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公开(公告)号：WO2009120372A3
公开(公告)日：2010-01-07
申请号：PCT/US2009001926
申请日：2009-03-27
Applicant: PACIFIC BIOSCIENCES CALIFORNIA , TRAVERS KEVIN , OTTO GEOFF , TURNER STEPHEN , HEINER CHERYL , MA CONGCONG
Inventor： TRAVERS KEVIN , OTTO GEOFF , TURNER STEPHEN , HEINER CHERYL , MA CONGCONG
IPC: C12Q1/68
CPC classification number: G06F19/22 , C12Q1/6806 , C12Q1/6855 , C12Q1/6869 , C12Q1/689 , C12Q2525/307 , C12Q2525/301 , C12Q2525/155 , C12Q2531/125 , C12Q2535/122
Abstract: Compositions and methods for nucleic acid sequencing include template constructs that comprise double stranded portions in a partially or completely contiguous constructs, to provide for redundant sequence determination through one or both of sequencing sense and antisense strands, and iteratively sequencing the entire construct multiple times. Additional sequence components are also optionally included within such template constructs. Methods are also provided for the use and preparation of these constructs as well as sequencing compositions for their application.
Abstract translation: 用于核酸测序的组合物和方法包括在部分或完全邻接的构建体中包含双链部分的模板构建体，以通过测序有义链和反义链中的一个或两个进行冗余序列测定，并对整个构建体进行多次迭代测序。 额外的序列成分也可选地包括在这样的模板构建体内。 还提供了这些构建体的使用和制备方法以及其应用的测序组合物。
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公开(公告)号：WO2009120374A3
公开(公告)日：2009-12-17
申请号：PCT/US2009001930
申请日：2009-03-27
Applicant: PACIFIC BIOSCIENCES CALIFORNIA , PATEL PRANAV , BJORNSON KEITH , TRAVERS KEVIN , HEINER CHERYL
Inventor： PATEL PRANAV , BJORNSON KEITH , TRAVERS KEVIN , HEINER CHERYL
Abstract: Provided are methods and compositions for the production of linear single- stranded nucleic acids, which can be used as templates in high-throughput sequencing systems. Also provided are methods and compositions for the production of closed single- stranded nucleic acid loops, which can be used as templates in high-throughput sequencing systems.
Abstract translation: 提供用于生产线性单链核酸的方法和组合物，其可以在高通量测序系统中用作模板。 还提供了用于生产封闭的单链核酸环的方法和组合物，其可以用作高通量测序系统中的模板。
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公开(公告)号：CA2719747C
公开(公告)日：2018-02-20
申请号：CA2719747
申请日：2009-03-27
Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC
Inventor： TRAVERS KEVIN , OTTO GEOFF , TURNER STEPHEN , HEINER CHERYL , MA CONGCONG
IPC: C12Q1/68 , C12Q1/6869
Abstract: Compositions and methods for nucleic acid sequencing include template constructs that comprise double stranded portions in a partially or completely contiguous constructs, to provide for redundant sequence determination through one or both of sequencing sense and antisense strands, and iteratively sequencing the entire construct multiple times. Additional sequence components are also optionally included within such template constructs. Methods are also provided for the use and preparation of these constructs as well as sequencing compositions for their application.
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公开(公告)号：AU2015202111B9
公开(公告)日：2017-07-27
申请号：AU2015202111
申请日：2015-04-24
Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC
Inventor： TRAVERS KEVIN , OTTO GEOFF , TURNER STEPHEN , HEINER CHERYL , MA CONGCONG
IPC: C12Q1/68
Abstract: Compositions and methods for nucleic acid sequencing include template constructs that comprise double stranded portions in a partially or completely contiguous constructs, to provide for redundant sequence determination through one or both of sequencing sense and antisense strands, and iteratively sequencing the entire construct multiple times. Additional sequence components are also optionally included within such template constructs. Methods are also provided for the use and preparation of these constructs as well as sequencing compositions for their application.
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公开(公告)号：BRPI0909212A2
公开(公告)日：2015-08-18
申请号：BRPI0909212
申请日：2009-03-27
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： TRAVERS KEVIN , OTTO GEOFF , TURNER STEPHEN , HEINER CHERYL , MA CONGCONG
IPC: C12Q1/68
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Patent Agency Ranking
公开(公告)号：AU2008307617A1
公开(公告)日：2009-04-09
申请号：AU2008307617
申请日：2008-09-26
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： TURNER STEPHEN , TRAVERS KEVIN , HEINER CHERYL
Abstract: Methods of separating tagged nucleic acid fragments from populations of fragments are provided. The fragments are produced from a population of tagged nucleic acids. In some cases, the population of tagged nucleic acids comprises a population of clonal nucleic acids.
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公开(公告)号：WO2012065043A9
公开(公告)日：2012-12-20
申请号：PCT/US2011060338
申请日：2011-11-11
Applicant: PACIFIC BIOSCIENCES CALIFORNIA , FLUSBERG BENJAMIN , KORLACH JONAS , WEGENER JEFFREY , CLARK TYSON A , VILFAN IGOR , KISLYUK ANDREY , TURNER STEPHEN , SORENSON JON , TRAVERS KEVIN , HEINER CHERYL , TOMANEY AUSTIN B , MARKS PATRICK , LEE JESSICA , JIA LEI , WEBSTER DALE , LYLE JOHN , HANES JEREMIAH , PUGLISI JOSEPH
Inventor： FLUSBERG BENJAMIN , KORLACH JONAS , WEGENER JEFFREY , CLARK TYSON A , VILFAN IGOR , KISLYUK ANDREY , TURNER STEPHEN , SORENSON JON , TRAVERS KEVIN , HEINER CHERYL , TOMANEY AUSTIN B , MARKS PATRICK , LEE JESSICA , JIA LEI , WEBSTER DALE , LYLE JOHN , HANES JEREMIAH , PUGLISI JOSEPH
CPC classification number: C12Q1/6869 , C12Q1/6837 , C12Q1/6858 , C12Q1/6874 , C12Q1/689 , C12Q2600/154 , C12Q2537/164 , C12Q2527/113 , C12Q2521/101 , C12Q2525/307 , C12Q2525/117
Abstract: Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, abasic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid.
Abstract translation: 提供了用于表征修饰的核酸的方法，组合物和系统。 在某些优选的实施方案中，提供单分子测序方法用于鉴定核酸序列内的修饰的核苷酸。 通过本文提供的方法可检测的修饰包括化学修饰的碱基，酶修饰的碱基，无碱基位点，非天然碱基，二级结构和与模板核酸结合的试剂。
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公开(公告)号：WO2012065043A3
公开(公告)日：2012-08-16
申请号：PCT/US2011060338
申请日：2011-11-11
Applicant: PACIFIC BIOSCIENCES CALIFORNIA , FLUSBERG BENJAMIN , KORLACH JONAS , WEGENER JEFFREY , CLARK TYSON A , VILFAN IGOR , KISLYUK ANDREY , TURNER STEPHEN , SORENSON JON , TRAVERS KEVIN , HEINER CHERYL , TOMANEY AUSTIN B , MARKS PATRICK , LEE JESSICA , JIA LEI , WEBSTER DALE , LYLE JOHN , HANES JEREMIAH , PUGLISI JOSEPH
Inventor： FLUSBERG BENJAMIN , KORLACH JONAS , WEGENER JEFFREY , CLARK TYSON A , VILFAN IGOR , KISLYUK ANDREY , TURNER STEPHEN , SORENSON JON , TRAVERS KEVIN , HEINER CHERYL , TOMANEY AUSTIN B , MARKS PATRICK , LEE JESSICA , JIA LEI , WEBSTER DALE , LYLE JOHN , HANES JEREMIAH , PUGLISI JOSEPH
CPC classification number: C12Q1/6869 , C12Q1/6837 , C12Q1/6858 , C12Q1/6874 , C12Q1/689 , C12Q2600/154 , C12Q2537/164 , C12Q2527/113 , C12Q2521/101 , C12Q2525/307 , C12Q2525/117
Abstract: Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, abasic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid.
Abstract translation: 提供了方法，组合物和系统用于表征修饰的核酸。 在某些优选实施方案中，提供单分子测序方法用于鉴定核酸序列内的修饰的核苷酸。 通过本文提供的方法可检测的修饰物包括化学修饰的碱基，酶修饰的碱基，脱碱基位点，非天然碱基，二级结构和与模板核酸结合的试剂。
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公开(公告)号：WO2010068289A3
公开(公告)日：2010-10-14
申请号：PCT/US2009006517
申请日：2009-12-10
Applicant: PACIFIC BIOSCIENCES CALIFORNIA , FLUSBERG BENJAMIN , TURNER STEPHEN , LEE JESSICA , JIA LEI , KORLACH JONAS , SORENSON JON , WEBSTER DALE , LYLE JOHN , TRAVERS KEVIN , HANES JEREMIAH
Inventor： FLUSBERG BENJAMIN , TURNER STEPHEN , LEE JESSICA , JIA LEI , KORLACH JONAS , SORENSON JON , WEBSTER DALE , LYLE JOHN , TRAVERS KEVIN , HANES JEREMIAH
CPC classification number: C12Q1/6869 , C12Q1/6837 , C12Q1/6858 , C12Q2561/113 , C12Q2537/164 , C12Q2527/113 , C12Q2521/101 , C12Q2525/307 , C12Q2525/117
Abstract: Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, abasic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid.
Abstract translation: 提供了方法，组合物和系统用于表征修饰的核酸。 在某些优选实施方案中，提供单分子测序方法用于鉴定核酸序列内的修饰的核苷酸。 通过本文提供的方法可检测的修饰物包括化学修饰的碱基，酶修饰的碱基，脱碱基位点，非天然碱基，二级结构和与模板核酸结合的试剂。
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公开(公告)号：WO2009045344A3
公开(公告)日：2009-07-09
申请号：PCT/US2008011206
申请日：2008-09-26
Applicant: PACIFIC BIOSCIENCES CALIFORNIA , HEINER CHERYL , TURNER STEPHEN , TRAVERS KEVIN
Inventor： HEINER CHERYL , TURNER STEPHEN , TRAVERS KEVIN
CPC classification number: C12Q1/6806 , C12Q1/6869 , C12Q2563/179 , C12Q2563/155 , C12Q2525/307
Abstract: Methods of preparing nucleic acid templates and providing the nucleic acid templates to low copy number reaction volumes are provided. Related compositions of nucleic acid templates are also provided.
Abstract translation: 提供了制备核酸模板并将核酸模板提供给低拷贝数反应体积的方法。 还提供了核酸模板的相关组合物。
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