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    SHORT TANDEM REPEAT MULTIPLEX SYSTEM
    3.
    发明申请
    SHORT TANDEM REPEAT MULTIPLEX SYSTEM 审中-公开
    短距离重复多重系统

    公开(公告)号：WO2014039997A1

    公开(公告)日：2014-03-13

    申请号：PCT/US2013/058816

    申请日：2013-09-09

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： MULERO, Julio ,  GOPINATH, Siddhita

    IPC: C12Q1/68

    CPC classification number: C12Q1/6888 ,  C12Q2600/16

    Abstract: Methods and materials are disclosed for use in simultaneously amplifying at least 10 loci, D1S1656, D2S441, D2S1338, D6S1043, D10S1248, HUMTH01, D12S391, D19S433, D22S1045 and amelogenin, from genomic DNA in a single multiplex reaction such that a unique assay layout is achieved. Also disclosed are methods and materials for use in the analysis of the products of such reactions.

    Abstract translation: 公开了用于在单个多重反应中从基因组DNA同时扩增至少10个基因座D1S1656，D2S441，D2S1338，D6S1043，D10S1248，HUMTH01，D12S391，D19S433，D22S1045和牙釉蛋白的方法和材料，使得独特的测定布局为 实现。 还公开了用于分析这些反应的产物的方法和材料。

    MESYLATE BASED MASTER MIX
    5.
    发明申请
    MESYLATE BASED MASTER MIX 审中-公开

    公开(公告)号：WO2018237024A1

    公开(公告)日：2018-12-27

    申请号：PCT/US2018/038531

    申请日：2018-06-20

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： ZHONG, Chang ,  MULERO, Julio ,  MENCHEN, Steven

    IPC: C12Q1/686 ,  C12Q1/6848

    Abstract: Disclosed herein are mesylate containing compositions, methods of use of such compositions and kits of components encompassing such compositions for improving the amplification of nucleic acids, especially in the presence of enzymatic inhibitors. These find particular use in forensic and environmental analyses. The instant disclosure provides new compositions, methods and kits of components for overcoming PCR inhibition. In some embodiments disclosed herein is a PCR master mix, the PCR master mix encompassing a mesylate.

    SE33 MUTATIONS IMPACTING GENOTYPE CONCORDANCE
    6.
    发明申请
    SE33 MUTATIONS IMPACTING GENOTYPE CONCORDANCE 审中-公开
    SE33突变影响基因型的意义

    公开(公告)号：WO2012040403A1

    公开(公告)日：2012-03-29

    申请号：PCT/US2011/052667

    申请日：2011-09-21

    Applicant: LIFE TECHNOLOGIES CORPORATION ,  GREEN, Robert ,  WANG, Dennis ,  MULERO, Julio ,  LAGACE, Robert

    Inventor： GREEN, Robert ,  WANG, Dennis ,  MULERO, Julio ,  LAGACE, Robert

    IPC: C12Q1/68

    CPC classification number: C12Q1/6827 ,  C12Q1/686 ,  C12Q1/6888 ,  C12Q2537/143 ,  C12Q2600/156

    Abstract: [ Disclosed are primer set compositions, methods and kits for human identification using the highly complex sequence locus, SE33 (ACTBP2) in single and multiplex PCR reactions. Additionally, disclosed are three newly discovered single nucleotide polymorphisms (SNPs) within the SE33 locus that can cause discordance seen as mobility shift or allelic dropout. Also disclosed are kits useful in human identification.

    Abstract translation: 公开了使用高度复杂的序列位点的人类鉴定的引物组合物，方法和试剂盒，SE33（ACTBP2）在单次和多重PCR反应中。 另外，所公开的是在SE33基因座内的三个新发现的单核苷酸多态性（SNP），其可以引起不一致，被视为移动性偏移或等位基因缺失。 还公开了可用于人类鉴定的试剂盒。

    AMELOGENIN SNP ON CHROMOSOME X
    7.
    发明申请
    AMELOGENIN SNP ON CHROMOSOME X 审中-公开

    公开(公告)号：WO2011020075A2

    公开(公告)日：2011-02-17

    申请号：PCT/US2010/045544

    申请日：2010-08-13

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： MULERO, Julio ,  GREEN, Robert ,  LAGACE, Robert ,  HENNESSY, Lori

    IPC: C12Q1/68

    CPC classification number: C07H21/04 ,  C12Q1/6879 ,  C12Q2600/156

    Abstract: Disclosed are methods for gender determination in the intron 1 region of the amelogenin locus and a newly discovered single nucleotide polymorphism (SNP) within the X chromosome of the amelogenin locus which can cause allelic dropout. Also disclosed are kits useful in gender determination.

    Abstract translation: 本发明公开了一种用于性别测定的方法，该方法用于在羊角蛋白素基因座的内含子1区域和新发现的单核苷酸多态性（SNP），其可以引起等位基因缺失。 还公开了可用于性别测定的试剂盒。

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