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    SUBSTRATES AND OPTICAL SYSTEMS AND METHODS OF USE THEREOF
    1.
    发明专利
    SUBSTRATES AND OPTICAL SYSTEMS AND METHODS OF USE THEREOF 未知

    公开(公告)号：CA3063032A1

    公开(公告)日：2010-03-25

    申请号：CA3063032

    申请日：2009-09-15

    Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC

    Inventor： ZHONG CHENG FRANK ,  LUNDQUIST PAUL ,  FOQUET MATHIEU ,  KORLACH JONAS ,  BAYANDORIAN HOVIG

    Abstract: The present invention provides an integrated optical device (2300), comprising:a) a first component (2302) comprising a waveguide (2312) disposed upon or within a substrate and a plurality of nanometer-scale apertures (2308) comprising analyte regions (2310), wherein the analyte regions (2310) are disposed sufficiently proximal to a core of the waveguide (2312) to be illuminated by an evanescent field emanating from the core when optical energy is passed through the waveguide;b) a second component (2304) comprising a microlens array that collects optical energy signals from the analyte regions (2310) and directs the optical energy signals so collected to a detector (2320); andc) a third component (2306) comprising the detector (2320).

    Integrated target waveguide devices and systems for optical coupling
    2.
    发明专利
    Integrated target waveguide devices and systems for optical coupling 未知

    公开(公告)号：AU2016276980B2

    公开(公告)日：2021-09-23

    申请号：AU2016276980

    申请日：2016-06-11

    Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC

    Inventor： WANG SHANG ,  FOQUET MATHIEU ,  LUNDQUIST PAUL ,  RULISON AARON ,  MCDONALD MARK ,  HERRMANN ARIEL

    IPC: G02B6/26 ,  G02B6/34

    Abstract: Integrated target waveguide devices and optical analytical systems comprising such devices are provided. The target devices include an optical coupler that is optically coupled to an integrated waveguide and that is configured to receive optical input from an optical source through free space, particularly through a low numerical aperture interface. The devices and systems are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices provide for the efficient and reliable coupling of optical excitation energy from an optical source to the optical reactions. Optical signals emitted from the reactions can thus be measured with high sensitivity and discrimination. The devices and systems are well suited for miniaturization and high throughput.

    INTEGRATED TARGET WAVEGUIDE DEVICES AND SYSTEMS FOR OPTICAL COUPLING
    7.
    发明专利
    INTEGRATED TARGET WAVEGUIDE DEVICES AND SYSTEMS FOR OPTICAL COUPLING 未知

    公开(公告)号：CA2989344A1

    公开(公告)日：2016-12-15

    申请号：CA2989344

    申请日：2016-06-11

    Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC

    Inventor： WANG SHANG ,  FOQUET MATHIEU ,  LUNDQUIST PAUL ,  RULISON AARON ,  MCDONALD MARK ,  HERRMANN ARIEL

    IPC: G02B6/26 ,  G02B6/34

    Abstract: Integrated target waveguide devices and optical analytical systems comprising such devices are provided. The target devices include an optical coupler that is optically coupled to an integrated waveguide and that is configured to receive optical input from an optical source through free space, particularly through a low numerical aperture interface. The devices and systems are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices provide for the efficient and reliable coupling of optical excitation energy from an optical source to the optical reactions. Optical signals emitted from the reactions can thus be measured with high sensitivity and discrimination. The devices and systems are well suited for miniaturization and high throughput.

    Integrated target waveguide devices and systems for optical coupling
    10.
    发明专利
    Integrated target waveguide devices and systems for optical coupling 未知

    公开(公告)号：AU2016276980A1

    公开(公告)日：2018-01-25

    申请号：AU2016276980

    申请日：2016-06-11

    Applicant: PACIFIC BIOSCIENCES CALIFORNIA INC

    Inventor： WANG SHANG ,  FOQUET MATHIEU ,  LUNDQUIST PAUL ,  RULISON AARON ,  MCDONALD MARK ,  HERRMANN ARIEL

    IPC: G02B6/26 ,  G02B6/34

    Abstract: Integrated target waveguide devices and optical analytical systems comprising such devices are provided. The target devices include an optical coupler that is optically coupled to an integrated waveguide and that is configured to receive optical input from an optical source through free space, particularly through a low numerical aperture interface. The devices and systems are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices provide for the efficient and reliable coupling of optical excitation energy from an optical source to the optical reactions. Optical signals emitted from the reactions can thus be measured with high sensitivity and discrimination. The devices and systems are well suited for miniaturization and high throughput.

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