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    ACETYLATION OF GP41 FRAGMENTS
    1.
    发明申请
    ACETYLATION OF GP41 FRAGMENTS 审中-公开
    GP41片段的乙酰化

    公开(公告)号：WO02103026A2

    公开(公告)日：2002-12-27

    申请号：PCT/EP0205782

    申请日：2002-05-27

    Applicant: HOFFMANN LA ROCHE

    Inventor： HOESS EVA ,  MEIER THOMAS ,  PESTLIN GABRIELE ,  POPP FRIEDRICH ,  REICHERT KLAUS ,  SCHMUCK RAINER ,  SCHNEIDINGER BERND ,  SEIDEL CHRISTOPH ,  TISCHER WILHELM

    IPC: C12N15/09 ,  A61K38/00 ,  A61P31/12 ,  A61P31/18 ,  C07K14/155 ,  C07K14/16 ,  C12N1/21 ,  C12N15/62 ,  C12P21/02 ,  C12P21/00

    CPC classification number: C07K14/005 ,  C07K2319/00 ,  C12N2740/15022 ,  C12N2740/16122 ,  C12P21/02

    Abstract: A process for the production of an antifusogenic peptide of a length of about 10 to 50 amino acids in a prokaryotic host cell, characterized in that, under such conditions that inclusion bodies of said non-fusion antifusogenic peptide or said fusion peptide are formed, a) in said host cell there is expressed a nucleic acid encoding said antifusogenic peptide as a non-fusion peptide or encoding a fusion peptide of a length of about 14 to 70 amino acids consisting of said antifusogenic peptide N-terminally linked to a further peptide of a length of about 4 to 30 amino acids; b) said host cell is cultivated; c) said inclusion bodies are recovered and solubilized; d) in the case of said fusion peptide said antifusogenic peptide is cleaved off from said further peptide; and e) said antifusogenic peptide is isolated.

    Abstract translation: 一种在原核宿主细胞中生产长度约10至50个氨基酸的抗融合肽的方法，其特征在于，在形成所述非融合抗融合肽或所述融合肽的包涵体的条件下， ）在所述宿主细胞中表达编码所述抗融合肽作为非融合肽或编码长度约为14至70个氨基酸的融合肽的核酸，所述融合肽由所述抗融合肽组成，所述融合肽与N-末端连接的另一个肽 长度约4至30个氨基酸; b）培养宿主细胞; c）所述包涵体被回收和溶解; d）在所述融合肽的情况下，所述抗融合肽从所述另外的肽切除; 和e）分离所述抗融合肽。

    USE OF ASC AS A MARKER FOR COLORECTAL CANCER
    4.
    发明申请
    USE OF ASC AS A MARKER FOR COLORECTAL CANCER 审中-公开
    使用ASC作为彩色癌症的标记

    公开(公告)号：WO2006066917A2

    公开(公告)日：2006-06-29

    申请号：PCT/EP2005013869

    申请日：2005-12-22

    Applicant: ROCHE DIAGNOSTICS GMBH ,  HOFFMANN LA ROCHE ,  ANDRES HERBERT ,  HAGMANN MARIE-LUISE ,  KARL JOHANN ,  KUNERT URSULA ,  PESTLIN GABRIELE

    Inventor： ANDRES HERBERT ,  HAGMANN MARIE-LUISE ,  KARL JOHANN ,  KUNERT URSULA ,  PESTLIN GABRIELE

    IPC: G01N33/574

    CPC classification number: G01N33/57419

    Abstract: The present invention relates to the diagnosis of colorectal cancer. It discloses the use of protein ASC (apoptosis-associated speck-like protein containing a caspase­associated recruitment domain) in the diagnosis of colorectal cancer. It relates to a method for diagnosis of colorectal cancer from a liquid sample, derived from an individual by measuring ASC in said sample. Measurement of ASC can, e.g., be used in the early detection or diagnosis of colorectal cancer.

    Abstract translation: 本发明涉及结肠直肠癌的诊断。 它公开了在结肠直肠癌诊断中使用蛋白质ASC（含有胱天蛋白酶相关募集域的凋亡相关斑点样蛋白）。 本发明涉及一种通过测量所述样品中ASC的来自个体的来自液体样品的结肠直肠癌的诊断方法。 ASC的测量可以例如用于结肠直肠癌的早期检测或诊断。

    USO DE LA ASC, COMO MARCADOR PARA CANCER COLORRECTAL.
    7.
    发明专利
    USO DE LA ASC, COMO MARCADOR PARA CANCER COLORRECTAL. 未知

    公开(公告)号：ES2323429T3

    公开(公告)日：2009-07-15

    申请号：ES05820046

    申请日：2005-12-22

    Applicant: HOFFMANN LA ROCHE

    Inventor： ANDRES HERBERT ,  HAGMANN MARIE-LUISE ,  KARL JOHANN ,  KUNERT URSULA ,  PESTLIN GABRIELE

    IPC: G01N33/574

    Abstract: Un procedimiento para valorar el cáncer colorrectal (CRC), in vitro, que comprende las etapas de a) la medición, en una muestra, de la concentración de proteína semejante al moteado asociado a la apoptosis que contiene un dominio de reclutamiento asociado a la caspasa (ASC), b) opcionalmente, la medición, en una muestra, de la concentración determinada de uno o más marcadores adicionales distintos del cáncer colorrectal, y c) correlacionar la concentración determinada en la etapa (a), y opcionalmente, las concentraciones determinadas en la etapa b), a la diagnosis de cáncer colorrectal, en donde, un elevado nivel de ASC, es indicativo para CRC.

    USE OF ASC AS A MARKER FOR COLORECTAL CANCER
    8.
    发明专利
    USE OF ASC AS A MARKER FOR COLORECTAL CANCER 未知

    公开(公告)号：CA2586654A1

    公开(公告)日：2006-06-29

    申请号：CA2586654

    申请日：2005-12-22

    Applicant: HOFFMANN LA ROCHE

    Inventor： KARL JOHANN ,  HAGMANN MARIE-LUISE ,  ANDRES HERBERT ,  KUNERT URSULA ,  PESTLIN GABRIELE

    IPC: G01N33/574

    Abstract: The present invention relates to the diagnosis of colorectal cancer. It discloses the use of protein ASC (apoptosis-associated speck-like protein containing a caspase-associated recruitment domain) in the diagnosis of colorectal cancer. It relates to a method for diagnosis of colorectal cancer from a liquid sample, derived from an individual by measuring ASC in said sample. Measurement of ASC can, e.g., be used in the early detection or diagnosis of colorectal cancer.

    USE OF ASC AS A MARKER FOR COLORECTAL CANCER
    10.
    发明专利
    USE OF ASC AS A MARKER FOR COLORECTAL CANCER 未知

    公开(公告)号：CA2586654C

    公开(公告)日：2010-10-05

    申请号：CA2586654

    申请日：2005-12-22

    Applicant: HOFFMANN LA ROCHE

    Inventor： ANDRES HERBERT ,  HAGMANN MARIE-LUISE ,  KARL JOHANN ,  KUNERT URSULA ,  PESTLIN GABRIELE

    IPC: G01N33/574

    Abstract: The present invention relates to the diagnosis of colorectal cancer. It discloses the use of protein ASC (apoptosis-associated speck-like protein containing a caspase~associated recruitment domain) in the diagnosis of colorectal cancer. It relates to a method for diagnosis of colorectal cancer from a liquid sample, derived from an individual by measuring ASC in said sample. Measurement of ASC can, e.g., be used in the early detection or diagnosis of colorectal cancer.

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