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    SUBSTITUTED POLYCYCLIC ANTIBACTERIAL COMPOUNDS
    2.
    发明申请
    SUBSTITUTED POLYCYCLIC ANTIBACTERIAL COMPOUNDS 审中-公开
    取代的多环抗菌化合物

    公开(公告)号：WO2016025933A3

    公开(公告)日：2016-04-07

    申请号：PCT/US2015045433

    申请日：2015-08-15

    Applicant: PTC THERAPEUTICS INC

    Inventor： WANG JIASHI ,  GERASYUTO ALEKSEY IGOREVICH ,  ARNOLD MICHAEL A ,  KARP GARY MITCHELL ,  QI HONGYAN ,  WOLL MATTHEW G ,  ZHANG NANJING ,  BRANSTROM ARTHUR A ,  NARASIMHAN JANA ,  DUMBLE MELISSA L ,  HEDRICK JEAN ,  WEETALL MARIA L

    IPC: A61K31/4353

    CPC classification number: A61K45/06 ,  C07D471/04 ,  C07D491/147

    Abstract: The present description relates to substituted polycyclic compounds and forms and pharmaceutical compositions thereof and methods of using such compounds, forms or compositions thereof for treating or ameliorating Neisseria gonorrhoeae and Neisseria meningiditis. The present description relates to a compound of Formula (I), Formula (II), Formula (III) or Formula (IV): wherein the dashed line "----- " represents an optional double bond and R1, R2, R5, X and Z are as defined herein, and forms and compositions thereof, and also relates to uses of a compound of Formula (I), Formula (II), Formula (III) or Formula (IV) or a form thereof and methods for treating or ameliorating Neisseria gonorrhoeae (N. gonorrhoeae) or Neisseria meningitidis (N. meningitidis) in a subject in need thereof, comprising, administering an effective amount of the compound to the subject.

    Abstract translation: 本说明书涉及取代的多环化合物及其形式及其药物组合物，以及使用这些化合物，其形式或组合物治疗或改善淋病奈瑟氏球菌和脑膜炎奈瑟球菌的方法。 本发明涉及式（I），式（II），式（III）或式（IV）的化合物：其中虚线“-----”表示任选的双键，并且R 1，R 2，R 5 ，X和Z如本文所定义，以及其形式和组成，并且还涉及式（I），式（II），式（III）或式（IV）的化合物或其形式的用途及其用途 在有需要的受试者中治疗或改善淋病奈瑟氏球菌（淋病奈瑟氏球菌）或脑膜炎奈瑟氏球菌（脑膜炎奈瑟氏球菌），包括向受试者施用有效量的化合物。

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