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    SEQUENCING DEVICE
    1.
    发明申请
    SEQUENCING DEVICE 审中-公开
    顺序设备

    公开(公告)号：WO2015195831A1

    公开(公告)日：2015-12-23

    申请号：PCT/US2015/036277

    申请日：2015-06-17

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： SCHULTZ, Jonathan ,  ROSWECH, Todd ,  HOSHIZAKI, Jon ,  CARRILLO, Albert ,  BALL, James

    IPC: B01L3/00 ,  G01N35/10

    CPC classification number: C12Q1/6869 ,  B01F1/0027 ,  B01F5/0683 ,  B01F11/0048 ,  B01F11/0071 ,  B01L3/502 ,  B01L3/505 ,  B01L3/527 ,  B01L3/563 ,  B01L2200/04 ,  B01L2200/16 ,  B01L2300/022 ,  B01L2300/0681 ,  B01L2300/0861 ,  B01L2300/123 ,  B01L2400/0481 ,  B01L2400/0487 ,  B01L2400/0655 ,  B01L2400/0683 ,  C12Q1/6806 ,  G01N27/4145 ,  G01N35/1002 ,  G01N35/1095 ,  Y10T436/11 ,  Y10T436/143333

    Abstract: A method of preparing reagents includes inserting a cartridge into an instrument. The cartridge includes a plurality of reagent enclosures disposed in a cavity of the cartridge and exposing a port to an exterior of the cartridge. Each reagent enclosure includes a reagent container including a reagent and an internal cavity defining a compressible volume, an opening defined through the reagent container to the internal cavity. The method further includes connecting a plurality of fluid ports to the openings of the plurality of reagent enclosures; applying a solution through the fluid ports to at least partially fill the plurality of reagent enclosures; and cycling a pressure of the cavity, whereby for each of the reagent enclosures, during increasing pressure, the solution enters the internal cavity of the reagent container, combines with the reagent, and compresses the compressible volume, and during decreasing pressure, the compressible volume decreases and the reagent is ejected through the opening.

    Abstract translation: 制备试剂的方法包括将药筒插入仪器中。 盒包括设置在盒的空腔中并将端口暴露于盒的外部的多个试剂盒。 每个试剂盒包括试剂容器，其包括试剂和限定可压缩体积的内腔，通过试剂容器限定到内腔的开口。 该方法还包括将多个流体端口连接到多个试剂盒的开口; 通过所述流体端口施加溶液以至少部分地填充所述多个试剂外壳; 并且循环空腔的压力，由此对于每个试剂外壳，在增加的压力期间，溶液进入试剂容器的内腔，与试剂结合，并压缩可压缩体积，并且在减压期间，可压缩体积 减少，试剂通过开口排出。

    DEVICES INCORPORATING A MULTILANE FLOW CELL
    2.
    发明申请
    DEVICES INCORPORATING A MULTILANE FLOW CELL 审中-公开

    公开(公告)号：WO2021034705A1

    公开(公告)日：2021-02-25

    申请号：PCT/US2020/046481

    申请日：2020-08-14

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： BUIE, Creighton ,  REED, Mark ,  CARRILLO, Albert

    IPC: B01L3/00 ,  G01N27/414

    Abstract: A sensor device includes a substrate having a die attached to the substrate. The die includes an array of sensors and an array of wells cooperatively disposed over the array of sensors. The array of wells is exposed by the substrate. The sensor device further includes a flow cell secured to the substrate and defining a flow space disposed over the die and accessible to the array of wells. The flow cell defines a plurality of separate volumes. Each separate volume of the plurality of separate volumes has an inlet and an outlet. The plurality of separate volumes are separated by dividers. The dividers cover a set of wells of the array of wells.

    DEVICE, SYSTEM AND METHOD FOR FLUID DELIVERY FOR SEQUENCING
    3.
    发明申请
    DEVICE, SYSTEM AND METHOD FOR FLUID DELIVERY FOR SEQUENCING 审中-公开

    公开(公告)号：WO2020243404A1

    公开(公告)日：2020-12-03

    申请号：PCT/US2020/035086

    申请日：2020-05-29

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： CARRILLO, Albert ,  DONOHUE, John

    IPC: C12Q1/6869 ,  C12Q1/68 ,  G01N35/10 ,  C12Q1/00 ,  B01L3/00

    Abstract: Various embodiments of a fluidic system of the present teachings are configured to execute a sequence of fluidic operations over the course of a next generation sequencing analysis for the sequential delivery of various solutions used over the course of analysis to a multilane sensor device. Exemplary fluidic operations include washing, priming and nucleotide reagent delivery through a fluidic multiplexer block that is configured to provide independent fluid distribution to each lane of a multilane sensor device used for detection during an analysis. Accordingly, any number or combination of lanes can be used during an analysis, so that during an analysis one lane in any position can be used singly during a run, all four lanes can be used simultaneously during a run, or any combination of lanes can be used simultaneously during a run.

    SEQUENCING DEVICE
    7.
    发明公开
    SEQUENCING DEVICE 审中-公开
    测序装置

    公开(公告)号：EP3157678A1

    公开(公告)日：2017-04-26

    申请号：EP15733595.1

    申请日：2015-06-17

    Applicant: Life Technologies Corporation

    Inventor： SCHULTZ, Jonathan ,  ROSWECH, Todd ,  HOSHIZAKI, Jon ,  CARRILLO, Albert ,  BALL, James

    IPC: B01L3/00 ,  G01N35/10

    CPC classification number: C12Q1/6869 ,  B01F1/0027 ,  B01F5/0683 ,  B01F11/0048 ,  B01F11/0071 ,  B01L3/502 ,  B01L3/505 ,  B01L3/527 ,  B01L3/563 ,  B01L2200/04 ,  B01L2200/16 ,  B01L2300/022 ,  B01L2300/0681 ,  B01L2300/0861 ,  B01L2300/123 ,  B01L2400/0481 ,  B01L2400/0487 ,  B01L2400/0655 ,  B01L2400/0683 ,  C12Q1/6806 ,  G01N27/4145 ,  G01N35/1002 ,  G01N35/1095 ,  Y10T436/11 ,  Y10T436/143333

    Abstract: A method of preparing reagents includes inserting a cartridge into an instrument. The cartridge includes a plurality of reagent enclosures disposed in a cavity of the cartridge and exposing a port to an exterior of the cartridge. Each reagent enclosure includes a reagent container including a reagent and an internal cavity defining a compressible volume, an opening defined through the reagent container to the internal cavity. The method further includes connecting a plurality of fluid ports to the openings of the plurality of reagent enclosures; applying a solution through the fluid ports to at least partially fill the plurality of reagent enclosures; and cycling a pressure of the cavity, whereby for each of the reagent enclosures, during increasing pressure, the solution enters the internal cavity of the reagent container, combines with the reagent, and compresses the compressible volume, and during decreasing pressure, the compressible volume decreases and the reagent is ejected through the opening.

    Abstract translation: 制备试剂的方法包括将药筒插入器械中。 盒包括多个试剂外壳，所述试剂外壳设置在盒的空腔中并且将端口暴露于盒的外部。 每个试剂外壳包括试剂容器，该试剂容器包括试剂和限定可压缩容积的内腔，开口通过试剂容器限定到内腔。 该方法还包括将多个流体端口连接到多个试剂外壳的开口; 通过所述流体端口施加溶液以至少部分地填充所述多个试剂外壳; 并且循环腔的压力，由此对于每个试剂腔，在增加压力期间，溶液进入试剂容器的内腔，与试剂结合并压缩可压缩容积，并且在减压过程中，可压缩容积 减少并且试剂通过开口喷射。

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