公开(公告)号：AU2023221847A1

公开(公告)日：2024-09-05

申请号：AU2023221847

申请日：2023-02-16

Applicant: PTC THERAPEUTICS INC

Inventor： ZHANG XIAOYAN ,  ALAM RAUFUL ,  BEJCEK LAUREN ,  GILBERT BRADLEY B ,  HOSSEYNI SEYEDMORTEZA ,  HUARTE EDUARDO ,  LLI JING ,  LIU YAO ,  NIEDERER KYLE ,  PARKER ERICA N ,  PILLAI MEENU ,  RASTELLI ETTORE ,  SYDORENKO NADIYA ,  ZHANG NANJING ,  ZHENG TIANYI ,  WOLL MATTHEW G ,  - HANDOKO

IPC: A61K31/407 ,  A61K31/4162 ,  A61K31/53 ,  C07D487/04

Abstract: The present invention relates to compounds that are useful as inhibitors of NOD-like receptor protein 3 (NLRP3) inflammasome pathway, processes for the preparation of said compounds, pharmaceutical compositions comprising said compounds, methods of using said compounds in the treatment of various diseases and disorders, and medicaments containing them, and their use in diseases and disorders mediated by NLRP3.