公开(公告)号：EP3561059A1

公开(公告)日：2019-10-30

申请号：EP17885347.9

申请日：2017-12-22

Applicant: Institute for Basic Science

Inventor： KIM, Jin-Soo ,  KIM, Kyoung Mi ,  RYU, Seuk Min

IPC: C12N15/10 ,  C12N15/85 ,  C12N15/877 ,  C12N9/16 ,  C12N9/78 ,  C12N9/02 ,  C07K14/47

Abstract: Provided are a base editing composition comprising deaminase and target-specific nuclease, a base editing method using the base editing composition, and a method for producing a genetically modified animal. The base editing composition has a base editing activity in mammalian embryos.

公开(公告)号：EP3492096A1

公开(公告)日：2019-06-05

申请号：EP17834796.9

申请日：2017-07-27

Applicant: Institute for Basic Science ,  Seoul National University R&DB Foundation ,  Seoul National University Hospital

Inventor： KIM, Jin-Soo ,  KIM, Jeong Hun ,  PARK, Sung Wook ,  KIM, Kyoung Mi

IPC: A61K38/17 ,  A61K48/00

Abstract: Provided are: a pharmaceutical composition for preventing and/or treating ocular diseases, containing a Cas9 protein and a guide RNA targeting VEGF-A; and a ribonucleoprotein containing a Cas9 protein and a guide RNA targeting VEGF-A.