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公开(公告)号：BR112013002182B1
公开(公告)日：2022-05-03
申请号：BR112013002182
申请日：2011-07-28
Applicant: ONCOTHERAPY SCIENCE INC
Inventor： AHMED FERYAN , DECORNEZ HELENE , JOEL R WALKER , HUNTLEY RAYMOND , HISADA SHOJI , MATSUO YO , NAKAMURA YUSUKE
IPC: A61K31/47 , A61P35/00 , A61P43/00 , C07D215/46 , C07D215/54 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D409/04 , C07D409/06 , C07D409/14 , C07D413/06 , C07D453/02 , C07D471/04
Abstract: compostos derivados de quinolina, composição farmacêutica, inibidor de melk, agente modulador de expressão de melk, agente antitumor, agente terapêutico e/ou preventivo para uma doença que envolve a superexpressão de melk contendo os mesmos e uso dos referidos compostos a presente invenção se refere a um composto derivado de quinolina para inibir a atividade de melk, um método para a preparação do mesmo, e uma composição farmacêutica contendo o com posto como um ingrediente ativo, o qual é representado pela fórmula (i): (i) ou um sal farmaceuticamente aceitável do mesmo, visto que melk, cinase de zíper de leucina embrionária materna, foi previamente identificada como um novo membro da família de snf1/ampk serina-treonina cinase que está envolvida no desenvolvimento embrionário de mamífero. o gene foi mostra do desempenhar um papel importante na renovação de célula tronco, sendo que, melk, recentemente, mostrou ser super-regulada em câncer de mama, células de câncer de pulmão, bexiga, linfoma e cervical.
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公开(公告)号：CA2999852A1
公开(公告)日：2017-04-06
申请号：CA2999852
申请日：2016-09-12
Applicant: ONCOTHERAPY SCIENCE INC
Inventor： MATSUO YO , HISADA SHOJI , NAKAMURA YUSUKE , CHAKRABARTI ANJAN , RAWAT MANISH , RAI SANJAY , SATYANARAYANA ARVAPALLI VENKATA , DUAN ZHIYONG , TALUKDAR ARINDAM , RAVULA SRINIVAS , DECORNEZ HELENE
IPC: A01N43/90
Abstract: The present invention directs to a compound represented by formula (I).
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公开(公告)号：AU2011235319A1
公开(公告)日：2012-10-11
申请号：AU2011235319
申请日：2011-03-29
Applicant: ONCOTHERAPY SCIENCE INC
Inventor： NAKAMURA YUSUKE , MATSUO YO , HISADA SHOJI , AHMED FERYAN , HUNTLEY RAYMOND , SAJJADI-HASHEMI ZOHREH , JENKINS DAVID M , KARGBO ROBERT B , CUI WENGE , GAUUAN POLIVINA JOLICIA F , WALKER JOEL R , DECORNEZ HELENE , GURRAM MAHENDER
IPC: A01N43/42 , C07D221/06
Abstract: Trycyclic compounds are provided. These compounds are PBK inhibitors, and are useful for the treatment of PBK related diseases, including cancer.
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公开(公告)号：RU2729187C1
公开(公告)日：2020-08-05
申请号：RU2018115695
申请日：2016-09-12
Applicant: ONCOTHERAPY SCIENCE INC
Inventor： MATSUO YO , HISADA SHOJI , NAKAMURA YUSUKE , CHAKRABARTI ANJAN , RAWAT MANISH , RAI SANJAY , SATYANARAYANA ARVAPALLI VENKATA , DUAN ZHIYONG , TALUKDAR ARINDAM , RAVULA SRINIVAS , DECORNEZ HELENE
IPC: C07D471/04 , A61K31/519 , A61P35/00 , C07D487/04
Abstract: Изобретениеотноситсяк соединению, представленномуформулой (I), илиегофармацевтическиприемлемойсоли:.Значениерадикалов R, R, R, R, R, R, X, Xи n определенов формулеизобретения. Такжепредложеныфармацевтическаякомпозиция, способлеченияилипредотвращениязаболевания, вкотороевовлеченасверхэкспрессия SUV39H2, иприменениесоединенияформулы (I) дляизготовлениялекарственногосредства. Предложенноесоединенияобладаетингибирующейактивностьюв отношении SUV39H2 иможетприменятьсядлялечениязлокачественнойопухоли. 4 н. и 14 з.п. ф-лы, 13 табл.
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公开(公告)号：BR112013002182A2
公开(公告)日：2016-05-31
申请号：BR112013002182
申请日：2011-07-28
Applicant: ONCOTHERAPY SCIENCE INC
Inventor： AHMED FERYAN , DECORNEZ HELENE , WALKER JOEL R , HUNTLEY RAYMOND , HISADA SHOJI , MATSUO YO , NAKAMURA YUSUKE
Abstract: derivados de quinolina e inibidores de melk contendo os mesmos. a presente invenção refere-se a um composto representado por fórmula (i).
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Patent Agency Ranking
公开(公告)号：AU2011282588A1
公开(公告)日：2013-03-21
申请号：AU2011282588
申请日：2011-07-28
Applicant: ONCOTHERAPY SCIENCE INC
Inventor： MATSUO YO , HISADA SHOJI , NAKAMURA YUSUKE , AHMED FERYAN , HUNTLEY RAYMOND , WALKER JOEL R , DECORNEZ HELENE
Abstract: The present invention directs a compound represented by formula (I).
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公开(公告)号：SG184376A1
公开(公告)日：2012-11-29
申请号：SG2012072807
申请日：2011-03-29
Applicant: ONCOTHERAPY SCIENCE INC
Inventor： NAKAMURA YUSUKE , MATSUO YO , HISADA SHOJI , AHMED FERYAN , HUNTLEY RAYMOND , SAJJADI-HASHEMI ZOHREH , JENKINS DAVID M , KARGBO ROBERT B , CUI WENGE , GAUUAN POLIVINA JOLICIA F , WALKER JOEL R , DECORNEZ HELENE , GURRAM MAHENDER
Abstract: Trycyclic compounds are provided. These compounds are PBK inhibitors, and are useful for the treatment of PBK related diseases, including cancer.
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公开(公告)号：BR112012023836B1
公开(公告)日：2022-02-01
申请号：BR112012023836
申请日：2011-03-29
Applicant: ONCOTHERAPY SCIENCE INC
Inventor： DAVID M JENKINS , AHMED FERYAN , DECORNEZ HELENE , JOEL R WALKER , GURRAM MAHENDER , POLIVINA JOLICIA F GAUUAN , HUNTLEY RAYMOND , ROBERT B KARGBO , HISADA SHOJI , CUI WENGE , MATSUO YO , NAKAMURA YUSUKE , SAJJADI-HASHEMI ZOHREH
IPC: C07D213/64 , A61P35/00 , C07D221/06 , C07D221/16 , C07D401/04 , C07D401/10 , C07D487/04 , C07D495/04 , C07D513/04 , C07D519/00
Abstract: compostos tricíclicos, composição farmacêutica compreendendo os referidos compostos, inibidor de pbk contendo os mesmos e uso dos referidos compostos. a presente invenção refere-se a compostos tricíclicos que são fornecidos. estes compostos são inibidores de pbk, e são úteis para o tratamento de doenças relacionadas com pbk, incluindo câncer.
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公开(公告)号：CA2806332C
公开(公告)日：2017-11-14
申请号：CA2806332
申请日：2011-07-28
Applicant: ONCOTHERAPY SCIENCE INC
Inventor： MATSUO YO , HISADA SHOJI , NAKAMURA YUSUKE , AHMED FERYAN , HUNTLEY RAYMOND , WALKER JOEL R , DECORNEZ HELENE
IPC: C07D215/46 , A61K31/47 , A61K31/496 , A61K31/506 , A61K31/5377 , A61P35/00 , C07D401/00 , C07D409/00
Abstract: The present disclosure relates to a quinoline derivative of formula I: (see formula I) The derivatives are useful for inhibiting MELK activity. There is also provided a method for the preparation the derivatives, the use of same for the treatment of diseases that involve overexpression of MELK and a pharmaceutical composition containing the derivatives.
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公开(公告)号：CA2792941C
公开(公告)日：2017-09-12
申请号：CA2792941
申请日：2011-03-29
Applicant: ONCOTHERAPY SCIENCE INC
Inventor： NAKAMURA YUSUKE , MATSUO YO , HISADA SHOJI , AHMED FERYAN , HUNTLEY RAYMOND , SAJJADI-HASHEMI ZOHREH , JENKINS DAVID M , KARGBO ROBERT B , CUI WENGE , GAUUAN POLIVINA JOLICIA F , WALKER JOEL R , DECORNEZ HELENE , GURRAM MAHENDER
IPC: C07D495/04 , A61K31/4365 , A61K31/444 , A61P35/00
Abstract: Trycyclic compounds are provided. These compounds are PBK inhibitors, and are useful for the treatment of PBK related diseases, including cancer.
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