公开(公告)号：CA2786569C

公开(公告)日：2019-04-09

申请号：CA2786569

申请日：2011-01-28

Applicant: MICRONICS INC

Inventor： BATTRELL C FREDERICK ,  SPRAGUE ISAAC ,  BRAGD MATTHEW SCOTT ,  CAPODANNO JASON

IPC: B01L3/00

Abstract: A microfluidic cartridge and methods for performing a diagnostic, molecular or biochemical assay thereon, where all dried and/or liquid reagents necessary for the assay are contained in the cartridge and the assay requires only the addition of sample. Pneumohydraulic features, chamber and diaphragm technologies are introduced for overcoming the problems of bubble interference and reagent washout during operation of a microfluidic cartridge. The cartridges are inserted into a host instrument for performance of an assay and the cartridge is supplied as a consumable.

公开(公告)号：WO2011094577A3

公开(公告)日：2011-11-03

申请号：PCT/US2011022973

申请日：2011-01-28

Applicant: MICRONICS INC ,  BATTRELL C FREDERICK ,  SPRAGUE ISAAC ,  BRAGD MATTHEW SCOTT ,  CAPODANNO JASON

Inventor： BATTRELL C FREDERICK ,  SPRAGUE ISAAC ,  BRAGD MATTHEW SCOTT ,  CAPODANNO JASON

IPC: B01L3/00

CPC classification number: B01L3/50273 ,  B01L3/52 ,  B01L7/52 ,  B01L7/525 ,  B01L2200/0684 ,  B01L2200/14 ,  B01L2200/16 ,  B01L2300/044 ,  B01L2300/0672 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/087 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2400/0481 ,  B01L2400/0487 ,  B01L2400/0638 ,  G01N21/03 ,  G01N21/0332 ,  G01N21/17 ,  G01N21/64 ,  G01N21/6428 ,  Y10T137/0318

Abstract: A microfluidic cartridge and methods for performing a diagnostic, molecular or biochemical assay thereon, where all dried and/or liquid reagents necessary for the assay are contained in the cartridge and the assay requires only the addition of sample. Pneumohydraulic features, chamber and diaphragm technologies are introduced for overcoming the problems of bubble interference and reagent washout during operation of a microfluidic cartridge. The cartridges are inserted into a host instrument for performance of an assay and the cartridge is supplied as a consumable.

Abstract translation: 微流控筒和用于在其上进行诊断，分子或生物化学测定的方法，其中所述测定所需的所有干燥和/或液体试剂都包含在所述盒中，并且所述测定仅需添加样品。 引入气动液压特性，腔室和隔膜技术，以克服在微流控筒操作期间气泡干扰和试剂冲洗的问题。 将盒式磁盘插入到主仪器中以进行测定，并且将盒作为消耗品提供。

公开(公告)号：CA2786569A1

公开(公告)日：2011-08-04

申请号：CA2786569

申请日：2011-01-28

Applicant: MICRONICS INC

Inventor： BATTRELL C FREDERICK ,  SPRAGUE ISAAC ,  BRAGD MATTHEW SCOTT ,  CAPODANNO JASON

IPC: B01L3/00

Abstract: A microfluidic cartridge and methods for performing a diagnostic, molecular or biochemical assay thereon, where all dried and/or liquid reagents necessary for the assay are contained in the cartridge and the assay requires only the addition of sample. Pneumohydraulic features, chamber and diaphragm technologies are introduced for overcoming the problems of bubble interference and reagent washout during operation of a microfluidic cartridge. The cartridges are inserted into a host instrument for performance of an assay and the cartridge is supplied as a consumable.

公开(公告)号：AU2007265628A1

公开(公告)日：2008-01-03

申请号：AU2007265628

申请日：2007-06-22

Applicant: MICRONICS INC

Inventor： CLEMMENS JOHN ,  CAPODANNO JASON ,  GERDES JOHN ,  MORDUE STEPHEN ,  HOEKSTRA DENISE MAXINE ,  WILLIFORD JOHN R ,  BATTRELL C FREDERICK

IPC: B01F13/00 ,  B01L3/00 ,  F04B43/02 ,  G01N33/543

Abstract: Microfluidic methods and devices for heterogeneous binding and agglutination assays are disclosed, with improvements relating to mixing and to reagent and sample manipulation in systems designed for safe handling of clinical test samples.

公开(公告)号：WO2008147382A1

公开(公告)日：2008-12-04

申请号：PCT/US2007020810

申请日：2007-09-27

Applicant: MICRONICS INC ,  BATTRELL C FREDERICK ,  GERDES JOHN ,  BREIDFORD WAYNE L ,  CAPODANNO JASON ,  MORDUE STEPHEN ,  CLEMMENS JOHN ,  HOEKSTRA DENISE MAXINE ,  LANCASTER CHRISTY A ,  WILLIFORD JOHN R ,  MALONEY PATRICK ,  HAAB JOAN

Inventor： BATTRELL C FREDERICK ,  GERDES JOHN ,  BREIDFORD WAYNE L ,  CAPODANNO JASON ,  MORDUE STEPHEN ,  CLEMMENS JOHN ,  HOEKSTRA DENISE MAXINE ,  LANCASTER CHRISTY A ,  WILLIFORD JOHN R ,  MALONEY PATRICK ,  HAAB JOAN

IPC: B01L3/00 ,  B01F13/00 ,  G01N33/00

CPC classification number: G01N33/5302 ,  B01F11/0071 ,  B01F13/0059 ,  B01L3/502715 ,  B01L7/52 ,  B01L2300/0636 ,  B01L2300/069 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0481 ,  B01L2400/0487 ,  B01L2400/0638

Abstract: Combinations of microfluidic diagnostic testing modules (71, 72) for simultaneous evaluations of serological and molecular biological targets are provided, and include panel testing for both antibodies (or antigens) and nucleic acid targets in one single-use device. These improvements are directed to evaluating the overall progress and activity of a pathogenic process in real time, at the point of care, not merely the presence or absence of a particular diagnostic marker, which can often be incomplete or misleading.

Abstract translation: 提供了用于同时评估血清学和分子生物学靶标的微流体诊断测试模块（71,72）的组合，并且包括在一次性使用的装置中对抗体（或抗原）和核酸靶标的面板测试。 这些改进旨在评估致病过程的总体进展和活动，而不仅仅是特定诊断标记的存在或不存在，这通常是不完整的或具有误导性的。

公开(公告)号：WO2008002462A3

公开(公告)日：2008-09-18

申请号：PCT/US2007014522

申请日：2007-06-22

Applicant: MICRONICS INC ,  BATTRELL C FREDERICK ,  GERDES JOHN ,  CLEMMENS JOHN ,  MORDUE STEPHEN ,  CAPODANNO JASON ,  HOEKSTRA DENISE MAXINE ,  WILLIFORD JOHN R

Inventor： BATTRELL C FREDERICK ,  GERDES JOHN ,  CLEMMENS JOHN ,  MORDUE STEPHEN ,  CAPODANNO JASON ,  HOEKSTRA DENISE MAXINE ,  WILLIFORD JOHN R

IPC: G01N33/543 ,  B01F13/00 ,  B01L3/00 ,  F04B43/02

CPC classification number: B01L3/50273 ,  B01F11/0071 ,  B01F11/0074 ,  B01F13/0059 ,  B01L3/502738 ,  B01L2300/0636 ,  B01L2300/0681 ,  B01L2300/069 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2400/0481 ,  B01L2400/0638 ,  B01L2400/086 ,  F04B43/043 ,  F04B43/06 ,  G01N33/54366 ,  Y10T436/255

Abstract: Microf luidic methods and devices for heterogeneous binding and agglutination assays are disclosed, with improvements relating to mixing and to reagent and sample manipulation in systems designed for safe handling of clinical test samples. In operation, sample port (2), via microchannel (3), is used to introduce test sample into the reservoir of left bellows pump (4). Similarly, "waste" port (9), via microchannel (10), is used to introduce and discard reagent solutions into and out of the fluid chambers of right bellows pump (8). Ports (2) and (9) extend through the device cover (14) and are continuous with the fluid chambers of bellows pumps (4) and (8). Microchannels (3) and (10) may be modified to include valves (not shown). Active reciprocal flow of fluid between the right and left reservoirs is conducted through assay chamber (5) via focusing apertures (6) and (7).

Abstract translation: 公开了用于非均相结合和凝集测定的微流化方法和装置，其中涉及用于安全处理临床测试样品的系统中的混合和试剂和样品操作的改进。 在操作中，采样孔（2）通过微通道（3）用于将测试样品引入左波纹管泵（4）的储液器中。 类似地，通过微通道（10）的“废物”端口（9）用于将试剂溶液引入和丢弃进入右波纹管泵（8）的流体室。 端口（2）和（9）延伸穿过设备盖（14）并与波纹管泵（4）和（8）的流体室连续。 微通道（3）和（10）可以被修改为包括阀（未示出）。 通过聚焦孔（6）和（7）通过测定室（5）进行左右储存器之间的主动的流体流动。