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公开(公告)号：WO2009120372A3
公开(公告)日：2010-01-07
申请号：PCT/US2009001926
申请日：2009-03-27
Applicant: PACIFIC BIOSCIENCES CALIFORNIA , TRAVERS KEVIN , OTTO GEOFF , TURNER STEPHEN , HEINER CHERYL , MA CONGCONG
Inventor： TRAVERS KEVIN , OTTO GEOFF , TURNER STEPHEN , HEINER CHERYL , MA CONGCONG
IPC: C12Q1/68
CPC classification number: G06F19/22 , C12Q1/6806 , C12Q1/6855 , C12Q1/6869 , C12Q1/689 , C12Q2525/307 , C12Q2525/301 , C12Q2525/155 , C12Q2531/125 , C12Q2535/122
Abstract: Compositions and methods for nucleic acid sequencing include template constructs that comprise double stranded portions in a partially or completely contiguous constructs, to provide for redundant sequence determination through one or both of sequencing sense and antisense strands, and iteratively sequencing the entire construct multiple times. Additional sequence components are also optionally included within such template constructs. Methods are also provided for the use and preparation of these constructs as well as sequencing compositions for their application.
Abstract translation: 用于核酸测序的组合物和方法包括在部分或完全邻接的构建体中包含双链部分的模板构建体，以通过测序有义链和反义链中的一个或两个进行冗余序列测定，并对整个构建体进行多次迭代测序。 额外的序列成分也可选地包括在这样的模板构建体内。 还提供了这些构建体的使用和制备方法以及其应用的测序组合物。
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2.发明申请ARTICLES HAVING LOCALIZED MOLECULES DISPOSED THEREON AND METHODS OF PRODUCING SAME 审中-公开具有本地化分子的制品及其生产方法
公开(公告)号：WO2007123763A3
公开(公告)日：2008-11-06
申请号：PCT/US2007008019
申请日：2007-03-29
Applicant: PACIFIC BIOSCIENCES CALIFORNIA , RANK DAVID R , WEGENER JEFFERY , KORLACH JONAS , ROITMAN DANIEL , XU YUE , LYLE JOHN , TURNER STEPHEN , PELUSO PAUL , OTTO GEOFF
Inventor： RANK DAVID R , WEGENER JEFFERY , KORLACH JONAS , ROITMAN DANIEL , XU YUE , LYLE JOHN , TURNER STEPHEN , PELUSO PAUL , OTTO GEOFF
CPC classification number: C12Q1/6874 , B01J19/0046 , B01J2219/00427 , B01J2219/0045 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00635 , B01J2219/00637 , B01J2219/00639 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , B82Y20/00 , B82Y30/00 , C12Q1/6837 , Y10T29/49002 , C12Q2565/629 , C12Q2527/127
Abstract: Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the substrate. The methods may include optical, chemical and/or mechanical processes for the deposition, removal, activation and/or deactivation of chemical groups in selected regions of the substrate to provide selective active regions of the substrate.
Abstract translation: 通过使用底物的元素来辅助活性化学基团在基底的所需区域中的定位来制备具有选定的活性化学区域的基底的方法。 所述方法可以包括用于沉积，去除，激活和/或去活衬底的选定区域中的化学基团的光学，化学和/或机械方法，以提供衬底的选择性活性区域。
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公开(公告)号：ES2385015T3
公开(公告)日：2012-07-17
申请号：ES07754529
申请日：2007-03-29
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： RANK DAVID R , WEGENER JEFFERY , KORLACH JONAS , ROITMAN DANIEL , XU YUE , LYLE JOHN , TURNER STEPHEN , PELUSO PAUL , OTTO GEOFF , CICERO RONALD L
Abstract: Un método de proporcionar un sustrato que tiene una enzima inmovilizada selectivamente sobre él, comprendiendoel método:proporcionar un sustrato que tiene un primer componente de la superficie que comprende SiO2 y un segundocomponente de la superficie que comprende un metal u óxido metálico;poner en contacto el sustrato con una primera composición que se asocia selectivamente con el primer componentede la superficie, comprendiendo dicha primera composición un silano;acoplar la enzima a la primera composición; yponer en contacto el sustrato con una segunda composición que se asocia selectivamente con el segundocomponente de la superficie, comprendiendo dicha segunda composición un compuesto que comprende uno o másgrupos ácido fosfónico o fosfato.
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公开(公告)号：MX2010010600A
公开(公告)日：2011-03-30
申请号：MX2010010600
申请日：2009-03-27
Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC
Inventor： TURNER STEPHEN , TRAVERS KEVIN , OTTO GEOFF , HEINER CHERYL , MA CONGCONG
IPC: C12Q1/68
Abstract: Se describen composiciones y métodos para secuenciación de ácido nucleico que incluyen constructos de plantilla que comprenden porciones de doble hebra en constructos parcial o completamente contiguos, para proveer determinación de secuencia redundante por medio de una o ambas de secuenciación de hebras de sentido y anti-sentido y secuenciación iterativamente de todo el constructo múltiples veces. Componentes de secuencia adicionales son también incluidos opcionalmente dentro de tales constructos de plantilla. También se proveen métodos para el uso y preparación de estos constructor, también corno composiciones de secuenciación para su aplicación.
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公开(公告)号：AU2009229157A1
公开(公告)日：2009-10-01
申请号：AU2009229157
申请日：2009-03-27
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： MA CONGCONG , OTTO GEOFF , TURNER STEPHEN , HEINER CHERYL , TRAVERS KEVIN
IPC: C12Q1/68
Abstract: Compositions and methods for nucleic acid sequencing include template constructs that comprise double stranded portions in a partially or completely contiguous constructs, to provide redundant sequence determination through one or both of sequencing sense and antisense strands, and iteratively sequencing the entire construct multiple times. Additional sequence components are also optionally included within such template constructs. Methods are also provided for the use and preparation of these constructs as well as sequencing compositions for their application.
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Patent Agency Ranking
公开(公告)号：CA2645758A1
公开(公告)日：2007-11-01
申请号：CA2645758
申请日：2007-03-29
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： OTTO GEOFF , WEGENER JEFFERY , KORLACH JONAS , RANK DAVID R , XU YUE , PELUSO PAUL , ROITMAN DANIEL , TURNER STEPHEN , LYLE JOHN
Abstract: Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the substrate. The methods may include optical, chemical and/or mechanical processes for the deposition, removal, activation and/or deactivation of chemical groups in selected regions of the substrate to provide selective active regions of the substrate.
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公开(公告)号：AU2006330947A1
公开(公告)日：2007-07-05
申请号：AU2006330947
申请日：2006-12-21
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： BIBILLO AREK , MITSIS PAUL , PHAM THANG , CHRISTIANS FRED C , MURPHY DEVON , PARK INSIL , HANZEL DAVID K , LYLE JOHN , RANK DAVID R , CLARK SONYA , PELUSO PAUL , OTTO GEOFF
IPC: C12Q1/68
Abstract: Compositions that include polymerases with features for improving entry of nucleotide analogues into active site regions and for coordinating with the nucleotide analogues in the active site region are provided. Methods of making the polymerases and of using the polymerases in sequencing and DNA replication and amplification as well as kinetic models of polymerase activity and computer-implemented methods of using the models are also provided.
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公开(公告)号：CA2719747C
公开(公告)日：2018-02-20
申请号：CA2719747
申请日：2009-03-27
Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC
Inventor： TRAVERS KEVIN , OTTO GEOFF , TURNER STEPHEN , HEINER CHERYL , MA CONGCONG
IPC: C12Q1/68 , C12Q1/6869
Abstract: Compositions and methods for nucleic acid sequencing include template constructs that comprise double stranded portions in a partially or completely contiguous constructs, to provide for redundant sequence determination through one or both of sequencing sense and antisense strands, and iteratively sequencing the entire construct multiple times. Additional sequence components are also optionally included within such template constructs. Methods are also provided for the use and preparation of these constructs as well as sequencing compositions for their application.
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公开(公告)号：AU2015202111B9
公开(公告)日：2017-07-27
申请号：AU2015202111
申请日：2015-04-24
Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC
Inventor： TRAVERS KEVIN , OTTO GEOFF , TURNER STEPHEN , HEINER CHERYL , MA CONGCONG
IPC: C12Q1/68
Abstract: Compositions and methods for nucleic acid sequencing include template constructs that comprise double stranded portions in a partially or completely contiguous constructs, to provide for redundant sequence determination through one or both of sequencing sense and antisense strands, and iteratively sequencing the entire construct multiple times. Additional sequence components are also optionally included within such template constructs. Methods are also provided for the use and preparation of these constructs as well as sequencing compositions for their application.
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公开(公告)号：BRPI0909212A2
公开(公告)日：2015-08-18
申请号：BRPI0909212
申请日：2009-03-27
Applicant: PACIFIC BIOSCIENCES CALIFORNIA
Inventor： TRAVERS KEVIN , OTTO GEOFF , TURNER STEPHEN , HEINER CHERYL , MA CONGCONG
IPC: C12Q1/68
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