中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

65 records (took 0.026 seconds)

    OLIGOPHOSPHORAMIDATES
    6.
    发明申请
    OLIGOPHOSPHORAMIDATES 审中-公开

    公开(公告)号：WO2008141799A8

    公开(公告)日：2009-11-05

    申请号：PCT/EP2008004022

    申请日：2008-05-20

    Applicant: ROCHE DIAGNOSTICS GMBH ,  HOFFMANN LA ROCHE ,  HEINDL DIETER ,  SEIDEL CHRISTOPH ,  THUER WILMA

    Inventor： HEINDL DIETER ,  SEIDEL CHRISTOPH ,  THUER WILMA

    IPC: C07F9/24 ,  C08G79/04

    CPC classification number: C07F9/585 ,  C07F9/5355 ,  C07F9/62 ,  C07F9/65062 ,  C07F9/65515 ,  C07F9/655363 ,  C07F9/65583 ,  C07F9/65586 ,  C07F9/6561 ,  C08G79/04 ,  Y02P20/55

    Abstract: The trivalent phosphorous atom of a compound is reacted with a reagent in such a manner that a stable phosphate mimetic is formed. Phosphoramidites with a phosphorous atom containing at least one hydroxyl residue which is provided with a protective group are reacted for this purpose with a free hydroxyl group: In the first synthesis cycle the hydroxyl group is linked to a solid support via a cleavable or non-cleavable linker. In further synthesis cycles the hydroxyl group is created by cleavage of the protective group from the growing oligomer. This results in formation of a phosphorous acid triester which is reacted with azides. Compounds of Formula (I) are produced.

    Abstract translation: 使化合物的三价磷原子与试剂反应，形成稳定的磷酸酯模拟物。 具有至少一个含有保护基团的羟基残基的磷原子的亚磷酰胺与该游离羟基反应：在第一个合成循环中，羟基通过可裂解或不可裂解的方式与固体支持物连接 连接。 在进一步的合成循环中，通过从生长的低聚物中切割保护基而产生羟基。 这导致形成与叠氮化物反应的亚磷酸三酯。 制备式（I）的化合物。

    ACETYLATION OF GP41 FRAGMENTS
    7.
    发明申请
    ACETYLATION OF GP41 FRAGMENTS 审中-公开
    GP41片段的乙酰化

    公开(公告)号：WO02103026A2

    公开(公告)日：2002-12-27

    申请号：PCT/EP0205782

    申请日：2002-05-27

    Applicant: HOFFMANN LA ROCHE

    Inventor： HOESS EVA ,  MEIER THOMAS ,  PESTLIN GABRIELE ,  POPP FRIEDRICH ,  REICHERT KLAUS ,  SCHMUCK RAINER ,  SCHNEIDINGER BERND ,  SEIDEL CHRISTOPH ,  TISCHER WILHELM

    IPC: C12N15/09 ,  A61K38/00 ,  A61P31/12 ,  A61P31/18 ,  C07K14/155 ,  C07K14/16 ,  C12N1/21 ,  C12N15/62 ,  C12P21/02 ,  C12P21/00

    CPC classification number: C07K14/005 ,  C07K2319/00 ,  C12N2740/15022 ,  C12N2740/16122 ,  C12P21/02

    Abstract: A process for the production of an antifusogenic peptide of a length of about 10 to 50 amino acids in a prokaryotic host cell, characterized in that, under such conditions that inclusion bodies of said non-fusion antifusogenic peptide or said fusion peptide are formed, a) in said host cell there is expressed a nucleic acid encoding said antifusogenic peptide as a non-fusion peptide or encoding a fusion peptide of a length of about 14 to 70 amino acids consisting of said antifusogenic peptide N-terminally linked to a further peptide of a length of about 4 to 30 amino acids; b) said host cell is cultivated; c) said inclusion bodies are recovered and solubilized; d) in the case of said fusion peptide said antifusogenic peptide is cleaved off from said further peptide; and e) said antifusogenic peptide is isolated.

    Abstract translation: 一种在原核宿主细胞中生产长度约10至50个氨基酸的抗融合肽的方法，其特征在于，在形成所述非融合抗融合肽或所述融合肽的包涵体的条件下， ）在所述宿主细胞中表达编码所述抗融合肽作为非融合肽或编码长度约为14至70个氨基酸的融合肽的核酸，所述融合肽由所述抗融合肽组成，所述融合肽与N-末端连接的另一个肽 长度约4至30个氨基酸; b）培养宿主细胞; c）所述包涵体被回收和溶解; d）在所述融合肽的情况下，所述抗融合肽从所述另外的肽切除; 和e）分离所述抗融合肽。

    IMPROVED PROCESS FOR PRODUCING MAGNETIC MONODISPERSE POLYMER PARTICLES
    10.
    发明专利
    IMPROVED PROCESS FOR PRODUCING MAGNETIC MONODISPERSE POLYMER PARTICLES 未知

    公开(公告)号：CA2926883A1

    公开(公告)日：2015-06-11

    申请号：CA2926883

    申请日：2014-12-03

    Applicant: HOFFMANN LA ROCHE

    Inventor： SEIDEL CHRISTOPH ,  BOLLE JENS CHRISTIAN ,  RECKLIES SANDRA

    IPC: H01F1/00 ,  C08F257/02

    Abstract: Disclosed in here is a simplified process for producing magnetic polymer particles, the process comprising the steps of (a) providing a composition with the following components, a liquid monomer which is radical polymerizable, a radical initiator which is soluble in the monomer, a steric stabilizer, and a ferrofluid comprising surfactant-coated colloidal magnetic particles in a carrier fluid which is miscible with the monomer; (b) preparing an emulsion from a polar solvent which is immiscible with the monomer, and the composition of step (a); (c) adding seed polymer particles to the emulsion, mixing to form a seeded emulsion, and incubating the seeded emulsion, thereby swelling the seed polymer particles; (d) activating the radical initiator and polymerizing the monomer in the swollen seed polymer particles; thereby producing the magnetic polymer particles. As a result of the process monodisperse magnetic particles can be provided. The particles are characterized by a uniform distribution of magnetic material, and an absence of magnetite bleeding.

Patent Agency Ranking