公开(公告)号：DE69611444T2

公开(公告)日：2001-06-07

申请号：DE69611444

申请日：1996-05-16

Applicant: KAO CORP

Inventor： MURAYAMA KOICHI ,  HOSHINO MASAHIDE ,  KUSUOKU HIROSHI ,  NAGAI MINORU ,  SUGINO KIYOKO

IPC: C07D303/18 ,  A61K8/00 ,  A61K8/30 ,  A61K8/41 ,  A61K8/42 ,  A61K8/68 ,  A61K31/16 ,  A61K31/195 ,  A61Q5/00 ,  A61Q19/00 ,  C07C217/28 ,  C07C231/02 ,  C07C231/12 ,  C07C233/05 ,  C07C233/18 ,  A61K7/48

公开(公告)号：DE69611444D1

公开(公告)日：2001-02-08

申请号：DE69611444

申请日：1996-05-16

Applicant: KAO CORP

Inventor： MURAYAMA KOICHI ,  HOSHINO MASAHIDE ,  KUSUOKU HIROSHI ,  NAGAI MINORU ,  SUGINO KIYOKO

IPC: C07D303/18 ,  A61K8/00 ,  A61K8/30 ,  A61K8/41 ,  A61K8/42 ,  A61K8/68 ,  A61K31/16 ,  A61K31/195 ,  A61Q5/00 ,  A61Q19/00 ,  C07C217/28 ,  C07C231/02 ,  C07C231/12 ,  C07C233/05 ,  C07C233/18 ,  A61K7/48

公开(公告)号：JP2003119173A

公开(公告)日：2003-04-23

申请号：JP2002219266

申请日：2002-07-29

Applicant: KAO CORP

Inventor： NAGAI MINORU ,  MURAYAMA KOICHI ,  HOSHINO TADAHIDE ,  KUSUOKU HIROSHI ,  YAMAMURO AKIRA ,  SUGINO KIYOKO

IPC: A61K8/30 ,  A61K8/00 ,  A61K8/42 ,  A61Q19/00 ,  C07C233/18 ,  C07C235/08

Abstract: PROBLEM TO BE SOLVED: To provide an amide derivative enhancing water retention of the horny layer and excellent in ameliorating effect to the chapped skin. SOLUTION: The amide derivative is expressed by formula (2). (In the formula R and R are each same or different linear or branched 1-40C hydrocarbon group which optionally has a hydroxyl group, Z is H or 2,3-dihydroxypropyl group, m is 1-6 and n is 0-3.).

公开(公告)号：JPH08319233A

公开(公告)日：1996-12-03

申请号：JP12482495

申请日：1995-05-24

Applicant: KAO CORP

Inventor： MURAYAMA KOICHI ,  HOSHINO TADAHIDE ,  KUSUOKU HIROSHI ,  NAGAI MINORU ,  SUGINO KIYOKO

IPC: A61K8/00 ,  A61K8/04 ,  A61K8/30 ,  A61K8/42 ,  A61K31/16 ,  A61P17/00 ,  A61P43/00 ,  A61Q5/00 ,  A61Q7/00 ,  A61Q19/00 ,  A61Q19/08 ,  A61K7/00 ,  A61K7/06 ,  A61K7/48

Abstract: PURPOSE: To prepare a dermal preparation for external use excellent in improving skin roughness and a hair cosmetic of improved hair feeling by increasing keratin moisture retention. CONSTITUTION: This preparation contains an amido derivative of the formula (R and R are each a 1-40C hydrocarbon which can be hydroxylated; R is a 3-6C alkylene; R is a 1-12C alkoxy). The blending amounts are 0.001-50wt.% in emulsion type dermal preparation for external use, 1-50wt.% in oil type dermal preparation for external use, 0.001-5wt.% in shampoo as hair cosmetic, 0.1-20wt.% in rinse, hair treatment, conditioner and 0.01-5wt.% in hair liquid and hair tonic. The dermal preparation for external use is effective for preventing and curing skin roughness and skin aging. The hair cosmetic is excellent in hair and scalp protection with retention while improves hair feeling.

公开(公告)号：JPH09249517A

公开(公告)日：1997-09-22

申请号：JP6272696

申请日：1996-03-19

Applicant: KAO CORP

Inventor： NAGAI MINORU ,  MURAYAMA KOICHI ,  HOSHINO TADAHIDE ,  KUSUOKU HIROSHI ,  YAMAMURO AKIRA ,  SUGINO KIYOKO

IPC: A61K8/30 ,  A61K8/00 ,  A61K8/42 ,  A61Q19/00 ,  C07C233/18 ,  C07C235/08 ,  A61K7/00 ,  A61K7/48

Abstract: PROBLEM TO BE SOLVED: To obtain the subject preparation effective for improving the moisture- retaining performance of the cuticle layer and exhibiting excellent chapped skin improving effect by using a specific partly new amide derivative as an active component and optionally adding a nonionic surfactant to the component. SOLUTION: This preparation contains about 0.1-20wt.% of an amide derivative of formula I [R and R are each a 1-40C hydrocarbon group which may have OH; X and Y are each O or methylene (X and Y are not O at the same time); Z is H or 2,3-dihydroxypropyl; (m) is 1-6; (n) is 0-3]. The system is preferably further incorporated with about 0.1-5wt.% of a surfactant (e.g. a glyceryl ether). The compound of formula II is a new compound among the compounds of formula I. The compound of formula I or the compound of formula III which is one of the compound of formula I can be produced e.g. from the amide derivative of formula IV via an amide derivative of formula V (R is methoxymethyl, etc.). A compound wherein Z is 2,3-dihydroxypropyl can be produced from the compound of formula III via two steps.

公开(公告)号：JPH08319263A

公开(公告)日：1996-12-03

申请号：JP12482595

申请日：1995-05-24

Applicant: KAO CORP

Inventor： MURAYAMA KOICHI ,  HOSHINO TADAHIDE ,  KUSUOKU HIROSHI ,  NAGAI MINORU ,  SUGINO KIYOKO

IPC: C07D303/18 ,  A61K8/00 ,  A61K8/30 ,  A61K8/41 ,  A61K8/42 ,  A61K8/68 ,  A61K31/16 ,  A61K31/195 ,  A61Q5/00 ,  A61Q19/00 ,  C07C217/28 ,  C07C231/02 ,  C07C231/12 ,  C07C233/05 ,  C07C233/18 ,  A61K7/00 ,  A61K7/06

Abstract: PURPOSE: To obtain an amide derivative, represented by a specific formula, having excellent water holding and water cutoff abilities and further excellent improving effects on the water holding ability of a horny layer and useful as a dermal preparation for external use and a hair cosmetic, etc. CONSTITUTION: A amide derivative of formula I [R and R are each a 1-40C (hydroxylated)hydrocarbon; R is a 1-6C alkylene or a single bond; R is H, a 1-12C alkoxy or 2,3-dihydroxypropyloxy, with the proviso that R is H when R is the single bond]. Furthermore, the derivative is preferably obtained by reacting, e.g. a glycidyl ether of formula II with an amine of formula III (R is H or a 1-12C alkoxy, with the proviso that R is H when R is the single bond) (at ambient temperature to 150 deg.C), then reacting the resultant amino-alcohol derivative with methyl ester of a fatty acid, etc., in the presence of a basic catalyst (at ambient temperature to 150 deg.C under atmospheric pressure to 0.01mmHg), further reacting the prepared amide derivative with an epoxide such as epichlorohydrin in the presence of potassium hydroxide, etc., (at ambient temperature to 150 deg.C) and hydrating the resultant amide derivative of formula IV under basic conditions, etc., at ambient temperature to 300 deg.C.