公开(公告)号：JP2002338566A

公开(公告)日：2002-11-27

申请号：JP2002106212

申请日：2002-04-09

Applicant: SERVIER LAB

Inventor： PEGLION JEAN-LOUIS ,  POITEVIN CHRISTOPHE ,  VILAINE JEAN-PAUL ,  VILLENEUVE NICOLE ,  BOURGUIGNON MARIE PIERRE ,  THOLLON CATHERINE

IPC: C07D417/14 ,  A61K31/00 ,  A61K31/437 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  A61K31/513 ,  A61K31/551 ,  A61P3/06 ,  A61P3/10 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P43/00 ,  C07D209/08 ,  C07D211/00 ,  C07D211/26 ,  C07D211/58 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D417/06 ,  C07D471/04 ,  C07D491/04

Abstract: PROBLEM TO BE SOLVED: To provide a medicine useful for the treatment of a disease or a pathological state which is known that the disorder of endothelial function is the cause of the disease and/or the mechanism of worsening the disease because the medicine can limit the disorder of the endothelial function or the reduction of ability for utilizing the blood vessel. SOLUTION: The compound represented by formula (I) [wherein, V is a single bond or the like; M is a single bond or the like; A and E are each a nitrogen atom or the like; R3 is an aryl or a heteroaryl A group which may be substituted as necessary; Y is an aryloxy which may be substituted as necessary or the like], the isomer, the hydrate, the solvate or the addition salt with a pharmaceutically acceptable acid are provided. The pharmaceutical composition containing the compound is also provided.

公开(公告)号：JP2002193932A

公开(公告)日：2002-07-10

申请号：JP2001311565

申请日：2001-10-09

Applicant: SERVIER LAB

Inventor： PEGLION JEAN-LOUIS ,  VILAINE JEAN-PAUL ,  VILLENEUVE NICOLE ,  THOLLON CATHERINE ,  BOURGUIGNON MARIE-PIERRE ,  POITEVIN CHRISTOPHE

IPC: C07D491/056 ,  A61K31/438 ,  A61K31/445 ,  A61K31/4525 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/497 ,  A61P9/00 ,  A61P9/04 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  C07D211/22 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D417/14 ,  C07D471/04 ,  C07D491/04 ,  C07D491/107 ,  C07D519/00

Abstract: PROBLEM TO BE SOLVED: To provide a compound which can restrain endothelium malfunction and the drop in possible use of NO by blood vessels, and is useful for the treatment of the crisis and expansion of the legion of atherosclerosis, the prevention of diseases complicated with it, the prevention of a blood vessel complication after blood vessel bypass, vasodilation, blood vessel re-circulation and heart transplantation, the treatment of cardiac muscle or peripheral ischemia, cardiac incompetence and pulmonary hypertension. SOLUTION: The compound represented by formula (1) [X is a 5 to 12-membered heterocyclic group or the like; n is 0 or 1; R1 is hydrogen atom or the like; Ra is single bond or the like; A is nitrogen atom or the like; E is nitrogen atom or the like; Rb is single bond or the like; W is an aryl or the like] and its optical isomer, its hydrate, its solvate and its addition salt with a pharmaceutically acceptable acid are included.

公开(公告)号：WO2008037888A3

公开(公告)日：2008-06-12

申请号：PCT/FR2007001557

申请日：2007-09-25

Applicant: SERVIER LAB ,  PEGLION JEAN-LOUIS ,  POITEVIN CHRISTOPHE ,  MILLAN MARK ,  BROCCO MAURICETTE

Inventor： PEGLION JEAN-LOUIS ,  POITEVIN CHRISTOPHE ,  MILLAN MARK ,  BROCCO MAURICETTE

IPC: C07D498/04 ,  A61K31/538 ,  A61P25/00

CPC classification number: C07D498/04

Abstract: Compounds of formula (I), of trans relative configuration: in which: X is an oxygen atom or an NR 2 group, Y is a group selected from -CH 2 -, -(CH 2 ) 2 - and -CH=CH-, R 1 and R 2 , which may be identical or different, are each a hydrogen atom or a group selected from alkyl, cycloalkyl and cycloalkylalkyl, in racemic form or in the form of optical isomers, and also addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof. Said compounds are useful as dopaminergic receptor ligands for the treatment of central nervous system diseases.

Abstract translation: 式（I）化合物：反式相对构型：其中：X为氧原子或NR 2 H 2基团，Y为选自-CH 2 - ， - （CH 2）2 - 和 - CH = CH-，R 1和R 2， 其可以相同或不同，分别为氢原子或选自烷基，环烷基和环烷基烷基的基团，外消旋形式或旋光异构体形式，以及其与药学上可接受的酸及其水合物的加成盐 。 所述化合物可用作治疗中枢神经系统疾病的多巴胺能受体配体。

公开(公告)号：CY1120034T1

公开(公告)日：2018-12-12

申请号：CY181100138

申请日：2018-02-05

Applicant: SERVIER LAB

Inventor： CHIMENTI STEFANO ,  COURCHAY CHRISTINE ,  DESSINGES AIMÉE ,  GELLIBERT FRANÇOISE ,  GOUMENT BERTRAND ,  KONNERT MARC ,  PEGLION JEAN-LOUIS ,  POITEVIN CHRISTOPHE ,  VILAINE JEAN-PAUL ,  VILLENEUVE NICOLE

IPC: C07D217/02 ,  A61K31/472 ,  A61P9/00 ,  C07D217/24 ,  C07D405/06

Abstract: Ηεφεύρεσηαφοράσενέαπαράγωγαισοκινολίνηςτουτύπου (I), στησύνθεσηαυτώνκαιστηνχρήσηαυτώνστηνπρόληψηή/καιθεραπείαπαθολογιώνπουπροκύπτουναπότηνενεργοποίησητου RhoA/ROCK μονοπατιούκαιτηνφωσφορυλίωσητηςελαφράςαλύσουμυοσίνης. To Χαντιπροσωπεύειομάδα -C(=O)-, -CH(OH)- ή -CH2- καιοιάλλοιυποκατάστατεςαντιπροσωπεύουνδιάφορεςομάδεςόπωςαυτέςπουορίζονταιστηναξίωση 1.

公开(公告)号：PL3107900T3

公开(公告)日：2018-04-30

申请号：PL15709289

申请日：2015-02-20

Applicant: SERVIER LAB

Inventor： CHIMENTI STEFANO ,  COURCHAY CHRISTINE ,  DESSINGES AIMÉE ,  GELLIBERT FRANÇOISE ,  GOUMENT BERTRAND ,  KONNERT MARC ,  PEGLION JEAN-LOUIS ,  POITEVIN CHRISTOPHE ,  VILAINE JEAN-PAUL ,  VILLENEUVE NICOLE

IPC: C07D217/02 ,  A61K31/472 ,  A61P9/00 ,  C07D217/24 ,  C07D405/06

公开(公告)号：SG11201605662TA

公开(公告)日：2016-08-30

申请号：SG11201605662T

申请日：2015-02-20

Applicant: SERVIER LAB

Inventor： CHIMENTI STEFANO ,  COURCHAY CHRISTINE ,  DESSINGES AIMÉE ,  GELLIBERT FRANÇOISE ,  GOUMENT BERTRAND ,  KONNERT MARC ,  PEGLION JEAN-LOUIS ,  POITEVIN CHRISTOPHE ,  VILAINE JEAN-PAUL ,  VILLENEUVE NICOLE

IPC: A61K31/472 ,  C07D217/02 ,  A61P9/00 ,  C07D217/24 ,  C07D405/06

Abstract: Medicinal products containing the same which are useful in treating or preventing pathologies which are the result of activation of the RhoA/ROCK pathway and phosphorylation of the myosin light chain.

公开(公告)号：AU2015220659A1

公开(公告)日：2016-08-04

申请号：AU2015220659

申请日：2015-02-20

Applicant: SERVIER LAB

Inventor： CHIMENTI STEFANO ,  COURCHAY CHRISTINE ,  DESSINGES AIMEE ,  GELLIBERT FRANCOISE ,  GOUMENT BERTRAND ,  KONNERT MARC ,  PEGLION JEAN-LOUIS ,  POITEVIN CHRISTOPHE ,  VILAINE JEAN-PAUL ,  VILLENEUVE NICOLE

IPC: C07D217/02 ,  A61K31/472 ,  A61P9/00 ,  C07D217/24 ,  C07D405/06

Abstract: The invention relates to novel isoquinoline derivatives of formula (I), to the synthesis thereof, and to the use of same in the prevention and/or treatment of pathologies resulting from the activation of the RhoA/ROCK pathway and the phosphorylation of the light chain of myosin. X represents a group -C(=0)-, -CH(OH)- or -CH

公开(公告)号：FR3017868A1

公开(公告)日：2015-08-28

申请号：FR1451389

申请日：2014-02-21

Applicant: SERVIER LAB

Inventor： CHIMENTI STEFANO ,  COURCHAY CHRISTINE ,  DESSINGES AIMEE ,  GELLIBERT FRANCOISE ,  GOUMENT BERTRAND ,  KONNERT MARC ,  PEGLION JEAN-LOUIS ,  POITEVIN CHRISTOPHE ,  VILAINE JEAN-PAUL ,  VILLENEUVE NICOLE

IPC: C07D215/20 ,  A61K31/472 ,  A61P9/00 ,  A61P9/10 ,  C07D215/04

Abstract: Composé de formule (I) : dans laquelle les substituants sont tels que définis dans la revendication 1. Médicaments.

公开(公告)号：ES2351945T3

公开(公告)日：2011-02-14

申请号：ES07291135

申请日：2007-09-25

Applicant: SERVIER LAB

Inventor： MILLAN MARK ,  POITEVIN CHRISTOPHE ,  BROCCO MAURICETTE ,  PEGLION JEAN-LOUIS

IPC: C07D498/04 ,  A61K31/538 ,  A61P25/00

Abstract: Compuestos de fórmula I, con configuración relativa trans: en la que: X representa un átomo de oxígeno o un grupo NR2, Y representa un grupo seleccionado de entre -CH2-, -(CH2)2- y -CH=CH-, R1 y R2, idénticos o diferentes, representan cada uno un átomo de hidrógeno o un grupo seleccionado de entre alquilo(C1-C6) lineal o ramificado, cicloalquilo(C3-C8) y cicloalquilalquilo donde la parte alquilo tiene de 1 a 6 átomos de carbono y es lineal o ramificada y la parte cicloalquilo tiene de 3 a 8 átomos de carbono, en su forma racémica o isómeros ópticos, así como sus sales de adición de un ácido farmacéuticamente aceptable y sus hidratos.

公开(公告)号：SI1905775T1

公开(公告)日：2010-10-29

申请号：SI200730350

申请日：2007-09-25

Applicant: SERVIER LAB

Inventor： PEGLION JEAN-LOUIS ,  POITEVIN CHRISTOPHE ,  MILLAN MARK ,  BROCCO MAURICETTE

IPC: C07D498/00 ,  A61K31/5375 ,  A61P25/00