公开(公告)号：ES2197681T3

公开(公告)日：2004-01-01

申请号：ES99951826

申请日：1999-10-07

Applicant: MOTOROLA INC

Inventor： BURDON JEREMY W ,  HUANG RONG-FONG ,  WILCOX DAVID ,  NACLERIO NICHOLAS J ,  BRISCOE CYNTHIA ANN GORSUCH ,  GRODZINSKI PIOTR

IPC: G01N35/08 ,  B01J19/00 ,  B01J19/24 ,  B01J35/02 ,  B01L3/00 ,  B01L7/00 ,  B28B11/00 ,  B32B18/00 ,  B81B1/00 ,  C12M1/00 ,  C40B60/14 ,  F04B19/00 ,  F28D9/00 ,  F28F13/00 ,  G01N30/02 ,  G01N30/52 ,  G01N30/60 ,  G01N35/00 ,  G01N37/00 ,  H05K1/02 ,  H05K1/03 ,  H05K3/46

Abstract: A multilayered microfluidic DNA analysis system includes a cell lysis chamber, a DNA separation chamber, a DNA amplification chamber, and a DNA detection system. The multilayered microfluidic DNA analysis system is provided as a substantially monolithic structure formed from a plurality of green-sheet layers sintered together. The substantially monolithic structure has defined therein a means for heating the DNA amplification chamber and a means for cooling the DNA amplification chamber. The means for heating and means for cooling operate to cycle the temperature of the DNA amplification chamber as required for performing a DNA amplification process, such as PCR.

公开(公告)号：AU2571502A

公开(公告)日：2002-06-18

申请号：AU2571502

申请日：2001-11-19

Applicant: MOTOROLA INC

Inventor： BURDON JEREMY W ,  MIESEM ROSS A ,  KORIPELLA CHOWDARY RAMESH

IPC: H01L21/48 ,  H05K1/03 ,  H05K3/40 ,  H01L23/498

Abstract: A method for forming an electrically isolated via in a multilayer ceramic package and an electrical connection formed within the via are disclosed. The method includes punching a first via in a first layer, filling the first via with a cross-linkable paste, curing the paste to form an electrical insulator precursor and forming the via in the insulator precursor. The electrical connection formed includes an insulator made from a cross-linked paste supported by a substrate of a multilayer ceramic package and a conductive connection supported by the insulator.

公开(公告)号：AU2082701A

公开(公告)日：2001-06-18

申请号：AU2082701

申请日：2000-12-11

Applicant: MOTOROLA INC

Inventor： BRISCOE CYNTHIA G ,  BURDON JEREMY W ,  CHAN TONY ,  FOLEY BARBARA ,  GRODZINSKI PIOTR ,  HAWKINS GEORGE ,  HUANG RONG-FONG ,  KAHN PETER ,  MARRERO ROBERT ,  MCGARRY MARK W ,  TUGGLE TODD ,  YU HUINAN

IPC: G01N31/20 ,  B01J19/00 ,  B01L3/00 ,  B01L7/00 ,  C12M1/00 ,  C12N15/09 ,  C40B40/02 ,  C40B50/06 ,  C40B60/14 ,  G01N30/02 ,  G01N30/52 ,  G01N30/60 ,  G01N30/66 ,  G01N35/00 ,  G01N37/00

公开(公告)号：AU6418499A

公开(公告)日：2000-05-01

申请号：AU6418499

申请日：1999-10-07

Applicant: MOTOROLA INC

Inventor： BURDON JEREMY W ,  HUANG RONG-FONG ,  WILCOX DAVID ,  NACLERIO NICHOLAS J ,  BRISCOE CYNTHIA ANN GORSUCH ,  GRODZINSKI PIOTR ,  YU HUINAN ,  MARRERO ROBERT ,  GALLAGHER SEAN ROSS ,  CHAN YUK-TONG ,  FOLEY BARBARA MCNEIL ,  DAI XUNHU

IPC: G01N35/08 ,  B01J19/00 ,  B01J19/24 ,  B01J35/02 ,  B01L3/00 ,  B01L7/00 ,  B28B11/00 ,  B32B18/00 ,  B81B1/00 ,  C12M1/00 ,  C40B60/14 ,  F04B19/00 ,  F28D9/00 ,  F28F13/00 ,  G01N30/02 ,  G01N30/52 ,  G01N30/60 ,  G01N35/00 ,  G01N37/00 ,  H05K1/02 ,  H05K1/03 ,  H05K3/46

Abstract: A multilayered microfluidic DNA analysis system includes a cell lysis chamber, a DNA separation chamber, a DNA amplification chamber, and a DNA detection system. The multilayered microfluidic DNA analysis system is provided as a substantially monolithic structure formed from a plurality of green-sheet layers sintered together. The substantially monolithic structure has defined therein a means for heating the DNA amplification chamber and a means for cooling the DNA amplification chamber. The means for heating and means for cooling operate to cycle the temperature of the DNA amplification chamber as required for performing a DNA amplification process, such as PCR.

公开(公告)号：AT236719T

公开(公告)日：2003-04-15

申请号：AT99951826

申请日：1999-10-07

Applicant: MOTOROLA INC

Inventor： BURDON JEREMY W ,  HUANG RONG-FONG ,  WILCOX DAVID ,  NACLERIO NICHOLAS J ,  BRISCOE CYNTHIA ANN GORSUCH ,  GRODZINSKI PIOTR ,  YU HUINAN ,  MARRERO ROBERT ,  GALLAGHER SEAN ROSS ,  CHAN YUK-TONG ,  FOLEY BARBARA BARENBURG ,  DAI XUNHU

IPC: G01N35/08 ,  B01J19/00 ,  B01J19/24 ,  B01J35/02 ,  B01L3/00 ,  B01L7/00 ,  B28B11/00 ,  B32B18/00 ,  B81B1/00 ,  C12M1/00 ,  C40B60/14 ,  F04B19/00 ,  F28D9/00 ,  F28F13/00 ,  G01N30/02 ,  G01N30/52 ,  G01N30/60 ,  G01N35/00 ,  G01N37/00 ,  H05K1/02 ,  H05K1/03 ,  H05K3/46

Abstract: A multilayered microfluidic DNA analysis system includes a cell lysis chamber, a DNA separation chamber, a DNA amplification chamber, and a DNA detection system. The multilayered microfluidic DNA analysis system is provided as a substantially monolithic structure formed from a plurality of green-sheet layers sintered together. The substantially monolithic structure has defined therein a means for heating the DNA amplification chamber and a means for cooling the DNA amplification chamber. The means for heating and means for cooling operate to cycle the temperature of the DNA amplification chamber as required for performing a DNA amplification process, such as PCR.

公开(公告)号：CA2393690A1

公开(公告)日：2001-06-14

申请号：CA2393690

申请日：2000-12-11

Applicant: MOTOROLA INC

Inventor： KAHN PETER ,  BURDON JEREMY W ,  GRODZINSKI PIOTR ,  MARRERO ROBERT ,  HAWKINS GEORGE ,  BRISCOE CYNTHIA G ,  TUGGLE TODD ,  YU HUINAN ,  HUANG RONG-FONG ,  MCGARRY MARK W ,  CHAN TONY ,  FOLEY BARBARA

IPC: G01N31/20 ,  B01J19/00 ,  B01L3/00 ,  B01L7/00 ,  C12M1/00 ,  C12N15/09 ,  C40B40/02 ,  C40B50/06 ,  C40B60/14 ,  G01N30/02 ,  G01N30/52 ,  G01N30/60 ,  G01N30/66 ,  G01N35/00 ,  G01N37/00

Abstract: The invention relates generally to methods and apparatus for conducting analyses, particularly microfluidic devices. In preferred aspects, the devic es are fabricated using ceramic multilayer technology to form devices in which parallel, independently controlled molecular reactions, such as nucleic acid amplification reactions including the polymerase chain reaction (PCR) can be performed. Additionally, the devices can include and comprise micro-gas chromatographs similarly fabricated from ceramics.

公开(公告)号：AU2003279879A1

公开(公告)日：2004-05-04

申请号：AU2003279879

申请日：2003-10-07

Applicant: MOTOROLA INC

Inventor： ALLMEN PAUL A VON ,  WILCOX DAVID L ,  BURDON JEREMY W

IPC: C23C8/36 ,  C23C16/50 ,  H01J37/32 ,  C23C16/04 ,  B81B1/00 ,  B81C1/00 ,  C23C14/04

公开(公告)号：AU2002360476A1

公开(公告)日：2003-06-30

申请号：AU2002360476

申请日：2002-12-05

Applicant: MOTOROLA INC

Inventor： ROBERTS PETER C ,  ZENHAUSERN FREDERIC ,  BURDON JEREMY W ,  SADLER DANIEL J

IPC: B01L3/00 ,  B01L7/00 ,  C12Q1/68 ,  C12Q1/6834 ,  G01N33/543 ,  B01J19/00

Abstract: An electrochemical analysis device and method for analyzing biomolecular samples, including a means for holding a sample on a substrate platform, a thermal sensor, a biosensor formed having a specific spatial resolution as related to the thermal sensor, and a means for providing radiation to the biomolecular sample. The means for holding the sample, the thermal sensor, the biosensor, and the means for providing radiation all three-dimensionally integrated with the substrate platform, thereby defining a compact biomolecular analysis device having a volume resolution of less than 50 micro liters. During operation, radiation is provided to the biomolecular sample to provide for a constant temperature at which hybridization of the biomolecules takes place. The temperature of the biomolecular sample is monitored and controlled by the integrated thermal sensor and the integrated heater. Once hybridization takes place, the change in electric condition (e.g. voltage, current and/or power) is recorded and identification of the molecule within biomolecular sample is made by utilizing an exterior reader.

公开(公告)号：AU2002326579A1

公开(公告)日：2003-04-14

申请号：AU2002326579

申请日：2002-08-07

Applicant: MOTOROLA INC

Inventor： BURDON JEREMY W ,  HUANG RONG FONG

IPC: B32B37/04 ,  C04B35/10 ,  C04B35/638 ,  C04B37/00 ,  H01C17/065 ,  C03B29/00 ,  H01F17/00 ,  H01G4/12

Abstract: An intermediate low-pressure laminated ceramic device is formed from a plurality of layers of unfired ceramic material each including ceramic particles in an organic binder. A polymer interfacial layer having a glass transition temperature such that it flows at a temperature below a temperature required for the unfired ceramic layers to substantially deform, is deposited on one surface of each of the unfired ceramic layers. The unfired ceramic layers are stacked with an interfacial layer positioned between adjacent unfired ceramic layers in the stack. The stack is heated to a temperature greater than the glass transition temperature of the interfacial layers and a pressure is applied to the heated stack below approximately 1200 psi to fixedly bond the plurality of layers in the stack together.

公开(公告)号：CA2346059A1

公开(公告)日：2000-04-20

申请号：CA2346059

申请日：1999-10-07

Applicant: MOTOROLA INC

Inventor： GRODZINSKI PIOTR ,  GALLAGHER SEAN ROSS ,  BURDON JEREMY W ,  FOLEY BARBARA MCNEIL ,  HUANG RONG-FONG ,  DAI XUNHU ,  BRISCOE CYNTHIA ANN GORSUCH ,  NACLERIO NICHOLAS J ,  YU HUINAN ,  MARRERO ROBERT ,  WILCOX DAVID ,  CHAN YUK-TONG

IPC: G01N35/08 ,  B01J19/00 ,  B01J19/24 ,  B01J35/02 ,  B01L3/00 ,  B01L7/00 ,  B28B11/00 ,  B32B18/00 ,  B81B1/00 ,  C12M1/00 ,  C40B60/14 ,  F04B19/00 ,  F28D9/00 ,  F28F13/00 ,  G01N30/02 ,  G01N30/52 ,  G01N30/60 ,  G01N35/00 ,  G01N37/00 ,  H05K1/02 ,  H05K1/03 ,  H05K3/46

Abstract: A multilayered microfluidic device having a substantially monolithic structu re is formed by sintering together a plurality of green-sheet layers. The substantially monolithic structure has an inlet port for receiving fluid, an outlet port for releasing fluid, and an interconnection between the inlet po rt and the outlet port. The substantially monolithic structure may also include a variety of components to enable useful interaction with the fluid, such as electrically conductive pathways, heaters, fluid sensors, fluid motion transducers, and optically transmissive portions. The components are preferably fabricated using thick-film or green-sheet technology and are preferably co-fired with and sintered to the green-sheet layers to become integral with the substantially monolithic structure. By using an adhesive t o bind the green-sheet layers together, the multilayered microfluidic device m ay be fabricated without the application of high pressures. Selection of an adhesive with a polymer that decomposes at a higher temperature than the binder present in the green-sheet layers promotes stability of the interface s during the firing process and promotes void-free sintering within the interfacial regions.