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1.发明专利
公开(公告)号：JP2004049240A
公开(公告)日：2004-02-19
申请号：JP2003276312
申请日：2003-07-17
Inventor： SCHNEIDINGER BERND , MEIER THOMAS , SCHMUCK RAINER , SHAO ZHIXIN
Abstract: PROBLEM TO BE SOLVED: To provide a conjugate of alkaline phosphatase available for a quantitative determination of the alkaline phosphatase as a standard and reproducibly produced by a simple method.
SOLUTION: The conjugate of tissue non-specific alkaline phosphatase (tns-AP) and dextran in the invention is obtained by reacting a non-glycosylated tns-AP with an activated dextran in an aqueous solution , stopping the reaction, and isolating the conjugate of tns-AP and dextran from the solution.
COPYRIGHT: (C)2004,JPO-
公开(公告)号：JP2005058236A
公开(公告)日：2005-03-10
申请号：JP2004235542
申请日：2004-08-12
Inventor： ANKENBAUER WALTRAUD , MAIER THOMAS , DEUFEL ANNETTE , HEINDL DIETER , BETZL GISELA , SCHMUCK RAINER , SCHNEIDINGER BERND , STREY JESSICA
IPC: C12N15/09 , A61K38/45 , C07H21/04 , C07K14/195 , C07K19/00 , C11D3/386 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N9/12 , C12N9/22 , C12N15/00 , C12N15/11 , C12N15/52 , C12N15/54 , C12N15/62 , C12N15/63 , C12P21/02 , C12Q1/68
CPC classification number: C12N9/1252
Abstract: PROBLEM TO BE SOLVED: To provide a peptide having an increased thermal stability and a thermally stable DNA polymerase activity and a method for forming a purified peptide. SOLUTION: Disclosed is a peptide having a specific amino acid sequence and a DNA polymerase activity. COPYRIGHT: (C)2005,JPO&NCIPI
Abstract translation: 待解决的问题：提供具有增加的热稳定性和热稳定的DNA聚合酶活性的肽以及形成纯化肽的方法。 解决方案：公开了具有特定氨基酸序列和DNA聚合酶活性的肽。 版权所有（C）2005，JPO＆NCIPI
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公开(公告)号：KR20200135444A
公开(公告)日：2020-12-02
申请号：KR20207030180
申请日：2019-03-22
Applicant: HOFFMANN LA ROCHE
Inventor： BUESSER ALEXANDER , HUSCHTO TONY , PETRICH WOLFGANG , RAVIZZA STEFAN , SCHNEIDINGER BERND
Abstract: 본개시는만성신장질환 (CKD) 의위험에대해피험자를스크리닝하기위한방법에관한것이고, 그방법은: 피험자에대한복수의마커파라미터들을나타내는마커데이터를수신하는단계로서, 이러한복수의마커파라미터들은, 측정기간동안피험자에대해, 연령값, 크레아티닌의샘플레벨, 및알부민의샘플레벨을나타내는, 상기마커데이터를수신하는단계; 및, 복수의마커파라미터들로부터피험자에대한앓고있는 CKD 의위험을나타내는위험인자를결정하는단계를포함하고, 여기서, 상기결정하는단계는: 알부민의샘플레벨보다더 높게연령값에가중치를부여하는단계, 및, 알부민의샘플레벨보다더 높게크레아티닌의샘플레벨에가중치를부여하는단계를포함한다. 추가로, 만성신장질환 (CKD) 의위험에대해피험자를스크리닝하기위한컴퓨터-구현방법및 피험자를스크리닝하기위한방법이제공된다.
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4.发明专利
公开(公告)号：JP2003304889A
公开(公告)日：2003-10-28
申请号：JP2003099615
申请日：2003-04-02
Applicant: F Hoffmann La Roche Ag , エフ.ホフマン−ラ ロシュ アーゲー
Inventor： MUELLER RAINER , PAJATSCH MARKUS , CURDT INGO , SOBEK HARALD DR , SCHMIDT MANFRED , SUPPMANN BERNHARD , SONN KIRSTEN , SCHNEIDINGER BERND
CPC classification number: C12N9/1264 , C12Y207/07031 , G01N2510/00
Abstract: PROBLEM TO BE SOLVED: To provide a terminal deoxynucleotidyl transferase having uniform state with sufficient enzymatic activity. SOLUTION: The transferase is a truncated TdT derivative wherein at most 161 amino acids at the N-terminal are truncated and exhibiting enzymatic activity in a solution containing Co 2+ ion corresponding to 20-30 times the enzymatic activity of natural terminal deoxynucleotidyl transferase (TdT). COPYRIGHT: (C)2004,JPO
Abstract translation: 要解决的问题：提供具有均匀状态的末端脱氧核苷酸转移酶，具有足够的酶活性。 解决方案：转移酶是截短的TdT衍生物，其N-末端的至多161个氨基酸被截短并且在含有对应于20-30倍的Co
2 + 离子的溶液中表现出酶活性 天然末端脱氧核苷酸转移酶（TdT）的酶活性。 版权所有（C）2004，JPO -
公开(公告)号：WO02103026A2
公开(公告)日：2002-12-27
申请号：PCT/EP0205782
申请日：2002-05-27
Applicant: HOFFMANN LA ROCHE
Inventor： HOESS EVA , MEIER THOMAS , PESTLIN GABRIELE , POPP FRIEDRICH , REICHERT KLAUS , SCHMUCK RAINER , SCHNEIDINGER BERND , SEIDEL CHRISTOPH , TISCHER WILHELM
IPC: C12N15/09 , A61K38/00 , A61P31/12 , A61P31/18 , C07K14/155 , C07K14/16 , C12N1/21 , C12N15/62 , C12P21/02 , C12P21/00
CPC classification number: C07K14/005 , C07K2319/00 , C12N2740/15022 , C12N2740/16122 , C12P21/02
Abstract: A process for the production of an antifusogenic peptide of a length of about 10 to 50 amino acids in a prokaryotic host cell, characterized in that, under such conditions that inclusion bodies of said non-fusion antifusogenic peptide or said fusion peptide are formed, a) in said host cell there is expressed a nucleic acid encoding said antifusogenic peptide as a non-fusion peptide or encoding a fusion peptide of a length of about 14 to 70 amino acids consisting of said antifusogenic peptide N-terminally linked to a further peptide of a length of about 4 to 30 amino acids; b) said host cell is cultivated; c) said inclusion bodies are recovered and solubilized; d) in the case of said fusion peptide said antifusogenic peptide is cleaved off from said further peptide; and e) said antifusogenic peptide is isolated.
Abstract translation: 一种在原核宿主细胞中生产长度约10至50个氨基酸的抗融合肽的方法，其特征在于，在形成所述非融合抗融合肽或所述融合肽的包涵体的条件下， ）在所述宿主细胞中表达编码所述抗融合肽作为非融合肽或编码长度约为14至70个氨基酸的融合肽的核酸，所述融合肽由所述抗融合肽组成，所述融合肽与N-末端连接的另一个肽 长度约4至30个氨基酸; b）培养宿主细胞; c）所述包涵体被回收和溶解; d）在所述融合肽的情况下，所述抗融合肽从所述另外的肽切除; 和e）分离所述抗融合肽。
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Patent Agency Ranking
公开(公告)号：AU2004203649B2
公开(公告)日：2006-01-12
申请号：AU2004203649
申请日：2004-08-06
Applicant: HOFFMANN LA ROCHE
Inventor： DEUFEL ANNETTE , STREY JESSICA , BETZL GISELA , ANKENBAUER WALTRAUD , SCHNEIDINGER BERND , MEIER THOMAS , HEINDL DIETER , SCHMUCK RAINER
IPC: C12N15/09 , C12N15/52 , A61K38/45 , C07H21/04 , C07K14/195 , C07K19/00 , C11D3/386 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N9/12 , C12N9/22 , C12N15/00 , C12N15/11 , C12N15/54 , C12N15/62 , C12N15/63 , C12P21/02 , C12Q1/68
Abstract: It was found that a fragment of native Thermus aquaticus DNA polymerase (TaqWT) lacking 288 N-terminal amino acids (Taq DELTA 288) possesses an increased thermostability over TaqWT, Taq DELTA 279, and Taq DELTA 289. The present invention therefore provides Taq DELTA 288, recombinant expression vectors encoding the same or derivatives thereof, as well as purification protocols for Taq DELTA 288. The invention also encompasses kits containing Taq DELTA 288 as well as the use of Taq DELTA 288 and kits containing Taq DELTA 288. In addition, the invention encompasses methods for the sequencing a nucleic acid template and methods for amplifying a target nucleic acid.
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公开(公告)号：BRPI0403221A
公开(公告)日：2005-07-12
申请号：BRPI0403221
申请日：2004-08-12
Applicant: HOFFMANN LA ROCHE
Inventor： ANKENBAUER WALTRAUD , MEIER THOMAS , DEUFEL ANNETTE , HEINDL DIETER , BETZL GISELA , SCHMUCK RAINER , SCHNEIDINGER BERND , STREY JESSICA
IPC: C12N15/09 , A61K38/45 , C07H21/04 , C07K14/195 , C07K19/00 , C11D3/386 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N9/12 , C12N9/22 , C12N15/00 , C12N15/11 , C12N15/52 , C12N15/54 , C12N15/62 , C12N15/63 , C12P21/02 , C12Q1/68
Abstract: It was found that a fragment of native Thermus aquaticus DNA polymerase (TaqWT) lacking 288 N-terminal amino acids (Taq DELTA 288) possesses an increased thermostability over TaqWT, Taq DELTA 279, and Taq DELTA 289. The present invention therefore provides Taq DELTA 288, recombinant expression vectors encoding the same or derivatives thereof, as well as purification protocols for Taq DELTA 288. The invention also encompasses kits containing Taq DELTA 288 as well as the use of Taq DELTA 288 and kits containing Taq DELTA 288. In addition, the invention encompasses methods for the sequencing a nucleic acid template and methods for amplifying a target nucleic acid.
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公开(公告)号：DK3543702T3
公开(公告)日：2023-01-09
申请号：DK18163573
申请日：2018-03-23
Applicant: F HOFFMANN LA ROCHE AG
Inventor： PETRICH WOLFGANG , HUSCHTO TONY , SCHNEIDINGER BERND
IPC: G01N33/68
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公开(公告)号：CA2423887C
公开(公告)日：2008-01-22
申请号：CA2423887
申请日：2003-04-01
Applicant: HOFFMANN LA ROCHE
Inventor： PAJATSCH MARKUS , MUELLER RAINER , SOBEK HARALD , CURDT INGO , SONN KIRSTEN , SCHMIDT MANFRED , SUPPMANN BERNHARD , SCHNEIDINGER BERND
IPC: C12N9/12 , C12N15/09 , C12N9/10 , C12N15/54 , C12N15/63 , C12P19/34 , C12P21/02 , C12Q1/48 , G01N33/573
Abstract: Truncated terminal deoxynucleotidyl transferase (TdT) derivative from calf thymus characterized in that the derivative in comparison to the native TdT is N- terminally truncated by up to 161 amino acids and has a 20- 30-fold higher enzyme activity in solutions containing Co~ions, and it's recombinant production and use.
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公开(公告)号：CA2474734A1
公开(公告)日：2005-02-12
申请号：CA2474734
申请日：2004-08-11
Applicant: HOFFMANN LA ROCHE
Inventor： SCHNEIDINGER BERND , STREY JESSICA , ANKENBAUER WALTRAUD , DEUFEL ANNETTE , HEINDL DIETER , BETZL GISELA , SCHMUCK RAINER , MEIER THOMAS
IPC: C12N15/09 , A61K38/45 , C07H21/04 , C07K14/195 , C07K19/00 , C11D3/386 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N9/12 , C12N9/22 , C12N15/00 , C12N15/11 , C12N15/52 , C12N15/54 , C12N15/62 , C12N15/63 , C12P21/02 , C12Q1/68
Abstract: It was found that a fragment of native Thermus aquaticus DNA polymerase (TaqWT) lacking 288 N-terminal amino acids (Taq.DELTA.288) possesses an increased thermostability over TaqWT, Taq.DELTA.279, and Taq.DELTA.289. The present invention therefore provides Taq.DELTA.288, recombinant expression vectors encoding th e same or derivatives thereof, as well as purification protocols for Taq.DELTA.288. Th e invention also encompasses kits containing Taq.DELTA.288 as well as the use of Taq.DELTA.288 and kits containing Taq.DELTA.288. In addition, the invention encompasses methods for the sequencing a nucleic acid template and methods for amplifying a target nucle ic acid.
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