公开(公告)号：WO2004106903A8

公开(公告)日：2005-04-07

申请号：PCT/JP2004007442

申请日：2004-05-25

Applicant: OLYMPUS CORP ,  NAMBA AKIHIRO ,  SAWADA RYUJI

Inventor： NAMBA AKIHIRO ,  SAWADA RYUJI

IPC: G01N21/64 ,  G02B21/00

CPC classification number: G01N21/76 ,  G01N21/6458 ,  G02B21/0076

Abstract: A measuring device (100) comprising a cofocal-point optical microscope (110), an excitation light source unit (130) that emits an excitation light for generating fluorescence from a fluorescent material, and a light receiving unit (140). The cofocal-point optical microscope (110) has an excitation light input port (112) for capturing an excitation light from the excitation light source unit (130), and an output port (113) for outputting fluorescence generated by an excitation light. The light receiving unit (140) has an input unit (141) for capturing a signal light including fluoresence from the microscope (110). The input unit (141) of the light receiving unit (140) is optically connected to the output port (113) of the microscope (110) via an optical fiber (153).

Abstract translation: 包括共焦点光学显微镜（110）的测量装置（100），发射用于从荧光材料产生荧光的激发光的激发光源单元（130）和光接收单元（140）。 共焦点光学显微镜（110）具有用于捕获来自激发光源单元（130）的激发光的激发光输入端口（112）和用于输出由激发光产生的荧光的输出端口（113）。 光接收单元（140）具有用于从显微镜（110）捕获包括荧光的信号光的输入单元（141）。 光接收单元（140）的输入单元（141）经由光纤（153）与显微镜（110）的输出端口（113）光学连接。

公开(公告)号：AT543117T

公开(公告)日：2012-02-15

申请号：AT05710206

申请日：2005-02-15

Applicant: OLYMPUS CORP

Inventor： HARADA MITSUO ,  NAMBA AKIHIRO ,  FUKUOKA MORINAO

IPC: G02B21/00 ,  G02B21/02 ,  G02B21/33

Abstract: A retention mechanism for an immersion medium (31) for use in a device which observes/measures a sample by use of an objective lens (10), wherein a member for retaining the immersion medium near a tip portion of the objective lens is constituted by a first material (± portion) having a low affinity with the immersion medium, and a second material (² portion) which has a high affinity with the immersion medium, the retention mechanism being provided with a supply unit (34) and a drip draining unit (35) for supplying respectively draining the immersion medium.

公开(公告)号：AT503177T

公开(公告)日：2011-04-15

申请号：AT04734732

申请日：2004-05-25

Applicant: OLYMPUS CORP

Inventor： NAMBA AKIHIRO ,  SAWADA RYUJI

IPC: G01N21/64 ,  G02B21/00

Abstract: Onto a surface of an Al x Ga y In 1-x-y As z P 1-z (0‰¤x, y, z‰¤1) layer including GaAs alone or an InP substrate, an electron beam controlled to an arbitrary electron beam diameter and current density is irradiated so as to selectively substitute or generate Ga 2 O 3 for a natural oxide layer formed on the Al x Ga y In 1-x-y As z P 1-z layer surface, then the Al x Ga y In 1-x-y As z P 1-z layer surface is dry-etched by a bromide in single atomic layer units, whereby the natural oxide layer other than the part substituted by the Ga 2 O 3 and Al x Ga y In 1-x-y As z P 1-z substrate are removed.

公开(公告)号：EP1526373A4

公开(公告)日：2010-03-17

申请号：EP03760934

申请日：2003-06-20

Applicant: OLYMPUS CORP

Inventor： NAMBA AKIHIRO ,  ISHIBASHI KIYOCHIKA ,  HORIKAWA YOSHIAKI

IPC: G01N21/64 ,  G02B21/00

CPC classification number: G01N21/6458 ,  G01N21/6408 ,  G02B21/0076

公开(公告)号：EP2023127A4

公开(公告)日：2011-06-08

申请号：EP07744527

申请日：2007-05-31

Applicant: OLYMPUS CORP

Inventor： NAMBA AKIHIRO ,  SUZUKI HIROBUMI

IPC: G01N21/78 ,  C12M1/00 ,  C12Q1/02 ,  G01N21/64 ,  G01N33/483 ,  G03B15/00 ,  H04N5/225

CPC classification number: G01N21/6458 ,  G02B21/0088 ,  G02B21/06 ,  G02B21/34 ,  G02B21/361 ,  G02B21/367

Abstract: The present invention aims to provide an analyzing method of a feeble light image for quickly and correctly analyzing an image of a biological specimen that emits a feeble light. In the present invention, when analyzing an image of a biological specimen that emits a feeble light, at least one reference position relating to a target region to be analyzed of the biological specimen is determined by using electromagnetic energy that is different from the feeble light to the target region, a focal position for the feeble light corresponding to the target region with respect to the reference position is determined, an image according to the feeble light is formed by performing a focusing onto the determined focal position, numerical values of necessary measurement parameter are extracted from the feeble light image, and the evaluation of the target region is carried out based on the extracted numerical values of the parameter.

Abstract translation: 本发明旨在提供一种用于快速且正确地分析发出微弱光的生物样本的图像的微弱光图像的分析方法。 在本发明中，当分析发出微弱光的生物样本的图像时，通过使用与微弱光不同的电磁能来确定与生物样本的要分析的目标区域有关的至少一个参考位置 确定目标区域，相对于基准位置对应于目标区域的微弱光的焦点位置，通过对确定的焦点位置进行聚焦，形成根据微弱光的图像，必要的测量参数的数值 从弱光图像中提取，并且基于提取的参数数值来执行目标区域的评估。

公开(公告)号：EP1967885A4

公开(公告)日：2011-01-05

申请号：EP06843705

申请日：2006-12-26

Applicant: OLYMPUS CORP

Inventor： SUZUKI HIROBUMI ,  OHASHI YOKO ,  SATO CHIAKI ,  FUKUOKA MORINAO ,  NAMBA AKIHIRO

IPC: G02B21/00 ,  C12M1/34 ,  C12Q1/02 ,  G01N21/76 ,  G01N33/68

CPC classification number: G01N21/6458 ,  G02B21/0088

公开(公告)号：EP1930717A4

公开(公告)日：2013-12-25

申请号：EP06810944

申请日：2006-09-29

Applicant: OLYMPUS CORP

Inventor： NAMBA AKIHIRO ,  SUZUKI HIROBUMI ,  ISHIWATA HIROSHI

IPC: G01N21/64 ,  G01N21/76 ,  G02B21/00 ,  G02B21/24

CPC classification number: G01N21/6458 ,  G02B21/244 ,  G02B21/245

Abstract: The present invention aims to provide a focal position determining method, a focal position determining apparatus, and the like that can determine the focal position of the objective lens focused on an observed target region at the time of setting a specimen, when a specific region in a specimen is defined as the observed target region, and the luminescence of the observed target region is observed. In the present invention, light is irradiated to the specimen, the focal position of the objective lens is changed, the changed focal position is measured, the specimen to which the light is irradiated is imaged at the changed focal position, feature data is calculated based on the imaged image, the process of changing the focal position, the process of measuring the focal position, the process of imaging the specimen, and the process of calculating the feature data are repeatedly executed, at least one focal position is selected from the accumulated plural focal positions by the execution based on the plural feature data accumulated by the execution, and the focal position of the objective lens focused on the observed target region in the specimen is determined based on the selected focal position. The focal position of the objective lens is determined, and then, a digital zooming and optical zooming are performed to magnify the imaged image with a desired magnification for display.

公开(公告)号：EP1717628A4

公开(公告)日：2010-03-03

申请号：EP05710206

申请日：2005-02-15

Applicant: OLYMPUS CORP

Inventor： HARADA MITSUO ,  NAMBA AKIHIRO ,  FUKUOKA MORINAO

IPC: G02B21/00 ,  G02B21/02 ,  G02B21/33

CPC classification number: G02B21/33 ,  Y10T29/49826 ,  Y10T436/25

公开(公告)号：EP1637871A4

公开(公告)日：2008-03-12

申请号：EP04734732

申请日：2004-05-25

Applicant: OLYMPUS CORP

Inventor： NAMBA AKIHIRO ,  SAWADA RYUJI

IPC: G01N21/64 ,  G02B21/00

CPC classification number: G01N21/76 ,  G01N21/6458 ,  G02B21/0076

Abstract: A measuring device (100) comprising a cofocal-point optical microscope (110), an excitation light source unit (130) that emits an excitation light for generating fluorescence from a fluorescent material, and a light receiving unit (140). The cofocal-point optical microscope (110) has an excitation light input port (112) for capturing an excitation light from the excitation light source unit (130), and an output port (113) for outputting fluorescence generated by an excitation light. The light receiving unit (140) has an input unit (141) for capturing a signal light including fluoresence from the microscope (110). The input unit (141) of the light receiving unit (140) is optically connected to the output port (113) of the microscope (110) via an optical fiber (153).