公开(公告)号：WO2008049997A3

公开(公告)日：2008-09-12

申请号：PCT/FR2007001708

申请日：2007-10-17

Applicant: SERVIER LAB ,  MARCHAND PASCAL ,  BADONNEAU VINCENT ,  PIESSARD SYLVIE ,  DUFLOS MURIEL ,  BOUTIN JEAN ALBERT ,  AUDINOT VALERIE ,  DELAGRANGE PHILIPPE ,  GAIGNARD DANIEL-HENRI

Inventor： MARCHAND PASCAL ,  BADONNEAU VINCENT ,  PIESSARD SYLVIE ,  DUFLOS MURIEL ,  BOUTIN JEAN ALBERT ,  AUDINOT VALERIE ,  DELAGRANGE PHILIPPE ,  GAIGNARD DANIEL-HENRI

IPC: C07D209/32 ,  A61K31/4045

CPC classification number: C07D209/14

Abstract: Compounds of formula (I): in which: R 1 is an alkyl, cycloalkyl or cycloalkylalkyl group, R 2 and R 3 form, together with the nitrogen atom which bears them, a heterocycle comprising from 5 to 8 ring members, and n is 2 to 6; medicaments.

Abstract translation: 式（I）化合物：其中：R 1是烷基，环烷基或环烷基烷基，R 2和R 3， 带有它们的氮原子，包含5至8个环成员的杂环，n为2至6; 药物。

公开(公告)号：WO2008049997A8

公开(公告)日：2009-05-22

申请号：PCT/FR2007001708

申请日：2007-10-17

Applicant: SERVIER LAB ,  MARCHAND PASCAL ,  BABONNEAU VINCENT ,  PIESSARD SYLVIE ,  DUFLOS MURIEL ,  BOUTIN JEAN ALBERT ,  AUDINOT VALERIE ,  DELAGRANGE PHILIPPE ,  CAIGNARD DANIEL-HENRI

Inventor： MARCHAND PASCAL ,  BABONNEAU VINCENT ,  PIESSARD SYLVIE ,  DUFLOS MURIEL ,  BOUTIN JEAN ALBERT ,  AUDINOT VALERIE ,  DELAGRANGE PHILIPPE ,  CAIGNARD DANIEL-HENRI

IPC: C07D209/32 ,  A61K31/4045

CPC classification number: C07D209/14

Abstract: Compounds of formula (I): in which: R1 is an alkyl, cycloalkyl or cycloalkylalkyl group, R2 and R3 form, together with the nitrogen atom which bears them, a heterocycle comprising from 5 to 8 ring members, and n is 2 to 6; medicaments.

Abstract translation: 式（I）化合物：其中：R1是烷基，环烷基或环烷基烷基，R2和R3与带有它们的氮原子一起形成包含5至8个环成员的杂环，n是2至6 ; 药物。

公开(公告)号：WO2008049996A3

公开(公告)日：2008-06-19

申请号：PCT/FR2007001707

申请日：2007-10-17

Applicant: SERVIER LAB ,  MARCHAND PASCAL ,  BABONNEAU VINCENT ,  PIESSARD SYLVIE ,  DUFLOS MURIEL ,  BOUTIN JEAN ALBERT ,  AUDINOT VALERIE ,  DELAGRANGE PHILIPPE ,  CAIGNARD DANIEL-HENRI

Inventor： MARCHAND PASCAL ,  BABONNEAU VINCENT ,  PIESSARD SYLVIE ,  DUFLOS MURIEL ,  BOUTIN JEAN ALBERT ,  AUDINOT VALERIE ,  DELAGRANGE PHILIPPE ,  CAIGNARD DANIEL-HENRI

IPC: C07D209/42 ,  A61K31/404 ,  A61P1/00 ,  A61P9/00 ,  A61P15/00 ,  A61P25/00 ,  A61P35/00

CPC classification number: C07D209/42

Abstract: The invention relates to compounds of formula (I), in which: R is an alkyl, cycloalkyl or cycloalkylalkyl group, R is a linear or branched (C 1 -C 6 ) alkyl group, and n is 1 to 6, and to the use thereof for the treatment of disorders in the melatoninergic system, such as sleep disorders, stress, anxiety, cardiovascular pathologies, etc..

Abstract translation: 本发明涉及式（I）化合物，其中：R是烷基，环烷基或环烷基烷基，R是直链或支链（C 1 -C 6 - ）烷基，n为1至6，以及其用于治疗褪黑激素系统中的疾病的用途，例如睡眠障碍，应激，焦虑，心血管病变等。

公开(公告)号：UA91646C2

公开(公告)日：2010-08-10

申请号：UAA200904633

申请日：2007-10-17

Applicant: SERVIER LAB

Inventor： MARCHAND PASCAL ,  BABONNEAU VINCENT ,  PIESSARD SYLVIE ,  DUFLOS MURIEL ,  BOUTIN JEAN ALBERT ,  AUDINOT VALERIE ,  DELAGRANGE PHILIPPE ,  GAIGNARD DANIEL-HENRI

IPC: C07D209/42 ,  A61K31/404 ,  A61P3/04 ,  A61P15/00 ,  A61P25/00 ,  A61P35/00

公开(公告)号：MA30795B1

公开(公告)日：2009-10-01

申请号：MA31791

申请日：2009-04-16

Applicant: SERVIER LAB

Inventor： MARCHAND PASCAL ,  BABONNEAU VINCENT ,  PIESSARD SYLVIE ,  DUFLOS MURIEL ,  BOUTIN JEAN ALBERT ,  AUDINOT VALERIE ,  DELAGRANGE PHILIPPE ,  CAIGNARD DANIEL-HENRI

IPC: C07D209/42 ,  A61K31/404 ,  A61P1/00 ,  A61P15/00 ,  A61P25/00 ,  A61P35/00 ,  A61P9/00

Abstract: COMPOSÉS DE FORMULE (I), DANS LAQUELLE R1 REPRÉSENTE UN GROUPEMENT ALKYLE, CYCLOALKYLE, OU CYCLOALKYLALKYLE; R2 REPRÉSENTE UN GROUPEMENT ALKYLE (C1-C6) LINÉAIRE OU RAMIFIÉ; ET N REPRÉSENTE 1 À 6, ET LEUR UTILISATION POUR TRAITER LES TROUBLES DU SYSTÈME MÉLATONINERGIQUE TELS QUE LES TROUBLES DU SOMMEIL, LE STRESS, L'ANXIÉTÉ, LES PATHOLOGIES CARDIOVASCULAIRES, ETC.

公开(公告)号：BRPI0717453A2

公开(公告)日：2013-12-24

申请号：BRPI0717453

申请日：2007-10-17

Applicant: SERVIER LAB

Inventor： MARCHAND PASCAL ,  BABONNEAU VINCENT ,  PIESSARD SYLVIE ,  DUFLOS MURIEL ,  BOUTIN JEAN-ALBERT ,  AUDINOT VALERIE ,  DELAGRANGE PHILIPPE ,  CAIGNARD DANIEL-HENRI

IPC: C07D209/42 ,  A61K31/404 ,  A61P1/00 ,  A61P9/00 ,  A61P15/00 ,  A61P25/00 ,  A61P35/00

Abstract: Indole derivatives (I), their enantiomers, diastereomers and their acid/base addition salts are new. Indole derivatives of formula (I), their enantiomers, diastereomers and their acid/base addition salts are new. R 11-6C alkyl, 3-8C cycloalkyl or 3-8C cycloalkyl-1-6C alkyl, preferably methyl; R 21-6C alkyl, preferably methyl, ethyl or propyl; and n : 1-6, preferably 2. An independent claim is included for the preparation of (I). [Image] ACTIVITY : Hypnotic; Tranquilizer; Antidepressant; Cardiovascular-Gen; Gastrointestinal-Gen; Neuroleptic; Anorectic; Anticonvulsant; Antidiabetic; Antiparkinsonian; Nootropic; Antimigraine; Neuroprotective; Endocrine-Gen; Contraceptive; Immunomodulator; Cytostatic. MECHANISM OF ACTION : Melatonin receptor binder. The affinity of (I) to bind with melatonin receptors MT1 and MT2 was tested using 2-[ 1> 2> 5>I]-iodomelatonin as reference radioligand. The results showed that (I) exhibited an inhibition constant value of less than 1 mu M.

公开(公告)号：ZA200902413B

公开(公告)日：2010-07-28

申请号：ZA200902413

申请日：2007-10-17

Applicant: SERVIER LAB

Inventor： MARCHAND PASCAL ,  BABONNEAU VINCENT ,  PIESSARD SYLVIE ,  DUFLOS MURIEL ,  BOUTIN JEAN ALBERT ,  AUDINOT VALERIE ,  DELAGRANGE PHILIPPE ,  GAIGNARD DANIEL-HENRI

IPC: A61K20100101 ,  A61P20100101 ,  C07D20100101

Abstract: Indole derivatives (I), their enantiomers, diastereomers and their acid/base addition salts are new. Indole derivatives of formula (I), their enantiomers, diastereomers and their acid/base addition salts are new. R 11-6C alkyl, 3-8C cycloalkyl or 3-8C cycloalkyl-1-6C alkyl, preferably methyl; R 21-6C alkyl, preferably methyl, ethyl or propyl; and n : 1-6, preferably 2. An independent claim is included for the preparation of (I). [Image] ACTIVITY : Hypnotic; Tranquilizer; Antidepressant; Cardiovascular-Gen; Gastrointestinal-Gen; Neuroleptic; Anorectic; Anticonvulsant; Antidiabetic; Antiparkinsonian; Nootropic; Antimigraine; Neuroprotective; Endocrine-Gen; Contraceptive; Immunomodulator; Cytostatic. MECHANISM OF ACTION : Melatonin receptor binder. The affinity of (I) to bind with melatonin receptors MT1 and MT2 was tested using 2-[ 1> 2> 5>I]-iodomelatonin as reference radioligand. The results showed that (I) exhibited an inhibition constant value of less than 1 mu M.

公开(公告)号：FR2907452B1

公开(公告)日：2008-12-12

申请号：FR0609114

申请日：2006-10-18

Applicant: SERVIER LAB

Inventor： MARCHAND PASCAL ,  BABONNEAU VINCENT ,  PIESSARD SYLVIE ,  DUFLOS SYLVIE ,  BOUTIN JEAN ALBERT ,  AUDINOT VALERIE ,  DELAGRANGE PHILIPPE ,  CAIGNARD DANIEL HENRI

IPC: C07D209/42 ,  A61K31/404 ,  A61P3/04 ,  A61P15/00 ,  A61P25/00 ,  A61P35/00

Abstract: Indole derivatives (I), their enantiomers, diastereomers and their acid/base addition salts are new. Indole derivatives of formula (I), their enantiomers, diastereomers and their acid/base addition salts are new. R 11-6C alkyl, 3-8C cycloalkyl or 3-8C cycloalkyl-1-6C alkyl, preferably methyl; R 21-6C alkyl, preferably methyl, ethyl or propyl; and n : 1-6, preferably 2. An independent claim is included for the preparation of (I). [Image] ACTIVITY : Hypnotic; Tranquilizer; Antidepressant; Cardiovascular-Gen; Gastrointestinal-Gen; Neuroleptic; Anorectic; Anticonvulsant; Antidiabetic; Antiparkinsonian; Nootropic; Antimigraine; Neuroprotective; Endocrine-Gen; Contraceptive; Immunomodulator; Cytostatic. MECHANISM OF ACTION : Melatonin receptor binder. The affinity of (I) to bind with melatonin receptors MT1 and MT2 was tested using 2-[ 1> 2> 5>I]-iodomelatonin as reference radioligand. The results showed that (I) exhibited an inhibition constant value of less than 1 mu M.

公开(公告)号：CA2666497A1

公开(公告)日：2008-05-02

申请号：CA2666497

申请日：2007-10-17

Applicant: SERVIER LAB

Inventor： MARCHAND PASCAL ,  PIESSARD SYLVIE ,  BOUTIN JEAN ALBERT ,  DUFLOS MURIEL ,  AUDINOT VALERIE ,  BABONNEAU VINCENT ,  DELAGRANGE PHILIPPE ,  CAIGNARD DANIEL-HENRI

IPC: C07D209/42 ,  A61K31/404 ,  A61P1/00 ,  A61P9/00 ,  A61P15/00 ,  A61P25/00 ,  A61P35/00

Abstract: Composés de formule (I), dans laquelle R1 représente un groupement alkyle , cycloalkyle, ou cycloalkylalkyle; R2 représente un groupement alkyle (C1-C 6) linéaire ou ramifié; et n représente 1 à 6, et leur utilisation pour trai ter les troubles du système mélatoninergique tels que les troubles du sommei l, le stress, l'anxiété, les pathologies cardiovasculaires, etc.

公开(公告)号：UA91645C2

公开(公告)日：2010-08-10

申请号：UAA200904632

申请日：2007-10-17

Applicant: SERVIER LAB

Inventor： MARCHAND PASCAL ,  BABONNEAU VINCENT ,  PIESSARD SYLVIE ,  DUFLOS MURIEL ,  BOUTIN JEAN ALBERT ,  AUDINOT VALERIE ,  DELAGRANGE PHILIPPE ,  GAIGNARD DANIEL-HENRI

IPC: C07D209/32 ,  A61K31/454 ,  A61P3/04 ,  A61P15/00 ,  A61P25/00 ,  A61P35/00