公开(公告)号：WO2009096616A1

公开(公告)日：2009-08-06

申请号：PCT/KR2008/000603

申请日：2008-01-31

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  LEE, Changjoon Justin ,  KANG, Sang-Soo ,  HAN, Kyung-Suk ,  ROH, Eun-Joo ,  PARK, Jae-Yong

Inventor： LEE, Changjoon Justin ,  KANG, Sang-Soo ,  HAN, Kyung-Suk ,  ROH, Eun-Joo ,  PARK, Jae-Yong

IPC: A61K31/522

CPC classification number: A61K31/522

Abstract: An agent for inhibiting the activity of inositol-1,4,5-triphospate receptor subtype 3 (IP 3 R3), containing caffeine and/or its analogs, and/or their pharmaceutically acceptable salts, as an active ingredient, is provided. A composition for preventing and/or treating a disease associated with Ca 2+ release through IP 3 R3, containing the IP 3 R3 inhibiting agent, is also provided.

Abstract translation: 提供了用于抑制含有咖啡因和/或其类似物的肌醇-1,4,5-三磷酸受体亚型3（IP3R3）和/或其药学上可接受的盐作为活性成分的活性的药剂。 还提供了用于预防和/或治疗与包含IP3R3抑制剂的IP3R3释放相关的疾病的组合物。

公开(公告)号：WO2011025230A9

公开(公告)日：2011-03-03

申请号：PCT/KR2010/005653

申请日：2010-08-24

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  LEE, Changjoon Justin ,  LEE, Soo-Jung ,  YOON, Bo-Eun

Inventor： LEE, Changjoon Justin ,  LEE, Soo-Jung ,  YOON, Bo-Eun

IPC: A61K31/465 ,  A61K31/7105 ,  A61P25/08 ,  A61P25/28

Abstract: A GABA (gamma-aminobutyric acid) release-inhibiting agent in the cerebellum and a composition for treating pathological symptoms caused by over-release of GABA in the cerebellum, each comprising a Bestrophin 1(Best1) channel inhibitor as an active ingredient; a GABA release-promoting agent in the cerebellum and a composition for treating pathological symptoms caused by the deficit of GABA in the cerebellum, each comprising a Best1 channel activator as an active ingredient; and a method for screening a GABA release-regulating agent in the cerebellum, which uses Best1 channel as target, are provided.

公开(公告)号：WO2009096612A1

公开(公告)日：2009-08-06

申请号：PCT/KR2008/000564

申请日：2008-01-30

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  LEE, Changjoon Justin ,  WOO, Dong-Ho ,  PARK, Hyung-Ju

Inventor： LEE, Changjoon Justin ,  WOO, Dong-Ho ,  PARK, Hyung-Ju

IPC: A61K48/00 ,  C12N15/11

CPC classification number: C12N15/1138 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/53

Abstract: A novel use of anion channels, preferably Ca 2+ -activated anion channels (CAACs), in regulating release of neurotransmitters from neurons and/or astrocytes is provided. More specifically, CAAC activity regulators, agents for regulating neurotransmitter release comprising such CAAC activity regulators, and methods of screening agents for regulating neurotransmitter release using CAAC as a target.

Abstract translation: 提供阴离子通道，优选Ca2 +活化阴离子通道（CAAC）在调节神经元和/或星形胶质细胞释放神经递质中的新用途。 更具体地，CAAC活性调节剂，用于调节包含这种CAAC活性调节剂的神经递质释放剂，以及使用CAAC作为靶标调节神经递质释放调节剂的方法。

公开(公告)号：WO2009096615A1

公开(公告)日：2009-08-06

申请号：PCT/KR2008/000602

申请日：2008-01-31

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  LEE, Changjoon Justin ,  ROH, Eun-Joo ,  CHOI, Jin-Kyu ,  HAN, Kyung-Suk ,  PARK, Jung-Eun ,  KANG, Sang-Soo

Inventor： LEE, Changjoon Justin ,  ROH, Eun-Joo ,  CHOI, Jin-Kyu ,  HAN, Kyung-Suk ,  PARK, Jung-Eun ,  KANG, Sang-Soo

IPC: A61K31/522

CPC classification number: A61K31/522

Abstract: A composition for preventing and/or treating brain tumor, containing caffeine and/or its analog, and/or their pharmaceutically acceptable salt, as an active ingredient, is provided. The composition for preventing or treating brain tumor has an activity to inhibit invasion, migration, and proliferation of brain tumor cells, and thereby very effective for the prevention and treatment of brain tumor.

Abstract translation: 提供了用于预防和/或治疗含有咖啡因和/或其类似物的脑肿瘤和/或其药学上可接受的盐作为活性成分的组合物。 用于预防或治疗脑肿瘤的组合物具有抑制脑肿瘤细胞的侵袭，迁移和增殖的活性，因此对预防和治疗脑肿瘤非常有效。

公开(公告)号：EP3202759A1

公开(公告)日：2017-08-09

申请号：EP15847985.7

申请日：2015-09-24

Applicant: Korea Institute of Science and Technology

Inventor： PARK, Ki Duk ,  LEE, Changjoon Justin ,  KIM, Dong Jin ,  PAE, Ae Nim ,  CHOO, Hyun Ah ,  MIN, Sun Joon ,  KANG, Yong Koo ,  KIM, Yun Kyung ,  SONG, Hyo Jung ,  CHOI, Ji Won ,  NAM, Min Ho ,  HEO, Jun Young ,  YEON, Seul Ki ,  JANG, Bo Ko ,  JU, Eun Ji ,  JO, Seon Mi ,  PARK, Jong-Hyun

IPC: C07C237/20 ,  C07C237/04 ,  C07C231/12 ,  C07C309/04 ,  A61K31/16 ,  A61K31/167

Abstract: The present disclosure relates to an α-aminoamide derivative compound and a pharmaceutical composition containing the same. According to various embodiments of the present disclosure, provided is a therapeutic agent which can overcome the disadvantages of existing drugs used as a MAO-B inhibitor and, specifically, reversibly inhibits MAO-B through a non-covalent bond so as to alleviate or eliminate the side effects of the existing drugs which exhibit a therapeutic effect by irreversibly acting via a covalent bond with MAO-B. Particularly, a new compound having superior stability and efficacy compared to the existing reversible MAO-B inhibitors may be provided.

Abstract translation: 本公开涉及α-氨基酰胺衍生物化合物和含有其的药物组合物。 根据本公开的各种实施方式，提供了一种治疗剂，其可以克服现有药物用作MAO-B抑制剂的缺点，并且具体地通过非共价键可逆地抑制MAO-B，从而缓解或消除 现有药物通过与MAO-B通过共价键发挥不可逆作用而表现出治疗效果的副作用。 特别地，可以提供与现有可逆MAO-B抑制剂相比具有优良稳定性和功效的新化合物。

公开(公告)号：EP2470180A2

公开(公告)日：2012-07-04

申请号：EP10812243.3

申请日：2010-08-24

Applicant: Korea Institute of Science and Technology

Inventor： LEE, Changjoon Justin ,  LEE, Soo-Jung ,  YOON, Bo-Eun

IPC: A61K31/465 ,  A61K31/7105 ,  A61P25/08 ,  A61P25/28

CPC classification number: A61K31/00 ,  A61K31/185 ,  A61K31/196 ,  A61K31/455 ,  A61K31/7105 ,  A61K31/713 ,  A61K38/043 ,  A61K38/08 ,  G01N33/9426 ,  G01N2500/10

Abstract: A GABA (gamma-aminobutyric acid) release-inhibiting agent in the cerebellum and a composition for treating pathological symptoms caused by over-release of GABA in the cerebellum, each comprising a Bestrophin 1(Best1) channel inhibitor as an active ingredient; a GABA release-promoting agent in the cerebellum and a composition for treating pathological symptoms caused by the deficit of GABA in the cerebellum, each comprising a Best1 channel activator as an active ingredient; and a method for screening a GABA release-regulating agent in the cerebellum, which uses Best1 channel as target, are provided.

公开(公告)号：EP2470180B1

公开(公告)日：2014-03-12

申请号：EP10812243.3

申请日：2010-08-24

Applicant: Korea Institute of Science and Technology

Inventor： LEE, Changjoon Justin ,  LEE, Soo-Jung ,  YOON, Bo-Eun

IPC: A61K31/465 ,  A61K31/7105 ,  G01N33/48 ,  A61P25/08 ,  A61P25/28 ,  A61P25/00

CPC classification number: A61K31/00 ,  A61K31/185 ,  A61K31/196 ,  A61K31/455 ,  A61K31/7105 ,  A61K31/713 ,  A61K38/043 ,  A61K38/08 ,  G01N33/9426 ,  G01N2500/10