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公开(公告)号：AU2006204858A1
公开(公告)日：2006-07-20
申请号：AU2006204858
申请日：2006-01-13
Applicant: MICRONICS INC
Inventor： KOKORIS MARK , CLEMMENS JOHN , MORDUE STEPHEN , BREIDFORD WAYNE L , NABAVI MELUD , MCRUER ROBERT , GERDES JOHN , CAPADANNO JASON , LANCASTER CHRISTY A , BATTRELL C FREDERICK
Abstract: The present invention relates to microfluidic devices and methods for detecting rare cells. The disclosed microfluidic devices and methods integrate and automate sample preparation, cell labeling, cell sorting and enrichment, and DNA/RNA analysis of sorted cells.
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公开(公告)号：AU2007265628A1
公开(公告)日：2008-01-03
申请号：AU2007265628
申请日：2007-06-22
Applicant: MICRONICS INC
Inventor： CLEMMENS JOHN , CAPODANNO JASON , GERDES JOHN , MORDUE STEPHEN , HOEKSTRA DENISE MAXINE , WILLIFORD JOHN R , BATTRELL C FREDERICK
IPC: B01F13/00 , B01L3/00 , F04B43/02 , G01N33/543
Abstract: Microfluidic methods and devices for heterogeneous binding and agglutination assays are disclosed, with improvements relating to mixing and to reagent and sample manipulation in systems designed for safe handling of clinical test samples.
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公开(公告)号：ES2393758T3
公开(公告)日：2012-12-27
申请号：ES07753229
申请日：2007-03-15
Applicant: MICRONICS INC
Inventor： BATTRELL C FREDERICK , GERDES JOHN , WILLIFORD JOHN R , HOEKSTRA DENISE MAXINE , BREIDFORD WAYNE L , MORDUE STEPHEN , CLEMMENS JOHN , NABAVI MELUD , KOKORIS MARK
Abstract: Cartucho microfluídico integrado que comprende: a. un medio para extraer ácidos nucleicos de una muestra biológica; b. un medio para sintetizar amplicones; c. un medio para detectar amplicones; y, una cámara de aislamiento de residuos, en donde dicho medio para extraer ácidos nucleicos de una muestra biológica comprende un subcircuito fluídico para extraer ácidos nucleicos de una muestra biológica con fase sólida; dicho medio para sintetizar amplicones comprende un subcircuito fluídico para sintetizar amplicones sin un elemento de mezcla mecánica; y dicho medio para detectar amplicones comprende un subcircuito fluídico con una cámara de detección múltiplex y una ventana óptica en un miembro desechable único integrado, y los componentes fluídicos del miembro único integrado se controlan mediante una serie de elementos internos de control neumático que comprenden válvulas accionadas mediante diafragmas y cámaras de fuelle, en donde dicha serie de elementos internos de control neumático están provistos de un circuito de interconexión neumática para la conexión a un distribuidor controlable y externo de impulsión neumática.
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公开(公告)号：WO2006076567A3
公开(公告)日：2006-09-21
申请号：PCT/US2006001211
申请日：2006-01-13
Applicant: MICRONICS INC , LANCASTER CHRISTY A , BATTRELL C FREDERICK , CAPADANNO JASON , GERDES JOHN , KOKORIS MARK , NABAVI MELUD , MORDUE STEPHEN , MCRUER ROBERT , CLEMMENS JOHN , BREIDFORD WAYNE L
Inventor： LANCASTER CHRISTY A , BATTRELL C FREDERICK , CAPADANNO JASON , GERDES JOHN , KOKORIS MARK , NABAVI MELUD , MORDUE STEPHEN , MCRUER ROBERT , CLEMMENS JOHN , BREIDFORD WAYNE L
CPC classification number: F16K99/0001 , B01L3/50273 , B01L3/502738 , B01L3/502753 , B01L3/502761 , B01L3/502776 , B01L7/52 , B01L2200/0636 , B01L2200/0647 , B01L2200/10 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2400/0487 , B01L2400/0633 , F16K99/0007 , F16K99/0034 , F16K99/0046 , F16K2099/008 , F16K2099/0084 , G01N1/34 , G01N15/1459 , G01N15/1463 , G01N15/1484 , G01N2015/0069 , G01N2015/1409 , G01N2015/1486 , G01N2015/149
Abstract: The present invention relates to microfluidic devices and methods for detecting rare cells. The disclosed microfluidic devices and methods integrate and automate sample preparation, cell labeling, cell sorting and enrichment, and DNA/RNA analysis of sorted cells.
Abstract translation: 本发明涉及用于检测稀有细胞的微流体装置和方法。 所公开的微流体装置和方法整合和自动化分选细胞的样品制备，细胞标记，细胞分选和富集以及DNA / RNA分析。
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公开(公告)号：WO2007106579A2
公开(公告)日：2007-09-20
申请号：PCT/US2007006584
申请日：2007-03-15
Applicant: MICRONICS INC , BATTRELL C FREDERICK , GERDES JOHN , WILLIFORD JOHN R , HOEKSTRA DENISE MAXINE , BREIDFORD WAYNE L , MORDUE STEPHEN , CLEMMENS JOHN , NABAVI MELUD , KOKORIS MARK
Inventor： BATTRELL C FREDERICK , GERDES JOHN , WILLIFORD JOHN R , HOEKSTRA DENISE MAXINE , BREIDFORD WAYNE L , MORDUE STEPHEN , CLEMMENS JOHN , NABAVI MELUD , KOKORIS MARK
CPC classification number: C12Q1/6834 , B01F11/0071 , B01F13/0059 , B01L3/5027 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L7/52 , B01L2200/082 , B01L2200/10 , B01L2200/16 , B01L2300/0663 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2400/0481 , B01L2400/0638 , B01L2400/0655 , C12Q1/686 , C12Q2563/131 , C12Q2525/197 , C12Q2563/143 , C12Q2565/629
Abstract: Integrated microfluidic cartridges for nucleic acid extraction, amplification, and detection from clinical samples are disclosed. The devices are single-entry, sanitary, and disposable. The devices enable simplex or multiplex nucleic acid target detection, as for example: assay panels for multiple infectious agents, or assay panels for cancerous cell types. Methods for use of microfluidic cartridges in a fully automated, pneumatically controlled apparatus are also disclosed.
Abstract translation: 公开了用于从临床样品进行核酸提取，扩增和检测的集成微流控柱。 这些设备是单进入，卫生和一次性的。 该装置能够进行单核或多重核酸靶标检测，例如：用于多种感染剂的测定板，或用于癌细胞类型的测定板。 还公开了在全自动气动控制装置中使用微流控盒的方法。
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Patent Agency Ranking
公开(公告)号：HK1126824A1
公开(公告)日：2009-09-11
申请号：HK09105845
申请日：2009-06-30
Applicant: MICRONICS INC
Inventor： BATTRELL C FREDERICK , GERDES JOHN , WILLIFORD JOHN R , HOEKSTRA DENISE MAXINE , BREIDFORD WAYNE L , MORDUE STEPHEN , CLEMMENS JOHN , NABAVI MELUD , KOKORIS MARK
IPC: B01L20060101 , C12Q20060101
Abstract: Integrated microfluidic cartridges for nucleic acid extraction, amplification, and detection from clinical samples are disclosed. The devices are single-entry, sanitary, and disposable. The devices enable simplex or multiplex nucleic acid target detection, as for example: assay panels for multiple infectious agents, or assay panels for cancerous cell types. Methods for use of microfluidic cartridges in a fully automated, pneumatically controlled apparatus are also disclosed.
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公开(公告)号：AU2007225038A1
公开(公告)日：2007-09-20
申请号：AU2007225038
申请日：2007-03-15
Applicant: MICRONICS INC
Inventor： BATTRELL C FREDERICK , KOKORIS MARK , WILLIFORD JOHN R , NABAVI MELUD , GERDES JOHN , MORDUE STEPHEN , CLEMMENS JOHN , BREIDFORD WAYNE L , HOEKSTRA DENISE MAXINE
Abstract: Integrated microfluidic cartridges for nucleic acid extraction, amplification, and detection from clinical samples are disclosed. The devices are single-entry, sanitary, and disposable. The devices enable simplex or multiplex nucleic acid target detection, as for example: assay panels for multiple infectious agents, or assay panels for cancerous cell types. Methods for use of microfluidic cartridges in a fully automated, pneumatically controlled apparatus are also disclosed.
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公开(公告)号：WO2008147382A1
公开(公告)日：2008-12-04
申请号：PCT/US2007020810
申请日：2007-09-27
Applicant: MICRONICS INC , BATTRELL C FREDERICK , GERDES JOHN , BREIDFORD WAYNE L , CAPODANNO JASON , MORDUE STEPHEN , CLEMMENS JOHN , HOEKSTRA DENISE MAXINE , LANCASTER CHRISTY A , WILLIFORD JOHN R , MALONEY PATRICK , HAAB JOAN
Inventor： BATTRELL C FREDERICK , GERDES JOHN , BREIDFORD WAYNE L , CAPODANNO JASON , MORDUE STEPHEN , CLEMMENS JOHN , HOEKSTRA DENISE MAXINE , LANCASTER CHRISTY A , WILLIFORD JOHN R , MALONEY PATRICK , HAAB JOAN
CPC classification number: G01N33/5302 , B01F11/0071 , B01F13/0059 , B01L3/502715 , B01L7/52 , B01L2300/0636 , B01L2300/069 , B01L2300/0816 , B01L2300/0864 , B01L2400/0481 , B01L2400/0487 , B01L2400/0638
Abstract: Combinations of microfluidic diagnostic testing modules (71, 72) for simultaneous evaluations of serological and molecular biological targets are provided, and include panel testing for both antibodies (or antigens) and nucleic acid targets in one single-use device. These improvements are directed to evaluating the overall progress and activity of a pathogenic process in real time, at the point of care, not merely the presence or absence of a particular diagnostic marker, which can often be incomplete or misleading.
Abstract translation: 提供了用于同时评估血清学和分子生物学靶标的微流体诊断测试模块（71,72）的组合，并且包括在一次性使用的装置中对抗体（或抗原）和核酸靶标的面板测试。 这些改进旨在评估致病过程的总体进展和活动，而不仅仅是特定诊断标记的存在或不存在，这通常是不完整的或具有误导性的。
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公开(公告)号：WO2006130299A3
公开(公告)日：2007-03-15
申请号：PCT/US2006017064
申请日：2006-05-03
Applicant: MICRONICS INC , GERDES JOHN , BATTRELL C FREDERICK , HOEKSTRA DENISE MAXINE , CLEMMENS JOHN , MORDUE STEPHEN
Inventor： GERDES JOHN , BATTRELL C FREDERICK , HOEKSTRA DENISE MAXINE , CLEMMENS JOHN , MORDUE STEPHEN
IPC: G01N33/543
CPC classification number: G01N33/54386 , G01N33/54366
Abstract: The present invention relates to microfluidic laminar flow detection strip devices and methods for using and making the same. The disclosed devices comprise: a first inlet; a microfluidic channel having a first end and a second end, wherein the first end is fluidly connected to the first inlet; a bellows pump fluidly connected to the second end of the microfluidic channel, wherein the bellows pump comprises an absorbent material disposed therein; a dried reagent zone within the microfluidic channel, wherein the dried reagent zone comprises a first reagent and a control reagent printed thereon, the first reagent comprising a first detection antibody conjugated to a dyed substrate bead or functionalized for colorimetric development, and the control reagent comprising a control detection antibody conjugated to a dyed substrate bead or functionalized for colorimetric development; a first bound antibody zone within the microfluidic channel, wherein the first bound antibody zone comprises a first bound antibody printed thereon; and a control zone within the microfluidic channel, wherein the control zone comprises a control bound antibody printed thereon.
Abstract translation: 本发明涉及微流体层流检测带装置及其制造方法。 所公开的装置包括：第一入口; 微流体通道，其具有第一端和第二端，其中所述第一端流体连接到所述第一入口; 流体连接到微流体通道的第二端的波纹管泵，其中波纹管泵包括设置在其中的吸收材料; 微流体通道内的干燥试剂区，其中干燥的试剂区包含印刷在其上的第一试剂和对照试剂，第一试剂包含与染色的底物珠缀合或用于比色显影官能化的第一检测抗体，并且对照试剂包含 与染色的基质珠缀合的对照检测抗体或用于比色显影功能化的对照检测抗体; 所述微流体通道内的第一结合抗体区，其中所述第一结合抗体区包含印刷在其上的第一结合抗体; 和微流体通道内的对照区，其中控制区包含印刷在其上的对照结合抗体。
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公开(公告)号：WO2013106458A3
公开(公告)日：2013-11-07
申请号：PCT/US2013020869
申请日：2013-01-09
Applicant: MICRONICS INC
Inventor： BATTRELL C FREDERICK , CLEMMENS JOHN , SPRAGUE ISAAC
CPC classification number: B01F11/0071 , B01L3/50273 , B01L2200/04 , B01L2200/0684 , B01L2200/0689 , B01L2200/141 , B01L2200/16 , B01L2300/021 , B01L2300/043 , B01L2300/0609 , B01L2300/0636 , B01L2300/0822 , B01L2300/0867 , B01L2300/0877 , B01L2300/0887 , B01L2300/123 , B01L2300/14 , B01L2400/043 , B01L2400/0439 , B01L2400/0487 , B01L2400/049
Abstract: A compact device for operatively coupling a solid planar substrate, for example a glass slide, to a microfluidic circuit and performing a reaction or reactions on organic matter bound to the face of the planar substrate. Typical reactions include binding, staining and/or labeling reactions. In use, a sealed reaction chamber is formed, the chamber enclosing the organic matter and at least a part of the solid substrate. Headspace in the sealed chamber between the solid substrate is generally of microfluidic dimensions, and diaphragm pump members are used to inject, exchange and/or mix the fluids in the chamber.
Abstract translation: 用于将固体平面基底（例如载玻片）可操作地耦合到微流体回路并且对结合到平面基底的面上的有机物质执行一个或多个反应的紧凑装置。 典型的反应包括结合，染色和/或标记反应。 在使用中，形成密封的反应室，该室封闭有机物质和至少一部分固体基质。 固体基质之间的密封室中的顶空通常具有微流体尺寸，隔膜泵构件用于注入，交换和/或混合室内的流体。
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