EVALUATION METHOD OF ORGANIC OR BIO- CONJUGATION ON NANOPARTICLES USING IMAGING OF TIME-OF-FLIGHT SECONDARY ION MASS SPECTROMETRY
    1.
    发明公开
    EVALUATION METHOD OF ORGANIC OR BIO- CONJUGATION ON NANOPARTICLES USING IMAGING OF TIME-OF-FLIGHT SECONDARY ION MASS SPECTROMETRY 无效
    使用飞行时间二次离子质谱法成像制备纳米粒子有机或生物结合的评估方法

    公开(公告)号:KR20090061175A

    公开(公告)日:2009-06-16

    申请号:KR20070128074

    申请日:2007-12-11

    Abstract: A method for evaluating bond between materials through imaging of time-of-flight secondary ion mass spectrometry(TOF-SIMS) is provided to evaluate the bond between organic, inorganic or bio material with nanoparticle and perform quantitative and qualitative analysis. A method for evaluating bond between materials using time-of-flight secondary ion mass spectrometry(TOF-SIMS) comprises: a step of forming the pattern of nanoparticle which is bonded with bio, organic or inorganic material on a substrate; a step of measuring the ion detection pattern of bond between nanoparticle and bond material on the substrate using the TOF-SIMS; and a step of comparing detection pattern of bio, organic or inorganic material and nanoparticle and determining the bond between bio, organic or inorganic material with nanoparticle.

    Abstract translation: 提供了通过飞行时间二次离子质谱(TOF-SIMS)成像来评估材料之间的结合的方法,以评估有机,无机或生物材料与纳米颗粒之间的键,并进行定量和定性分析。 使用飞行时间二次离子质谱法(TOF-SIMS)评估材料之间的结合的方法包括:在基材上形成与生物,有机或无机材料结合的纳米颗粒图案的步骤; 使用TOF-SIMS测量衬底上的纳米颗粒和键合材料之间的键的离子检测图案的步骤; 以及比较生物,有机或无机材料和纳米颗粒的检测模式并确定生物,有机或无机材料与纳米颗粒之间的键的步骤。

    QUANTIFICATION METHOD OF FUNCTIONAL GROUPS OF ORGANIC LAYER
    4.
    发明申请
    QUANTIFICATION METHOD OF FUNCTIONAL GROUPS OF ORGANIC LAYER 审中-公开
    有机层功能组数量化方法

    公开(公告)号:WO2010036038A2

    公开(公告)日:2010-04-01

    申请号:PCT/KR2009005454

    申请日:2009-09-24

    CPC classification number: G01N23/2255

    Abstract: A quantification method of functional groups in an organic thin layer includes: a) measuring an absolute quantity per unit area of an analysis reference material having functional groups included in a reference organic thin layerby means of MEIS spectroscopy; b) carrying out spectrometry for the same reference organic thin layer as in a) and thereby obtaining peak intensities of the functional groups in the reference organic thin layer; c) carrying out the same spectrometry as in b) for an organic thin layer to be analyzed having the same functional groups and thereby measuring peak intensities of the functional groups with unknown quantity; and d) comparing the peak intensities of the functional groups measured in b) with respect to the absolute quantity of the analysis reference material in a) and thereby determining the absolute quantity per unit area of the functional groups with unknown quantity measured in c).

    Abstract translation: 有机薄层中的官能团的定量方法包括:a)通过MEIS光谱测量具有包括在参考有机薄层中的官能团的分析参考材料的每单位面积的绝对量; b)进行与a)相同的参考有机薄层的光谱测定,从而获得参考有机薄层中的官能团的峰值强度; c)进行与b)相同的光谱测定,对于具有相同官能团的待分析有机薄层,从而测量具有未知量的官能团的峰强度; 和d)比较a)中测定的官能团的峰强度相对于分析参考物质的绝对量,从而确定在c)中测量的具有未知量的官能团的每单位面积的绝对量。

    HIGH-PRECISION VACUUM ELECTROSTATIC LENS FOR VACUUM
    6.
    发明申请
    HIGH-PRECISION VACUUM ELECTROSTATIC LENS FOR VACUUM 审中-公开
    真空高精度真空透镜

    公开(公告)号:WO2012153987A3

    公开(公告)日:2013-02-14

    申请号:PCT/KR2012003657

    申请日:2012-05-10

    CPC classification number: H01J37/12

    Abstract: The present invention relates to a structure for an electrostatic lens. The electrostatic lens of the present invention comprises a first electrode, a third electrode, and a second electrode interposed between the first electrode and the third electrode such that a predetermined spacing exists among the three electrodes. The center of each of the three electrodes has a through-hole through which a charged particle beam is to pass. The through-holes of the three electrodes are arranged in a line. Thus, an improved structure for an electrostatic lens may be obtained.

    Abstract translation: 本发明涉及静电透镜的结构。 本发明的静电透镜包括第一电极,第三电极和插在第一电极和第三电极之间的第二电极,使得在三个电极之间存在预定的间隔。 三个电极中的每一个具有通孔,通过该通孔。 三个电极的通孔排列成一行。 因此,可以获得用于静电透镜的改进的结构。

    DISEASE MARKER DETECTION KIT AND DISEASE MARKER DETECTION METHOD
    8.
    发明申请
    DISEASE MARKER DETECTION KIT AND DISEASE MARKER DETECTION METHOD 审中-公开
    疾病标记检测试剂盒和疾病标记检测方法

    公开(公告)号:WO2011162563A3

    公开(公告)日:2012-05-31

    申请号:PCT/KR2011004610

    申请日:2011-06-24

    CPC classification number: G01N33/57488 G01N33/553 G01N33/6848

    Abstract: A detection kit according to the present invention is a disease detection kit which is used together with secondary ion mass spectrometry to detect the disease marker contained in a biological sample. The detection kit comprises: a base on which a noble metal film is formed; a reactant which contains a peptide that specifically reacts with the disease marker; first storage means in which the reactant is stored; a sample which contains the biological sample of a possible disease carrier; second storage means in which the sample is stored; mixing means for mixing the reactant and the sample to produce a detection substance which contains the peptide which specifically reacts with the disease marker contained in the biological sample; and contact means for enabling the detection substance produced by the mixing means to contact the base, so as to bind the specifically reacted material to the noble metal film of the base.

    Abstract translation: 根据本发明的检测试剂盒是与二次离子质谱法一起使用以检测生物样品中所含的疾病标志物的疾病检测试剂盒。 检测试剂盒包括:形成有贵金属膜的基材; 含有特异性与疾病标记反应的肽的反应物; 存储反应物的第一储存装置; 包含可能的疾病携带者的生物样品的样品; 存储样品的第二存储装置; 混合装置,用于混合反应物和样品以产生检测物质,其含有与生物样品中所含的疾病标志物特异性反应的肽; 以及用于使得由混合装置产生的检测物质能够接触基底的接触装置,以便将特异反应的材料与基底的贵金属膜结合。

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