PL11000725

申请日：2006-12-04

Applicant: HOFFMANN LA ROCHE

Inventor： WEINERT STEFAN ,  GALLEY PAUL ,  THUKRAL AJAY ,  CHITTAJALLU SIVA ,  BUCK HARVEY ,  WAGNER ROBIN ,  MARCO KYM ,  LONG JAMES R ,  BOUSAMRA STEVEN

IPC: G16H20/10 ,  G06F9/44 ,  G16H10/60 ,  G16H20/60 ,  G16H40/63 ,  G16H40/67

公开(公告)号：CA3035874A1

公开(公告)日：2018-04-12

申请号：CA3035874

申请日：2017-08-16

Applicant: HOFFMANN LA ROCHE

Inventor： BUCK HARVEY ,  BEATY TERRY A ,  DUVALL STACY HUNT

IPC: G01N27/26 ,  G01N27/327 ,  G01N27/416

Abstract: Detection reagents, multi-analyte test elements, test systems, and multi-analyte measuring methods are provided. In particular, multi-analyte test elements have (1) a first working electrode and first counter electrode pair covered with a first analyte-specific reagent that includes an enzyme, a coenzyme and a first mediator and have (2) a second working electrode covered with a second analyte-specific reagent that includes an enzyme, a coenzyme and a second mediator, where the second mediator is different than the first mediator. The single counter electrode can be used as the counter electrode for both the first and second analyte measurements at their respective working electrodes. Moreover, the mediator concentrations, measurement ranges, and applied potential differences are not the same for each analyte-specific measurement.

公开(公告)号：HK1220006A1

公开(公告)日：2017-04-21

申请号：HK16107920

申请日：2016-07-07

Applicant: HOFFMANN LA ROCHE

Inventor： BUCK HARVEY ,  CARPENTER SCOTT E ,  PAN ZHENG ZHENG

IPC: G01N20060101

公开(公告)号：CA2949906A1

公开(公告)日：2014-09-18

申请号：CA2949906

申请日：2014-03-13

Applicant: HOFFMANN LA ROCHE

Inventor： BUCK HARVEY ,  CARPENTIER SCOTT E ,  PAN ZHENG ZHENG ,  VALVERDE-VENTURA RENE

IPC: G01N27/416

Abstract: Methods are disclosed for scaling body fluid analysis data to correct and/or compensate for confounding variables such as hematocrit (Hct), temperature, variations in electrode conductivity or combinations thereof before providing an analyte concentration. The scaling methods utilize current response data obtained from an AC block applied prior to a DC block to minimize the impact of such confounding variables upon the observed DC current response before creating descriptors or algorithms. The scaling methods therefore compensate the measured DC current by using data from the AC block made on the same sample. Also disclosed are devices, apparatuses and systems incorporating the various scaling methods.

公开(公告)号：AU2011313631A1

公开(公告)日：2013-02-07

申请号：AU2011313631

申请日：2011-10-01

Applicant: HOFFMANN LA ROCHE

Inventor： BUCK HARVEY ,  LICA GEORGETA ,  KOELKER KARL-HEINZ ,  RIEGER EWALD

IPC: A61B5/1473 ,  G01N27/327

Abstract: The present invention provides an electrochemical sensor that employs multiple electrode areas that are exposed for contact with a body fluid, e.g., when the sensor is inserted subcutaneously into a patient's skin. The exposed electrode areas are arranged symmetrically, such that a symmetrical potential distribution is produced when an AC signal is applied to the sensor. The sensors in accordance with these teachings can advantageously be used with AC signals to determine characteristics of the sensor and thus improve sensor performance. These teachings also provide a biocompatible sensor with multiple reference electrode areas that are exposed for contact with body fluid.

公开(公告)号：ES2861254T3

公开(公告)日：2021-10-06

申请号：ES11000725

申请日：2006-12-04

Applicant: HOFFMANN LA ROCHE

Inventor： WEINERT STEFAN ,  GALLEY PAUL ,  THUKRAL AJAY ,  CHITTAJALLU SIVA ,  BUCK HARVEY ,  WAGNER ROBIN ,  MARCO KYM ,  LONG JAMES ,  BOUSAMRA STEVEN

IPC: G16H20/10 ,  G06F9/44 ,  G16H10/60 ,  G16H20/60 ,  G16H40/63 ,  G16H40/67

Abstract: Un sistema (10) para determinar la información de administración de fármaco, comprendiendo el sistema (10) un dispositivo electrónico (12), en el que el dispositivo electrónico (12) comprende: un dispositivo de entrada (18) para proporcionar la entrada de usuario de información de prealimentación que tiene un primer componente de parámetro y un segundo componente de parámetro en una interfaz gráfica de usuario (50, 52, 54, 56, 60, 130), en el que la información de prealimentación contiene una estimación del contenido de carbohidratos de una comida o tentempié, correspondiente a una cantidad de carbohidratos que un paciente está a punto de ingerir, está ingiriendo o ha ingerido recientemente, usada como primer parámetro, así como una estimación de una velocidad de absorción global de glucosa de la comida por parte del paciente, usada como segundo parámetro, un dispositivo de almacenamiento de datos (16) que tiene almacenado en el mismo un mapa (50, 52, 54, 56, 60, 130) que correlaciona los valores del primer y segundo componente de parámetro con la información de administración de fármaco, y un procesador (14) sensible a dicha entrada de usuario de la información de prealimentación para determinar (110) la información de administración de fármaco correspondiente de acuerdo con el mapa.