公开(公告)号：US20220389517A1

公开(公告)日：2022-12-08

申请号：US17815082

申请日：2022-07-26

Applicant: SHIZUOKA PREFECTURE ,  SHIZUOKA PREFECTURAL UNIVERSITY CORPORATION

Inventor： Ken YAMAGUCHI ,  Masatoshi KUSUHARA ,  Masakuni SERIZAWA ,  Tohru MOCHIZUKI ,  Keiichi OHSHIMA ,  Keiichi HATAKEYAMA ,  Kenichi URAKAMI ,  Shumpei OHNAMI ,  Yasuto AKIYAMA ,  Kouji MARUYAMA ,  Kengo INOUE ,  Yuji SHIMODA ,  Takeshi NAGASHIMA ,  Yoshinobu ISHIKAWA

IPC: C12Q1/6886 ,  G01N33/574

Abstract: An object of the present invention is to provide a method for predicting a risk of developing cancer. DNA samples were prepared from blood and cancer tissues of 2480 cancer patients and analyzed for the nucleotide sequences of exon regions using NGS. As a result, among the cancer patients, 7 patients were confirmed to have D49H mutation or A159D mutation which is a germ cell mutation.

公开(公告)号：US20200255901A1

公开(公告)日：2020-08-13

申请号：US16322895

申请日：2017-08-03

Applicant: Shizuoka Prefecture ,  Shizuoka Prefectural University Corporation

Inventor： Ken YAMAGUCHI ,  Masatoshi KUSUHARA ,  Masakuni SERIZAWA ,  Tohru MOCHIZUKI ,  Keiichi OHSHIMA ,  Keiichi HATAKEYAMA ,  Kenichi URAKAMI ,  Shumpei OHNAMI ,  Yasuto AKIYAMA ,  Kouji MARUYAMA ,  Kengo INOUE ,  Yuji SHIMODA ,  Takeshi NAGASHIMA ,  Yoshinobu ISHIKAWA

IPC: C12Q1/6886 ,  G01N33/574

Abstract: An object of the present invention is to provide a method for predicting a risk of developing cancer. DNA samples were prepared from blood and cancer tissues of 2480 cancer patients and analyzed for the nucleotide sequences of exon regions using NGS. As a result, among the cancer patients, 7 patients were confirmed to have D49H mutation or A159D mutation which is a germ cell mutation.