公开(公告)号：DK0499681T3

公开(公告)日：1999-11-15

申请号：DK91106110

申请日：1991-04-17

Applicant: SCLAVO SPA

Inventor： RATTI GIULIO ,  COMANDUCCI MAURIZIO ,  TECCE MARIO F ,  GIULIANI MARZIA M

IPC: A61K38/00 ,  A61K39/00 ,  C07K14/295 ,  C07K16/12 ,  C12N15/30 ,  C12N15/74 ,  A61K39/118 ,  C07K15/00 ,  G01N33/569

Abstract: A plasmid isolated from Clamydia trachomatis is described, which comprises 8 genes encoding proteins useful in the formulation of vaccines or diagnostic test for determining the bacterium or specific antibodies generated during C. trachomatis infections; in particular the recombinant fusion MS2-pgp3D protein is described comprising polypeptidic sequences encoded by pCT and immunogenic in the course of infections in man. A method for preparing said protein in E.coli further described.

公开(公告)号：GR3030447T3

公开(公告)日：1999-09-30

申请号：GR990401491

申请日：1999-06-10

Applicant: SCLAVO SPA

Inventor： RATTI GIULIO ,  COMANDUCCI MAURIZIO ,  TECCE MARIO F ,  GIULIANI MARZIA M

IPC: A61K38/00 ,  A61K39/00 ,  C07K14/295 ,  C07K16/12 ,  C12N15/30 ,  C12N15/74 ,  A61K39/118 ,  G01N33/569

Abstract: A plasmid isolated from Clamydia trachomatis is described, which comprises 8 genes encoding proteins useful in the formulation of vaccines or diagnostic test for determining the bacterium or specific antibodies generated during C. trachomatis infections; in particular the recombinant fusion MS2-pgp3D protein is described comprising polypeptidic sequences encoded by pCT and immunogenic in the course of infections in man. A method for preparing said protein in E.coli further described.

公开(公告)号：IT1244462B

公开(公告)日：1994-07-15

申请号：IT2231290

申请日：1990-12-06

Applicant: SCLAVO SPA

Inventor： MAZZATENTA CARLO ,  RICCI STEFANO ,  RATTI GIULIO

IPC: C12Q1/70 ,  C07G ,  A61B

公开(公告)号：CA2057114A1

公开(公告)日：1992-06-07

申请号：CA2057114

申请日：1991-12-05

Applicant: SCLAVO SPA

Inventor： MAZZATENTA CARLO ,  RICCI STEFANO ,  RATTI GIULIO

IPC: C12Q1/70 ,  C12Q1/68

Abstract: There are described synthetic oligonucleotides suitable both as primers for the amplification of DNA segments from different human Papillomaviruses and as probe for typing said amplified segments and their use for manufacturing suitable diagnostic kits.

公开(公告)号：IT1226551B

公开(公告)日：1991-01-24

申请号：IT2155388

申请日：1988-07-29

Applicant: SCLAVO SPA

Inventor： TECCE MARIO FELICE ,  GIULIANI MARZIA MONICA ,  RICCI STEFANO ,  RATTI GIULIO ,  TERRANA BENEDETTO

IPC: G01N33/574 ,  C07K14/00 ,  C07K14/47 ,  C07K16/00 ,  C07K16/30 ,  C07K19/00 ,  C12N1/21 ,  C12N9/12 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12R1/19 ,  G01N33/577 ,  A61K

Abstract: A synthetic peptide endowed with immunological activity is disclosed, which is capable of inducing in mammals the formation of anti-peptide antibodies capable of recognizing human alpha-fetoprotein and of reacting with it, and incapable of recognizing albumin or its degradation products, with said peptide being essentially constituted by the aminoacidic sequence of formula (I), corresponding to 38- 119 region of human alpha-fetoprotein. Furthermore, the methods and means for preparing said peptide by means of the recombinant DNA techniques are reported. The synthetic peptide (I), like the polyclonal and monoclonal antipeptide antibodies are particularly suitable for the early diagnosis of hepatocellular carcinoma and of teratocarcinoma.

公开(公告)号：IT1224253B

公开(公告)日：1990-09-26

申请号：IT2013288

申请日：1988-04-08

Applicant: SCLAVO SPA

Inventor： RATTI GIULIO ,  COMANDUCCI MAURIZIO ,  RICCI STEFANO ,  GARUTI GIANCARLO ,  COSCO EGIDIO

IPC: C07K14/295 ,  C12Q1/68 ,  C12Q1/6841 ,  C12Q1/689 ,  C12Q

公开(公告)号：IT8821553D0

公开(公告)日：1988-07-29

申请号：IT2155388

申请日：1988-07-29

Applicant: SCLAVO SPA

Inventor： TECCE MARIO FELICE ,  GIULIANI MARZIA MONICA ,  RICCI STEFANO ,  RATTI GIULIO ,  TERRANA BENEDETTO

IPC: G01N33/574 ,  C07K14/00 ,  C07K14/47 ,  C07K16/00 ,  C07K16/30 ,  C07K19/00 ,  C12N1/21 ,  C12N9/12 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12R1/19 ,  G01N33/577 ,  A61K

Abstract: A synthetic peptide endowed with immunological activity is disclosed, which is capable of inducing in mammals the formation of anti-peptide antibodies capable of recognizing human alpha-fetoprotein and of reacting with it, and incapable of recognizing albumin or its degradation products, with said peptide being essentially constituted by the aminoacidic sequence of formula (I), corresponding to 38- 119 region of human alpha-fetoprotein. Furthermore, the methods and means for preparing said peptide by means of the recombinant DNA techniques are reported. The synthetic peptide (I), like the polyclonal and monoclonal antipeptide antibodies are particularly suitable for the early diagnosis of hepatocellular carcinoma and of teratocarcinoma.

公开(公告)号：IT1244706B

公开(公告)日：1994-08-08

申请号：ITMI910314

申请日：1991-02-07

Applicant: SCLAVO SPA

Inventor： RATTI GIULIO ,  COMANDUCCI MAURIZIO ,  TECCE MARIO FELICE ,  GIULIANI MARZIA

IPC: A61K38/00 ,  A61K39/00 ,  C07K14/295 ,  C07K16/12 ,  C12N15/30 ,  C12N15/74 ,  C12K ,  A61K

Abstract: A plasmid isolated from Clamydia trachomatis is described, which comprises 8 genes encoding proteins useful in the formulation of vaccines or diagnostic test for determining the bacterium or specific antibodies generated during C. trachomatis infections; in particular the recombinant fusion MS2-pgp3D protein is described comprising polypeptidic sequences encoded by pCT and immunogenic in the course of infections in man. A method for preparing said protein in E.coli further described.

公开(公告)号：ITMI910314D0

公开(公告)日：1991-02-07

申请号：ITMI910314

申请日：1991-02-07

Applicant: SCLAVO SPA ,  SCAVO

Inventor： RATTI GIULIO ,  COMANDUCCI MAURIZIO ,  TECCE MARIO FELICE ,  GIULIANI MARZIA

IPC: A61K38/00 ,  A61K39/00 ,  C07K14/295 ,  C07K16/12 ,  C12N15/30 ,  C12N15/74 ,  C12K ,  A61K

Abstract: A plasmid isolated from Clamydia trachomatis is described, which comprises 8 genes encoding proteins useful in the formulation of vaccines or diagnostic test for determining the bacterium or specific antibodies generated during C. trachomatis infections; in particular the recombinant fusion MS2-pgp3D protein is described comprising polypeptidic sequences encoded by pCT and immunogenic in the course of infections in man. A method for preparing said protein in E.coli further described.

公开(公告)号：IT9022312D0

公开(公告)日：1990-12-06

申请号：IT2231290

申请日：1990-12-06

Applicant: SCLAVO SPA

Inventor： MAZZATENTA CARLO ,  RICCI STEFANO ,  RATTI GIULIO

IPC: C12Q1/70 ,  G07H21/00