公开(公告)号：IL222080A

公开(公告)日：2018-05-31

申请号：IL22208012

申请日：2012-09-23

Applicant: ONCOTHERAPY SCIENCE INC ,  YUSUKE NAKAMURA ,  YO MATSUO ,  SHOJI HISADA ,  FERYAN AHMED ,  RAYMOND HUNTLEY ,  ZOHREH SAJJADI HASHEMI ,  DAVID M JENKINS ,  ROBERT B KARGBO ,  WENGE CUI ,  POLIVINA JOLICIA F GAUUAN ,  JOEL R WALKER ,  HELENE DECORNEZ ,  MAHENDER GURRAM

Inventor： YUSUKE NAKAMURA ,  YO MATSUO ,  SHOJI HISADA ,  FERYAN AHMED ,  RAYMOND HUNTLEY ,  ZOHREH SAJJADI-HASHEMI ,  DAVID M JENKINS ,  ROBERT B KARGBO ,  WENGE CUI ,  POLIVINA JOLICIA F GAUUAN ,  JOEL R WALKER ,  HELENE DECORNEZ ,  MAHENDER GURRAM

IPC: A61K20060101 ,  A61P20060101 ,  C07D20060101

Abstract: Tricyclic compounds are provided. These compounds are PBK inhibitors, and are useful for the treatment of PBK related diseases, including cancer.

公开(公告)号：BR112012023836B1

公开(公告)日：2022-02-01

申请号：BR112012023836

申请日：2011-03-29

Applicant: ONCOTHERAPY SCIENCE INC

Inventor： DAVID M JENKINS ,  AHMED FERYAN ,  DECORNEZ HELENE ,  JOEL R WALKER ,  GURRAM MAHENDER ,  POLIVINA JOLICIA F GAUUAN ,  HUNTLEY RAYMOND ,  ROBERT B KARGBO ,  HISADA SHOJI ,  CUI WENGE ,  MATSUO YO ,  NAKAMURA YUSUKE ,  SAJJADI-HASHEMI ZOHREH

IPC: C07D213/64 ,  A61P35/00 ,  C07D221/06 ,  C07D221/16 ,  C07D401/04 ,  C07D401/10 ,  C07D487/04 ,  C07D495/04 ,  C07D513/04 ,  C07D519/00

Abstract: compostos tricíclicos, composição farmacêutica compreendendo os referidos compostos, inibidor de pbk contendo os mesmos e uso dos referidos compostos. a presente invenção refere-se a compostos tricíclicos que são fornecidos. estes compostos são inibidores de pbk, e são úteis para o tratamento de doenças relacionadas com pbk, incluindo câncer.