公开(公告)号：JPH08208587A

公开(公告)日：1996-08-13

申请号：JP1617895

申请日：1995-02-02

Applicant: MITSUI PETROCHEMICAL IND

Inventor： NAGAI SUNAO ,  ISHITOKU TAKESHI ,  KIHARA NORIAKI

IPC: C07C259/06

Abstract: PURPOSE: To easily and safely produce the subject compounds useful as synthetic intermediates for pharmaceuticals and agrochemicals in high purities and efficiencries by distilling the compounds together with water and separating them from the mixture as an azeotropic mixture with water. CONSTITUTION: A mixture containing (A) an N,O-dialkylhydroxamic acid of formula I (R is H or a lower alkyl; R and R are each a lower alkyl) (preferably N,O-dimethylacetohydroxamic acid) or containing the component A and (B) an O-alkylhydroxamic acid of formula II (preferably O- methylacetohydroxamic acid) is distilled together with water and the component A is separated from the mixture as an azeotropic mixture with water to obtain the component A and/or the component B in purified state. The distillation is preferably carried out under a pressure of 10-250mmHg at 30-80 deg.C using 11-15 pts. of water based on 1 pt. of the component A.

公开(公告)号：JPH06234607A

公开(公告)日：1994-08-23

申请号：JP2456493

申请日：1993-02-12

Applicant: MITSUI PETROCHEMICAL IND

Inventor： TAKEMATSU TETSUO ,  ISHIDA TATSUKAZU ,  HAMADA NAOSHI ,  ISHITOKU TAKESHI ,  MATSUYOSHI TORU ,  NAGAI SUNAO

IPC: A01N37/10 ,  A01N43/66 ,  A01N47/30

Abstract: PURPOSE:To obtain a herbicidal composition capable of exhibiting complete control effect on weeds difficult to control by only single agent and simultaneously exhibiting synergistic herbicidal effects even at a low dose at which weeds can not be completely controlled as far as single agent is used and having high safety to the crops. CONSTITUTION:This herbicidal composition contains (A) a carbon compound of formula I [Ar us formula II (R to R are H, lower alkyl, lower alkoxyl; R is H, lower alkyl, lower alkoxyl or OH; R and R or R and R together form an alkylene chain which forms a 4-6 membered ring with binding C; R and R are connected to form ethylene dioxyl; R and R are connected to form dichloromethylene); A is CX (X is H, Cl, NO2 or CF3); B is H, methyl or methoxy], (B) atrazine of formula III and (C) 2,4-D of formula IV or its salt or ester. Furthermore, the composition is preferably blended with a cationic surfactant or an anionic surfactant and a nitrogen fertilizer (e.g. urea ammonium nitrate).

公开(公告)号：JPH04193803A

公开(公告)日：1992-07-13

申请号：JP31791290

申请日：1990-11-26

Applicant: MITSUI PETROCHEMICAL IND

Inventor： TAKEMATSU TETSUO ,  ISHITOKU TAKESHI ,  HAMADA NAOSHI ,  NAGAI SUNAO ,  ISHIDA TATSUKAZU

IPC: C07D317/46 ,  A01N25/32 ,  A01N47/30 ,  A01N47/36 ,  C07C211/03 ,  C07C211/09 ,  C07C211/35 ,  C07D307/80 ,  C07D311/74 ,  C07D405/12

Abstract: PURPOSE:To obtain a herbicide composition enhanced in safety to crops without lowering herbicidal effect, containing aurea compound having strong herbicidal effect or by combining the urea compound and other herbicides with a specific amine compound. CONSTITUTION:The objective composition containing (A) a urea compound expressed by formula I [Ar is formula II to formula VI (R to R and R to R are H, alkyl or alkoxy), etc.; A is N or CX (X is H, Cl, NO2 or CF3); B is H, methyl or methoxy] or a composition consisting of the above-mentioned urea compound and other herbicides and (B) a compound expressed by formula VII [R is alkyl, cycloalkylakyl, alicyclic hydrocarbon group, etc.; R is H, alkyl, alkenyl, D-Y (D is 2-4C alkylene; Y is OH or NH2); R is H, alkyl, hydroxyalkyl or aminoalkyl] as active ingredients.

公开(公告)号：JPH0363270A

公开(公告)日：1991-03-19

申请号：JP19948489

申请日：1989-08-02

Applicant: MITSUI PETROCHEMICAL IND

Inventor： TAN HIROAKI ,  NAGAI SUNAO ,  FUKUOKA ONORI ,  KIHARA NORIAKI

IPC: C07D311/60

Abstract: PURPOSE:To easily obtain the subject compound useful as a production intermediate for agricultural chemicals with a single reaction step under mild reactional condition by reacting two specific kinds of compounds in the presence of an acid catalyst. CONSTITUTION:The objective polyalkyl-2-alkoxy 7-hydroxycoumarone of formula II can be produced by reacting a compound of formula I (R is lower primary alkyl; R is H or lower primary alkyl) with a compound of formula R OH (R is lower alkyl) in the presence of an acid catalyst. The reaction can be performed at

公开(公告)号：JPH0951799A

公开(公告)日：1997-02-25

申请号：JP20876395

申请日：1995-08-16

Applicant: MITSUI PETROCHEMICAL IND

Inventor： NAGAI SUNAO ,  DOI YASUSHI ,  MATSUYOSHI TORU ,  TAN HIROAKI ,  ISHITOKU TAKESHI

IPC: C12P41/00

Abstract: PROBLEM TO BE SOLVED: To obtain the subject compound useful as an agent for circulatory system such as hypotensor and vasodilator in high optical purity on an industrial scale at a low cost by reacting a specific asymmetric dihydropyridine compound with an alcohol in the presence of an enzyme. SOLUTION: The objective optically active 1,4-dihydropyridine derivative useful as an agent for circulatory system such as hypotensor and vasodilator and expressed by formula II is produced in high optical purity on an industrial scale at a low cost by reacting an asymmetric dihydropyridine compound expressed by formula I (R is H or methyl; R is 2-cyanoethyl, 2-acetoxyethyl, 2-hydroxyethyl, an alkoxycarbonylmethyl or carbamoylmethyl) [e.g. 2-cyanoethyl- methyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarbox ylate] with an alcohol of the formula X(CH2 )n OH (X is a halogen or OH; (n) is 1-10) (e.g. 4-chlorobutanol) in the presence of an enzyme.

公开(公告)号：JPH0912524A

公开(公告)日：1997-01-14

申请号：JP15936095

申请日：1995-06-26

Applicant: MITSUI PETROCHEMICAL IND

Inventor： NAGAI SUNAO ,  OYOSHI HAJIME ,  TSURU KAZUTAKA ,  ISHITOKU TAKESHI

IPC: C07C239/20 ,  C07B61/00

Abstract: PURPOSE: To industrially produce an alkoxyamine in high yield and in high efficiency. CONSTITUTION: A hydroxamic acid of the formula R CONHOH (R is hydrogen, a 1-4C alkyl group or phenyl group) is reacted with a dialkyl sulfate of the formula (R O)2 SO2 (R is a 1-4C alkyl group) in the presence of a basic compound to produce an O-substituted hydroxamic acid of the formula R C0NHOR . A monoalkyl sulfate of the formula R OSO3 .1/nM (M is an alkali metal or an alkaline earth metal; n is the valence of M) as a decomposition product of a dialkyl sulfate is decomposed. The O-substituted hydroxamic acid is hydrolyzed in the presence of a basic compound to produce the objective alkoxyamine of the formula H2 N0R .

公开(公告)号：JPH03161406A

公开(公告)日：1991-07-11

申请号：JP29752189

申请日：1989-11-17

Applicant: MITSUI PETROCHEMICAL IND

Inventor： NAGAI SUNAO ,  HAMADA NAOSHI ,  TASHIRO KOJI ,  MATSUYOSHI TORU ,  ISHIDA TATSUKAZU

IPC: A01N47/30 ,  A01N47/36

Abstract: PURPOSE:To control injurious weeds without chemically injuring crops by diluting a composition containing a specific compound as an active ingredient with water when sprayed, adding a composition selected from a composition comprising an oil and a surfactant, a composition comprising a surfactant, etc., to the diluted solution and subsequently spraying the prepared aqueous dispersion on the crops. CONSTITUTION:A herbicide composition containing a compound of formula I [A is N or a group of formula II (X is Cl, nitro, trifluoromethyl); B is H, methyl or methoxy; R -R are the same or different H, lower alkyl, lower alkoxy or hydroxy] is diluted with water when sprayed, and the prepared diluted solution is mixed with a composition comprising an oil (e.g. soybean oil) and a surfactant (e.g. a fatty acid sorbitan ester), a composition comprising a surfactant, a composition comprising a solvent such as methanol, or a combination of the compositions to to prepare an aqueous dispersion or aqueous emulsion, which is applied to injurious weeds.

公开(公告)号：JPH01319462A

公开(公告)日：1989-12-25

申请号：JP15010288

申请日：1988-06-20

Applicant: MITSUI PETROCHEMICAL IND

Inventor： ISHIDA TATSUKAZU ,  NAGAI SUNAO ,  TSURU KAZUTAKA ,  HASHIMOTO ISAO

IPC: C07D213/64

Abstract: PURPOSE:To obtain the subject material useful as a herbicide or an intermediate thereof by one stage reaction inexpensively by reacting a substituted chloropyridine with a hydroxyurea in the presence of a base. CONSTITUTION:A compound shown by formula I (X and Y are H, Cl or CF3) is reacted with a compound shown by formula II (R1 and R2 are lower alkyl, lower cycloalkyl or R1 and R2 together with N form 4-8-membered ring) in the presence of 1-5mol based on 1mol compound shown by formula I of a base (e.g., hydroxide or alkoxide of alkali metal) at -30-30 deg.C for 0.5-10 hours while stirring to give a compound shown by formula III. The reaction can be optionally carried out by using a solvent such as alcohol, ether or DMF.

公开(公告)号：JPH05221814A

公开(公告)日：1993-08-31

申请号：JP18839592

申请日：1992-07-15

Applicant: MITSUI PETROCHEMICAL IND

Inventor： TAKEMATSU TETSUO ,  HAMADA NAOSHI ,  MATSUYOSHI TORU ,  KIHARA NORIAKI ,  KURAMOCHI HITOSHI ,  NAGAI SUNAO

IPC: A01N47/28

Abstract: PURPOSE:To obtain a herbicide composition by combining an N-arylurea derivative as a herbicide with a 2-(halogenated phenoxy)propionic acid as a herbicide or the propionic acid with sencor and isoproturon, etc. CONSTITUTION:A compound of formula I [Ar is group II (R to R are H, alkyl, etc.; R is H, alkyl, OH, etc., R and R , R and R , R and R or R and R form rung); A is C(X) (X is H, Cl, CF3, etc.); B is H, methyl, etc.] (e.g. compound wherein R to R are H, A is CH and B is CH3) is combined with a compound of formula III (n is 1 or 2; Y is H) to give a herbicide composition. Or the compound of formula I is combined with a compound of formula III or sencor of formula IV and further with a compound selected from isoproturon of formula V, chlorotoluron of formula VI and IROKISAN of formula VII to give a herbicide composition. The herbicide shows synergistically herbicidal effects with such a small amount of agent as not to completely control by a single agent and has safety to crops such as wheat.

公开(公告)号：JPH0226814A

公开(公告)日：1990-01-29

申请号：JP17487588

申请日：1988-07-15

Applicant: MITSUI PETROCHEMICAL IND

Inventor： NAGAI SUNAO ,  ISHIDA TATSUKAZU ,  TSUBOI AKIRA ,  HASHIMOTO ISAO

IPC: C01B21/093

Abstract: PURPOSE:To obtain high purity hydroxylamine-o-sulfonic acid only by washing in a high yield by washing crude hydroxylamine-o-sulfonic acid with specified ethers. CONSTITUTION:Crude hydroxylamine-o-sulfonic acid obtd. by sulfonating a mineral acid salt of hydroxylamine is washed with ethers selected among di-n- butyl ether, diisobutyl ether and di-n-propyl ether. Since the used ethers can be very easily recovered by washing with water and distillation in a high yield of about >=95%, the ethers are very economical.