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    COMPOSITIONS, METHODS, AND KITS FOR SYNTHESIS AND DETECTION OF NUCLEIC ACIDS
    1.
    发明申请
    COMPOSITIONS, METHODS, AND KITS FOR SYNTHESIS AND DETECTION OF NUCLEIC ACIDS 审中-公开
    合成和检测核酸的组合物，方法和试剂盒

    公开(公告)号：WO2017177025A1

    公开(公告)日：2017-10-12

    申请号：PCT/US2017/026386

    申请日：2017-04-06

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： LE, Ferrier ,  RAMAMOORTHI, Kalpith ,  WILDE, Joyce ,  FANTIN, Nicole ,  LANG, Jordan ,  DUPONT, David ,  STEVENS, Junko

    IPC: C12Q1/68

    Abstract: Compositions, methods, and kits for synthesizing, detecting, and/or quantifying nucleic acids are provided herein. Embodiments comprise a nucleic acid amplification composition comprising a thermostable DNA polymerase and agents which improve nucleic acid synthesis, amplification, detection, and/or quantification of nucleic acid targets in a crude extract or crude lysate sample.

    Abstract translation: 本文提供了用于合成，检测和/或定量核酸的组合物，方法和试剂盒。 实施方案包含核酸扩增组合物，其包含热稳定DNA聚合酶和改善粗提取物或粗溶解物样品中的核酸靶标的核酸合成，扩增，检测和/或定量的试剂。

    METHODS, KITS & COMPOSITIONS FOR DETERMINING GENE COPY NUMBERS
    3.
    发明申请
    METHODS, KITS & COMPOSITIONS FOR DETERMINING GENE COPY NUMBERS 审中-公开
    方法，用于确定基因拷贝数的组合物

    公开(公告)号：WO2016061111A1

    公开(公告)日：2016-04-21

    申请号：PCT/US2015/055344

    申请日：2015-10-13

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： LIU, Chunmei ,  DONG, Shoulian ,  STEVENS, Junko

    IPC: C12Q1/68

    CPC classification number: C12Q1/6851 ,  C12Q1/6853 ,  C12Q1/686 ,  C12Q1/6883 ,  C12Q2537/16 ,  C12Q2537/161 ,  C12Q2545/107 ,  C12Q2545/113 ,  C12Q2600/16

    Abstract: The present specification relates to methods, compositions, and kits for determining the presence of the number of copies of a gene. The present disclosure provides methods and compositions to determine zygosity in transgenic plants, number of transgenes in a plant or animal, karyotyping, determine CNV in human and animal samples, diagnose and detect diseases and conditions that are characterized by having variations in the number of copies of one or more genes.

    Abstract translation: 本说明书涉及用于确定基因拷贝数的存在的方法，组合物和试剂盒。 本公开提供了确定转基因植物接合度的方法和组合物，植物或动物中的转基因数量，核型分析，确定人和动物样品中的CNV，诊断和检测以拷贝数变化为特征的疾病和病症 的一个或多个基因。

    DNA METHYLATION DETECTION METHODS
    7.
    发明申请
    DNA METHYLATION DETECTION METHODS 审中-公开

    公开(公告)号：WO2010022098A3

    公开(公告)日：2010-02-25

    申请号：PCT/US2009/054220

    申请日：2009-08-18

    Applicant: LIFE TECHNOLOGIES CORPORATION ,  DONG, Shoulian ,  STEVENS, Junko

    Inventor： DONG, Shoulian ,  STEVENS, Junko

    IPC: C12Q1/68 ,  C12N15/11

    Abstract: The present teachings provide DNA methylation quantification methods that avoid bisulfite treatment of DNA. Methylation-specific binding proteins (MeDNA binding proteins) and non-methylation specific binding proteins (non-MeDNA binding proteins) are employed in various embodiments to modulate the accessibility of nucleic acids to primer extension reactions. After selectively removing the target nucleic acids, the extension products can be analyzed and methylation quantitated. In some embodiments, the analysis comprises real-time PCR.

    METHODS, KITS & COMPOSITIONS FOR DETERMINING GENE COPY NUMBERS
    8.
    发明公开
    METHODS, KITS & COMPOSITIONS FOR DETERMINING GENE COPY NUMBERS 审中-公开
    用于确定基因拷贝数的方法，试剂盒和组合物

    公开(公告)号：EP3207156A1

    公开(公告)日：2017-08-23

    申请号：EP15790334.5

    申请日：2015-10-13

    Applicant: Life Technologies Corporation

    Inventor： LIU, Chunmei ,  DONG, Shoulian ,  STEVENS, Junko

    IPC: C12Q1/68

    CPC classification number: C12Q1/6851 ,  C12Q1/6853 ,  C12Q1/686 ,  C12Q1/6883 ,  C12Q2537/16 ,  C12Q2537/161 ,  C12Q2545/107 ,  C12Q2545/113 ,  C12Q2600/16

    Abstract: The present specification relates to methods, compositions, and kits for determining the presence of the number of copies of a gene. The present disclosure provides methods and compositions to determine zygosity in transgenic plants, number of transgenes in a plant or animal, karyotyping, determine CNV in human and animal samples, diagnose and detect diseases and conditions that are characterized by having variations in the number of copies of one or more genes.

    Abstract translation: 本说明书涉及用于确定基因拷贝数的存在的方法，组合物和试剂盒。 本公开内容提供了用于确定转基因植物中的接合性，植物或动物中转基因的数量，核型分析，确定人和动物样品中的CNV，诊断和检测特征在于具有拷贝数量变化的疾病和病症的方法和组合物 的一个或多个基因。

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