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公开(公告)号：JP2004239894A
公开(公告)日：2004-08-26
申请号：JP2004004171
申请日：2004-01-09
Inventor： GHOSHAL MITALI , SIGLER GERALD , HUI RAYMOND A , HAWLEY RONALD , HOESS EVA , HUBER ERASMUS J , PATTERSON JOHN W , SALAMONE SALVATORE J , DORN ALLAN
IPC: G01N33/531 , C07D307/88 , C07D405/12 , C07D473/08 , C07J19/00 , C07J41/00 , C07J43/00 , G01N33/53 , G01N33/535 , G01N33/573 , G01N33/58 , G01N33/78 , G01N33/94
CPC classification number: C07D405/12 , C07D307/88 , C07D473/08 , C07H15/20 , C07H15/22 , C07H15/24 , C07J17/00 , C07J19/005 , C07J41/0005 , C07J41/0055 , C07J43/003 , G01N33/53 , G01N33/535 , G01N33/5735 , G01N33/581 , G01N33/78 , G01N33/9453 , G01N2333/904
Abstract: PROBLEM TO BE SOLVED: To provide an enzyme inhibition immunoassay for measuring analytes in biological samples. SOLUTION: The method for measuring analytes in biological samples is characterized in that uncompetitive inhibitor is coupled to a ligand and utilized in a homogeneous assay. The analyte can be a drug, drug derivative, hormone, polypeptide, or oligonucleotide. Novel compounds, assay reagents, and packaged kits, useful for performing such measurements, are also provided. COPYRIGHT: (C)2004,JPO&NCIPI
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公开(公告)号：JP2009132716A
公开(公告)日：2009-06-18
申请号：JP2008302955
申请日：2008-11-27
Inventor： BLIND RENE , FINK GERHARD , HOESS EVA , KYTZIA HANS-JOACHIM
CPC classification number: G01N33/532 , A61K47/55
Abstract: PROBLEM TO BE SOLVED: To provide a composition and a method for stabilizing a conjugate comprising two moieties, for example, an analyte and a label, covalently linked by a thiourea linker.
SOLUTION: The composition contains (a) a purified conjugate comprising two moieties covalently linked by the thiourea linker, and (b) thiourea or a derivative thereof in free form.
COPYRIGHT: (C)2009,JPO&INPITAbstract translation: 待解决的问题：提供用于稳定缀合物的组合物和方法，其包含由硫脲接头共价连接的两个部分，例如分析物和标记。 组合物包含（a）包含由硫脲连接体共价连接的两个部分的纯化的缀合物，和（b）游离形式的硫脲或其衍生物。 版权所有（C）2009，JPO＆INPIT
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公开(公告)号：JP2007126466A
公开(公告)日：2007-05-24
申请号：JP2006329870
申请日：2006-12-06
Inventor： GHOSHAL MITALI , SIGLER GERALD , HUI RAYMOND A , HAWLEY RONALD , HOESS EVA , HUBER ERASMUS J , PATTERSON JOHN W , SALAMONE SALVATORE J , DORN ALLAN
IPC: C07D405/12 , G01N33/531 , C07D307/88 , C07D473/08 , C07H15/26 , C07J17/00 , C07J19/00 , C07J41/00 , C07J43/00 , G01N33/53 , G01N33/535 , G01N33/573 , G01N33/58 , G01N33/78 , G01N33/94
CPC classification number: C07D405/12 , C07D307/88 , C07D473/08 , C07H15/20 , C07H15/22 , C07H15/24 , C07J17/00 , C07J19/005 , C07J41/0005 , C07J41/0055 , C07J43/003 , G01N33/53 , G01N33/535 , G01N33/5735 , G01N33/581 , G01N33/78 , G01N33/9453 , G01N2333/904
Abstract: PROBLEM TO BE SOLVED: To provide an enzyme inhibition immunoassay for the measurement of an analyte in biological samples. SOLUTION: This invention provides a method for the measurement of an analyte in biological samples whereby an uncompetitive inhibitor is coupled to a ligand and utilized in a homogeneous assay. The analyte can be a drug or drug derivative, hormone, polypeptide, or oligonucleotide. The invention also provides novel compounds, assay reagents and packaged kits useful for performing such measurements. COPYRIGHT: (C)2007,JPO&INPIT
Abstract translation: 要解决的问题：提供用于测量生物样品中的分析物的酶抑制免疫测定。 解决方案：本发明提供了一种用于测量生物样品中的分析物的方法，由此使非竞争性抑制剂与配体偶联并用于均一测定中。 分析物可以是药物或药物衍生物，激素，多肽或寡核苷酸。 本发明还提供了可用于进行这种测量的新型化合物，测定试剂和包装的试剂盒。 版权所有（C）2007，JPO＆INPIT
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公开(公告)号：WO0227315A3
公开(公告)日：2002-07-11
申请号：PCT/EP0111118
申请日：2001-09-26
Applicant: ROCHE DIAGNOSTICS GMBH , HOFFMANN LA ROCHE , ANDRES HERBERT , JOSEL HANS-PETER , HOESS EVA , HERRMANN RUPERT , ELTZ HERBERT VON DER
Inventor： ANDRES HERBERT , JOSEL HANS-PETER , HOESS EVA , HERRMANN RUPERT , VON DER ELTZ HERBERT
IPC: G01N33/543 , C07F15/00 , C07K1/107 , C07K5/02 , C07K7/02 , C07K14/00 , C07K14/16 , C07K19/00 , C12N15/09 , C12Q1/68 , G01N33/53 , G01N33/531 , G01N33/532 , G01N33/533 , G01N33/547 , G01N33/58 , G01N33/68 , C07K14/18
CPC classification number: G01N33/6845 , C07K1/1075 , C07K1/1077 , C07K14/001 , G01N33/5306 , G01N33/531 , G01N33/532 , G01N33/533 , G01N33/68
Abstract: The present invention concerns new compounds comprising a branched linker and their use for producing conjugates for applications in diagnostic or therapeutic methods.
Abstract translation: 本发明涉及包含支链接头的新化合物及其用于制备用于诊断或治疗方法的缀合物的用途。
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公开(公告)号：WO0227317A3
公开(公告)日：2003-09-12
申请号：PCT/EP0111101
申请日：2001-09-26
Applicant: ROCHE DIAGNOSTICS GMBH , HOFFMANN LA ROCHE , HOESS EVA , ANDRES HERBERT , DONIE FREDERIC , VOGEL RUDOLF , JOSEL HANS-PETER , HERRMANN RUPERT , ELTZ HERBERT VON DER
Inventor： HOESS EVA , ANDRES HERBERT , DONIE FREDERIC , VOGEL RUDOLF , JOSEL HANS-PETER , HERRMANN RUPERT , VON DER ELTZ HERBERT
IPC: A61K47/48 , C07K1/107 , G01N30/88 , G01N33/53 , G01N33/531 , G01N33/532 , G01N33/533 , G01N33/566 , G01N33/68
CPC classification number: C07K1/1077 , A61K47/643 , A61K47/6889 , G01N33/5306 , G01N33/531 , G01N33/68 , G01N33/6845 , Y10S435/961 , Y10S435/962
Abstract: The invention relates to a process for the production of a biomolecule-linker conjugate of uniform stochiometry. It especially relates to a conjugate consisting of a biomolecule of a molecular weight between 5 kD and 500 kD and a hydrophilic linker molecule said linker having a molecular weight between 1 and 15 kD and between 4 and 60 charged residues, characterized in that said conjugate comprises at least one biomelecule-linker product of uniform stoichiometry in a pre-selected amount.
Abstract translation: 本发明涉及一种制备均匀化学计量学的生物分子 - 接头共轭物的方法。 其特别涉及由分子量在5kD至500kD之间的生物分子和亲水性接头分子所组成的共轭物，所述接头分子量为1至15kD，4至60个带电荷的残基，其特征在于所述共轭物包含 至少一种具有预选量的均匀化学计量的生物分子 - 接头产物。
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Patent Agency Ranking
公开(公告)号：WO02103026A2
公开(公告)日：2002-12-27
申请号：PCT/EP0205782
申请日：2002-05-27
Applicant: HOFFMANN LA ROCHE
Inventor： HOESS EVA , MEIER THOMAS , PESTLIN GABRIELE , POPP FRIEDRICH , REICHERT KLAUS , SCHMUCK RAINER , SCHNEIDINGER BERND , SEIDEL CHRISTOPH , TISCHER WILHELM
IPC: C12N15/09 , A61K38/00 , A61P31/12 , A61P31/18 , C07K14/155 , C07K14/16 , C12N1/21 , C12N15/62 , C12P21/02 , C12P21/00
CPC classification number: C07K14/005 , C07K2319/00 , C12N2740/15022 , C12N2740/16122 , C12P21/02
Abstract: A process for the production of an antifusogenic peptide of a length of about 10 to 50 amino acids in a prokaryotic host cell, characterized in that, under such conditions that inclusion bodies of said non-fusion antifusogenic peptide or said fusion peptide are formed, a) in said host cell there is expressed a nucleic acid encoding said antifusogenic peptide as a non-fusion peptide or encoding a fusion peptide of a length of about 14 to 70 amino acids consisting of said antifusogenic peptide N-terminally linked to a further peptide of a length of about 4 to 30 amino acids; b) said host cell is cultivated; c) said inclusion bodies are recovered and solubilized; d) in the case of said fusion peptide said antifusogenic peptide is cleaved off from said further peptide; and e) said antifusogenic peptide is isolated.
Abstract translation: 一种在原核宿主细胞中生产长度约10至50个氨基酸的抗融合肽的方法，其特征在于，在形成所述非融合抗融合肽或所述融合肽的包涵体的条件下， ）在所述宿主细胞中表达编码所述抗融合肽作为非融合肽或编码长度约为14至70个氨基酸的融合肽的核酸，所述融合肽由所述抗融合肽组成，所述融合肽与N-末端连接的另一个肽 长度约4至30个氨基酸; b）培养宿主细胞; c）所述包涵体被回收和溶解; d）在所述融合肽的情况下，所述抗融合肽从所述另外的肽切除; 和e）分离所述抗融合肽。
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公开(公告)号：ES2369717T3
公开(公告)日：2011-12-05
申请号：ES08020499
申请日：2008-11-26
Applicant: ROCHE DIAGNOSTICS GMBH , HOFFMANN LA ROCHE
Inventor： BLIND RENE , FINK GERHARD , HOESS EVA , KYTZIA HANS-JOACHIM
IPC: G01N33/532 , A61K47/48
Abstract: Composición que contiene: a) un conjugado purificado que comprende dos grupos unidos covalentemente mediante una molécula conectora de tiourea, y b) tiourea o un derivado de la misma en forma libre, en la que dicho derivado de tiourea se selecciona de entre ditiobiurea, tiourea alquilada que presenta uno, dos, tres o la totalidad de los cuatro átomos de hidrógeno de la tiourea sustituidos con alquilo de seis o menos átomos de carbono, tiourea que presenta uno o ambos nitrógenos con acetilo o alquenilo C1-C6, y tiourea que presenta un puente alquilo o alquileno entre los dos átomos de nitrógeno de dos o tres átomos de C.
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公开(公告)号：AT518138T
公开(公告)日：2011-08-15
申请号：AT08020499
申请日：2008-11-26
Applicant: HOFFMANN LA ROCHE
Inventor： BLIND RENE , FINK GERHARD , HOESS EVA , KYTZIA HANS-JOACHIM
IPC: G01N33/532 , A61K47/48
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公开(公告)号：ES2360699T3
公开(公告)日：2011-06-08
申请号：ES04000298
申请日：2004-01-09
Applicant: ROCHE DIAGNOSTICS GMBH , HOFFMANN LA ROCHE
Inventor： GHOSHAL MITALI , SIGLER GERALD , HUI RAYMOND A , HAWLEY RONALD , HOESS EVA , HUBER ERASMUS J , PATTERSON JOHN W , SALAMONE SALVATORE J , DORN ALLAN
IPC: G01N33/53 , G01N33/531 , C07D307/88 , C07D405/12 , C07D473/08 , C07J19/00 , C07J41/00 , C07J43/00 , C12Q1/32 , G01N33/535 , G01N33/573 , G01N33/58 , G01N33/78 , G01N33/94
Abstract: Un conjugado ligando-inhibidor con una estructura **Fórmula** en la que n = 1-2 y x es -NH-CO-(CH2)3-fenitoína.
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公开(公告)号：AT313796T
公开(公告)日：2006-01-15
申请号：AT01969773
申请日：2001-09-26
Applicant: HOFFMANN LA ROCHE
Inventor： HOESS EVA , ANDRES HERBERT , DONIE FREDERIC , VOGEL RUDOLF , JOSEL HANS-PETER , HERRMANN RUPERT , VON DER ELTZ HERBERT
IPC: A61K47/48 , C07K1/107 , G01N30/88 , G01N33/53 , G01N33/531 , G01N33/532 , G01N33/533 , G01N33/566 , G01N33/68
Abstract: The invention relates to a conjugate consisting of a polypeptide having between 50 and 5000 amino acids and a hydrophilic linker molecule said linker having a molecular weight between 1 and 15 kD and between 4 and 60 charged residues, characterized in that said conjugate comprises at least one polypeptide-linker product of uniform stoichiometry in a pre-selected amount.
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