公开(公告)号：AU2003270751A1

公开(公告)日：2005-04-27

申请号：AU2003270751

申请日：2003-09-15

Applicant: INTEL CORP

Inventor： SU XING ,  BERLIN ANDREW A ,  CHAN SELENA ,  KIRCH STEVEN J ,  KOO TAE-WOONG ,  NEUBAUER GABI ,  RAO VALLURI ,  SUNDARARAJAN NARAYAN ,  YAMAKAWA MINEO

IPC: C12Q1/68

Abstract: The methods and apparatus disclosed herein concern nucleic acid sequencing by enhanced Raman spectroscopy. In certain embodiments of the invention, nucleotides are covalently attached to Raman labels before incorporation into a nucleic acid. In other embodiments, unlabeled nucleic acids are used. Exonuclease treatment of the nucleic acid results in the release of labeled or unlabeled nucleotides that are detected by Raman spectroscopy. In alternative embodiments of the invention, nucleotides released from a nucleic acid by exonuclease treatment are covalently cross-linked to nanoparticles and detected by surface enhanced Raman spectroscopy (SERS), surface enhanced resonance Raman spectroscopy (SERRS) and/or coherent anti-Stokes Raman spectroscopy (CARS). Other embodiments of the invention concern apparatus for nucleic acid sequencing.

公开(公告)号：EP2761787A4

公开(公告)日：2015-04-08

申请号：EP11873158

申请日：2011-09-30

Applicant: INTEL CORP

Inventor： GEBRE-SELASSIE EWUNNET ,  KESLING DAWSON W ,  KIRCH STEVEN J ,  LIMAYE RAHUL D ,  MUSA SHAH M ,  WANG FUGAO

IPC: H04B15/00 ,  H03L7/06 ,  H04B1/7085

CPC classification number: H03L7/08 ,  H03L7/06 ,  H04B1/7085