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    Method for screening agent for suppressing apocrine smell, and method for evaluating apocrine smell-generating ability
    3.
    发明专利
    Method for screening agent for suppressing apocrine smell, and method for evaluating apocrine smell-generating ability 审中-公开
    用于筛选APOCRINE SMELL的药剂的方法，以及评估APOCRINE SMELL生成能力的方法

    公开(公告)号：JP2011167082A

    公开(公告)日：2011-09-01

    申请号：JP2010031342

    申请日：2010-02-16

    Applicant: Kao Corp ,  花王株式会社

    Inventor： ICHIKAWA YOSHIAKI ,  ARAI NAOMI ,  KUSUOKU HIROSHI

    IPC: C12Q1/02 ,  G01N33/15 ,  G01N33/497 ,  G01N33/50

    Abstract: PROBLEM TO BE SOLVED: To provide a method for efficiently screening an agent for suppressing apocrine smell, and to provide a method for objectively, accurately and readily evaluating apocrine smell-generating ability.
    SOLUTION: The method for screening the agent for suppressing the apocrine smell selects a test substance having the activities for suppressing the apocrine smell by detecting the generation of the causative substance of the apocrine smell by Corynebacterium tuberculostearicum by bringing the microorganism into contact with a precursor of the causative substance of the apocrine smell in the presence of the test substance. The method for evaluating the apocrine smell-generating ability by the microorganism evaluates the apocrine smell-generating ability by bringing the Corynebacterium tuberculostearicum into contact with the precursor of the causative substance of the apocrine smell, detecting the generation of the causative substance of the apocrine smell by the microorganism, and measuring the generated amount of the causative substance of the apocrine smell.
    COPYRIGHT: (C)2011,JPO&INPIT

    Abstract translation: 要解决的问题：提供一种有效筛选用于抑制前分泌气味的药剂的方法，并提供一种客观，准确和容易地评估前分泌气味产生能力的方法。 解决方案：用于筛选用于抑制分泌气味的药剂的方法选择具有抑制顶分泌气味的活性的测试物质，通过使微生物与微生物接触来检测由结核杆菌（Corynebacterium cubercuulostearicum）产生的分泌物的致病物质的产生 在测试物质存在的情况下，前分泌气味的原因。 微生物评价异味发生能力的方法通过使结核杆菌结核菌与前分泌气味的致病物质的前体接触来检测分泌气味产生能力，检测分泌气味的致病物质的产生 通过微生物测定分泌物气味的致病物质的产生量。 版权所有（C）2011，JPO＆INPIT

    SKIN LOTION
    4.
    发明专利
    SKIN LOTION 失效

    公开(公告)号：JP2000095680A

    公开(公告)日：2000-04-04

    申请号：JP30775298

    申请日：1998-09-25

    Applicant: KAO CORP

    Inventor： SHIBUYA YUSUKE ,  ICHIKAWA YOSHIAKI ,  NONOMURA MASAMI ,  HORI KIMIHIKO ,  NISHIZAWA YOSHINORI

    IPC: A61K36/18 ,  A61K31/00 ,  A61K31/045 ,  A61P17/00 ,  A61P37/00 ,  A61P37/08 ,  A61P43/00

    Abstract: PROBLEM TO BE SOLVED: To obtain a skin lotion that has the effect of inhibiting the production of interleukin 4 and is useful for prevention and amelioration of allergic diseases, particularly atopic dermatitis by using a specific compound as an active ingredient. SOLUTION: The objective skin lotion includes a compound of formula I as an active ingredient. The compound of formula I is synthesized through known chemical processes, a commercially available product as it is, or extracts from a plant of Myrtaceae, for example, Eucalyptus gloulus or Rhodomyrtus tomentosa and the like. In one embodiment, the compounds of formulas II and III and the like can be cited as a compound of formula I. This skin lotion is used in ointment, toilet water, cream, milky lotion, pack, cosmetic foundation, in addition in bathing agent. Further, a base for external use and other pharmaceutical components can be formulated to this skin preparation.

    ANTIVIRAL SERUM, PRODUCTION THEREOF AND METHOD FOR DECIDING VIRUS INFECTION UTILIZING SAID SERUM
    7.
    发明专利
    ANTIVIRAL SERUM, PRODUCTION THEREOF AND METHOD FOR DECIDING VIRUS INFECTION UTILIZING SAID SERUM 失效

    公开(公告)号：JPH01134255A

    公开(公告)日：1989-05-26

    申请号：JP29228087

    申请日：1987-11-19

    Applicant: KAO CORP

    Inventor： USHIKU SHUICHI ,  ICHIKAWA YOSHIAKI ,  OTSUJI KAZUYA ,  SUGIMURA YORIO ,  OKAMOTO KIKUHIKO

    IPC: A61K39/42 ,  G01N33/569

    Abstract: PURPOSE:To exactly decide the virus infection of Pogostemon patchouly by using the antiviral serum obtd. by using the virus PaMMV which indicates a gentle mosaic-like disease symptom on the leaves of the Pogostemon patchouly when said virus infects the Pogostemon patchouly. CONSTITUTION:The infected leave juice of the Pogostemon patchouly infected with the PaMMV is inoculated to the vegetable of Chenopodiaceae and the juice obtd. from the inoculated leaves infected therewith is centrifugally separated. The supernatant thereof is then taken. A nonionic surfactant is added to the supernatant which is then repeatedly subjected to the centrifugal sepn. on a cane sugar cushion to purify the PaMMV. The purified PaMMV is infected to a mammal to immunize the mammal, from which the antiviral serum is obtd. The virus disease of the Pogostemon patchouly is diagnosed by an agar gel diffusion method, latex agglutination reaction method, fluorescent antibody method, enzyme antibody method or immune electron microscopy, etc., using the said antiviral serum.

    Endoplasmic reticulum stress model
    8.
    发明专利
    Endoplasmic reticulum stress model 审中-公开
    内生应力应变模型

    公开(公告)号：JP2011167081A

    公开(公告)日：2011-09-01

    申请号：JP2010031087

    申请日：2010-02-16

    Applicant: Kao Corp ,  花王株式会社

    Inventor： ICHIKAWA YOSHIAKI ,  HIGUCHI KAZUHIKO ,  YOSHIDA HIDEO

    IPC: C12N5/07 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/50 ,  G01N33/53

    Abstract: PROBLEM TO BE SOLVED: To provide an in vitro endoplasmic reticulum stress model prepared by a new method. SOLUTION: There are disclosed a method for preparing an endoplasmic reticulum stress model comprising a process of irradiating UVA to a culture cell, and an endoplasmic reticulum stress model prepared by the preparing method. COPYRIGHT: (C)2011,JPO&INPIT

    Abstract translation: 要解决的问题：提供一种通过新方法制备的体外内质网应激模型。 解决方案：公开了一种制备内质网应激模型的方法，包括将UVA照射到培养细胞的方法，以及通过制备方法制备的内质网应激模型。 版权所有（C）2011，JPO＆INPIT

    NOVEL STEROID COMPOUND AND INTERLEUKIN-1 PRODUCTION INHIBITOR CONTAINING THE SAME
    9.
    发明专利
    NOVEL STEROID COMPOUND AND INTERLEUKIN-1 PRODUCTION INHIBITOR CONTAINING THE SAME 失效

    公开(公告)号：JPH10291997A

    公开(公告)日：1998-11-04

    申请号：JP10303797

    申请日：1997-04-21

    Applicant: KAO CORP

    Inventor： KUSUOKU HIROSHI ,  NISHIZAWA YOSHINORI ,  FUJIKURA YOSHIAKI ,  ICHIKAWA YOSHIAKI ,  IMOKAWA GENJI

    IPC: A61K31/575 ,  A61P17/00 ,  A61P37/08 ,  A61P43/00 ,  C07J9/00

    Abstract: PROBLEM TO BE SOLVED: To obtain a subject novel compound that contains a specific steroid compound, shows an excellent transdermal absorption, stability and safety and is useful as a strongly effective interleukin 4 production inhibitor and as an antiallergic agent that is effective for prevention and treatment of atopic dermatitis. SOLUTION: This is a novel steroid compound represented by formula I (Me is methyl) and is useful as a strongly effective interleukin 4 production inhibitor excellent in transdermal absorption, stability and safety and as an antiallergic agent the has preventive and therapeutic effect on the atopic dermatitis. This steroid compound is obtained by extracting a kind of fungus, Elfvinga (Elfvinga applanta) that has been used as a Chinese medicine. This compound also can be prepared by oxidizing ergosterol of formula II with a selenium dioxide in the presence of methanol to form an isomer followed by treatment of the product with an acid catalyst in methanol to invert the methoxy group in the 3-position thereby giving the objective compound.

    Method for screening apocrine smell inhibitor and method for evaluating apocrine smell
    10.
    发明专利
    Method for screening apocrine smell inhibitor and method for evaluating apocrine smell 审中-公开
    筛选小蛋白小细胞抑制剂的方法及评价青蒿素的方法

    公开(公告)号：JP2010252710A

    公开(公告)日：2010-11-11

    申请号：JP2009107429

    申请日：2009-04-27

    Applicant: Kao Corp ,  花王株式会社

    Inventor： ICHIKAWA YOSHIAKI ,  ARAI NAOMI ,  KUSUOKU HIROSHI ,  AKIBA SHUNICHI ,  TAKEUCHI KATSUHIKO ,  YABUKI MASAYUKI

    IPC: C12N1/20 ,  C12Q1/02 ,  C12R1/44 ,  G01N33/15 ,  G01N33/50

    Abstract: PROBLEM TO BE SOLVED: To provide a method for efficiently screening an apocrine smell inhibitor, and to provide a method for objectively, accurately and readily evaluating the apocrine smell.
    SOLUTION: The method for screening the apocrine smell inhibitor includes bringing Staphylococcus lentus into contact with a substrate of a causative agent of the apocrine smell in the presence of a test object substance, and detecting the presence or absence of the formation of the causative agent of the apocrine smell by the microorganism to select the test object substance having the apocrine smell-inhibiting activity. The method for evaluating the apocrine smell includes bringing the Staphylococcus lentus into contact with the substrate of the causative agent of the apocrine smell, and detecting the presence or absence of the formation of the causative agent of the apocrine smell by the microorganism to evaluate the apocrine smell.
    COPYRIGHT: (C)2011,JPO&INPIT

    Abstract translation: 要解决的问题：提供一种有效筛选顶分泌气味抑制剂的方法，并提供一种客观，准确和容易地评估顶分泌气味的方法。 解决方案：筛选前分子嗅觉抑制剂的方法包括在试验物质存在下使葡萄球菌与顶分泌气的致病因子的底物接触，并检测是否存在 微生物分泌异味的致病因子，以选择具有前分泌气味抑制活性的检测对象物质。 用于评价前分泌气味的方法包括将葡萄球菌与顶分泌气的致病因子的底物接触，并检测微生物是否存在分泌异味的致病因子的形成以评估上分泌 闻。 版权所有（C）2011，JPO＆INPIT

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