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公开(公告)号：EP0439542A1
公开(公告)日：1991-08-07
申请号：EP89912578
申请日：1989-10-20
Applicant: UNIV LELAND STANFORD JUNIOR , SCLAVO SPA
Inventor： RELMAN DAVID A , DOMENIGHINI MARIO , RAPPUOLI RINO , FALKOW STANLEY
IPC: C12N15/09 , A61K31/70 , A61K38/00 , A61K39/00 , A61K39/10 , A61K39/395 , A61P37/04 , C07K14/235 , C12N1/21 , C12N5/10 , C12N9/12 , C12P21/02 , C12R1/01 , C12R1/19
CPC classification number: C12N9/127 , A61K39/00 , C07K14/235 , C07K2319/00 , C07K2319/40
Abstract: Des compositions d'acides nucléiques et de protéines obtenues à partir de B. pertussis peuvent se révéler utiles pour le diagnostic, la prévention et la thérapie de la coqueluche. En particulier, on peut exprimer un cadre ouvert de lecture et de codage de précurseurs de l'hémagglutinine filamenteuse comprenant à l'état intact la protéine de la partie correspondante à l'hémagglutinine filamenteuse, dans une grande variété d'hôtes, à des fins de production d'anticorps, d'immunodiagnostic ou de thérapie, ou à des fins de prophylaxie sous forme de vaccins.
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公开(公告)号：GR3018285T3
公开(公告)日：1996-03-31
申请号：GR950403403
申请日：1995-12-05
Applicant: SCLAVO SPA
Inventor： PIZZA MARIAGRAZIA , COVACCI ANTONELLO , RAPPUOLI RINO , NENCIONI LUCIANO
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公开(公告)号：AT127347T
公开(公告)日：1995-09-15
申请号：AT90107892
申请日：1990-04-25
Applicant: SCLAVO SPA
Inventor： PIZZA MARIAGRAZIA , COVACCI ANTONELLO , RAPPUOLI RINO , CALAMANDREI , NENCIONI LUCIANO
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公开(公告)号：DE3750094T2
公开(公告)日：1994-10-20
申请号：DE3750094
申请日：1987-01-28
Applicant: SCLAVO SPA
Inventor： RAPPUOLI RINO , NICOSIA ALFREDO , ARICO MARIA BEATRICE
IPC: C12N15/09 , A61K39/00 , A61K39/095 , A61K39/10 , C07K14/00 , C07K14/195 , C07K14/235 , C07K14/41 , C12N1/00 , C12N15/00 , C12N15/83 , C12P21/02 , C12Q1/68 , C12R1/19 , G01N33/50
Abstract: Cloning and sequencing of the EcoRI fragment of B. pertussis chromosomal DNA with 4696 base pairs, conta ining the genes which code for the five subunits of the pertussis toxin. A hybrid plasmid containing the DNA fragment or its further fragments and a micro-organism transformed by the hybrid plasmid and capable of expressing the cloned DNA fragment or further fragments thereof by synthesis of the pertussis toxin or one or more subunits of the pertussis toxin. The pertussis toxine or one or more subunits of the pertussis toxin so obtained are useful for the preparation of vaccines and diagnostic kits.
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公开(公告)号：ES2054701T3
公开(公告)日：1994-08-16
申请号：ES87830033
申请日：1987-01-28
Applicant: SCLAVO SPA
Inventor： RAPPUOLI RINO , NICOSIA ALFREDO , ARICO MARIA BEATRICE
IPC: C12N15/09 , A61K39/00 , A61K39/095 , A61K39/10 , C07K14/00 , C07K14/195 , C07K14/235 , C07K14/41 , C12N1/00 , C12N15/00 , C12N15/83 , C12P21/02 , C12Q1/68 , C12R1/19 , G01N33/50
Abstract: Cloning and sequencing of the EcoRI fragment of B. pertussis chromosomal DNA with 4696 base pairs, conta ining the genes which code for the five subunits of the pertussis toxin. A hybrid plasmid containing the DNA fragment or its further fragments and a micro-organism transformed by the hybrid plasmid and capable of expressing the cloned DNA fragment or further fragments thereof by synthesis of the pertussis toxin or one or more subunits of the pertussis toxin. The pertussis toxine or one or more subunits of the pertussis toxin so obtained are useful for the preparation of vaccines and diagnostic kits.
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Patent Agency Ranking
公开(公告)号：DE3889562D1
公开(公告)日：1994-06-23
申请号：DE3889562
申请日：1988-03-01
Applicant: ENIRICERCHE SPA , SCLAVO SPA
Inventor： VELATI BELLINI ADA , TOMA SALVATORE , GRANDI GUIDO , COLLETTI ELISABETTA , RIBOLI BARBARA , COSMINA PAOLA , TOGNONI ANGELO , PEDRONI PAOLA , RAPPUOLI RINO
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公开(公告)号：AT105864T
公开(公告)日：1994-06-15
申请号：AT88830078
申请日：1988-03-01
Applicant: ENIRICERCHE SPA , SCLAVO SPA
Inventor： VELATI BELLINI ADA , TOMA SALVATORE , GRANDI GUIDO , COLLETTI ELISABETTA , RIBOLI BARBARA , COSMINA PAOLA , TOGNONI ANGELO , PEDRONI PAOLA , RAPPUOLI RINO
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公开(公告)号：IT1238007B
公开(公告)日：1993-06-21
申请号：IT1928690
申请日：1990-02-07
Applicant: SCLAVO SPA
Inventor： PIZZA MARIAGRAZIA , COVACCI ANTONELLO , NENCIONI LUCIANO , RAPPUOLI RINO
IPC: C12K
Abstract: The toxin mutants (A) have at least one of the amino acid (AA) residues Glu129, Asp11, Trp26, Arg9, Phe50, Asp1, Arg13, Tyr130, Gly86, Ile88, Tyr89, Tyr8, Gly44, Thr53 and Gly80 of subunit S1 deleted and substd. by a natural AA. Also claimed are (a) Bordetella strains comprising (i) the gene encoding the wild type pertussin toxin; (ii) an expression and secretion regulation sequence; with the mutated subunit S1. E.g. Bordetella pertussis (W28)PT-9K/129G ATCC53894; B.parapertussis PT-129G ATCC 53892, PT-26l/129G ATCC 53893; B.bronchiseptica; (b) an immunogenic formulation. Details for obtg. (A) and Bordetella strains are given. Six specific examples of (A) are given, e.g. PT-13l/129G and PT-88E/89S have AA Glu129 + Arg13 and Ile88 + Tyr89 substd. by Gly+Ile and Glu+Ser respectively. (A), stable at 37 deg.C, have reduced or no mitogenicity of haemagglutinin activity and are obtd. by 0.035% and 0.42% formaldehyde treatment.
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公开(公告)号：IT9019286A1
公开(公告)日：1991-08-08
申请号：IT1928690
申请日：1990-02-07
Applicant: SCLAVO SPA
Inventor： COVACCI ANTONELLO , NENCIONI LUCIANO , PIZZA MARIAGRAZIA , RAPPUOLI RINO
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公开(公告)号：NO911673L
公开(公告)日：1991-06-26
申请号：NO911673
申请日：1991-04-26
Applicant: UNIV LELAND STANFORD JUNIOR , SCLAVO SPA
Inventor： RELMAN DAVID A , DOMENIGHINI MARIO , RAPPUOLI RINO , FALKOW STANLEY
IPC: A61K39/10 , C12N15/31 , C12P20060101 , C12P21/00
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