公开(公告)号：US3107346A

公开(公告)日：1963-10-15

申请号：US69438857

申请日：1957-11-04

Applicant: IBM

Inventor： DARWIN DANIEL P ,  REX DONALD K ,  KELLOGG ROBERT M

IPC: G06K17/00

CPC classification number: G06K17/0012 ,  G06K17/00 ,  Y10S221/01

公开(公告)号：US3011698A

公开(公告)日：1961-12-05

申请号：US85773759

申请日：1959-12-07

Applicant: IBM

Inventor： DARWIN DANIEL P ,  KELLOGG ROBERT M

IPC: F15B15/22

CPC classification number: F15B15/221 ,  Y10T83/8858

公开(公告)号：US3066859A

公开(公告)日：1962-12-04

申请号：US85782259

申请日：1959-12-07

Applicant: IBM

Inventor： DARWIN DANIEL P ,  KELLOGG ROBERT M

IPC: F15B21/08

CPC classification number: F15B21/08

公开(公告)号：CA989443A

公开(公告)日：1976-05-18

申请号：CA171174

申请日：1973-05-10

Applicant: IBM

Inventor： JONES ALAN L ,  JUDSON GEORGE T ,  KELLOGG ROBERT M

IPC: A61M39/02 ,  F16J15/36 ,  F16L27/08

公开(公告)号：CA1166215A

公开(公告)日：1984-04-24

申请号：CA381171

申请日：1981-07-06

Applicant: IBM

Inventor： KELLOGG ROBERT M ,  KRUGER VICTOR R

IPC: G01N33/48 ,  B04B1/02 ,  B04B5/04 ,  B04B11/00 ,  B04B1/04 ,  B04B11/06

Abstract: A centrifuge structure for automatically separating a plurality of aliquot samples of blood plasma for testing from an initial sample of whole blood. A centrifuge bowl is provided with a bottom surface sloping upwardly and outwardly and joined to a vertical circular outer wall. A plurality of radially extending vertical septa or partitions divide the outer portion of the bowl into a plurality of radially extending chambers. Each of these chambers is provided with an exit port in the bottom surface. Whole blood placed in the bowl is forced radially outward by the centrifugal action of the bowl when rotated, and separates into different fractions. The selected fractions are moved to the vicinity of the exit ports by selectively changing the rotational velocity of the centrifuge and are then valved to other containers by opening valves connected to the exit ports. EN979001

公开(公告)号：FR2392725A1

公开(公告)日：1978-12-29

申请号：FR7813284

申请日：1978-04-27

Applicant: IBM

Inventor： KELLOGG ROBERT M ,  KRUGER VICTOR R ,  MULZET ALFRED P

IPC: G01N33/48 ,  B04B5/04 ,  B04B1/00

Abstract: An improved centrifuge assembly comprising a channeled rotor assembly and a ring-like fluid container disposed in the channel, whereby the centrifugal separation effects in the fluid container are determined by the geometry of the channel in the rotor. The fluid container is preferably formed from semirigid plastic material in the form of a tube having a rectangular cross section and is considered a disposable item to be discarded after a single use. The rotor assembly preferably includes a removable filler piece or center piece formed from a single piece of material, such as rigid plastic, as by molding, dimensioned to form, with the wall of the centrifuge bowl, a circular channel having dimensions appropriate to receive the semirigid container, which is suitably bent and placed in the channel. Fluid connections are provided from each end of the container to an axially located multichannel rotating seal. The connections lie in a plurality of radial slots in the filler piece. Alternatively the entire assembly may be molded as a single entity, with a suitable channel and fluid line grooves being cast therein.

公开(公告)号：CA1074276A

公开(公告)日：1980-03-25

申请号：CA300350

申请日：1978-04-04

Applicant: IBM

Inventor： KELLOGG ROBERT M ,  MULZET ALFRED P

IPC: G01N33/48 ,  A61M1/36 ,  B04B5/00 ,  B04B5/04 ,  B04B11/00

Abstract: CENTRIFUGE COLLECTING CHAMBER An improved collecting chamber for use with centrifuges for separating particles of different density suspended in a fluid, especially for separating the various fractions in human blood. The chamber is provided with a partition or dam and a plurality of outlet tubes. These tubes are positioned so that they can draw off the various separated components of the blood. The divider prevents the mixing of the fractions after they enter the chamber. By properly regulating the output flow of the lines containing the packed red cells, and the plasma and red cells, the content of the buffy collect line is defined and can be maintained constant over relatively long periods of time without operator intervention.

公开(公告)号：CA1059090A

公开(公告)日：1979-07-24

申请号：CA265856

申请日：1976-11-16

Applicant: IBM

Inventor： KELLOGG ROBERT M ,  KRUGER VICTOR R

IPC: G01N33/48 ,  B04B5/04 ,  B04B5/00

Abstract: CENTRIFUGE FLUID CONTAINER A fluid container particularly useful in a centrifuge system for separating the various fractions in blood. The container comprises two circular sheets of flexible material, having central openings therein. The outer peripheral edges are sealed together, as well as annular-like portions extending outwardly from the central opening. Concentric-like inner and outer annularlike channels are thus formed at the outer peripheral portion of the assembly. Radial arcuate portions are sealed off, thereby providing interrupted annularlike channels. At a first end of the inner annular-like channel, an inlet tube is provided, extending outwardly from the central opening and communicating with the first end of the inner annular-like channel. At the outlet or second end of the inner annular-like channel, there is provided a radially extending inter-channel connector, which comprises a sealed off portion extending between the adjacent ends of the inner and outer annular-like channels. Also at this outlet end of the inner channel, a radially enlarged region is provided, acting as a first collecting chamber, into which an outlet tube is sealed, extending from the inner opening. A second collection chamber is provided at the outlet end of the outer annular-like channel. A plurality of outlet tubes extend radially outward from the center of the bag to open within the second collection chamber at different radial distances. Through these outlet tubes, selected separated portions of the fluid are withdrawn from the bag.

公开(公告)号：CA990255A

公开(公告)日：1976-06-01

申请号：CA159070

申请日：1972-12-13

Applicant: IBM

Inventor： JONES ALAN L ,  JUDSON GEORGE T ,  KELLOGG ROBERT M ,  KRUGER VICTOR R

IPC: A61M1/02 ,  A61M1/00 ,  A61M1/36 ,  A61M5/148 ,  B04B5/04

Abstract: Apparatus for processing blood, and particularly for washing blood cells, including a centrifuge head in which is arranged a flexible blood container connected by a rotating seal to tubing which permits the entrance and exit of wash liquid and supernatant. The flow of liquid in the tubing is controlled by valve arrangements which are operable to permit the entrance of wash liquid and removal of supernatant liquid. The flexible container fits over a flexible membrane also arranged inside the centrifuge head about a solid central core. The volume defined by this membrane and the core communicates via a passage in the core with a fluid reservoir by means of a control pump which allows fluid to enter and exit from the volume defined by the membrane. During operation the unwashed blood may be entered into the container or blood bag before or after the bag is placed in the centrifuge. The centrifuge is spun until cells have settled against the outside wall at which time the valve arrangements and the control pump are activated such that fluid is pumped into the centrifuge under the volume defined by the membrane thereby forcing a supernatant to flow out to a collect container. The centrifuge is then stopped and the wash solution enters the blood container through another valve arrangement, thereby allowing the removal of fluid from the volume inside the flexible membrane. Removal of the wash liquid is accomplished by the same process of removal as the removal of supernatant previously described. Provisions are made for electrical control of all the operations including an agitate operation in which the centrifuge is spun in alternate directions for only a few revolutions or goes through alternate accelerate-decelerate cycles while rotating in the same direction to thereby agitate the material in the blood bag or flexible container during the time that a wash solution is entering. The circuit arrangements are such that a high degree of flexibility in the programming of the various operations can be obtained.

公开(公告)号：FR2404470A1

公开(公告)日：1979-04-27

申请号：FR7826227

申请日：1978-09-08

Applicant: IBM

Inventor： KELLOGG ROBERT M ,  MULZET ALFRED P

IPC: G01N33/48 ,  B04B5/00 ,  B04B5/04 ,  B04B7/08 ,  G01N33/16

Abstract: An improved centrifuge assembly comprising a channeled rotor assembly and a fluid container disposed in the channel, whereby the centrifugal separation effects in the fluid container are determined by the geometry of the channel in the rotor. This arrangement is particularly useful for two-stage blood platelet separation. The fluid container is preferably formed from semirigid plastic material and is considered a disposable item to be discarded after a single use. The rotary assembly preferably includes a removable filler piece or center piece formed from a single piece of material, such as rigid plastic, as by machining or molding, and having therein an open-topped channel having dimensions appropriate to receive the semirigid container, which is suitably curved and placed in the channel. Fluid connections are provided from each end of the container and an intermediate point to an axially located multichannel rotating seal. The connections lie in a plurality of radial slots in the filler piece. The channel is divided into two distinct portions, the first portion of the channel being circular with a constant radius, and the second portion being spiral and having a plurality of radiuses, each measured from a different center, the spiral increasing radially outward from its juncture with the first stage. The intermediate fluid connection is established near the junction of the first stage and the second stage. The spiral portion of the channel and container may have an outward slope from bottom to top.