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    APPARATUSES, SYSTEMS AND METHODS FOR PROVIDING SCALABLE THERMAL CYCLERS AND ISOLATING THERMOELECTRIC DEVICES
    2.
    发明申请
    APPARATUSES, SYSTEMS AND METHODS FOR PROVIDING SCALABLE THERMAL CYCLERS AND ISOLATING THERMOELECTRIC DEVICES 审中-公开
    用于提供可扩展热循环和隔离热电装置的装置，系统和方法

    公开(公告)号：WO2015126621A1

    公开(公告)日：2015-08-27

    申请号：PCT/US2015/014357

    申请日：2015-02-04

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： LIM, Chee Kiong ,  LEE, Way Xuang ,  LOH, Wuh Ken ,  CHING, Chee Wee ,  KOO, Chin Yong ,  KOH, Siew Ying ,  TOH, Tiong Han ,  BOO, Kuan Moon ,  LAU, Soo Yong

    IPC: B01L7/00

    CPC classification number: B01L7/52 ,  B01L2200/147 ,  B01L2300/0829 ,  B01L2300/1805 ,  B01L2300/1822 ,  B01L2300/1883 ,  C12Q1/6806

    Abstract: In one aspect, a thermal cycler system including a sample block and a thermoelectric device is disclosed. In various embodiments, the sample block has a first surface configured to receive a plurality of reaction vessels and an opposing second surface. In various embodiments the thermoelectric device is operably coupled to the second surface of the sample block. In various embodiments a thermal control unit is provided. In various embodiments the thermal control unit includes a computer processing unit. In various embodiments the thermal control unit includes an electrical current source. In various embodiments the thermal control unit also includes an electrical interface portion configured to connect the thermoelectric device with the electrical current source by way of an electrical cable. In various embodiments the thermal control unit is oriented in a different plane than the sample block and thermoelectric cooler.

    Abstract translation: 一方面，公开了一种包括样品块和热电装置的热循环仪系统。 在各种实施例中，样品块具有构造成容纳多个反应容器和相对的第二表面的第一表面。 在各种实施例中，热电装置可操作地耦合到样品块的第二表面。 在各种实施例中，提供了热控制单元。 在各种实施例中，热控制单元包括计算机处理单元。 在各种实施例中，热控制单元包括电流源。 在各种实施例中，热控制单元还包括被配置为通过电缆将热电装置与电流源连接的电接口部分。 在各种实施例中，热控制单元定向在与样品块和热电冷却器不同的平面中。

    APPARATUSES, SYSTEMS AND METHODS FOR PROVIDING THERMOCYCLER THERMAL UNIFORMITY
    3.
    发明申请
    APPARATUSES, SYSTEMS AND METHODS FOR PROVIDING THERMOCYCLER THERMAL UNIFORMITY 审中-公开
    提供热分解器热稳定性的装置，系统和方法

    公开(公告)号：WO2015039014A1

    公开(公告)日：2015-03-19

    申请号：PCT/US2014/055615

    申请日：2014-09-15

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： SHIN, Hon Siu ,  KOO, Chin Yong ,  LEE, Way Xuang ,  LIM, Chee Kiong ,  CHING, Chee Wee ,  RAMACHANDRAN, Niroshan

    IPC: B01L7/00

    CPC classification number: B01L7/52 ,  B01L2200/147 ,  B01L2300/0829 ,  B01L2300/0848 ,  B01L2300/0887 ,  B01L2300/12 ,  B01L2300/1822

    Abstract: A thermal block assembly including a sample block and two or more thermoelectric devices, is disclosed. The sample block has a top surface configured to receive a plurality of reaction vessels and an opposing bottom surface. The thermoelectric devices are operably coupled to the sample block, wherein each thermoelectric device includes a housing for a thermal sensor and a thermal control interface with a controller. Each thermoelectric device is further configured to operate independently from each other to provide a substantially uniform temperature profile throughout the sample block.

    Abstract translation: 公开了一种包括样品块和两个或更多个热电装置的热块组件。 样品块具有构造成容纳多个反应容器和相对的底表面的顶表面。 热电装置可操作地耦合到样品块，其中每个热电装置包括用于热传感器的壳体和具有控制器的热控制界面。 每个热电装置进一步构造成彼此独立地操作以在整个样品块中提供基本均匀的温度分布。

    IMPROVED THERMAL UNIFORMITY FOR THERMAL CYCLER INSTRUMENTATION USING DYNAMIC CONTROL
    6.
    发明公开
    IMPROVED THERMAL UNIFORMITY FOR THERMAL CYCLER INSTRUMENTATION USING DYNAMIC CONTROL 审中-公开
    利用动态控制改善热循环器仪表的热一致性

    公开(公告)号：EP2556173A2

    公开(公告)日：2013-02-13

    申请号：EP11766806.1

    申请日：2011-04-08

    Applicant: Life Technologies Corporation

    Inventor： CONNER, Thomas A. ,  LIM, Chee Kiong ,  PALLAS, Michael C. ,  CHING, Chee Wee

    IPC: C12Q1/68 ,  C12M1/38 ,  G01N33/50

    CPC classification number: B01L7/52 ,  B01L2200/147 ,  B01L2300/1822 ,  B01L2300/1894

    Abstract: A method for performing polymerase chain reactions (PCR) for improving thermal non-uniformity is provided. The method includes measuring a first temperature, by a first sensor, of a first sample block sector of a sample block and measuring a second temperature, by a second sensor, of a second sample block sector of the sample block that is adjacent to the first sample block sector. The method further includes calculating, by a thermoelectric controller, a difference in temperature between the first temperature and the second temperature and adjusting, by the thermoelectric controller, the first temperature of the first sample block sector based on the difference in temperature by using one or more thermoelectric coolers. The one or more thermoelectric coolers is configured to heat or cool the first sample block sector by adjusting power output from the thermoelectric controller.

    Abstract translation: 提供了用于进行聚合酶链式反应（PCR）以改善热不均匀性的方法。 该方法包括：通过第一传感器测量样本块的第一样本块扇区的第一温度，并且通过第二传感器测量样本块的与第一样本块相邻的第二样本块扇区的第二温度 样本块部门。 该方法进一步包括通过热电控制器计算第一温度和第二温度之间的温度差并且通过热电控制器基于温度差通过使用一个或多个温度计来调整第一样本块扇区的第一温度 更多的热电冷却器。 一个或多个热电冷却器被配置为通过调整来自热电控制器的功率输出来加热或冷却第一样本块扇区。

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