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1.发明申请ESTRATRIENE DERIVATIVES AND THEIR USES AS 17BETA-HYDR0XYSTER0ID DEHYDROGENASE INHIBITORS 审中-公开雌二醇衍生物及其作为17BETA-HYDROXYSTER0ID DEHYDROGENASE抑制剂的用途
公开(公告)号：WO2008034796A3
公开(公告)日：2008-07-03
申请号：PCT/EP2007059785
申请日：2007-09-17
Applicant: SOLVAY PHARM GMBH , MESSINGER JOSEF , SCHOEN UWE , HUSEN BETTINA , THOLE HEINRICH-HUBERT , KOSKIMIES PASI , KALLIO LILA
Inventor： MESSINGER JOSEF , SCHOEN UWE , HUSEN BETTINA , THOLE HEINRICH-HUBERT , KOSKIMIES PASI , KALLIO LILA
CPC classification number: C07J43/003
Abstract: This invention relates to novel estratrien-triazoles of general formula (I) useful in therapy, especially for use in the treatment and/or prevention of a steroid hormone dependent disorder, preferably a steroid hormone dependent disease or disorder requiring the inhibition of a 17ß-hydroxysteroid dehydrogenase (17ß-HSD) such as 17ß-HSD type 1, type 2 or type 3 enzyme.
Abstract translation: 本发明涉及可用于治疗，特别是用于治疗和/或预防类固醇激素依赖性病症，优选类固醇激素依赖性疾病或病症的通式（I）的新颖的雌三醇 - 三唑，其需要抑制17β- 羟基类固醇脱氢酶（17β-HSD），如17β-HSD 1型，2型或3型酶。
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公开(公告)号：AU2004325692B2
公开(公告)日：2012-01-19
申请号：AU2004325692
申请日：2004-12-13
Applicant: SOLVAY PHARM GMBH
Inventor： HIRVELA LEENA , KOSKIMIES PASI , MESSINGER JOSEF , LEHTOVUORI PEKKA , THOLE HEINRICH-HUBERT , SAARENKETO PAULI , HUSEN BETTINA , VAN STEEN BARTHOLOMEUS JOHANNES , KALLIO LILA , KIVINIEMI JOHANNA , PENTIKAINEN OLLI TANELI , UNKILA MIKKO
IPC: C07D495/04 , A61K31/519
Abstract: This invention relates to novel substituted thiophenepyrimidinone derivatives and their use in therapy, especially for use in the treatment and/or prevention of a steroid hormone dependent diseases or disorder, such as steroid hormone dependent diseases or disorders requiring inhibition of 17&bgr;-hydroxysteroid dehydrogenase enzymes.
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3.发明专利
公开(公告)号：PL1828197T3
公开(公告)日：2009-11-30
申请号：PL04804787
申请日：2004-12-13
Applicant: SOLVAY PHARM GMBH
Inventor： HIRVELÄ LEENA , HUSEN BETTINA , KIVINIEMI JOHANNA , KOSKIMIES PASI , LEHTOVUORI PEKKA , MESSINGER JOSEF , PENTIKÄINEN OLLI TANELI , KALLIO LILA , SAARENKETO PAULI , THOLE HEINRICH-HUBERT , UNKILA MIKKO , VAN STEEN BARTHOLOMEUS JOHANNES
IPC: C07D495/04 , A61K31/519
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公开(公告)号：DE602004021145D1
公开(公告)日：2009-06-25
申请号：DE602004021145
申请日：2004-12-13
Applicant: SOLVAY PHARM GMBH
Inventor： HIRVELAE LEENA , HUSEN BETTINA , KIVINIEMI JOHANNA , KOSKIMIES PASI , LEHTOVUORI PEKKA , MESSINGER JOSEF , PENTIKAEINEN OLLI TANELI , KALLIO LILA , SAARENKETO PAULI , THOLE HEINRICH-HUBERT , UNKILA MIKKO , VAN STEEN BARTHOLOMEUS JOHANNES
IPC: C07D495/04 , A61K31/519
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公开(公告)号：CA2609726C
公开(公告)日：2013-10-01
申请号：CA2609726
申请日：2006-05-24
Applicant: SOLVAY PHARM GMBH
Inventor： MESSINGER JOSEF , THOLE HEINRICH-HUBERT , HUSEN BETTINA , KOSKIMIES PASI , KALLIO LILA , WESKE MICHAEL
Abstract: The present invention relates to novel substituted steroid derivatives which represent selectiv inhibitors of the 17.beta.-hydroxysteroid dehydrogenase type I (17.beta.-HSD1) and, in addition, which may represent inhibitors of the steroid sulphatase, as well as to their salts, to pharmaceutical preparations containing these compounds and to processes for the preparation of these compounds. Furthermore, the invention concerns the therapeutic use of said novel substituted steroid derivatives, particularly their use in the treatment or prevention of steroid hormone dependent diseases or disorders, such as steroid hormone dependent diseases or disorders requiring the inhibition of 17.beta.-hydroxysteroid dehydrogenase type I and/or steroid sulphatase enzymes and/or requiring the lowering of the endogenous 17.beta.-estradiol concentration.
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Patent Agency Ranking
公开(公告)号：HK1131157A1
公开(公告)日：2010-01-15
申请号：HK09109130
申请日：2009-10-02
Applicant: SOLVAY PHARM GMBH
Inventor： MESSINGER JOSEF , SCHOEN UWE , HUSEN BETTINA , HEINRICH-HUBERT THOLE H , KOSKIMIES PASI , KALLIO LILA
IPC: A61K20060101 , A61P20060101 , C07J20060101
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公开(公告)号：CA2663242A1
公开(公告)日：2008-03-27
申请号：CA2663242
申请日：2007-09-17
Applicant: SOLVAY PHARM GMBH
Inventor： SCHOEN UWE , KOSKIMIES PASI , THOLE HEINRICH-HUBERT , MESSINGER JOSEF , HUSEN BETTINA , KALLIO LILA
Abstract: This invention relates to novel estratrien-triazoles of general formula ( I) useful in therapy, especially for use in the treatment and/or prevention of a steroid hormone dependent disorder, preferably a steroid hormone depend ent disease or disorder requiring the inhibition of a 17.beta.-hydroxysteroi d dehydrogenase (17.beta.-HSD) such as 17.beta.-HSD type 1, type 2 or type 3 enzyme.
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公开(公告)号：AU2007299010A1
公开(公告)日：2008-03-27
申请号：AU2007299010
申请日：2007-09-17
Applicant: SOLVAY PHARM GMBH
Inventor： SCHOEN UWE , HUSEN BETTINA , MESSINGER JOSEF , KOSKIMIES PASI , KALLIO LILA , THOLE HEINRICH-HUBERT
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公开(公告)号：AU2007299010B2
公开(公告)日：2013-01-31
申请号：AU2007299010
申请日：2007-09-17
Applicant: SOLVAY PHARM GMBH
Inventor： MESSINGER JOSEF , HUSEN BETTINA , KALLIO LILA , SCHOEN UWE , THOLE HEINRICH-HUBERT , KOSKIMIES PASI
Abstract: This invention relates to novel estratrien-triazoles of general formula (I) useful in therapy, especially for use in the treatment and/or prevention of a steroid hormone dependent disorder, preferably a steroid hormone dependent disease or disorder requiring the inhibition of a 17&bgr;-hydroxysteroid dehydrogenase (17&bgr;-HSD) such as 17&bgr;-HSD type 1, type 2 or type 3 enzyme.
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公开(公告)号：AT431351T
公开(公告)日：2009-05-15
申请号：AT04804787
申请日：2004-12-13
Applicant: SOLVAY PHARM GMBH
Inventor： HIRVELAE LEENA , HUSEN BETTINA , KIVINIEMI JOHANNA , KOSKIMIES PASI , LEHTOVUORI PEKKA , MESSINGER JOSEF , PENTIKAEINEN OLLI TANELI , KALLIO LILA , SAARENKETO PAULI , THOLE HEINRICH-HUBERT , UNKILA MIKKO , VAN STEEN BARTHOLOMEUS JOHANNES
IPC: C07D495/04 , A61K31/519
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