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    HUMAN IDENTIFIATION USING A PANEL OF SNPS
    5.
    发明申请
    HUMAN IDENTIFIATION USING A PANEL OF SNPS 审中-公开

    公开(公告)号：WO2014012107A3

    公开(公告)日：2014-01-16

    申请号：PCT/US2013/050531

    申请日：2013-07-15

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： LAGACE, Robert

    IPC: C12Q1/68

    Abstract: The present invention provides methods, compositions, kits, systems and apparatus that are useful for multiplex PCR of one or more nucleic acids which belong to a panel of single nucleotide polymorphisms (SNPs) useful to identify a human. In particular, various target-specific primers are provided that allow for the selective amplification of one or more target sequences in the panel. In some aspects, amplified target sequences obtained using the disclosed methods, kits, systems and apparatuses can be used in various downstream processes including nucleic acid sequencing and used to identify a human.

    SE33 MUTATIONS IMPACTING GENOTYPE CONCORDANCE
    6.
    发明申请
    SE33 MUTATIONS IMPACTING GENOTYPE CONCORDANCE 审中-公开
    SE33突变影响基因型的意义

    公开(公告)号：WO2012040403A1

    公开(公告)日：2012-03-29

    申请号：PCT/US2011/052667

    申请日：2011-09-21

    Applicant: LIFE TECHNOLOGIES CORPORATION ,  GREEN, Robert ,  WANG, Dennis ,  MULERO, Julio ,  LAGACE, Robert

    Inventor： GREEN, Robert ,  WANG, Dennis ,  MULERO, Julio ,  LAGACE, Robert

    IPC: C12Q1/68

    CPC classification number: C12Q1/6827 ,  C12Q1/686 ,  C12Q1/6888 ,  C12Q2537/143 ,  C12Q2600/156

    Abstract: [ Disclosed are primer set compositions, methods and kits for human identification using the highly complex sequence locus, SE33 (ACTBP2) in single and multiplex PCR reactions. Additionally, disclosed are three newly discovered single nucleotide polymorphisms (SNPs) within the SE33 locus that can cause discordance seen as mobility shift or allelic dropout. Also disclosed are kits useful in human identification.

    Abstract translation: 公开了使用高度复杂的序列位点的人类鉴定的引物组合物，方法和试剂盒，SE33（ACTBP2）在单次和多重PCR反应中。 另外，所公开的是在SE33基因座内的三个新发现的单核苷酸多态性（SNP），其可以引起不一致，被视为移动性偏移或等位基因缺失。 还公开了可用于人类鉴定的试剂盒。

    AMELOGENIN SNP ON CHROMOSOME X
    7.
    发明申请
    AMELOGENIN SNP ON CHROMOSOME X 审中-公开

    公开(公告)号：WO2011020075A2

    公开(公告)日：2011-02-17

    申请号：PCT/US2010/045544

    申请日：2010-08-13

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： MULERO, Julio ,  GREEN, Robert ,  LAGACE, Robert ,  HENNESSY, Lori

    IPC: C12Q1/68

    CPC classification number: C07H21/04 ,  C12Q1/6879 ,  C12Q2600/156

    Abstract: Disclosed are methods for gender determination in the intron 1 region of the amelogenin locus and a newly discovered single nucleotide polymorphism (SNP) within the X chromosome of the amelogenin locus which can cause allelic dropout. Also disclosed are kits useful in gender determination.

    Abstract translation: 本发明公开了一种用于性别测定的方法，该方法用于在羊角蛋白素基因座的内含子1区域和新发现的单核苷酸多态性（SNP），其可以引起等位基因缺失。 还公开了可用于性别测定的试剂盒。

    HUMAN IDENTIFICATION USING A PANEL OF SNPS
    10.
    发明公开
    HUMAN IDENTIFICATION USING A PANEL OF SNPS 审中-公开

    公开(公告)号：EP3388533A1

    公开(公告)日：2018-10-17

    申请号：EP18170220.0

    申请日：2013-07-15

    Applicant: Life Technologies Corporation

    Inventor： LAGACE, Robert

    IPC: C12Q1/68

    CPC classification number: C12Q1/6853 ,  C12Q1/6855 ,  C12Q2525/131

    Abstract: The present invention provides methods, compositions, kits, systems and apparatus that are useful for multiplex PCR of one or more nucleic acids which belong to a panel of single nucleotide polymorphisms (SNPs) useful to identify a human. In particular, various target-specific primers are provided that allow for the selective amplification of one or more target sequences in the panel. In some aspects, amplified target sequences obtained using the disclosed methods, kits, systems and apparatuses can be used in various downstream processes including nucleic acid sequencing and used to identify a human.

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