公开(公告)号：WO2006029075A2

公开(公告)日：2006-03-16

申请号：PCT/US2005031532

申请日：2005-09-06

Applicant: REDDYS LAB LTD DR ,  REDDYS LAB LTD DR ,  DAS SAIBAL KUMAR ,  SINGH SUNIL KUMAR ,  MADHAVAN GURRAM RANGA ,  BHUNIYA DEBNATH ,  IQBAL JAVED ,  SHARMA SUDHIR KUMAR ,  CHAKRABARTI RANJAN

Inventor： DAS SAIBAL KUMAR ,  SINGH SUNIL KUMAR ,  MADHAVAN GURRAM RANGA ,  BHUNIYA DEBNATH ,  IQBAL JAVED ,  SHARMA SUDHIR KUMAR ,  CHAKRABARTI RANJAN

IPC: A61K31/519 ,  C07D487/02

CPC classification number: C07D487/04 ,  C07D239/90

Abstract: There are provided derivatives having PPAR agonist activity. The derivatives include compounds and/or their pharmaceutically acceptable salts; the compounds having the formula (I) wherein A has the structure (II) or (III); X is chosen from -CH 2 -, -O-, -NH-, and -S-; Y is chosen from -O-, -NH-, and -S-; Z, which may be located in any position of substitution, is hydrogen or halogen; R 1 and R 2 , which may be the same or different, are independently chosen from hydrogen and C 1 -C 8 alkyl, or R 1 and R 2 together form a carbocyclic ring having from 4 to 6 carbon atoms; R 3 is chosen from hydrogen and C 1 -C 8 alkyl; R 4 , R 5 , and R 6 , which may be the same or different, are independently chosen from hydrogen and C 1 -C 8 alkyl; and n is 1 to 6. Various embodiments and variants are provided. In accordance with other aspects, the invention also provides methods of producing a PPARa agonist activity in a mammal, the methods including administering to the mammal an effective amount of certain derivative(s) of the first aspect of the invention, a method of producing a PPARa agonist activity and a PPARa agonist activity in a mammal, the method including administering to the mammal an effective amount of certain derivative(s); and a pharmaceutical composition that includes the derivative(s) of the first aspect of the invention and one or more pharmaceutically-acceptable excipients. Various embodiments and variants are provided.

Abstract translation: 提供具有PPAR激动剂活性的衍生物。 衍生物包括化合物和/或其药学上可接受的盐; 具有式（I）的化合物其中A具有结构（II）或（III）; X选自-CH 2 - ， - O - ， - N - 和-S-; Y选自-O - ， - NH-和-S-; 可以位于任何取代位置的Z是氢或卤素; R 1和R 2可以相同或不同，独立地选自氢和C 1 -C 8烷基， 或者R 1和R 2一起形成具有4至6个碳原子的碳环; R 3选自氢和C 1 -C 8烷基; R 4，R 5，R 5和R 6可以相同或不同，独立地选自氢和C 1 C 8 -C 14烷基; 并且n为1至6.提供了各种实施方案和变体。 根据其它方面，本发明还提供了在哺乳动物中产生PPARα激动剂活性的方法，所述方法包括向哺乳动物施用有效量的本发明第一方面的某些衍生物， PPARα激动剂活性和PPARα激动剂活性，所述方法包括向哺乳动物施用有效量的某些衍生物; 和包含本发明第一方面的衍生物和一种或多种药学上可接受的赋形剂的药物组合物。 提供了各种实施例和变型。

公开(公告)号：WO2009019600A3

公开(公告)日：2009-12-30

申请号：PCT/IB2008002140

申请日：2008-08-08

Applicant: REDDYS LAB LTD DR ,  MISRA PARIMAL ,  CHAKRABARTI RANJAN ,  MADHURAREKHA CHINNABOINA ,  HASHAM SUMERA NIKHAT ,  POTLURI VIJAY KUMAR ,  SASMAL PRADIP KUMAR ,  DAS SAIBAL KUMAR ,  IQBAL JAVED

Inventor： MISRA PARIMAL ,  CHAKRABARTI RANJAN ,  MADHURAREKHA CHINNABOINA ,  HASHAM SUMERA NIKHAT ,  POTLURI VIJAY KUMAR ,  SASMAL PRADIP KUMAR ,  DAS SAIBAL KUMAR ,  IQBAL JAVED

IPC: G01N33/00

CPC classification number: C12Q1/485 ,  G01N2800/044

Abstract: A method for identifying an AMPK activator is provided. The method includes providing a sample of cells that include AMPK and perilipin, providing a sample of an AMPK activator-candidate, contacting the cell sample and the activator-candidate, and measuring a quantitative indicator of the AMPK activation within the cell sample after the contacting step.

Abstract translation: 提供了一种用于鉴定AMPK激活剂的方法。 该方法包括提供包含AMPK和肾上腺素的细胞样品，提供AMPK激活剂候选物的样品，接触细胞样品和活化剂候选物，并测量接触后细胞样品中AMPK活化的定量指标 步。

公开(公告)号：WO2007005785B1

公开(公告)日：2007-03-22

申请号：PCT/US2006025898

申请日：2006-06-30

Applicant: REDDYS LAB LTD DR ,  REDDYS LAB INC DR ,  POTLURI VIJAY KUMAR ,  DAS SAIBAL KUMAR ,  SASMAL PRADIP KUMAR ,  IQBAL JAVED ,  MISRA PARIMAL ,  CHAKRABARTI RANJAN ,  TALWAR RASHMI

Inventor： POTLURI VIJAY KUMAR ,  DAS SAIBAL KUMAR ,  SASMAL PRADIP KUMAR ,  IQBAL JAVED ,  MISRA PARIMAL ,  CHAKRABARTI RANJAN ,  TALWAR RASHMI

IPC: C07D277/14 ,  A61K31/426 ,  A61K31/5377 ,  C07D265/32

CPC classification number: C07D277/42

Abstract: The present application provides novel thiazole derivatives that are useful as activators of Adenosine 5'-Monophosphate-Activated Protein Kinase and pharmaceutical compositions containing such compounds.

Abstract translation: 本申请提供了可用作腺苷5'-单磷酸激活蛋白激酶的激活剂的新型噻唑衍生物和含有这些化合物的药物组合物。

公开(公告)号：WO2014045263A3

公开(公告)日：2014-05-15

申请号：PCT/IB2013058808

申请日：2013-09-24

Applicant: REDDYS LAB LTD DR

Inventor： IQBAL JAVED ,  DAHANUKAR VILAS HARESHWAR ,  ORUGANTI SRINIVAS ,  KANDAGATLA BHASKAR ,  KUNHIMON SYAM KUMAR UNNIARAN ,  SAGYAM RAJESHWAR REDDY ,  IRENI BABU ,  KONDEPUDI VEERA VENKATA SATYANARAYANA MURTHY ,  MUTTAVARAPU MURALI MOHAN ,  BUCCHIKONDA RAVINDER ,  GANGIREDDY RAJENDAR REDDY

IPC: C07D209/52 ,  C07C205/28 ,  C07C217/14 ,  C07D317/16 ,  C07D317/28

CPC classification number: C07D209/52 ,  C07B2200/07 ,  C07C35/06 ,  C07C43/315 ,  C07C215/20 ,  C07C217/44 ,  C07C223/02 ,  C07C255/46 ,  C07C271/16 ,  C07C271/18 ,  C07C309/66 ,  C07C2601/08 ,  C07D317/18 ,  C07D317/28 ,  C07F7/1856 ,  C07K5/0202 ,  C07K5/1024

Abstract: Provided are novel processes for preparation of (1S, 3aR, 6aS)-octahydrocyclopenta[c]pyrrole-1-carboxylic acid and its derivatives; land their use in preparation of Telaprevir.

Abstract translation: 提供（1S，3aR，6aS） - 八氢环戊二烯并[c]吡咯-1-羧酸及其衍生物的制备方法; 将其用于制备特拉匹韦尔。

公开(公告)号：WO2013175395A3

公开(公告)日：2014-01-30

申请号：PCT/IB2013054167

申请日：2013-05-21

Applicant: REDDYS LAB LTD DR

Inventor： VARANASI GANESH ,  MACHARLA PRABHAKAR ,  VEMPATI CHANDRASEKHAR ,  BANDICHHOR RAKESHWAR ,  DAHANUKAR VILAS HARESHWAR ,  IQBAL JAVED ,  ORUGANTI SRINIVAS ,  RAPOLU RAJESH KUMAR ,  NARIYAM MUNASWAMY SEKHAR ,  NETI SRINIVASAN

IPC: C07D209/02 ,  A61K31/403 ,  C07C13/615 ,  C07D209/52

CPC classification number: C07D209/52

Abstract: Improved processes for preparing saxagliptin or its salt and intermediates thereof are provided.

Abstract translation: 提供了制备沙格列汀或其盐及其中间体的改进方法。

公开(公告)号：WO2005082892A3

公开(公告)日：2006-03-23

申请号：PCT/IB2005000343

申请日：2005-02-11

Applicant: REDDYS LAB LTD DR ,  DAS JAGATTARAN ,  TAKHI MOHAMED ,  NATESAN SELVAKUMAR ,  TREHAN SANJAY ,  IQBAL JAVED ,  MAGADI SITARAM KUMAR ,  KANDEPU SREENIVAS

Inventor： DAS JAGATTARAN ,  TAKHI MOHAMED ,  NATESAN SELVAKUMAR ,  TREHAN SANJAY ,  IQBAL JAVED ,  MAGADI SITARAM KUMAR ,  KANDEPU SREENIVAS

IPC: C07D249/06 ,  C07D401/10 ,  C07D401/14 ,  C07D403/00 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12

CPC classification number: C07D403/06 ,  C07D249/06 ,  C07D401/10 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12

Abstract: The present invention relates to novel triazole compounds of formula (I), where all symbols are as defined in the detailed description; their pharmaceutically acceptable salts their stereosiomers thereof, their prodrugs, their rotamers, their pharmaceutical compositions containing them. The present invention also relates to a process for the preparation of the above said novel compounds.

Abstract translation: 本发明涉及新的式（I）三唑化合物，其中所有符号如详细描述中所定义; 其药学上可接受的盐，它们的立体异构体，它们的前药，它们的旋转异构体，它们含有它们的药物组合物。 本发明还涉及制备上述新化合物的方法。

公开(公告)号：WO2013190509A2

公开(公告)日：2013-12-27

申请号：PCT/IB2013055096

申请日：2013-06-21

Applicant: REDDYS LAB LTD DR

Inventor： NARIYAM SEKHAR MUNASWAMY ,  BHALERAO DINESH SHIVAJI ,  DAHANUKAR VILAS HARESHWAR ,  ORUGANTI SRINIVAS ,  RAPOLU RAJESH KUMAR ,  KANDAGATLA BHASKAR ,  IQBAL JAVED ,  KHOBARE SANDIP RAMDAS ,  KALLAM SRINIVASA REDDY ,  BANDA MALAVIKA ,  GARARE VIKAS SADASHIV ,  EDA VISHNUVARDHANA VEMA REDDY

CPC classification number: A61K38/06 ,  A61K38/55 ,  C07K5/0808

Abstract: The present application relates to processes for preparing intermediates of Boceprevir and their use in preparation of Boceprevir or its pharmaceutically acceptable salts thereof.

Abstract translation: 本申请涉及制备波普瑞韦中间体的方法及其在制备波普瑞韦或其药学上可接受的盐中的用途。

公开(公告)号：WO2012146980A3

公开(公告)日：2012-12-27

申请号：PCT/IB2012000922

申请日：2012-04-27

Applicant: REDDYS LAB LTD DR ,  KATKAM SRINIVAS ,  SAGYAM RAJESWAR REDDY ,  MORTHALA RAGHAVENDAR RAO ,  IRENI BABU ,  VINIGARI KRISHNA ,  RAMDOSS SURESH KUMAR ,  RANGINENI SRINIVASULU ,  TUMMALA ARJUNKUMAR ,  IQBAL JAVED ,  ORUGANTI SRINIVAS ,  KANDAGATLA BHASKAR

Inventor： KATKAM SRINIVAS ,  SAGYAM RAJESWAR REDDY ,  MORTHALA RAGHAVENDAR RAO ,  IRENI BABU ,  VINIGARI KRISHNA ,  RAMDOSS SURESH KUMAR ,  RANGINENI SRINIVASULU ,  TUMMALA ARJUNKUMAR ,  IQBAL JAVED ,  ORUGANTI SRINIVAS ,  KANDAGATLA BHASKAR

IPC: C07C211/00 ,  C07D333/20

CPC classification number: C07C205/45 ,  C07C201/10 ,  C07C201/12 ,  C07C213/00 ,  C07C213/02 ,  C07C213/10 ,  C07C215/28 ,  C07C205/04

Abstract: The present application provide processes for the preparation of fingolimod and its pharmaceutically acceptable salts, process for the purification of fingolimod hydrochloride and process for the preparation of amorphous fingolimod hydrochloride.

Abstract translation: 本申请提供了芬戈莫德及其药学上可接受的盐的制备方法，盐酸芬戈莫德的纯化方法和用于制备无定形芬戈莫德盐酸盐的方法。

公开(公告)号：WO2005035528A3

公开(公告)日：2005-06-02

申请号：PCT/IB2004003360

申请日：2004-10-14

Applicant: REDDYS LAB LTD DR ,  NATESAN SELVAKUMAR ,  DAS JAGATTARAN ,  TAKHI MOHAMED ,  TREHAN SANJAY ,  IQBAL JAVED ,  MAGADI SITARAM KUMAR ,  KANDEPU SREENIVAS

Inventor： NATESAN SELVAKUMAR ,  DAS JAGATTARAN ,  TAKHI MOHAMED ,  TREHAN SANJAY ,  IQBAL JAVED ,  MAGADI SITARAM KUMAR ,  KANDEPU SREENIVAS

IPC: A61K31/395 ,  A61K31/495 ,  A61K31/55 ,  A61P31/00 ,  C07D401/14 ,  C07D403/10

CPC classification number: C07D401/14 ,  C07D403/10

Abstract: The present invention relates to novel triazole compounds of formula (I), their prodrugs, their pharmaceutically acceptable salts and their stereoisomers thereof. The present invention also relates to a process for the preparation of the novel compound of the formula (I).

Abstract translation: 本发明涉及式（I）的新型三唑化合物，其前药，其药学上可接受的盐及其立体异构体。 本发明还涉及制备式（I）的新型化合物的方法。

公开(公告)号：WO2004069145A2

公开(公告)日：2004-08-19

申请号：PCT/IB2004000299

申请日：2004-02-06

Applicant: REDDYS LAB LTD DR ,  VEDULA MANOHAR SHARMA ,  KATTUBOINA VENKATA ADISESHU ,  IQBAL JAVED ,  RAMANUJAM RAJAGOPALAN ,  RAJAGOPAL SRIRAM ,  MAMIDI NAGA VENKATA SRINIVASA ,  JOSYULA RAMANATHAM ,  GUTTA MADHUSUDHAN

Inventor： VEDULA MANOHAR SHARMA ,  KATTUBOINA VENKATA ADISESHU ,  IQBAL JAVED ,  RAMANUJAM RAJAGOPALAN ,  RAJAGOPAL SRIRAM ,  MAMIDI NAGA VENKATA SRINIVASA ,  JOSYULA RAMANATHAM ,  GUTTA MADHUSUDHAN

IPC: A61K20060101 ,  C07D215/00 ,  C07D215/44 ,  C07D215/54 ,  C07D239/72 ,  C07D239/94 ,  A61K

CPC classification number: C07D239/94 ,  C07D215/44 ,  C07D215/54

Abstract: The present invention relates to novel anticancer agents, their pharmaceutically acceptable salts, their geometrical isomers and their pharmaceutically acceptable compositions containing them. the present invention more particularly relates to novel quinazoline compounds, their pharmaceutically acceptable salts and their pharmaceutically acceptable compositions containing them. the novel quinazoline compounds have the general formula (I), where all symbols are as defined in the specification.

Abstract translation: 本发明涉及新型抗癌剂，其药学上可接受的盐，它们的几何异构体及其含有它们的药学上可接受的组合物。 本发明更具体地涉及新的喹唑啉化合物，其药学上可接受的盐及其含有它们的药学上可接受的组合物。 新的喹唑啉化合物具有通式（I），其中所有符号如说明书中所定义。