公开(公告)号：GB2575000B

公开(公告)日：2021-11-24

申请号：GB201915070

申请日：2018-03-27

Applicant: IBM

Inventor： AMOS CAHAN ,  JAMES HEDRICK ,  MAREVA FEVRE ,  THEODORE VAN KESSEL ,  PEI-YUN HSUEH ,  HARIKLIA DELIGIANNI ,  RUDY J WOJTECKI ,  NATHANIEL PARK ,  YI YAN YANG ,  ZHEN CHANG LIANG ,  XIN DING

IPC: C08J3/24 ,  A61B17/56 ,  A61F2/01 ,  A61F2/24 ,  A61F2/30 ,  A61L27/34 ,  A61L29/08 ,  A61N1/36 ,  C07D495/04 ,  C08J7/00 ,  C09D7/65

Abstract: Antibacterial coatings and methods of making the antibacterial coatings are described herein. A first branched polyethylenimine (BPEI) layer is formed and a first glyoxal layer is formed on a surface of the BPEI layer. The first BPEI layer and the first glyoxal layer are cured to form a crosslinked BPEI coating. The first BPEI layer can be modified with superhydrophobic moieties, superhydrophilic moieties, or negatively charged moieties to increase the antifouling characteristics of the coating. The first BPEI layer can be modified with contact-killing bactericidal moieties to increase the bactericidal characteristics of the coating.

公开(公告)号：GB2575000A

公开(公告)日：2019-12-25

申请号：GB201915070

申请日：2018-03-27

Applicant: IBM

Inventor： AMOS CAHAN ,  JAMES HEDRICK ,  MAREVA FEVRE ,  THEODORE VAN KESSEL ,  PEI-YUN HSUEH ,  HARIKLIA DELIGIANNI ,  RUDY J WOJTECKI ,  NATHANIEL PARK ,  YI YAN YANG ,  ZHEN CHANG LIANG ,  XIN DING

IPC: C08J7/12 ,  A61L27/34 ,  A61L29/08 ,  C07D495/04 ,  C08J7/00

Abstract: Antibacterial coatings and methods of making the antibacterial coatings are described herein. A first branched polyethylenimine (BPEI) layer is formed and a first glyoxal layer is formed on a surface of the BPEI layer. The first BPEI layer and the first glyoxal layer are cured to form a crosslinked BPEI coating. The first BPEI layer can be modified with superhydrophobic moieties, superhydrophilic moieties, or negatively charged moieties to increase the antifouling characteristics of the coating. The first BPEI layer can be modified with contact-killing bactericidal moieties to increase the bactericidal characteristics of the coating.

公开(公告)号：GB2601667B

公开(公告)日：2023-01-25

申请号：GB202202352

申请日：2020-07-15

Applicant: IBM ,  AGENCY SCIENCE TECH & RES

Inventor： JAMES HEDRICK ,  YI YAN YANG ,  XIN DING ,  CHUAN YANG

IPC: C07D309/02 ,  A61K31/335 ,  A61K31/366 ,  A61K31/765 ,  A61K31/785 ,  A61P19/02 ,  A61P31/04 ,  C07F1/12 ,  C07F9/28 ,  C08L69/00

Abstract: Techniques regarding enhancing antimicrobial activity of antirheumatic agents by combination therapy are provided. For example, one or more embodiments described herein can regard a chemical composition comprising a polycarbonate polymer functionalized with a guanidinium functional group. The chemical composition can also comprise an antirheumatic agent, and the polycarbonate polymer can enhance an antimicrobial activity of the antirheumatic agent.

公开(公告)号：GB2601667A

公开(公告)日：2022-06-08

申请号：GB202202352

申请日：2020-07-15

Applicant: IBM ,  AGENCY SCIENCE TECH & RES

Inventor： JAMES HEDRICK ,  YI YAN YANG ,  XIN DING ,  CHUAN YANG

IPC: C07D309/02 ,  A61K31/335 ,  A61K31/366 ,  A61K31/765 ,  A61K31/785 ,  A61P19/02 ,  A61P31/04 ,  C07F1/12 ,  C07F9/28 ,  C08L69/00

Abstract: Techniques regarding enhancing antimicrobial activity of antirheumatic agents by combination therapy are provided. For example, one or more embodiments described herein can regard a chemical composition comprising a polycarbonate polymer functionalized with a guanidinium functional group. The chemical composition can also comprise an antirheumatic agent, and the polycarbonate polymer can enhance an antimicrobial activity of the antirheumatic agent.