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    METHOD AND APPARATUS FOR DETECTING NUCLEIC ACID DATA
    1.
    发明申请
    METHOD AND APPARATUS FOR DETECTING NUCLEIC ACID DATA 审中-公开
    用于检测核酸数据的方法和装置

    公开(公告)号：WO03062418B1

    公开(公告)日：2004-04-01

    申请号：PCT/JP0300668

    申请日：2003-01-24

    Applicant: OLYMPUS CORP ,  KOIKE HISASHI ,  NAGAOKA TOMONORI ,  SATOH TAKATOMO ,  KANEKO YOSHIOKI ,  HATANAKA MIDORI ,  FUKUOKA MORINAO ,  SAKAMOTO HIROKO ,  YONEKAWA HIROYUKI

    Inventor： KOIKE HISASHI ,  NAGAOKA TOMONORI ,  SATOH TAKATOMO ,  KANEKO YOSHIOKI ,  HATANAKA MIDORI ,  FUKUOKA MORINAO ,  SAKAMOTO HIROKO ,  YONEKAWA HIROYUKI

    IPC: C12N15/09 ,  C12Q1/68 ,  G01N33/50 ,  G01N33/53 ,  G01N33/566 ,  G01N33/58

    CPC classification number: C12Q1/6827 ,  C12Q1/6837 ,  C12Q2565/501 ,  C12Q2561/12 ,  C12Q2527/107

    Abstract: It is intended to provide a method of detecting the data of a target nucleic acid comprising bringing the target nucleic acid into contact with a probe having a sequence being complementary to at leas a part of the target nucleic acid sequence to form a hybrid of the target nucleic acid with the probe, and measuring a signal generated in an amount depending on the amount of the hybrid to thereby detect the data of the target nucleic acid, wherein the signal data are kinetically obtained. It is also intended to provide a method of detecting the data of a target nucleic acid comprising bringing the target nucleic acid into contact with a completely matching probe being completely complementary to at leas a part of the target nucleic acid sequence and one or more incompletely matching probes having a variation in at least a part of the completely matching probe to form hybrids of the target nucleic acid with the completely matching probe and with the incompletely matching probe, and detecting the data of the target nucleic acid based on the difference in the binding strength between the hybrids, characterized in that the signal data are kinetically obtained while continuously or stepwise altering the conditions of measuring or detecting the signals generated from the hybrids.

    Abstract translation: 旨在提供一种检测目标核酸的数据的方法，包括使靶核酸与具有与靶核酸序列的一部分互补的序列的探针接触，以形成目标核酸的杂交体 核酸，并且测量根据混合物的量产生的量的信号，从而检测目标核酸的数据，其中信号数据被动力学地获得。 还旨在提供一种检测靶核酸的数据的方法，包括使靶核酸与完全匹配的探针完全互补，所述完全匹配的探针与目标核酸序列的一部分完全互补，并且一个或多个不完全匹配 探针在完全匹配的探针的至少一部分上具有变异，以与完全匹配的探针和不完全匹配的探针形成靶核酸的杂交体，并且基于结合的差异检测靶核酸的数据 其特征在于，在连续或逐步地改变测量或检测从杂种产生的信号的条件下动态获得信号数据。

    2.
    发明专利
    未知

    公开(公告)号：AT543117T

    公开(公告)日：2012-02-15

    申请号：AT05710206

    申请日：2005-02-15

    Applicant: OLYMPUS CORP

    Inventor： HARADA MITSUO ,  NAMBA AKIHIRO ,  FUKUOKA MORINAO

    IPC: G02B21/00 ,  G02B21/02 ,  G02B21/33

    Abstract: A retention mechanism for an immersion medium (31) for use in a device which observes/measures a sample by use of an objective lens (10), wherein a member for retaining the immersion medium near a tip portion of the objective lens is constituted by a first material (± portion) having a low affinity with the immersion medium, and a second material (² portion) which has a high affinity with the immersion medium, the retention mechanism being provided with a supply unit (34) and a drip draining unit (35) for supplying respectively draining the immersion medium.

    METHOD OF DETECTING SUBSTANCE TO BE ANALYZED
    8.
    发明公开
    METHOD OF DETECTING SUBSTANCE TO BE ANALYZED 审中-公开
    用于检测的物质的方法加以分析

    公开(公告)号：EP1693672A4

    公开(公告)日：2008-06-11

    申请号：EP04819444

    申请日：2004-11-26

    Applicant: OLYMPUS CORP

    Inventor： SANUKI HIROMI ,  SAKAMOTO HIROKO ,  FUKUOKA MORINAO

    IPC: G01N33/543 ,  G01N33/557 ,  G01N33/58

    CPC classification number: G01N33/557 ,  G01N33/54306 ,  G01N33/581

    Abstract: A quick, easy and highly-sensitive method of detecting a substance to be analyzed is provided. Even if the amount of sample to be handled is very small, the analysis results are supported by quantitativeness. The method of detecting a substance to be analyzed is carried out in such a way that the strength of the signal derived from the labeled substance to be analyzed is measured in time series during an increase in the signal strength, the signal strength is represented by a function of time, and the quantitative value of the signal strength of when the slope of the approximated line of the measured signal strength is within the range of 0.5 to 1.5 times the slope of the approximated line of the signal strength previously measured is used.

    METHOD AND APPARATUS FOR DETECTING NUCLEIC ACID DATA
    9.
    发明公开
    METHOD AND APPARATUS FOR DETECTING NUCLEIC ACID DATA 审中-公开
    方法和设备检测NUCLEIC数据的

    公开(公告)号：EP1469067A4

    公开(公告)日：2007-05-23

    申请号：EP03703050

    申请日：2003-01-24

    Applicant: OLYMPUS CORP

    Inventor： KOIKE HISASHI ,  NAGAOKA TOMONORI ,  SATOH TAKATOMO ,  KANEKO YOSHIOKI ,  HATANAKA MIDORI ,  FUKUOKA MORINAO ,  SAKAMOTO HIROKO ,  YONEKAWA HIROYUKI

    IPC: C12N15/09 ,  C12Q1/68 ,  G01N33/50 ,  G01N33/53 ,  G01N33/566 ,  G01N33/58

    CPC classification number: C12Q1/6827 ,  C12Q1/6837 ,  C12Q2565/501 ,  C12Q2561/12 ,  C12Q2527/107

    Abstract: It is intended to provide a method of detecting the data of a target nucleic acid comprising bringing the target nucleic acid into contact with a probe having a sequence being complementary to at leas a part of the target nucleic acid sequence to form a hybrid of the target nucleic acid with the probe, and measuring a signal generated in an amount depending on the amount of the hybrid to thereby detect the data of the target nucleic acid, wherein the signal data are kinetically obtained. It is also intended to provide a method of detecting the data of a target nucleic acid comprising bringing the target nucleic acid into contact with a completely matching probe being completely complementary to at leas a part of the target nucleic acid sequence and one or more incompletely matching probes having a variation in at least a part of the completely matching probe to form hybrids of the target nucleic acid with the completely matching probe and with the incompletely matching probe, and detecting the data of the target nucleic acid based on the difference in the binding strength between the hybrids, characterized in that the signal data are kinetically obtained while continuously or stepwise altering the conditions of measuring or detecting the signals generated from the hybrids.

    Method for adhering polymeric substrate to inorganic substrate
    10.
    发明专利
    Method for adhering polymeric substrate to inorganic substrate 审中-公开
    将聚合物基材加入无机基材的方法

    公开(公告)号：JP2009275169A

    公开(公告)日：2009-11-26

    申请号：JP2008129627

    申请日：2008-05-16

    Applicant: Olympus Corp ,  オリンパス株式会社

    Inventor： SUGIMURA NATSUHIKO ,  FUKUOKA MORINAO

    IPC: C08J5/12 ,  C12M1/00

    Abstract: PROBLEM TO BE SOLVED: To provide a method for adhering a polymeric substrate to an inorganic substrate suitable for producing a polymer for biological experiments-inorganic composite material hardly affecting living bodies and giving no damage to optical characteristics inherently owned by material to be adhered. SOLUTION: In the method for adhering the polymeric substrate to the inorganic substrate by using an adhesive, the adhesive comprises a monomer or an oligomer which is a constituent of the polymer substrate as an effective ingredient. Vessels for biological experiments are produced by using the adhering method. COPYRIGHT: (C)2010,JPO&INPIT

    Abstract translation: 要解决的问题：提供一种将聚合物基材粘附到适于生产用于生物实验的聚合物的无机基材的方法 - 对生物体几乎不影响的无机复合材料，并且不会对材料固有的光学特性造成损害 坚持 解决方案：在通过使用粘合剂将聚合物基材粘合到无机基材上的方法中，粘合剂包含作为聚合物基材的组分的单体或低聚物作为有效成分。 通过使用粘附方法制造用于生物实验的容器。 版权所有（C）2010，JPO＆INPIT

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