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1.发明专利
公开(公告)号：PL3027602T3
公开(公告)日：2018-10-31
申请号：PL14758604
申请日：2014-07-22
Applicant: SERVIER LAB , VERNALIS R&D LTD
Inventor： CASARA PATRICK , LE DIGUARHER THIERRY , HENLIN JEAN-MICHEL , STARCK JÉRÔME-BENOÎT , LE TIRAN ARNAUD , DE NANTEUIL GUILLAUME , GENESTE OLIVIER , DAVIDSON JAMES EDWARD PAUL , MURRAY JAMES BROOKE , CHEN I-JEN , WALMSLEY CLAIRE , GRAHAM CHRISTOPHER JOHN , RAY STUART , MADDOX DANIEL , BEDFORD SIMON
IPC: C07D401/14 , A61K31/4709 , A61P35/00 , A61P37/00 , C07D401/10 , C07D405/14 , C07D471/04
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公开(公告)号：HRP20181333T1
公开(公告)日：2018-10-19
申请号：HRP20181333
申请日：2018-08-22
Applicant: SERVIER LAB , VERNALIS R&D LTD
Inventor： CASARA PATRICK , LE DIGUARHER THIERRY , HENLIN JEAN-MICHEL , STARCK JÉRÔME-BENOÎT , LE TIRAN ARNAUD , DE NANTEUIL GUILLAUME , GENESTE OLIVIER , DAVIDSON JAMES EDWARD PAUL , MURRAY JAMES BROOKE , CHEN I-JEN , WALMSLEY CLAIRE , GRAHAM CHRISTOPHER JOHN , RAY STUART , MADDOX DANIEL , BEDFORD SIMON
IPC: C07D401/14 , A61K31/4709 , A61P35/00 , A61P37/00 , C07D401/10 , C07D405/14 , C07D471/04
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公开(公告)号：CA2919572C
公开(公告)日：2017-06-20
申请号：CA2919572
申请日：2014-07-22
Applicant: VERNALIS (R&D) LTD , SERVIER LAB
Inventor： DAVIDSON JAMES EDWARD PAUL , MURRAY JAMES BROOKE , CHEN I-JEN , WALMSLEY CLAIRE , DODSWORTH MARK , MEISSNER JOHANNES W G , BROUGH PAUL , FEJES IMRE , TATAI JANOS , NYERGES MIKLOS , KOTSCHY ANDRAS , SZLAVIK ZOLTAN , GENESTE OLIVIER , LE TIRAN ARNAUD , LE DIGUARHER THIERRY , HENLIN JEAN-MICHEL , STARCK JEROME-BENOIT , GUILLOUZIC ANNE-FRANCOISE , DE NANTEUIL GUILLAUME
IPC: C07D401/14 , A61K31/4709 , A61K31/4725 , A61P35/00 , A61P37/00 , C07D401/10 , C07D405/14 , C07D409/14 , C07D471/04
Abstract: Compounds of formula (I): (I) wherein Het, R3, R4, R5, R7, R8, R9, T, p, p', q, and q' are as defined in the description are pro-apoptotic agents useful in the treatment of cancers and of auto-immune and immune system diseases.
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公开(公告)号：ZA201600415B
公开(公告)日：2017-03-29
申请号：ZA201600415
申请日：2016-01-12
Applicant: SERVIER LAB , VERNALIS (R&D) LTD
Inventor： GENESTE OLIVIER , DE NANTEUIL GUILLAUME , LE TIRAN ARNAUD , STARCK JÉRÔME-BENOÎT , HENLIN JEAN-MICHEL , LE DIGUARHER THIERRY , CASARA PATRICK , BEDFORD SIMON , MADDOX DANIEL , RAY STUART , GRAHAM CHRISTOPHER JOHN , WALMSLEY CLAIRE , CHEN I-JEN , MURRAY JAMES BROOKE , DAVIDSON JAMES EDWARD PAUL
Abstract: Medicinal products containing the same which are useful in treating conditions requiring a pro-apoptotic agent.
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公开(公告)号：MD4793C1
公开(公告)日：2022-09-30
申请号：MD20160018
申请日：2014-07-22
Applicant: SERVIER LAB , VERNALIS R&D LTD
Inventor： DAVIDSON JAMES EDWARD PAUL , MURRAY JAMES BROOKE , CHEN I-JEN , WALMSLEY CLAIRE , DODSWORTH MARK , MEISSNER JOHANNES W G , BROUGH PAUL , FEJES IMRE , TATAI JANOS , NYERGES MIKLOS , KOTSCHY ANDRAS , SZLAVIK ZOLTAN , GENESTE OLIVIER , LE TIRAN ARNAUD , LE DIGUARHER THIERRY , HENLIN JEAN-MICHEL , STARCK JÉRÔME-BENOÎT , GUILLOUZIC ANNE-FRANÇOISE , DE NANTEUIL GUILLAUME
IPC: C07D401/14 , A61K31/4709 , A61K31/4725 , A61P35/00 , A61P37/00 , C07D401/10 , C07D405/14 , C07D409/14 , C07D471/04
Abstract: Invenţia se referă la compuşi noi de izoindolină sau izochinolină, la un procedeu de obţinere a lor şi la compoziţii farmaceutice care le conţin. Prezenta invenţie se referă, în special, la compuşii cu formula (I):unde substituenţii sunt definiţi în descrierea invenţiei. Compuşii, conform invenţiei, au proprietăţi pro-apoptotice, fapt ce permite utilizarea lor în patologii care implică un defect în apoptoză, cum ar fi, de exemplu, în tratamentul cancerului, bolilor autoimune şi bolilor sistemului imunitar.Revendicări: 35
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Patent Agency Ranking
公开(公告)号：BR112016001333B1
公开(公告)日：2022-03-03
申请号：BR112016001333
申请日：2014-07-22
Applicant: SERVIER LAB , VERNALIS R&D LTD
Inventor： ARNAUD LE TIRAN , CHRISTOPHER JOHN GRAHAM , WALMSLEY CLAIRE , MADDOX DANIEL , GUILLAUME DE NANTEUIL , CHEN I-JEN , JAMES BROOKE MURRAY , JAMES EDWARD PAUL DAVIDSON , HENLIN JEAN-MICHEL , STARCK JÉRÔME-BENOÎT , GENESTE OLIVIER , CASARA PATRICK , BEDFORD SIMON , RAY STUART , THIERRY LE DIGUARHER
IPC: C07D401/10 , A61K31/4709 , A61P35/00 , A61P37/00 , C07D401/14 , C07D405/14 , C07D471/04
Abstract: derivados de indol e pirrol, processos para a produção dos mesmos e composições farmacêuticas contendo os mesmos. (i) a presente invenção refere-se aos compostos de fórmula (i), em que ra, rb, rc, rd, r3, r4, r5, a1, a2, t e w são como definidos na descrição. a invenção também se refere aos fármacos contendo os mesmos.
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公开(公告)号：AU2014294866B2
公开(公告)日：2018-09-27
申请号：AU2014294866
申请日：2014-07-22
Applicant: SERVIER LAB , VERNALIS R&D LTD
Inventor： CASARA PATRICK , LE DIGUARHER THIERRY , HENLIN JEAN-MICHEL , STARCK JEROME-BENOIT , LE TIRAN ARNAUD , DE NANTEUIL GUILLAUME , GENESTE OLIVIER , DAVIDSON JAMES EDWARD PAUL , MURRAY JAMES BROOKE , CHEN I-JEN , WALMSLEY CLAIRE , GRAHAM CHRISTOPHER JOHN , RAY STUART , MADDOX DANIEL , BEDFORD SIMON
IPC: C07D401/14 , A61K31/4709 , A61P35/00 , A61P37/00 , C07D401/10 , C07D405/14 , C07D471/04
Abstract: The invention relates to compounds of formula (I), wherein R
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公开(公告)号：SI3027602T1
公开(公告)日：2018-08-31
申请号：SI201430784
申请日：2014-07-22
Applicant: SERVIER LAB , VERNALIS R&D LTD
Inventor： CASARA PATRICK , LE DIGUARHER THIERRY , HENLIN JEAN-MICHEL , STARCK JEROME-BENOIT , LE TIRAN ARNAUD , DE NANTEUIL GUILLAUME , GENESTE OLIVIER , DAVIDSON JAMES EDWARD PAUL , MURRAY JAMES BROOKE , CHEN I-JEN , WALMSLEY CLAIRE , GRAHAM CHRISTOPHER JOHN , RAY STUART , MADDOX DANIEL , BEDFORD SIMON
IPC: C07D401/00 , A61K31/00 , A61P35/00 , A61P37/00 , C07D405/00 , C07D471/00
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公开(公告)号：EA028609B1
公开(公告)日：2017-12-29
申请号：EA201600121
申请日：2014-07-22
Applicant: SERVIER LAB , VERNALIS (R&D) LTD
Inventor： CASARA PATRICK , LE DIGUARHER THIERRY , HENLIN JEAN-MICHEL , STARCK JEROME-BENOIT , LE TIRAN ARNAUD , DE NANTEUIL GUILLAUME , GENESTE OLIVIER , DAVIDSON JAMES EDWARD PAUL , MURRAY JAMES BROOKE , CHEN I-JEN , WALMSLEY CLAIRE , GRAHAM CHRISTOPHER JOHN , RAY STUART , MADDOX DANIEL , BEDFORD SIMON
IPC: C07D401/14 , A61K31/4709 , A61P35/00 , A61P37/00 , C07D401/10 , C07D405/14 , C07D471/04
Abstract: Соединенияформулы (I)вкоторой R, R, R, R, R, R, R, A, A, T и W являютсятакими, какопределенов описании. Лекарственныесредства.
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公开(公告)号：HK1218754A1
公开(公告)日：2017-03-10
申请号：HK16106761
申请日：2016-06-13
Applicant: SERVIER LAB
Inventor： DAVIDSON JAMES EDWARD PAUL , MURRAY JAMES BROOKE , CHEN I-JEN , WALMSLEY CLAIRE , DODSWORTH MARK , MEISSNER JOHANNES W G , BROUGH PAUL , FEJES IMRE , TATAI JANOS , NYERGES MIKLOS , KOTSCHY ANDRAS , SZLAVIK ZOLTAN , GENESTE OLIVIER , LE TIRAN ARNAUD , LE DIGUARHER THIERRY , HENLIN JEAN-MICHEL , STARCK JRME-BENOT , GUILLOUZIC ANNE-FRANOISE , DE NANTEUIL GUILLAUME
IPC: C07D20060101 , A61K20060101 , A61P20060101
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