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公开(公告)号：WO2023004356A2
公开(公告)日：2023-01-26
申请号：PCT/US2022/073954
申请日：2022-07-20
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： HU, Yi-Zhen , EVANS, Brian
IPC: C09B23/08 , C09B1/00 , G01N21/00 , G01N21/64 , C07D201/00 , C07D471/00 , C07D519/00 , C07D471/04 , C09B23/083
Abstract: The present disclosure relates to new and useful azaindole cyanine (pyrrolo pyridine cyanine) compounds. Use of the compounds as dyes that operate in the far-red and near-IR spectral region in biological imaging, and methods of making the compounds are also disclosed herein. The azaindole cyanine (pyrrolo pyridine cyanine) compounds have formulas (I) and (II).
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公开(公告)号：WO2020132607A1
公开(公告)日：2020-06-25
申请号：PCT/US2019/068111
申请日：2019-12-20
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： EVANS, Brian , BENSON, Scott
Abstract: The present disclosure relates to N-protected NH-rhodamine dyes and their use in nucleic acid detection. In particular, the disclosure relates to methods of making N-protected NH-rhodamine dyes, and methods of use of N-protected NH-rhodamine dyes (e.g., human identification). Certain dyes provided herein have unique spectral properties that complement those in existing dye sets and can be used to expand the number of reporter dyes that can be included for HID applications and other biological assays. Those fluorescent compounds are useful to label synthetic oligonucleotides. Formula (I).
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公开(公告)号：WO2020132607A9
公开(公告)日：2020-06-25
申请号：PCT/US2019/068111
申请日：2019-12-20
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： EVANS, Brian , BENSON, Scott
Abstract: The present disclosure relates to N-protected NH-rhodamine dyes and their use in nucleic acid detection. In particular, the disclosure relates to methods of making N-protected NH-rhodamine dyes, and methods of use of N-protected NH-rhodamine dyes (e.g., human identification). Certain dyes provided herein have unique spectral properties that complement those in existing dye sets and can be used to expand the number of reporter dyes that can be included for HID applications and other biological assays. Those fluorescent compounds are useful to label synthetic oligonucleotides. Formula (I).
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公开(公告)号：WO2020033681A3
公开(公告)日：2020-02-13
申请号：PCT/US2019/045697
申请日：2019-08-08
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： YANG, Jongtae , WANG, Xin , HU, Yi-Zhen , GEE, Kyle , CHEN, Aimei , BENSON, Scott , EVANS, Brian , RUKAVISHNIKOV, Aleksey
IPC: C09B69/00 , C09B11/14 , G01N33/58 , C12Q1/6869
Abstract: Silicon-substituted rhodamine compounds are disclosed herein. Also described herein are Si R dyes comprising at least one vinyl groupattached to the Si atom (10 position) of the SiR dye. Derivatives, functionalized versions, conjugates, kits, related synthetic methods and uses of Si R compounds also are provided. Silicon-rhodamine (SiR) dyes can provide bright fluorescence at far red wavelengths and exhibit good photostability. The compounds described herein can be useful for fluorescent labeling and detection of biological samples. The compounds have the general structure (I) below.
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公开(公告)号：WO2020033681A2
公开(公告)日：2020-02-13
申请号：PCT/US2019/045697
申请日：2019-08-08
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： YANG, Jongtae , WANG, Xin , HU, Yi-Zhen , GEE, Kyle , CHEN, Aimei , BENSON, Scott , EVANS, Brian , RUKAVISHNIKOV, Aleksey
IPC: C09B69/00 , C09B11/14 , G01N33/58 , C12Q1/6869
Abstract: Silicon-substituted rhodamine compounds are disclosed herein. Also described herein are SiR dyes comprising at least one vinyl group attached to the Si atom (10 position) of the SiR dye. Derivatives, functionalized versions, conjugates, kits, related synthetic methods and uses of SiR compounds also are provided. Silicon-rhodamine (SiR) dyes can provide bright fluorescence at far red wavelengths and exhibit good photostability. The compounds described herein can be useful for fluorescent labeling and detection of biological samples.
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Patent Agency Ranking
公开(公告)号：WO2016090076A2
公开(公告)日：2016-06-09
申请号：PCT/US2015/063593
申请日：2015-12-03
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： ZHOU, Wenjun , GEE, Kyle , TENNICO, Yolanda , SLADE, Peter , KANG, Hee Chol , KHAN, Shaheer , EVANS, Brian , STRAY, James
IPC: C07D261/00 , G01N33/58
CPC classification number: C07C309/47 , C07C309/51 , C07C2603/50 , C07D311/84 , G01N33/582 , G01N2400/10
Abstract: The present disclosure is directed dye compounds containing a hydrazinyl substituent and optionally, one or more negatively charged groups, such as sulfonate, phosphate, phosphonate, and/or carboxylate groups and dye compounds containing an aminooxy substitutent. The compounds are useful in the detection of analytes containing aldehyde and ketone groups, including, for example, glycans.
Abstract translation: 本公开涉及含有肼基取代基和任选的一个或多个带负电荷的基团的染料化合物，例如磺酸盐，磷酸盐，膦酸盐和/或羧酸盐基团以及含有氨基氧基取代基的染料化合物。 该化合物可用于检测含醛和酮基的分析物，包括例如聚糖。
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公开(公告)号：WO2012125220A2
公开(公告)日：2012-09-20
申请号：PCT/US2012/021264
申请日：2012-01-13
Applicant: LIFE TECHNOLOGIES CORPORATION , XU, Tom , TRINH, Christopher , BORNARTH, Carole , EVANS, Brian , RATH, Mousumi , TRAN, Kathy
Inventor： XU, Tom , TRINH, Christopher , BORNARTH, Carole , EVANS, Brian , RATH, Mousumi , TRAN, Kathy
CPC classification number: C07H21/02 , C12N15/1006 , C12Q1/6809 , C12Q1/6834 , C12Q1/6876 , C12Q2600/178 , C12Q2525/207 , C12Q2563/149
Abstract: Method and compositions and kits for isolation, identification, and quantification of miRNAs and other small RNAs, including but not limited to, siRNAs, mRNAs, and snRNAs are disclosed. Methods of diagnosing a disease or its progression are also disclosed.
Abstract translation: 公开了用于分离，鉴定和定量miRNA和其他小RNA（包括但不限于siRNA，mRNA和snRNA）的方法和组合物和试剂盒。 还公开了诊断疾病或其进展的方法。
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公开(公告)号：WO2023004400A1
公开(公告)日：2023-01-26
申请号：PCT/US2022/074028
申请日：2022-07-21
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： LEVITZ, Andrew , MULLAH, Khairuzzaman Bashar , EVANS, Brian , BENSON, Scott C.
Abstract: The present disclosure relates to dibenzoxanthene compounds that are efficient quenchers of fluorescence, for example in the far red and near infrared spectrum. Applications using the dibenzoxanthene quenching compounds and methods of making same are also described. Also disclosed is a method of detecting or quantifying a target nucleic acid molecule in a sample by polymerase chain reaction (PCR). The compounds have the following formula (I).
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公开(公告)号：WO2020132487A1
公开(公告)日：2020-06-25
申请号：PCT/US2019/067925
申请日：2019-12-20
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： EVANS, Brian , BENSON, Scott , MULLAH, Khairuzzaman Bashar , YAN, Xiongwei
Abstract: The present invention is directed to f luorescent rhodamine dyes having spectral properties suited to the creation of multiplex assay systems for use in molecular biology, cell biology and molecular genetics. The rhodamine dyes have the following structure:
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公开(公告)号：EP3272885B1
公开(公告)日：2020-04-22
申请号：EP17190361.0
申请日：2012-01-13
Applicant: Life Technologies Corporation
Inventor： XU, Tom , TRINH, Christopher , BORNARTH, Carole , EVANS, Brian , RATH, Mousumi , TRAN, Kathy
IPC: C12Q1/6834 , C12Q1/6809 , C12Q1/6876 , C12N15/10 , C07H21/02
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