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公开(公告)号：WO2023004400A1
公开(公告)日：2023-01-26
申请号：PCT/US2022/074028
申请日：2022-07-21
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： LEVITZ, Andrew , MULLAH, Khairuzzaman Bashar , EVANS, Brian , BENSON, Scott C.
Abstract: The present disclosure relates to dibenzoxanthene compounds that are efficient quenchers of fluorescence, for example in the far red and near infrared spectrum. Applications using the dibenzoxanthene quenching compounds and methods of making same are also described. Also disclosed is a method of detecting or quantifying a target nucleic acid molecule in a sample by polymerase chain reaction (PCR). The compounds have the following formula (I).
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公开(公告)号：WO2012092403A1
公开(公告)日：2012-07-05
申请号：PCT/US2011/067680
申请日：2011-12-28
Applicant: LIFE TECHNOLOGIES CORPORATION , BENSON, Scott C. , MONIGHETTI, Cinna , KOEPF, Sandy M.
Inventor： BENSON, Scott C. , MONIGHETTI, Cinna , KOEPF, Sandy M.
CPC classification number: C12Q1/6818 , C09B15/00 , C12Q1/6844 , C12Q1/6851 , C12Q2527/125 , C12Q2545/101 , C12Q2561/113 , C12Q2563/107
Abstract: According to the present teachings, methods and compositions are provided that utilize at least one reference dye of formula (I): In some embodiments, a method comprises measuring a detection signal of a reporter dye and at least one reference dye of formula (I). In some embodiments, a composition comprises a reference dye of formula (1), a buffer, a selection of nucleotides and a protein.
Abstract translation: 根据本教导，提供利用至少一种式（I）的参考染料的方法和组合物：在一些实施方案中，一种方法包括测量报道染料和至少一种式（I）的参考染料的检测信号， 。 在一些实施方案中，组合物包含式（1）的参考染料，缓冲液，核苷酸和蛋白质的选择。
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公开(公告)号：WO2017007838A1
公开(公告)日：2017-01-12
申请号：PCT/US2016/041171
申请日：2016-07-06
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： MASTROIANNI, Alexander , BENSON, Scott C. , MENCHEN, Steven M. , SCOTT, John
CPC classification number: B01J19/0046 , B01J2219/00317 , B01J2219/005 , B01J2219/00545 , B01J2219/00648 , B01J2219/00659 , B01J2219/00677 , B01J2219/00722 , C12Q1/6806 , C12Q1/6837 , C12Q1/6869 , C12Q2535/122 , C12Q2563/155 , C12Q2565/607 , C12Q2565/629
Abstract: A method of preparing a discrete polymer network array include mixing a plurality of nucleic acid polymer networks with a plurality of color-activated polymer networks to form a dispersion, applying the dispersion to an array of wells, the nucleic acid polymer networks selectively depositing into wells of the array of wells, and rinsing the array of wells to selectively remove the plurality of color-activated polymer networks.
Abstract translation: 制备离散聚合物网络阵列的方法包括将多个核酸聚合物网络与多个着色活化聚合物网络混合以形成分散体，将该分散体施加到孔阵列上，将核酸聚合物网络选择性地沉积到孔中 的孔阵列，并且冲洗孔阵列以选择性地去除多个着色活化聚合物网络。
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公开(公告)号：EP2658998A1
公开(公告)日：2013-11-06
申请号：EP11811282.0
申请日：2011-12-28
Applicant: Life Technologies Corporation
Inventor： BENSON, Scott C. , MONIGHETTI, Cinna , KOEPF, Sandy M.
CPC classification number: C12Q1/6818 , C09B15/00 , C12Q1/6844 , C12Q1/6851 , C12Q2527/125 , C12Q2545/101 , C12Q2561/113 , C12Q2563/107
Abstract: According to the present teachings, methods and compositions are provided that utilize at least one reference dye of formula (I): In some embodiments, a method comprises measuring a detection signal of a reporter dye and at least one reference dye of formula (I). In some embodiments, a composition comprises a reference dye of formula (1), a buffer, a selection of nucleotides and a protein.
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公开(公告)号：EP4373890A1
公开(公告)日：2024-05-29
申请号：EP22753981.4
申请日：2022-07-21
Applicant: Life Technologies Corporation
Inventor： LEVITZ, Andrew , MULLAH, Khairuzzaman Bashar , EVANS, Brian , BENSON, Scott C.
CPC classification number: C09B67/0033 , C09B56/00 , C09B11/24 , C09B11/28 , C12Q1/686
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Patent Agency Ranking
公开(公告)号：EP4491743A2
公开(公告)日：2025-01-15
申请号：EP24201806.7
申请日：2019-03-01
Applicant: Life Technologies Corporation
Inventor： MULLAH, Khairuzzaman Bashar , EVANS, Brian , BENSON, Scott C. , CHANG, Chu-An , YAN, Xiongwei
IPC: C12Q1/686
Abstract: Disclosed is a probe for use in biological assays. The probe includes a fluorescent dye bound to a quencher compound through an oligonucleotide linker. Also disclosed are methods of using the probe, such as for a polymerase chain reaction (PCR), such as in a quantitative PCR reaction (qPCR), as well as kits including the probe.
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公开(公告)号：EP2658998B1
公开(公告)日：2015-04-22
申请号：EP11811282.0
申请日：2011-12-28
Applicant: Life Technologies Corporation
Inventor： BENSON, Scott C. , MONIGHETTI, Cinna , KOEPF, Sandy M.
CPC classification number: C12Q1/6818 , C09B15/00 , C12Q1/6844 , C12Q1/6851 , C12Q2527/125 , C12Q2545/101 , C12Q2561/113 , C12Q2563/107
Abstract: According to the present teachings, methods and compositions are provided that utilize at least one reference dye of formula (I): In some embodiments, a method comprises measuring a detection signal of a reporter dye and at least one reference dye of formula (I). In some embodiments, a composition comprises a reference dye of formula (1), a buffer, a selection of nucleotides and a protein.
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公开(公告)号：EP4491743A3
公开(公告)日：2025-03-19
申请号：EP24201806.7
申请日：2019-03-01
Applicant: Life Technologies Corporation
Inventor： MULLAH, Khairuzzaman Bashar , EVANS, Brian , BENSON, Scott C. , CHANG, Chu-An , YAN, Xiongwei
IPC: C07H21/00 , C12Q1/6818 , C12Q1/686
Abstract: Disclosed is a probe for use in biological assays. The probe includes a fluorescent dye bound to a quencher compound through an oligonucleotide linker. Also disclosed are methods of using the probe, such as for a polymerase chain reaction (PCR), such as in a quantitative PCR reaction (qPCR), as well as kits including the probe.
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公开(公告)号：EP3759117A1
公开(公告)日：2021-01-06
申请号：EP19710968.9
申请日：2019-03-01
Applicant: Life Technologies Corporation
Inventor： MULLAH, Khairuzzaman Bashar , EVANS, Brian , BENSON, Scott C. , CHANG, Chu-An , YAN, Xiongwei
IPC: C07H21/00 , C12Q1/6818 , C12Q1/686
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公开(公告)号：EP1802727B1
公开(公告)日：2018-04-04
申请号：EP05801162.8
申请日：2005-09-16
Applicant: Life Technologies Corporation
Inventor： GRAHAM, Ronald J. , ZOU, Ruiming , UPADHYA, Krishna G. , BENSON, Scott C.
IPC: C09K11/06 , C12Q1/68 , C09B15/00 , C07D219/04
CPC classification number: C07H21/00 , C07D219/06 , C09B15/00 , C09K11/06 , C09K2211/1011 , C09K2211/1029 , C12Q1/6816 , C12Q1/6869 , G01N33/582 , Y10S436/80 , Y10T436/143333
Abstract: The present teachings generally relate to fluorescent dyes, linkable forms of fluorescent dyes, energy transfer dyes, reagents labeled with fluorescent dyes and uses thereof.
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