公开(公告)号：GB2519914B

公开(公告)日：2018-03-14

申请号：GB201504011

申请日：2013-09-04

Applicant: IBM ,  AGENCY SCIENCE TECH & RES

Inventor： JAMES L HEDRICK ,  SHRINIVAS VENKATARAMAN ,  YI YAN YANG

IPC: A61K31/785 ,  A01N37/44 ,  A01N39/02 ,  A61L2/16 ,  A61P31/04

Abstract: An antimicrobial composition comprises an anionic drug and an amine polymer comprising a first repeat unit of formula (2): wherein a′ is an integer equal to 1 or 2, b′ is an integer equal to 1 or 2, and each R′ is an independent monovalent radical selected from the group consisting of hydrogen, methyl, ethyl, and combinations thereof. G′ is a divalent linking group selected from the group consisting of a single bond and groups comprising at least one carbon. X− is a negatively charged counterion. The drug and the amine polymer are bound by noncovalent interactions.

公开(公告)号：GB2583304B

公开(公告)日：2022-07-20

申请号：GB202010225

申请日：2018-12-04

Applicant: IBM ,  AGENCY SCIENCE TECH & RES

Inventor： JAMES HEDRICK ,  MAREVA FEVRE ,  NATHANIEL PARK ,  VICTORIA PIUNOVA ,  YI YAN YANG ,  PANG KERN JEREMY TAN ,  CHUAN YANG

IPC: C08G73/02 ,  C08G73/06

Abstract: Techniques regarding polymers with antimicrobial functionality are provided. For example, one or more embodiments described herein can regard a polymer, which can comprise a repeating ionene unit. The repeating ionene unit can comprise a cation distributed along a degradable backbone. The degradable backbone can comprise a terephthalamide structure. Further, the repeating ionene unit can have antimicrobial functionality.

公开(公告)号：GB2580240B

公开(公告)日：2020-12-16

申请号：GB202003173

申请日：2018-11-09

Applicant: IBM ,  AGENCY SCIENCE TECH & RES

Inventor： VICTORIA PIUNOVA ,  NOAH FREDERICK FINE NATHEL ,  JAMES HEDRICK ,  YI YAN YANG ,  WILLY CHIN ,  ZHI XIANG VOO

IPC: A61K47/50 ,  A01N33/12 ,  A01N43/90 ,  A01N47/06 ,  A01N59/00 ,  A01P1/00 ,  A61L2/23 ,  C08G64/00 ,  C08G64/42 ,  C09D5/14 ,  C09D169/00

Abstract: Techniques regarding star polymers with enhanced antimicrobial functionality are provided. For example, a polymer is provided that can comprise a core that can have a singlet oxygen generator and that can generate a singlet oxygen species upon irradiation with light. The polymer can also comprise a plurality of polycarbonate arms covalently bonded to the core. The plurality of polycarbonate arms can be degradable and can comprise a cation. Further, the plurality of polycarbonate arms can have antimicrobial functionality.

公开(公告)号：GB2543222A

公开(公告)日：2017-04-12

申请号：GB201701185

申请日：2015-09-01

Applicant: IBM ,  AGENCY FOR SCIENCE TECH AND RES (A*STAR)

Inventor： AMANDA CATHERINE ENGLER ,  DANIEL JOSEPH COADY ,  JAMES L HEDRICK ,  YI YAN YANG ,  XIYU KE

IPC: C08G64/02 ,  A61K47/34 ,  C08G64/42

Abstract: Water soluble biodegradable polymers were prepared by an organoacid catalyzed ring opening polymerization (ROP) of a cyclic carbonate monomer bearing an active ester side chain. The initial polymer comprising an active ester side chain was treated with an amino-alcohol, which transformed the active ester groups to N-substituted amide groups bearing mono-hydroxy alkyl groups and/or dihydroxy alkyl groups, thereby forming the water soluble polymers. The water- soluble polymers are non-toxic and exhibit stealth properties in buffered serum solution.

公开(公告)号：GB2583602B

公开(公告)日：2022-06-08

申请号：GB202009774

申请日：2018-11-30

Applicant: IBM ,  INST OF BIOENGINEERING AND NANOTECHNOLOGY

Inventor： JAMES HEDRICK ,  RUDY J WOJTECKI ,  NATHANIEL PARK ,  JEANNETTE M GARCIA ,  YI YAN YANG ,  EUNICE LEONG ,  WILLY CHIN ,  DYLAN BODAY ,  MAREVA FEVRE

IPC: C08F293/00 ,  A61K47/32 ,  A61K47/34 ,  C08G64/18 ,  C08G64/34

Abstract: The subject matter of this invention relates to block copolymers (BCPs) and, more particularly, to block copolymers capable of self-assembly into nanoparticles for the delivery of hydrophobic cargos. The BCPs include a hydrophobic block that contains a thioether functional group that is susceptible to oxidation, transforming the solubility of the block from hydrophobic to hydrophilic, thereby releasing the hydrophobic cargo of the nanoparticle.

公开(公告)号：GB2575000B

公开(公告)日：2021-11-24

申请号：GB201915070

申请日：2018-03-27

Applicant: IBM

Inventor： AMOS CAHAN ,  JAMES HEDRICK ,  MAREVA FEVRE ,  THEODORE VAN KESSEL ,  PEI-YUN HSUEH ,  HARIKLIA DELIGIANNI ,  RUDY J WOJTECKI ,  NATHANIEL PARK ,  YI YAN YANG ,  ZHEN CHANG LIANG ,  XIN DING

IPC: C08J3/24 ,  A61B17/56 ,  A61F2/01 ,  A61F2/24 ,  A61F2/30 ,  A61L27/34 ,  A61L29/08 ,  A61N1/36 ,  C07D495/04 ,  C08J7/00 ,  C09D7/65

Abstract: Antibacterial coatings and methods of making the antibacterial coatings are described herein. A first branched polyethylenimine (BPEI) layer is formed and a first glyoxal layer is formed on a surface of the BPEI layer. The first BPEI layer and the first glyoxal layer are cured to form a crosslinked BPEI coating. The first BPEI layer can be modified with superhydrophobic moieties, superhydrophilic moieties, or negatively charged moieties to increase the antifouling characteristics of the coating. The first BPEI layer can be modified with contact-killing bactericidal moieties to increase the bactericidal characteristics of the coating.

公开(公告)号：GB2575000A

公开(公告)日：2019-12-25

申请号：GB201915070

申请日：2018-03-27

Applicant: IBM

Inventor： AMOS CAHAN ,  JAMES HEDRICK ,  MAREVA FEVRE ,  THEODORE VAN KESSEL ,  PEI-YUN HSUEH ,  HARIKLIA DELIGIANNI ,  RUDY J WOJTECKI ,  NATHANIEL PARK ,  YI YAN YANG ,  ZHEN CHANG LIANG ,  XIN DING

IPC: C08J7/12 ,  A61L27/34 ,  A61L29/08 ,  C07D495/04 ,  C08J7/00

Abstract: Antibacterial coatings and methods of making the antibacterial coatings are described herein. A first branched polyethylenimine (BPEI) layer is formed and a first glyoxal layer is formed on a surface of the BPEI layer. The first BPEI layer and the first glyoxal layer are cured to form a crosslinked BPEI coating. The first BPEI layer can be modified with superhydrophobic moieties, superhydrophilic moieties, or negatively charged moieties to increase the antifouling characteristics of the coating. The first BPEI layer can be modified with contact-killing bactericidal moieties to increase the bactericidal characteristics of the coating.

公开(公告)号：GB2543222B

公开(公告)日：2017-06-28

申请号：GB201701185

申请日：2015-09-01

Applicant: IBM ,  AGENCY FOR SCIENCE TECH AND RES (A*STAR)

Inventor： AMANDA CATHERINE ENGLER ,  DANIEL JOSEPH COADY ,  JAMES L HEDRICK ,  YI YAN YANG ,  XIYU KE

IPC: C08G64/02 ,  A61K47/34 ,  C08G64/42

Abstract: Water soluble biodegradable polymers were prepared by an organoacid catalyzed ring opening polymerization (ROP) of a cyclic carbonate monomer bearing an active ester side chain. The initial polymer comprising an active ester side chain was treated with an amino-alcohol, which transformed the active ester groups to N-substituted amide groups bearing mono-hydroxy alkyl groups and/or dihydroxy alkyl groups, thereby forming the water soluble polymers. The water-soluble polymers are non-toxic and exhibit stealth properties in buffered serum solution.

公开(公告)号：GB2601667B

公开(公告)日：2023-01-25

申请号：GB202202352

申请日：2020-07-15

Applicant: IBM ,  AGENCY SCIENCE TECH & RES

Inventor： JAMES HEDRICK ,  YI YAN YANG ,  XIN DING ,  CHUAN YANG

IPC: C07D309/02 ,  A61K31/335 ,  A61K31/366 ,  A61K31/765 ,  A61K31/785 ,  A61P19/02 ,  A61P31/04 ,  C07F1/12 ,  C07F9/28 ,  C08L69/00

Abstract: Techniques regarding enhancing antimicrobial activity of antirheumatic agents by combination therapy are provided. For example, one or more embodiments described herein can regard a chemical composition comprising a polycarbonate polymer functionalized with a guanidinium functional group. The chemical composition can also comprise an antirheumatic agent, and the polycarbonate polymer can enhance an antimicrobial activity of the antirheumatic agent.

公开(公告)号：GB2583426B

公开(公告)日：2022-07-27

申请号：GB202010334

申请日：2018-12-04

Applicant: IBM ,  AGENCY SCIENCE TECH & RES

Inventor： JAMES HEDRICK ,  MAREVA FEVRE ,  VICTORIA PIUNOVA ,  NATHANIEL PARK ,  PANG KERN JEREMY TAN ,  YI YAN YANG ,  MU SAN ZHANG

IPC: C08G73/00 ,  A01N33/12 ,  A01N37/30 ,  A01N43/50 ,  C07C233/61 ,  C07C233/78

Abstract: Techniques regarding ionene compositions with antimicrobial functionality are provided. For example, one or more embodiments can comprise a monomer, which can comprise a single ionene unit. The single ionene unit can comprise a cation distributed along a molecular backbone. Also, a hydrophobic functional group can be covalently bonded to the molecular backbone, and the single ionene unit can have antimicrobial functionality.