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公开(公告)号：CA2919572C
公开(公告)日：2017-06-20
申请号：CA2919572
申请日：2014-07-22
Applicant: VERNALIS (R&D) LTD , SERVIER LAB
Inventor： DAVIDSON JAMES EDWARD PAUL , MURRAY JAMES BROOKE , CHEN I-JEN , WALMSLEY CLAIRE , DODSWORTH MARK , MEISSNER JOHANNES W G , BROUGH PAUL , FEJES IMRE , TATAI JANOS , NYERGES MIKLOS , KOTSCHY ANDRAS , SZLAVIK ZOLTAN , GENESTE OLIVIER , LE TIRAN ARNAUD , LE DIGUARHER THIERRY , HENLIN JEAN-MICHEL , STARCK JEROME-BENOIT , GUILLOUZIC ANNE-FRANCOISE , DE NANTEUIL GUILLAUME
IPC: C07D401/14 , A61K31/4709 , A61K31/4725 , A61P35/00 , A61P37/00 , C07D401/10 , C07D405/14 , C07D409/14 , C07D471/04
Abstract: Compounds of formula (I): (I) wherein Het, R3, R4, R5, R7, R8, R9, T, p, p', q, and q' are as defined in the description are pro-apoptotic agents useful in the treatment of cancers and of auto-immune and immune system diseases.
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公开(公告)号：MD4793C1
公开(公告)日：2022-09-30
申请号：MD20160018
申请日：2014-07-22
Applicant: SERVIER LAB , VERNALIS R&D LTD
Inventor： DAVIDSON JAMES EDWARD PAUL , MURRAY JAMES BROOKE , CHEN I-JEN , WALMSLEY CLAIRE , DODSWORTH MARK , MEISSNER JOHANNES W G , BROUGH PAUL , FEJES IMRE , TATAI JANOS , NYERGES MIKLOS , KOTSCHY ANDRAS , SZLAVIK ZOLTAN , GENESTE OLIVIER , LE TIRAN ARNAUD , LE DIGUARHER THIERRY , HENLIN JEAN-MICHEL , STARCK JÉRÔME-BENOÎT , GUILLOUZIC ANNE-FRANÇOISE , DE NANTEUIL GUILLAUME
IPC: C07D401/14 , A61K31/4709 , A61K31/4725 , A61P35/00 , A61P37/00 , C07D401/10 , C07D405/14 , C07D409/14 , C07D471/04
Abstract: Invenţia se referă la compuşi noi de izoindolină sau izochinolină, la un procedeu de obţinere a lor şi la compoziţii farmaceutice care le conţin. Prezenta invenţie se referă, în special, la compuşii cu formula (I):unde substituenţii sunt definiţi în descrierea invenţiei. Compuşii, conform invenţiei, au proprietăţi pro-apoptotice, fapt ce permite utilizarea lor în patologii care implică un defect în apoptoză, cum ar fi, de exemplu, în tratamentul cancerului, bolilor autoimune şi bolilor sistemului imunitar.Revendicări: 35
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公开(公告)号：HK1218754A1
公开(公告)日：2017-03-10
申请号：HK16106761
申请日：2016-06-13
Applicant: SERVIER LAB
Inventor： DAVIDSON JAMES EDWARD PAUL , MURRAY JAMES BROOKE , CHEN I-JEN , WALMSLEY CLAIRE , DODSWORTH MARK , MEISSNER JOHANNES W G , BROUGH PAUL , FEJES IMRE , TATAI JANOS , NYERGES MIKLOS , KOTSCHY ANDRAS , SZLAVIK ZOLTAN , GENESTE OLIVIER , LE TIRAN ARNAUD , LE DIGUARHER THIERRY , HENLIN JEAN-MICHEL , STARCK JRME-BENOT , GUILLOUZIC ANNE-FRANOISE , DE NANTEUIL GUILLAUME
IPC: C07D20060101 , A61K20060101 , A61P20060101
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公开(公告)号：CU20160010A7
公开(公告)日：2016-06-29
申请号：CU20160010
申请日：2014-07-22
Applicant: SERVIER LAB , VERNALIS R&D LTD
Inventor： DAVIDSON JAMES EDWARD PAUL , MURRAY JAMES BROOKE , CHEN I-JEN , WALMSLEY CLAIRE , DODSWORTH MARK , MEISSNER JOHANNES W G , BROUGH PAUL , FEJES IMRE , TATAI JÁNOS , NYERGES MIKLÓS , KOTSCHY ANDRÁS , SZLÁVIK ZOLTÁN , GENESTE OLIVIER , LE TIRAN ARNAUD , LE DIGUARHER THIERRY , HENLIN JEAN-MICHEL , STARCK JÉRÔME-BENOÎT , GUILLOUZIC ANNE-FRANÇOISE , DE NANTEUIL GUILLAUME
IPC: A61K31/4709 , A61K31/4725 , A61P35/00 , A61P37/00 , C07D401/10 , C07D401/14 , C07D405/14 , C07D409/14 , C07D471/04
Abstract: Nuevos derivados de isoindolina o de isoquinolina de fórmula (I) útiles como inhibidores antiapoptóticos Bcl-2 ESPACIO PARA FÓRMULA en la que Het, R3, R4, R5, R7, R8, R9, T, p, p', q, y q' son como se han definido en la descripción y composiciones farmacéuticas que los contienen. Los compuestos de la presente invención tienen características muy valiosas en el campo de la apoptosis y la cancerología.
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公开(公告)号：MX2016000904A
公开(公告)日：2016-04-25
申请号：MX2016000904
申请日：2014-07-22
Applicant: SERVIER LAB
Inventor： NANTEUIL GUILLAUME DE , DIGUARHER THIERRY LE , GENESTE OLIVIER , STARCK JÉRÔME-BENOÎT , GUILLOUZIC ANNE-FRANÇOISE , FEJES IMRE , HENLIN JEAN-MICHEL , CHEN I-JEN , TATAI JANOS , NYERGES MIKLOS , MURRAY JAMES BROOKE , TIRAN ARNAUD LE , WALMSLEY CLAIRE , DAVIDSON JAMES EDWARD PAUL , DODSWORTH MARK , MEISSNER JOHANNES W G , BROUGH PAUL , KOTSCHY ANDRAS , SZLAVIK ZOLTAN
IPC: C07D401/14 , A61K31/4709 , A61K31/4725 , A61P35/00 , A61P37/00 , C07D401/10 , C07D405/14 , C07D409/14 , C07D471/04
Abstract: Compuestos de fórmula (I): (ver Fórmula) en la que Het, R3, R4, R5, R7, R8, R9, T, p, p', q, y q' son como se han definido en la descripción, son agentes pro-apoptóticos útiles en el tratamiento cánceres y de enfermedades auto-inmunes y del sistema inmunitario.
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Patent Agency Ranking
公开(公告)号：PH12016500034B1
公开(公告)日：2016-03-28
申请号：PH12016500034
申请日：2016-01-06
Applicant: SERVIER LAB , VERNALIS R AND D LTD
Inventor： MEISSNER JOHANNES W G , BROUGH PAUL , FEJES IMRE , TATAI JANOS , DAVIDSON JAMES EDWARD PAUL , MURRAY JAMES BROOKE , CHEN I-JEN , WALMSLEY CLAIRE , DODSWORTH MARK , NYERGES MIKLOS , KOTSCHY ANDRAS , SZLAVIK ZOLTAN , GENESTE OLIVIER , LE TIRAN ARNAUD , LE DIGUARHER THIERRY , HENLIN JEAN-MICHEL , STARCK JRME-BENOT , GUILLOUZIC ANNE-FRANOISE , DE NANTEUIL GUILLAUME
IPC: A61K31/4725 , A61K31/4709 , A61K45/00 , A61P35/00 , A61P37/00 , A61P43/00 , C07D401/10 , C07D401/14 , C07D405/14 , C07D409/14 , C07D471/04
Abstract: Compounds of formula (I): (I) wherein Het, R3, R4, R5, R7, R8, R9, T, p, p', q, and q' are as defined in the description. Medicaments.
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公开(公告)号：DOP2016000009A
公开(公告)日：2016-03-15
申请号：DO2016000009
申请日：2016-01-11
Applicant: VERNALIS R&D LTD , SERVIER LAB
Inventor： TIRAN ARNAUD LE , DIGUARHER THIERRY LE , HENLIN JEAN-MICHEL , NANTEUIL GUILLAUME DE , FEJES IMRE , NYERGES MIKLOS , MURRAY JAMES BROOKE , KOTSCHY ANDRAS , SZLAVIK ZOLTAN , DAVIDSON JAMES EDWARD PAUL , CHEN I-JEN , WALMSLEY CLAIRE , DODSWORTH MARK , MEISSNER JOHANNES W G , BROUGH PAUL , TATAI JANOS , GENESTE OLIVIER , STARCK JÉRÔME-BENOÎT , GUILLOUZIC ANNE-FRANÇOISE
IPC: A61K31/4709 , A61K31/4725 , A61P35/00 , A61P37/00 , C07D401/10 , C07D401/14 , C07D405/14 , C07D409/14 , C07D471/04
Abstract: Compuestos de fórmula (I): en la que Het, R3, R4, R5, R7, R8, R9, T, p, p, q, y q son como se han definido en la descripción. Medicamentos.
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公开(公告)号：UY35664A
公开(公告)日：2015-01-30
申请号：UY35664
申请日：2014-07-15
Applicant: SERVIER LAB , VERNALIS R & D LTD
Inventor： FEJES IMRE , ANNE-FRANÇOISE GUILLOUZIC , LAZLO NYERGES MIKLOS , JÁNOS TATAI , BROUGH PAUL , DODSWORTH MARK , KOTSCHY ANDRAS , JOHANNES MEISSNER , SZLAVIK ZOLTAN , I-JEN CHEN , PAUL DAVIDSON JAMES EDWARD , GUILLAUME DE NANTEUIL , GENESTE OLIVIER , JEAN-MICHEL HENLIN , THIERRY LE DIGUARHER , ARNAUD LE TIRAN , BROOKE MURRAY JAMES , JÉRÔME-BENOÎT STARCK
IPC: A61P35/00 , A61K31/472 , A61K31/551 , C07D207/00 , C07D209/02 , C07D217/00 , C07D223/14 , C07D225/06 , C07D401/14
Abstract: Compuestos de fórmula (I): en la que Het, R3, R4, R5, R7, R8, R9, T, p, p?, q, y q? son como se 5 han definido en la descripción.
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公开(公告)号：CY1121247T1
公开(公告)日：2020-05-29
申请号：CY191100175
申请日：2019-02-11
Applicant: SERVIER LAB
Inventor： DAVIDSON JAMES EDWARD PAUL , MURRAY JAMES BROOKE , CHEN I-JEN , WALMSLEY CLAIRE , DODSWORTH MARK , MEISSNER JOHANNES W G , BROUGH PAUL , FEJES IMRE , TATAI JANOS , NYERGES MIKLOS , KOTSCHY ANDRÁS , SZLAVIK ZOLTAN , GENESTE OLIVIER , LE TIRAN ARNAUD , LE DIGUARHER THIERRY , HENLIN JEAN-MICHEL , STARCK JÉRÔME-BENOÎT , GUILLOUZIC ANNE-FRANÇOISE , DE NANTEUIL GUILLAUME
IPC: C07D401/14 , A61K31/4709 , A61K31/4725 , A61P35/00 , A61P37/00 , C07D401/10 , C07D405/14 , C07D409/14 , C07D471/04
Abstract: Ενώσειςτουτύπου (I): (I) όπου Het, R3, R4, R5, R7, R8, R9, Τ, p, p', q και q' είναιόπωςορίζεταιστηνπεριγραφήείναιπρο-αποπτωτικοίπαράγοντεςχρήσιμοιστηθεραπείακαρκίνωνκαιαυτο-άνοσωνκαιτουανοσοποιητικούσυστήματοςασθενειών.
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公开(公告)号：ME03346B
公开(公告)日：2019-10-20
申请号：MEP201935
申请日：2014-07-22
Applicant: SERVIER LAB , VERNALIS R&D LTD
Inventor： DAVIDSON JAMES EDWARD PAUL , MURRAY JAMES BROOKE , CHEN I-JEN , WALMSLEY CLAIRE , DODSWORTH MARK , MEISSNER JOHANNES W G , BROUGH PAUL , FEJES IMRE , TATAI JANOS , NYERGES MIKLOS , KOTSCHY ANDRAS , SZLAVIK ZOLTAN , GENESTE OLIVIER , LE TIRAN ARNAUD , LE DIGUARHER THIERRY , HENLIN JEAN-MICHEL , STARCK JÉRÔME-BENOÎT , GUILLOUZIC ANNE-FRANÇOISE , DE NANTEUIL GUILLAUME
IPC: A61K31/4709 , A61K31/4725 , A61P35/00 , A61P37/00 , C07D401/10 , C07D401/14 , C07D405/14 , C07D409/14 , C07D471/04
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