Abstract:
A method for evaluating bond between materials through imaging of time-of-flight secondary ion mass spectrometry(TOF-SIMS) is provided to evaluate the bond between organic, inorganic or bio material with nanoparticle and perform quantitative and qualitative analysis. A method for evaluating bond between materials using time-of-flight secondary ion mass spectrometry(TOF-SIMS) comprises: a step of forming the pattern of nanoparticle which is bonded with bio, organic or inorganic material on a substrate; a step of measuring the ion detection pattern of bond between nanoparticle and bond material on the substrate using the TOF-SIMS; and a step of comparing detection pattern of bio, organic or inorganic material and nanoparticle and determining the bond between bio, organic or inorganic material with nanoparticle.
Abstract:
Die Erfindung betrifft ein Flugzeit-basierenden Massenmikroskopsystems für eine Ultrahochgeschwindigkeits-multimodale Massenanalyse, das zeitgleich einen Laserstrahl und einen Ionenstrahl einsetzten kann, um sowohl Analysen im niedermolekularen Molekulargewichtsbereich, wie beispielsweise an Arzneistoffen/Metabolomen/Lipiden/Peptiden als auch Analysen im hochmolekularen Molekulargewichtsbereich, wie beispielsweise an Genen/Proteinen, durchzuführen, ohne dabei durch das Molekulargewicht des zu analysierenden Objekts eingeschränkt zu sein, und das eine deutlich erhöhte Messgeschwindigkeit durch Verwendung eins Mikroskop-Modus anstelle eines Mikrosonden-Modus aufweist.
Abstract:
The present invention aims to provide a pulsing cluster gas ion gun for a flight time based mass analysis, which enables significantly superior mass resolving power in executing a mass analysis on the basis of a flight time, thereby enabling all analyses of various drug/metabolome/lipid/peptide/gene/protein.
Abstract:
A quantification method of functional groups in an organic thin layer includes: a) measuring an absolute quantity per unit area of an analysis reference material having functional groups included in a reference organic thin layerby means of MEIS spectroscopy; b) carrying out spectrometry for the same reference organic thin layer as in a) and thereby obtaining peak intensities of the functional groups in the reference organic thin layer; c) carrying out the same spectrometry as in b) for an organic thin layer to be analyzed having the same functional groups and thereby measuring peak intensities of the functional groups with unknown quantity; and d) comparing the peak intensities of the functional groups measured in b) with respect to the absolute quantity of the analysis reference material in a) and thereby determining the absolute quantity per unit area of the functional groups with unknown quantity measured in c).
Abstract:
A method for direct quantification of the areal density (number per surface area of a substrate) of an analyte including a biochemical substance bound on the surface of a substrate and for direct quantification of the binding efficiency of biochemical substances is disclosed. Specifically, the areal density of an analyte including a biochemical substance bound on the surface of a substrate, and the binding efficiency between a first biochemical substance fixed on the substrate surface and a second biochemical substance is measured by ion scattering spectroscopy (ISS).
Abstract:
The present invention relates to a structure for an electrostatic lens. The electrostatic lens of the present invention comprises a first electrode, a third electrode, and a second electrode interposed between the first electrode and the third electrode such that a predetermined spacing exists among the three electrodes. The center of each of the three electrodes has a through-hole through which a charged particle beam is to pass. The through-holes of the three electrodes are arranged in a line. Thus, an improved structure for an electrostatic lens may be obtained.
Abstract:
The present invention aims to provide a flight time based mass microscope system for an ultra high-speed multi mode mass analysis, for using a laser beam or an ion beam simultaneously to enable both a low-molecular weight analysis such as for drug/metabolome/lipid/peptide, or a high molecular weight analysis such as for genes/protein, without being limited by the molecular weight of the object being analyzed, and for significantly increasing the measurement speed by using a microscope method instead of a scanning method.
Abstract:
A detection kit according to the present invention is a disease detection kit which is used together with secondary ion mass spectrometry to detect the disease marker contained in a biological sample. The detection kit comprises: a base on which a noble metal film is formed; a reactant which contains a peptide that specifically reacts with the disease marker; first storage means in which the reactant is stored; a sample which contains the biological sample of a possible disease carrier; second storage means in which the sample is stored; mixing means for mixing the reactant and the sample to produce a detection substance which contains the peptide which specifically reacts with the disease marker contained in the biological sample; and contact means for enabling the detection substance produced by the mixing means to contact the base, so as to bind the specifically reacted material to the noble metal film of the base.