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    Polymer coating containing drug powder of controlled morphology
    1.
    发明专利
    Polymer coating containing drug powder of controlled morphology 有权
    包含控制性形态药物的聚合物涂层

    公开(公告)号：JP2012183441A

    公开(公告)日：2012-09-27

    申请号：JP2012151964

    申请日：2012-07-06

    Applicant: Micell Technologies Inc ,  ミセル テクノロジーズ、インコーポレイテッド

    Inventor： TAYLOR DOUG ,  MCCLAIN JIM ,  SMOKE CLINT ,  COLE MIKE ,  DEYOUNG JAMES

    IPC: A61L15/00 ,  A61L27/00 ,  A61L29/00 ,  A61L31/00

    CPC classification number: A61F2/82 ,  A61F2210/0076 ,  A61F2250/0067 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/426 ,  A61L2300/606 ,  A61L2300/63 ,  A61L2420/08 ,  Y10T428/264 ,  Y10T428/265 ,  Y10T428/31507 ,  Y10T428/31544 ,  Y10T428/31551 ,  Y10T428/31663 ,  Y10T428/31786 ,  Y10T428/31935 ,  Y10T428/31938

    Abstract: PROBLEM TO BE SOLVED: To provide an effective method for depositing inert polymers and pharmaceutical or biological agents onto a substrate, where the collection process is efficient, the coating produced is conformal, substantially defect-free and uniform, the composition of the coating can be regulated and the morphology and/or secondary structure of the pharmaceutical or biological agents can be controlled.SOLUTION: The method for depositing a coating comprising a polymer and pharmaceutical agent on a substrate includes steps of: discharging at least one pharmaceutical agent in a therapeutically desirable morphology in dry powder form through a first orifice; discharging at least one polymer in dry powder form through a second orifice; depositing the polymer and/or pharmaceutical particles onto the substrate, wherein an electrical potential is maintained between the substrate and the pharmaceutical and/or polymer particles, thereby forming the coating; and sintering the coating under conditions that do not substantially modify the morphology of the pharmaceutical agent.

    Abstract translation: 要解决的问题：为了提供将惰性聚合物和药物或生物试剂沉积到基材上的有效方法，其中收集过程是有效的，所生产的涂层是共形的，基本上无缺陷的和均匀的， 可以调节涂层，并且可以控制药物或生物制剂的形态和/或二级结构。 解决方案：将包含聚合物和药剂的涂层沉积在基材上的方法包括以下步骤：通过第一孔排出至少一种治疗上需要的干粉形式的药剂; 通过第二孔排出至少一种干粉形式的聚合物; 将聚合物和/或药物颗粒沉积到基底上，其中在基底和药物和/或聚合物颗粒之间保持电位，从而形成涂层; 并在不显着改变药剂形态的条件下烧结涂层。 版权所有（C）2012，JPO＆INPIT

    Recubrimientos que contienen múltiples fármacos
    3.
    发明专利
    Recubrimientos que contienen múltiples fármacos 未知

    公开(公告)号：ES2540059T3

    公开(公告)日：2015-07-08

    申请号：ES07756094

    申请日：2007-04-26

    Applicant: MICELL TECHNOLOGIES INC

    Inventor： DEYOUNG JAMES ,  TAYLOR DOUG ,  MCCLAIN JIM ,  SMOKE CLINT ,  COLE MIKE

    IPC: B05D3/00 ,  A61L2/00 ,  A61L31/10 ,  A61L31/16

    Abstract: Un método de preparación de un stent coronario de elución de multifármacos que comprende: a. proporcionar una estructura de stent; b. depositar sobre dicha estructura de stent una primera capa que comprende un primer agente farmacéutico; c. depositar una segunda capa que comprende un segundo agente farmacéutico; donde dicho primero y segundo agentes farmacéuticos se seleccionan a partir de dos clases diferentes de agentes farmacéuticos, en donde los agentes farmacéuticos comprenden un fármaco macrólido inmunosupresor (limus), y en donde dicho fármaco macrólido inmunosupresor es al menos 50% cristalino.

    Polymer coatings containing drug powder of controlled morphology
    4.
    发明专利
    Polymer coatings containing drug powder of controlled morphology 未知

    公开(公告)号：AU2011256902A1

    公开(公告)日：2012-01-19

    申请号：AU2011256902

    申请日：2011-12-16

    Applicant: MICELL TECHNOLOGIES INC

    Inventor： TAYLOR DOUG ,  MCCLAIN JIM ,  SMOKE CLINT ,  COLE MIKE ,  DEYOUNG JAMES

    IPC: B05D3/00 ,  A61L2/00

    Abstract: C:\Documnsand Scuin\pSXD\LalSettins\Tcmp\DcsCorp\OCR\3AGEo IOCRdo-L2/620II A method for depositing a coating comprising a polymer and pharmaceutical agent on a substrate, comprising the following steps: discharging at least one pharmaceutical agent in a therapeutically desirable morphology in dry powder form through a first orifice; discharging at least one polymer in dry powder form through a second orifice; depositing the polymer and/or pharmaceutical particles onto said substrate; wherein an electrical potential is maintained between the substrate and the pharmaceutical and/or polymer particles, thereby forming said coating; and sintering said coating under conditions that do not substantially modify the morphology of said pharmaceutical agent. 4-j 4-04 = ) I -j co0 xo: uit a, 6s....MAas S u H r -

    COATINGS CONTAINING MULTIPLE DRUGS
    8.
    发明专利
    COATINGS CONTAINING MULTIPLE DRUGS 未知

    公开(公告)号：CA2650590A1

    公开(公告)日：2007-11-08

    申请号：CA2650590

    申请日：2007-04-26

    Applicant: MICELL TECHNOLOGIES INC

    Inventor： DEYOUNG JAMES ,  SMOKE CLINT ,  COLE MIKE ,  MCCLAIN JIM ,  TAYLOR DOUG

    IPC: A61F13/00 ,  A61F2/00 ,  A61F2/06

    Abstract: A method for depositing a coating comprising a polymer and at least two pharmaceutical agents on a substrate, comprising the following steps: providing a stent framework; depositing on said stent framework a first layer comprising a first pharmaceutical agent; depositing a second layer comprising a second pharmaceutical agent; Wherein said first and second pharmaceutical agents are selected from two different classes of pharmaceutical agents.

    Coatings containing multiple drugs
    9.
    发明专利
    Coatings containing multiple drugs 未知

    公开(公告)号：AU2007243268A1

    公开(公告)日：2007-11-08

    申请号：AU2007243268

    申请日：2007-04-26

    Applicant: MICELL TECHNOLOGIES INC

    Inventor： SMOKE CLINT ,  TAYLOR DOUG ,  COLE MIKE ,  MCCLAIN JIM ,  DEYOUNG JAMES

    IPC: A61K9/14

    Abstract: A method for depositing a coating comprising a polymer and at least two pharmaceutical agents on a substrate, comprising the following steps: providing a stent framework; depositing on said stent framework a first layer comprising a first pharmaceutical agent; depositing a second layer comprising a second pharmaceutical agent; Wherein said first and second pharmaceutical agents are selected from two different classes of pharmaceutical agents.

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